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Volume 104, Issue 9

November 1 2004

In this Issue

INSIDE BLOOD
BLOOD WORK
REVIEW ARTICLES
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

CLINICAL OBSERVATIONS

Gene expression arrays and the therapist's dilemma

A. Thomas Look

View Articletitled, Gene expression arrays and the therapist's dilemma

GENE THERAPY

Your Ad here: optimizing adenoviral vector-based vaccines

H. Kim Lyerly

View Articletitled, Your Ad here: optimizing adenoviral vector-based vaccines

CLINICAL OBSERVATIONS

Autologous transplantation for newly diagnosed follicular lymphoma: cure at last or not yet?

Koen van Besien

View Articletitled, Autologous transplantation for newly diagnosed follicular lymphoma: cure at last or not yet?

GENE THERAPY

Testing novel hemophilia therapies: of mice and men

David Lillicrap

View Articletitled, Testing novel hemophilia therapies: of mice and men

HEMOSTASIS

The endothelial life insurance plan

David C. Sane

View Articletitled, The endothelial life insurance plan

HEMOSTASIS

Endothelial progenitor cells: reporting for duty

Monica Bessler

View Articletitled, Endothelial progenitor cells: reporting for duty

CLINICAL OBSERVATIONS

Great oaks from little acorns

Bruce Matthew Camitta

View Articletitled, Great oaks from little acorns

IMMUNOBIOLOGY

New ways for lymphocytes to meet

Michael L. Dustin

View Articletitled, New ways for lymphocytes to meet

HEMOSTASIS

Antiphospholipid antibodies: a mosaic of pathogenic effects?

Silvia S. Pierangeli

View Articletitled, Antiphospholipid antibodies: a mosaic of pathogenic effects?

RED CELLS

Iron and cell proliferation: another piece of the puzzle

Prem Ponka

View Articletitled, Iron and cell proliferation: another piece of the puzzle

BLOOD WORK

Erythroblastic island

View Articletitled, Erythroblastic island

REVIEW ARTICLES

Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications
Clinical Trials & Observations

Kiarash Kojouri,Sara K. Vesely,Deirdra R. Terrell,James N. George

View Articletitled, Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications

From the bench to the bedside: ways to improve rituximab efficacy
Brief Report

Guillaume Cartron,Hervé Watier,Josée Golay,Philippe Solal-Celigny

View Articletitled, From the bench to the bedside: ways to improve rituximab efficacy

CHEMOKINES

A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow
Clinical Trials & Observations

Robert F. Wynn,Claire A. Hart,Carla Corradi-Perini,Liam O'Neill,Caroline A. Evans,J. Ed Wraith,Leslie J. Fairbairn,Ilaria Bellantuono

View Articletitled, A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes
Clinical Trials & Observations

Norman J. Lacayo,Soheil Meshinchi,Paivi Kinnunen,Ron Yu,Yan Wang,Christianna M. Stuber,Lorrie Douglas,Romina Wahab,David L. Becton,Howard Weinstein,Myron N. Chang,Cheryl L. Willman,Jerald P. Radich,Robert Tibshirani,Yaddanapudi Ravindranath,Branimir I. Sikic,Gary V. Dahl

View Articletitled, Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes

Imatinib mesylate (STI571) for treatment of children with Philadelphia chromosome-positive leukemia: results from a Children's Oncology Group phase 1 study
Clinical Trials & Observations

Martin A. Champagne,Renaud Capdeville,Mark Krailo,Wenchun Qu,Bin Peng,Marianne Rosamilia,Martine Therrien,Ulrike Zoellner,Susan M. Blaney,Mark Bernstein

View Articletitled, Imatinib mesylate (STI571) for treatment of children with Philadelphia chromosome-positive leukemia: results from a Children's Oncology Group phase 1 study

Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma
Clinical Trials & Observations

Norma C. Gutiérrez,Juan L. García,Jesús M. Hernández,Eva Lumbreras,Mariana Castellanos,Ana Rasillo,Gema Mateo,José M. Hernández,Sonia Pérez,Alberto Orfao,Jesús F. San Miguel

