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Volume 104, Issue 6

September 15 2004

In this Issue

INSIDE BLOOD
PERSPECTIVES
ERRATA
REVIEW ARTICLES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

HEMATOPOIESIS

Too much ERK, not enough erythrocytes

Thomas M. Guadagno

View Articletitled, Too much ERK, not enough erythrocytes

IMMUNOBIOLOGY

CD20 Trek: the next generation

Ronald P. Taylor

View Articletitled, CD20 Trek: the next generation

HEMATOPOIESIS

A mastermind revealed

Shiv Pillai

View Articletitled, A mastermind revealed

TRANSPLANTATION

Sharpening therapeutic strategy in AL amyloidosis

Giampaolo Merlini

View Articletitled, Sharpening therapeutic strategy in AL amyloidosis

HEMOSTASIS

A more clinically relevant mouse model of hemophilia B

Katherine Parker Ponder

View Articletitled, A more clinically relevant mouse model of hemophilia B

HEMOSTASIS

APC stripped bare

Roger J. S. Preston,David A. Lane

View Articletitled, APC stripped bare

IMMUNOBIOLOGY

Plasmacytoid dendritic cell: vive le dilettante!

Marco Colonna

View Articletitled, Plasmacytoid dendritic cell: vive le dilettante!

HEMATOPOIESIS

Vitamin A metabolism and stemness

Edward F. Srour

View Articletitled, Vitamin A metabolism and stemness

NEOPLASIA

Reducing cholesterol and overcoming drug resistance

Steven Grant

View Articletitled, Reducing cholesterol and overcoming drug resistance

PERSPECTIVES

Do antiangiogenic protein fragments have amyloid properties?

Martijn F. B. G. Gebbink,Emile E. Voest,Arie Reijerkerk

View Articletitled, Do antiangiogenic protein fragments have amyloid properties?

ERRATA

Erratum for vol. 102, p. 2292

View Articletitled, Erratum for vol. 102, p. 2292

REVIEW ARTICLES

Integrins: dynamic scaffolds for adhesion and signaling in platelets

Sanford J. Shattil,Peter J. Newman

View Articletitled, Integrins: dynamic scaffolds for adhesion and signaling in platelets

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Reduced-intensity allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia with multilineage dysplasia using fludarabine, busulphan, and alemtuzumab (FBC) conditioning
Clinical Trials & Observations

Aloysius Y. L. Ho,Antonio Pagliuca,Michelle Kenyon,Jane E. Parker,Aleksandar Mijovic,Stephen Devereux,Ghulam J. Mufti

View Articletitled, Reduced-intensity allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia with multilineage dysplasia using fludarabine, busulphan, and alemtuzumab (FBC) conditioning

Outcome with the hyper-CVAD regimens in lymphoblastic lymphoma
Clinical Trials & Observations

Deborah A. Thomas,Susan O'Brien,Jorge Cortes,Francis J. Giles,Stefan Faderl,Srdan Verstovsek,Alessandra Ferrajoli,Charles Koller,Miloslav Beran,Sherry Pierce,Chul S. Ha,Fernando Cabanillas,Michael J. Keating,Hagop Kantarjian

View Articletitled, Outcome with the hyper-CVAD regimens in lymphoblastic lymphoma

GENE THERAPY

Adenovirus-mediated intralesional interferon-γ gene transfer induces tumor regressions in cutaneous lymphomas
Clinical Trials & Observations

Reinhard Dummer,Jessica C. Hassel,Friederike Fellenberg,Stefan Eichmüller,Tanja Maier,Philippe Slos,Bruce Acres,Pascal Bleuzen,Vincent Bataille,Patrick Squiban,Günter Burg,Mirjana Urosevic

View Articletitled, Adenovirus-mediated intralesional interferon-γ gene transfer induces tumor regressions in cutaneous lymphomas

HEMATOPOIESIS

C/EBPα deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo

Victoria Heath,Hyung Chan Suh,Matthew Holman,Katie Renn,John M. Gooya,Sarah Parkin,Kimberly D. Klarmann,Mariaestela Ortiz,Peter Johnson,Jonathan Keller

View Articletitled, C/EBPα deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo

Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity

David A. Hess,Todd E. Meyerrose,Louisa Wirthlin,Timothy P. Craft,Phillip E. Herrbrich,Michael H. Creer,Jan A. Nolta

View Articletitled, Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity

Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments

Eiichi Morii,Keisuke Oboki,Katsuhiko Ishihara,Tomoko Jippo,Toshio Hirano,Yukihiko Kitamura

View Articletitled, Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments

Extracellular nucleotides are potent stimulators of human hematopoietic stem cells in vitro and in vivo