View Articletitled, Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma

Myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission prolongs progression-free survival in follicular lymphoma: results of a prospective, randomized trial of the German Low-Grade Lymphoma Study Group
Clinical Trials & Observations

Georg Lenz,Martin Dreyling,Eva Schiegnitz,Roswitha Forstpointner,Hannes Wandt,Mathias Freund,Georg Hess,Lorenz Truemper,Volker Diehl,Martin Kropff,Michael Kneba,Norbert Schmitz,Bernd Metzner,Markus Pfirrmann,Michael Unterhalt,Wolfgang Hiddemann

View Articletitled, Myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission prolongs progression-free survival in follicular lymphoma: results of a prospective, randomized trial of the German Low-Grade Lymphoma Study Group

Comparison of initial characteristics and long-term outcome of patients with lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphoma at clinical stages IA and IIA prospectively treated by brief anthracycline-based chemotherapies plus extended high-dose irradiation
Clinical Trials & Observations

Pierre Feugier,Eric Labouyrie,Malika Djeridane,Arash Jenabian,Viviane Dubruille,Christian Berthou,Christiane Ghandour,Bernard Desablens,Yasmine Chaït,Philippe Casassus,Vincent Delwail,Norbert Ifrah,Annick Le Mevel,Thierry Lamy,Josette Brière,Pierre Colonna,Jean-Marie Andrieu

View Articletitled, Comparison of initial characteristics and long-term outcome of patients with lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphoma at clinical stages IA and IIA prospectively treated by brief anthracycline-based chemotherapies plus extended high-dose irradiation

Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects
Clinical Trials & Observations

Leon J. Schurgers,Martin J. Shearer,Karly Hamulyák,Elisabeth Stöcklin,Cees Vermeer

View Articletitled, Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects

Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital

Ching-Hon Pui,John T. Sandlund,Deqing Pei,Dario Campana,Gaston K. Rivera,Raul C. Ribeiro,Jeffrey E. Rubnitz,Bassem I. Razzouk,Scott C. Howard,Melissa M. Hudson,Cheng Cheng,Larry E. Kun,Susana C. Raimondi,Frederick G. Behm,James R. Downing,Mary V. Relling,William E. Evans

View Articletitled, Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital

GENE THERAPY

Targeted retroviral transduction of c-kit⁺ hematopoietic cells using novel ligand display technology

Anil Chandrashekran,Myrtle Y. Gordon,Colin Casimir

View Articletitled, Targeted retroviral transduction of c-kit+ hematopoietic cells using novel ligand display technology

Multistep process through which adenoviral vector vaccine overcomes anergy to tumor-associated antigens

Yucheng Tang,Lixin Zhang,Jing Yuan,Hakan Akbulut,Jonathan Maynard,Phyllis-Jean Linton,Albert Deisseroth

View Articletitled, Multistep process through which adenoviral vector vaccine overcomes anergy to tumor-associated antigens

Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy

Simon N. Waddington,Megha S. Nivsarkar,Ajay R. Mistry,Suzanne M. K. Buckley,Geoffrey Kemball-Cook,Karen L. Mosley,Kyriacos Mitrophanous,Pippa Radcliffe,Maxine V. Holder,Mairi Brittan,Anastasios Georgiadis,Faisal Al-Allaf,Brian W. Bigger,Lisa G. Gregory,H. Terence Cook,Robin R. Ali,Adrian Thrasher,Edward G. D. Tuddenham,Mike Themis,Charles Coutelle

View Articletitled, Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy

HEMATOPOIESIS

Human marrow megakaryocyte differentiation: multiparameter correlative analysis identifies von Willebrand factor as a sensitive and distinctive marker for early (2N and 4N) megakaryocytes

Aaron Tomer

View Articletitled, Human marrow megakaryocyte differentiation: multiparameter correlative analysis identifies von Willebrand factor as a sensitive and distinctive marker for early (2N and 4N) megakaryocytes

Suspended cells from trabecular bone by collagenase digestion become virtually identical to mesenchymal stem cells obtained from marrow aspirates
Brief Report

Yusuke Sakaguchi,Ichiro Sekiya,Kazuyoshi Yagishita,Shizuko Ichinose,Kenichi Shinomiya,Takeshi Muneta

View Articletitled, Suspended cells from trabecular bone by collagenase digestion become virtually identical to mesenchymal stem cells obtained from marrow aspirates

Susceptibility of human fetal mesencyhmal stem cells to Kaposi sarcoma-associated herpesvirus

Christopher H. Parsons,Barbara Szomju,Dean H. Kedes

View Articletitled, Susceptibility of human fetal mesencyhmal stem cells to Kaposi sarcoma-associated herpesvirus

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

A novel type 2A von Willebrand factor mutation located at the last nucleotide of exon 26 (3538G>A) causes skipping of 2 nonadjacent exons

Paula D. James,Lee A. O'Brien,Carol A. Hegadorn,Colleen R. P. Notley,Gary D. Sinclair,Christine Hough,Man-Chiu Poon,David Lillicrap

View Articletitled, A novel type 2A von Willebrand factor mutation located at the last nucleotide of exon 26 (3538G>A) causes skipping of 2 nonadjacent exons

Role of endogenous thrombin in tumor implantation, seeding, and spontaneous metastasis

Liang Hu,Merlin Lee,Wendy Campbell,Roman Perez-Soler,Simon Karpatkin

View Articletitled, Role of endogenous thrombin in tumor implantation, seeding, and spontaneous metastasis

Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood

David A. Ingram,Laura E. Mead,Hiromi Tanaka,Virginia Meade,Amy Fenoglio,Kelly Mortell,Karen Pollok,Michael J. Ferkowicz,David Gilley,Mervin C. Yoder

View Articletitled, Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood

Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro

Mihail Hristov,Wolfgang Erl,Stefan Linder,Peter C. Weber

View Articletitled, Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro

Novel hemophilia B mouse models exhibiting a range of mutations in the Factor IX gene

Denise E. Sabatino,Elina Armstrong,Shyrie Edmonson,Yi-Lin Liu,Marc Pleimes,Joerg Schuettrumpf,Julie Fitzgerald,Roland W. Herzog,Valder R. Arruda,Katherine A. High

View Articletitled, Novel hemophilia B mouse models exhibiting a range of mutations in the Factor IX gene

Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide

Baard Olav Jensen,Frode Selheim,Stein Ove Døskeland,Adrian R. L. Gear,Holm Holmsen

View Articletitled, Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide

Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome
Brief Report

Jacob H. Rand,Xiao-Xuan Wu,Robert Lapinski,Waander L. van Heerde,Chris P. Reutelingsperger,Pojen P. Chen,Thomas L. Ortel

View Articletitled, Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome

The homozygous FcγRIIIa-158V genotype is a risk factor for heparin-induced thrombocytopenia in patients with antibodies to heparin-platelet factor 4 complexes

Yves Gruel,Claire Pouplard,Dominique Lasne,Charlotte Magdelaine-Beuzelin,Chloé Charroing,Hervé Watier

View Articletitled, The homozygous FcγRIIIa-158V genotype is a risk factor for heparin-induced thrombocytopenia in patients with antibodies to heparin-platelet factor 4 complexes

IMMUNOBIOLOGY

Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution
Clinical Trials & Observations

Terry J. Fry,Manoj Sinha,Matthew Milliron,Yu-Waye Chu,Veena Kapoor,Ronald E. Gress,Elaine Thomas,Crystal L. Mackall

View Articletitled, Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution

A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo

Matthias Gunzer,Carsten Weishaupt,Anja Hillmer,Yasmin Basoglu,Peter Friedl,Kurt E. Dittmar,Waldemar Kolanus,Georg Varga,Stephan Grabbe