Roberto M. Lemoli,Davide Ferrari,Miriam Fogli,Lara Rossi,Cinzia Pizzirani,Sylvia Forchap,Paola Chiozzi,Diletta Vaselli,Francesco Bertolini,Thomas Foutz,Michela Aluigi,Michele Baccarani,Francesco Di Virgilio

View Articletitled, Extracellular nucleotides are potent stimulators of human hematopoietic stem cells in vitro and in vivo

Bystander destruction of hematopoietic progenitor and stem cells in a mouse model of infusion-induced bone marrow failure

Jichun Chen,Karen Lipovsky,Felicia M. Ellison,Rodrigo T. Calado,Neal S. Young

View Articletitled, Bystander destruction of hematopoietic progenitor and stem cells in a mouse model of infusion-induced bone marrow failure

Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors

Jing Zhang,Harvey F. Lodish

View Articletitled, Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors

Rescue of lethal c-Kit^W/W mice by erythropoietin

Claudia Waskow,Grzegorz Terszowski,Céline Costa,Max Gassmann,Hans-Reimer Rodewald

View Articletitled, Rescue of lethal c-KitW/W mice by erythropoietin

Mastermind critically regulates Notch-mediated lymphoid cell fate decisions

Ivan Maillard,Andrew P. Weng,Andrea C. Carpenter,Carlos G. Rodriguez,Hong Sai,Lanwei Xu,David Allman,Jon C. Aster,Warren S. Pear

View Articletitled, Mastermind critically regulates Notch-mediated lymphoid cell fate decisions

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Impaired platelet responses to thrombin and collagen in AKT-1–deficient mice

Juhua Chen,Sarmishtha De,Derek S. Damron,William S. Chen,Nissim Hay,Tatiana V. Byzova

View Articletitled, Impaired platelet responses to thrombin and collagen in AKT-1–deficient mice

Pathogenic antiphospholipid antibody: an antigen-selected needle in a haystack

Patricia Lieby,Vincent Poindron,Stamatiki Roussi,Cyril Klein,Anne-Marie Knapp,Jean-Claude Garaud,Martine Cerutti,Thierry Martin,Jean-Louis Pasquali

View Articletitled, Pathogenic antiphospholipid antibody: an antigen-selected needle in a haystack

Role of protein kinase Cζ in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1

Xiaochun Li,Christopher N. Hahn,Michelle Parsons,Jenny Drew,Mathew A. Vadas,Jennifer R. Gamble

View Articletitled, Role of protein kinase Cζ in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1

Histone H1–like protein participates in endothelial cell–specific activation of the von Willebrand factor promoter

Xinyu Wang,Yiwen Peng,Yuliang Ma,Nadia Jahroudi

View Articletitled, Histone H1–like protein participates in endothelial cell–specific activation of the von Willebrand factor promoter

Creation of a mouse expressing defective human factor IX

Da-Yun Jin,Tai-Ping Zhang,Tong Gui,Darrel W. Stafford,Paul E. Monahan

View Articletitled, Creation of a mouse expressing defective human factor IX

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity

Laurent O. Mosnier,Andrew J. Gale,Subramanian Yegneswaran,John H. Griffin

View Articletitled, Activated protein C variants with normal cytoprotective but reduced anticoagulant activity

Reciprocal cross-talk between P2Y₁ and P2Y₁₂ receptors at the level of calcium signaling in human platelets

Adam R. Hardy,Matthew L. Jones,Stuart J. Mundell,Alastair W. Poole

View Articletitled, Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets

Heparin-activated antithrombin interacts with the autolysis loop of target coagulation proteases

Likui Yang,Chandrashekhara Manithody,Alireza R. Rezaie

View Articletitled, Heparin-activated antithrombin interacts with the autolysis loop of target coagulation proteases

Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jκ

Farrell MacKenzie,Patrick Duriez,Bruno Larrivée,Linda Chang,Ingrid Pollet,Fred Wong,Calvin Yip,Aly Karsan

View Articletitled, Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jκ

Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium

Joachim R. Göthert,Sonja E. Gustin,J. Anke M. van Eekelen,Uli Schmidt,Mark A. Hall,Stephen M. Jane,Anthony R. Green,Berthold Göttgens,David J. Izon,C. Glenn Begley

View Articletitled, Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium

IMMUNOBIOLOGY

Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers α-defensin production

Anick Chalifour,Pascale Jeannin,Jean-François Gauchat,Aline Blaecke,Martine Malissard,Thien N'Guyen,Nathalie Thieblemont,Yves Delneste

View Articletitled, Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers α-defensin production

Humoral immunity to HIV-1: kinetics of antibody responses in chronic infection reflects capacity of immune system to improve viral set point
Clinical Trials & Observations

Alexandra Trkola,Herbert Kuster,Christine Leemann,Annette Oxenius,Catherine Fagard,Hansjakob Furrer,Manuel Battegay,Pietro Vernazza,Enos Bernasconi,Rainer Weber,Bernard Hirschel,Sebastian Bonhoeffer,Huldrych F. Günthard,for the Swiss HIV Cohort Study

View Articletitled, Humoral immunity to HIV-1: kinetics of antibody responses in chronic infection reflects capacity of immune system to improve viral set point

Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

Jessica L. Teeling,Ruth R. French,Mark S. Cragg,Jeroen van den Brakel,Marielle Pluyter,Haichun Huang,Claude Chan,Paul W. H. I. Parren,C. Erik Hack,Michael Dechant,Thomas Valerius,Jan G. J. van de Winkel,Martin J. Glennie

View Articletitled, Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

FcγRIII discriminates between 2 subsets of Vγ9Vδ2 effector cells with different responses and activation pathways

Daniela F. Angelini,Giovanna Borsellino,Mary Poupot,Adamo Diamantini,Rémy Poupot,Giorgio Bernardi,Fabrizio Poccia,Jean-Jacques Fournié,Luca Battistini

View Articletitled, FcγRIII discriminates between 2 subsets of Vγ9Vδ2 effector cells with different responses and activation pathways

Supplemental data

Murine plasmacytoid dendritic cells induce effector/memory CD8⁺ T-cell responses in vivo after viral stimulation

Géraldine Schlecht,Sylvie Garcia,Nicolas Escriou,Antonio A. Freitas,Claude Leclerc,Gilles Dadaglio

View Articletitled, Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation

Supplemental data

NEOPLASIA

Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells

Deborah E. Banker,Sasha J. Mayer,Henry Y. Li,Cheryl L. Willman,Frederick R. Appelbaum,Richard A. Zager

View Articletitled, Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells

The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion–mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase

Ralf Schmidmaier,Philipp Baumann,Meral Simsek,Farshid Dayyani,Bertold Emmerich,Gerold Meinhardt

View Articletitled, The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion–mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase

Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias

Susan E. Shetzline,Ravikumar Rallapalli,Kelley J. Dowd,Shaomin Zou,Yuji Nakata,Cezary R. Swider,Anna Kalota,John K. Choi,Alan M. Gewirtz

View Articletitled, Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias

Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition

Patrick Brown,Soheil Meshinchi,Mark Levis,Todd A. Alonzo,Robert Gerbing,Beverly Lange,Robert Arceci,Donald Small

View Articletitled, Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition

Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database

Lynn R. Goldin,Ruth M. Pfeiffer,Xinjun Li,Kari Hemminki

View Articletitled, Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database

Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML
Clinical Trials & Observations

Jingrui Jiang,J. Guillermo Paez,Jeffrey C. Lee,Ronghai Bo,Richard M. Stone,Daniel J. DeAngelo,Ilene Galinsky,Brian M. Wolpin,Anna Jonasova,Paula Herman,Edward A. Fox,Titus J. Boggon,Michael J. Eck,Ellen Weisberg,James D. Griffin,D. Gary Gilliland,Matthew Meyerson,William R. Sellers

View Articletitled, Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML

PHAGOCYTES

An endothelial laminin isoform, laminin 8 (α4β1γ1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis

Zenebech Wondimu,Tarekegn Geberhiwot,Sulev Ingerpuu,Erkki Juronen,Xun Xie,Lennart Lindbom,Masayuki Doi,Jarkko Kortesmaa,Jill Thyboll,Karl Tryggvason,Bengt Fadeel,Manuel Patarroyo

View Articletitled, An endothelial laminin isoform, laminin 8 (α4β1γ1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis

Heat-shock protein 70 exerts opposing effects on Vpr-dependent and Vpr-independent HIV-1 replication in macrophages

Sergey Iordanskiy,Yuqi Zhao,Paola DiMarzio,Isabelle Agostini,Larisa Dubrovsky,Michael Bukrinsky

View Articletitled, Heat-shock protein 70 exerts opposing effects on Vpr-dependent and Vpr-independent HIV-1 replication in macrophages

RED CELLS

Directed differentiation and mass cultivation of pure erythroid progenitors from mouse embryonic stem cells

Sebastian Carotta,Sandra Pilat,Andreas Mairhofer,Uwe Schmidt,Helmut Dolznig,Peter Steinlein,Hartmut Beug

View Articletitled, Directed differentiation and mass cultivation of pure erythroid progenitors from mouse embryonic stem cells