View Articletitled, A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo

Supplemental data

HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation

Anna Smed-Sörensen,Karin Loré,Lilian Walther-Jallow,Jan Andersson,Anna-Lena Spetz

View Articletitled, HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation

Paxillin selectively associates with constitutive and chemoattractant-induced high-affinity α4β1 integrins: implications for integrin signaling

Sharon J. Hyduk,Jiwon Oh,Haiyan Xiao,Mian Chen,Myron I. Cybulsky

View Articletitled, Paxillin selectively associates with constitutive and chemoattractant-induced high-affinity α4β1 integrins: implications for integrin signaling

GPI-anchor deficiency in myeloid cells causes impaired FcγR effector functions

Wouter L. W. Hazenbos,Björn E. Clausen,Junji Takeda,Taroh Kinoshita

View Articletitled, GPI-anchor deficiency in myeloid cells causes impaired FcγR effector functions

Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition

David E. Sloane,Nicodemus Tedla,Muyiwa Awoniyi,Donald W. MacGlashan, Jr,Luis Borges,K. Frank Austen,Jonathan P. Arm

View Articletitled, Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition

Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells

William J. Grossman,James W. Verbsky,Benjamin L. Tollefsen,Claudia Kemper,John P. Atkinson,Timothy J. Ley

View Articletitled, Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells

E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII)

Nienke van der Stoep,Edwin Quinten,Marisa Marcondes Rezende,Peter J. van den Elsen

View Articletitled, E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII)

KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity

Yanmei Han,Minghui Zhang,Nan Li,Taoyong Chen,Yi Zhang,Tao Wan,Xuetao Cao

View Articletitled, KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity

NEOPLASIA

Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518

Jennifer J. Clark,Jan Cools,David P. Curley,Jin-Chen Yu,Nathalie A. Lokker,Neill A. Giese,D. Gary Gilliland

View Articletitled, Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518

Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor

Nisha Shah,Rebecca J. Asch,Alana S. Lysholm,Tucker W. LeBien

View Articletitled, Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor

Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia

Gerard Tobin,Ulf Thunberg,Karin Karlsson,Fiona Murray,Anna Laurell,Kerstin Willander,Gunilla Enblad,Mats Merup,Juhani Vilpo,Gunnar Juliusson,Christer Sundström,Ola Söderberg,Göran Roos,Richard Rosenquist

View Articletitled, Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia

VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis

Steven Le Gouill,Klaus Podar,Martine Amiot,Teru Hideshima,Dharminder Chauhan,Kenji Ishitsuka,Shaji Kumar,Noopur Raje,Paul G. Richardson,Jean-Luc Harousseau,Kenneth C. Anderson

View Articletitled, VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis

Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo

Eunice S. Wang,Julie Teruya-Feldstein,Yan Wu,Zhenping Zhu,Daniel J. Hicklin,Malcolm A. S. Moore

View Articletitled, Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo

The small GTPase Rac1 links the Kaposi sarcoma–associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia

Silvia Montaner,Akrit Sodhi,Joan-Marc Servitja,Amanda K. Ramsdell,Ana Barac,Earl T. Sawai,J. Silvio Gutkind

View Articletitled, The small GTPase Rac1 links the Kaposi sarcoma–associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia

Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis

Ian J. Griswold,Lei J. Shen,Paul La Rosée,Shadmehr Demehri,Michael C. Heinrich,Rita M. Braziel,Laura McGreevey,Andrea D. Haley,Neill Giese,Brian J. Druker,Michael W.N. Deininger

View Articletitled, Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis

Characterization of acute lymphoblastic leukemia progenitor cells

Charlotte V. Cox,Roger S. Evely,Anthony Oakhill,Derwood H. Pamphilon,Nicholas J. Goulden,Allison Blair

View Articletitled, Characterization of acute lymphoblastic leukemia progenitor cells

Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations

Susan Branford,Zbigniew Rudzki,Ian Parkinson,Andrew Grigg,Kerry Taylor,John F. Seymour,Simon Durrant,Peter Browett,Anthony P. Schwarer,Chris Arthur,John Catalano,Michael F. Leahy,Robin Filshie,Kenneth Bradstock,Richard Herrmann,David Joske,Kevin Lynch,Tim Hughes

View Articletitled, Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations

Strong expression of FOXP1 identifies a distinct subset of diffuse large B-cell lymphoma (DLBCL) patients with poor outcome
Clinical Trials & Observations Brief Report

Sharon L. Barrans,James A. L. Fenton,Alison Banham,Roger G. Owen,Andrew S. Jack

View Articletitled, Strong expression of FOXP1 identifies a distinct subset of diffuse large B-cell lymphoma (DLBCL) patients with poor outcome

BCL2 protein expression parallels its mRNA level in normal and malignant B cells
Brief Report

Yulei Shen,Javeed Iqbal,James Z. Huang,Guimei Zhou,Wing C. Chan

View Articletitled, BCL2 protein expression parallels its mRNA level in normal and malignant B cells

Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump
Brief Report

Herman Burger,Hans van Tol,Antonius W. M. Boersma,Mariël Brok,Erik A. C. Wiemer,Gerrit Stoter,Kees Nooter

View Articletitled, Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump

Protease inhibitors potentiate chemotherapy-induced neutropenia
Clinical Trials & Observations Brief Report

Mark Bower,Neil McCall-Peat,Natalie Ryan,Liz Davies,Anne Marie Young,Srirupa Gupta,Mark Nelson,Brian Gazzard,Justin Stebbing

View Articletitled, Protease inhibitors potentiate chemotherapy-induced neutropenia

PHAGOCYTES

Dual role of phagocytic NADPH oxidase in bacterial killing

Balázs K. Rada,Miklós Geiszt,Krisztina Káldi,Csaba Timár,Erzsébet Ligeti

View Articletitled, Dual role of phagocytic NADPH oxidase in bacterial killing

RED CELLS

KCl cotransport mediates abnormal sulfhydryl-dependent volume regulation in sickle reticulocytes

Clinton H. Joiner,R. Kirk Rettig,Maorong Jiang,Robert S. Franco

View Articletitled, KCl cotransport mediates abnormal sulfhydryl-dependent volume regulation in sickle reticulocytes

Ability of Plasmodium falciparum to invade Southeast Asian ovalocytes varies between parasite lines

Alfred Cortés,Ariadna Benet,Brian M. Cooke,John W. Barnwell,John C. Reeder

View Articletitled, Ability of Plasmodium falciparum to invade Southeast Asian ovalocytes varies between parasite lines

Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation

Nghia T.V. Le,Des R. Richardson

View Articletitled, Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation

TRANSPLANTATION

Limits of HLA mismatching in unrelated hematopoietic cell transplantation
Clinical Trials & Observations

Effie W. Petersdorf,Claudio Anasetti,Paul J. Martin,Ted Gooley,Jerald Radich,Mari Malkki,Ann Woolfrey,Anajane Smith,Eric Mickelson,John A. Hansen

View Articletitled, Limits of HLA mismatching in unrelated hematopoietic cell transplantation

Human fetal, cord blood, and adult lymphocyte progenitors have similar potential for generating B cells with a diverse immunoglobulin repertoire

Grant R. Kolar,Takafumi Yokota,Maria Isabel D. Rossi,Swapan K. Nath,J. Donald Capra

View Articletitled, Human fetal, cord blood, and adult lymphocyte progenitors have similar potential for generating B cells with a diverse immunoglobulin repertoire

Supplemental data

CORRESPONDENCE

Do β-globin, GATA-1,or EpoR regulatory domains specifically mark erythroid progenitors in transgenic reporter mice?

Norio Suzuki,Shigehiko Imagawa,Constance T. Noguchi,Masayuki Yamamoto

View Articletitled, Do β-globin, GATA-1,or EpoR regulatory domains specifically mark erythroid progenitors in transgenic reporter mice?