TRANSPLANTATION

Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation
Clinical Trials & Observations

Angela Dispenzieri,Morie A. Gertz,Robert A. Kyle,Martha Q. Lacy,Mary F. Burritt,Terry M. Therneau,Joseph P. McConnell,Mark R. Litzow,Dennis A. Gastineau,Ayalew Tefferi,David J. Inwards,Ivana N. Micallef,Stephen M. Ansell,Luis F. Porrata,Michelle A. Elliott,William J. Hogan,S. Vincent Rajkumar,Rafael Fonseca,Philip R. Greipp,Thomas E. Witzig,John A. Lust,Steven R. Zeldenrust,Denise S. Snow,Susan R. Hayman,Christopher G. A. McGregor,Allan S. Jaffe

View Articletitled, Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation

Improvement in quality of life of patients with AL amyloidosis treated with high-dose melphalan and autologous stem cell transplantation
Clinical Trials & Observations

David C. Seldin,Jennifer J. Anderson,Vaishali Sanchorawala,Karim Malek,Daniel G. Wright,Karen Quillen,Kathleen T. Finn,John L. Berk,Laura M. Dember,Rodney H. Falk,Martha Skinner

View Articletitled, Improvement in quality of life of patients with AL amyloidosis treated with high-dose melphalan and autologous stem cell transplantation

Supplemental data

Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation
Clinical Trials & Observations

Kristina M. Adams,Leona A. Holmberg,Wendy Leisenring,Alexander Fefer,Katherine A. Guthrie,Tracy S. Tylee,George B. McDonald,William I. Bensinger,J. Lee Nelson

View Articletitled, Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation

Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor Study
Clinical Trials & Observations

K. Scott Baker,James G. Gurney,Kirsten K. Ness,Ravi Bhatia,Stephen J. Forman,Liton Francisco,Philip B. McGlave,Leslie L. Robison,David S. Snyder,Daniel J. Weisdorf,Smita Bhatia

View Articletitled, Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor Study

CORRESPONDENCE

Increased resistance to activated protein C in women taking third-generation oral contraceptives?

Jean-Christophe Gris,Eva Nouvellon-Cochery,Pierre Marès

View Articletitled, Increased resistance to activated protein C in women taking third-generation oral contraceptives?

A91V is a polymorphism in the perforin gene not causative of an FHLH phenotype

Udo zur Stadt,Karin Beutel,Belinda Weber,Hartmut Kabisch,Reinhard Schneppenheim,Gritta Janka

View Articletitled, A91V is a polymorphism in the perforin gene not causative of an FHLH phenotype

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Issue Archive

Table of Contents

INSIDE BLOOD

PERSPECTIVES

ERRATA

REVIEW ARTICLES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Reduced-intensity allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia with multilineage dysplasia using fludarabine, busulphan, and alemtuzumab (FBC) conditioning Clinical Trials & Observations

Outcome with the hyper-CVAD regimens in lymphoblastic lymphoma Clinical Trials & Observations

GENE THERAPY

Adenovirus-mediated intralesional interferon-γ gene transfer induces tumor regressions in cutaneous lymphomas Clinical Trials & Observations

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

Humoral immunity to HIV-1: kinetics of antibody responses in chronic infection reflects capacity of immune system to improve viral set point Clinical Trials & Observations

NEOPLASIA

Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML Clinical Trials & Observations

PHAGOCYTES

RED CELLS

TRANSPLANTATION

Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation Clinical Trials & Observations

Improvement in quality of life of patients with AL amyloidosis treated with high-dose melphalan and autologous stem cell transplantation Clinical Trials & Observations

Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation Clinical Trials & Observations

Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor Study Clinical Trials & Observations

CORRESPONDENCE

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American Society of Hematology

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Reduced-intensity allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia with multilineage dysplasia using fludarabine, busulphan, and alemtuzumab (FBC) conditioning
Clinical Trials & Observations

Outcome with the hyper-CVAD regimens in lymphoblastic lymphoma
Clinical Trials & Observations

Adenovirus-mediated intralesional interferon-γ gene transfer induces tumor regressions in cutaneous lymphomas
Clinical Trials & Observations

Humoral immunity to HIV-1: kinetics of antibody responses in chronic infection reflects capacity of immune system to improve viral set point
Clinical Trials & Observations

Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML
Clinical Trials & Observations

Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation
Clinical Trials & Observations

Improvement in quality of life of patients with AL amyloidosis treated with high-dose melphalan and autologous stem cell transplantation
Clinical Trials & Observations

Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation
Clinical Trials & Observations

Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor Study
Clinical Trials & Observations