IL-1 gene cluster polymorphisms and development of primary gastric B-cell lymphoma in Helicobacter pylori infection

Stephan Hellmig,Steffen Vollenberg,Maria-Elisabeth Goebeler-Kolve,Wolfgang Fischbach,Jochen Hampe,Ulrich Robert Fölsch,Stefan Schreiber

View Articletitled, IL-1 gene cluster polymorphisms and development of primary gastric B-cell lymphoma in Helicobacter pylori infection

The PRV-1 gene expression in essential thrombocythemia

Luciana Teofili,Maurizio Martini,Francesco Guidi,Daniela Venditti,Giuseppe Leone,M. Luigi Larocca

View Articletitled, The PRV-1 gene expression in essential thrombocythemia

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Deironing the spleen with luspatercept

Cold comfort in sickle cell disease

Cold agglutinin syndrome with unexpected bone marrow CD5⁺ diffuse large B-cell lymphoma

Deciphering and Disrupting PIEZO1-TMEM16F Interplay in Hereditary Xerocytosis

CAR T-Cell Therapy in Multiple Myeloma: Mission Accomplished?

Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

REVIEW ARTICLES

Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications Clinical Trials & Observations

From the bench to the bedside: ways to improve rituximab efficacy Brief Report

CHEMOKINES

A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow Clinical Trials & Observations

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes Clinical Trials & Observations

Imatinib mesylate (STI571) for treatment of children with Philadelphia chromosome-positive leukemia: results from a Children's Oncology Group phase 1 study Clinical Trials & Observations

Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma Clinical Trials & Observations

Myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission prolongs progression-free survival in follicular lymphoma: results of a prospective, randomized trial of the German Low-Grade Lymphoma Study Group Clinical Trials & Observations

Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

Suspended cells from trabecular bone by collagenase digestion become virtually identical to mesenchymal stem cells obtained from marrow aspirates Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome Brief Report

IMMUNOBIOLOGY

Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution Clinical Trials & Observations

NEOPLASIA

Strong expression of FOXP1 identifies a distinct subset of diffuse large B-cell lymphoma (DLBCL) patients with poor outcome Clinical Trials & Observations Brief Report

BCL2 protein expression parallels its mRNA level in normal and malignant B cells Brief Report

Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump Brief Report

Protease inhibitors potentiate chemotherapy-induced neutropenia Clinical Trials & Observations Brief Report

PHAGOCYTES

RED CELLS

TRANSPLANTATION

Limits of HLA mismatching in unrelated hematopoietic cell transplantation Clinical Trials & Observations

CORRESPONDENCE

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American Society of Hematology

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Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications
Clinical Trials & Observations

From the bench to the bedside: ways to improve rituximab efficacy
Brief Report

A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow
Clinical Trials & Observations

Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes
Clinical Trials & Observations

Imatinib mesylate (STI571) for treatment of children with Philadelphia chromosome-positive leukemia: results from a Children's Oncology Group phase 1 study
Clinical Trials & Observations

Prognostic and biologic significance of chromosomal imbalances assessed by comparative genomic hybridization in multiple myeloma
Clinical Trials & Observations

Myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission prolongs progression-free survival in follicular lymphoma: results of a prospective, randomized trial of the German Low-Grade Lymphoma Study Group
Clinical Trials & Observations

Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects
Clinical Trials & Observations

Suspended cells from trabecular bone by collagenase digestion become virtually identical to mesenchymal stem cells obtained from marrow aspirates
Brief Report

Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome
Brief Report

Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution
Clinical Trials & Observations

Strong expression of FOXP1 identifies a distinct subset of diffuse large B-cell lymphoma (DLBCL) patients with poor outcome
Clinical Trials & Observations Brief Report

BCL2 protein expression parallels its mRNA level in normal and malignant B cells
Brief Report

Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump
Brief Report

Protease inhibitors potentiate chemotherapy-induced neutropenia
Clinical Trials & Observations Brief Report

Limits of HLA mismatching in unrelated hematopoietic cell transplantation
Clinical Trials & Observations