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Issue Archive

Volume 104, Issue 2
July 15 2004
Blood Cover Image for Volume 104, Issue 2

Table of Contents

INSIDE BLOOD

NEOPLASIA
A “Ras-in-ALL” model of signaling?
Mignon Loh,Kevin M. Shannon
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CLINICAL OBSERVATIONS, INTERVENTIONS, & THERAPEUTIC TRIALS
Childhood stroke frequency decreased in California during 1999 and 2000
Darleen R. Powars
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HEMOSTASIS, THROMBOSIS, & VASCULAR BIOLOGY
Dotting the I of an I-domain
Joel S. Bennett
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HEMOSTASIS, THROMBOSIS, & VASCULAR BIOLOGY
Clotting and cancer progression: platelets count
Michael E. Bromberg
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HEMOSTASIS, THROMBOSIS, & VASCULAR BIOLOGY
Anticoagulation by a thrombin precursor
Sriram Krishnaswamy
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IMMUNOBIOLOGY
The WHIMs of leukocytes
Steven M. Holland
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NEOPLASIA
CB2, a paradigm for a novel class of “onco-GPCRs”?
Pierre Casellas
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NEOPLASIA
CXCR-4: homing in on Flt3
Mark Levis
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TRANSPLANTATION
When to transplant in myelodysplasia? Markov helps
Jeff Szer
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PLENARY PAPERS

Genetic evidence for lineage-related and differentiation stage–related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia
Marco Tartaglia,Simone Martinelli,Giovanni Cazzaniga,Viviana Cordeddu,Ivano Iavarone,Monica Spinelli,Chiara Palmi,Claudio Carta,Andrea Pession,Maurizio Aricò,Giuseppe Masera,Giuseppe Basso,Mariella Sorcini,Bruce D. Gelb,Andrea Biondi
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Supplemental data

CHEMOKINES

Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments
Inger Øynebråten,Oddmund Bakke,Per Brandtzaeg,Finn-Eirik Johansen,Guttorm Haraldsen
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Health, economic, and quality-of-life effects of erythropoietin and granulocyte colony-stimulating factor for the treatment of myelodysplastic syndromes: a randomized, controlled trial
Clinical Trials & Observations
Nicole Casadevall,Pierre Durieux,Stéphanie Dubois,François Hemery,Eric Lepage,Marie-Catherine Quarré,Gandhi Damaj,Stéphane Giraudier,Agnès Guerci,Guy Laurent,Hervé Dombret,Christine Chomienne,Vincent Ribrag,Aspasia Stamatoullas,Jean-Pierre Marie,Anne Vekhoff,Frédéric Maloisel,Robert Navarro,François Dreyfus,Pierre Fenaux,for the Groupe Français des Myélodysplasies
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A systematic approach to diagnosis of mature T-cell leukemias reveals heterogeneity among WHO categories
Clinical Trials & Observations
Marco Herling,Joseph D. Khoury,LaBaron T. Washington,Madeleine Duvic,Michael J. Keating,Dan Jones
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Declining stroke rates in Californian children with sickle cell disease
Clinical Trials & Observations
Heather J. Fullerton,Robert J. Adams,Shoujun Zhao,S. Claiborne Johnston
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Proteomics applied to the clinical follow-up of patients after allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations
Thorsten Kaiser,Haytham Kamal,Andreas Rank,Hans-Jochem Kolb,Ernst Holler,Arnold Ganser,Bernd Hertenstein,Harald Mischak,Eva Maria Weissinger
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Individualized risks of first adverse events in patients with Fanconi anemia
Clinical Trials & Observations
Philip S. Rosenberg,Yi Huang,Blanche P. Alter
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GENE THERAPY

A novel maxizyme vector targeting a bcr-abl fusion gene induced specific cell death in Philadelphia chromosome–positive acute lymphoblastic leukemia
Yasushi Soda,Kenzaburo Tani,Yuansong Bai,Minoru Saiki,Minghan Chen,Kiyoko Izawa,Seiichiro Kobayashi,Satoshi Takahashi,Kaoru Uchimaru,Tomoko Kuwabara,Masaaki Warashina,Tsuyoshi Tanabe,Hiroyuki Miyoshi,Kanji Sugita,Shinpei Nakazawa,Arinobu Tojo,Kazunari Taira,Shigetaka Asano
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ABC transporter inhibitors that are substrates enhance lentiviral vector transduction into primitive hematopoietic progenitor cells
Brian M. Davis,Laurent Humeau,Vladimir Slepushkin,Gwendolyn Binder,Lauren Korshalla,Yajin Ni,E. Oluwakemi Ogunjimi,Lan-Fei Chang,Xiaobin Lu,Boro Dropulic
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HEMATOPOIESIS

Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice
Els Henckaerts,Jessica C. Langer,Hans-Willem Snoeck
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

LDL oxidized by hypochlorous acid causes irreversible platelet aggregation when combined with low levels of ADP, thrombin, epinephrine, or macrophage-derived chemokine (CCL22)
Leon G. Coleman, Jr,Renata K. Polanowska-Grabowska,Marek Marcinkiewicz,Adrian R. L. Gear
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Monoclonal antibody IAC-1 is specific for activated α2β1 and binds to amino acids 199 to 201 of the integrin α2 I-domain
Anne Schoolmeester,Karen Vanhoorelbeke,Shinya Katsutani,Hilde Depraetere,Hendrik B. Feys,Johan M. W. Heemskerk,Marc F. Hoylaerts,Hans Deckmyn
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Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis
Eric Camerer,Aisha A. Qazi,Daniel N. Duong,Ivo Cornelissen,Rommel Advincula,Shaun R. Coughlin
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Direct evidence of leukocyte adhesion in arterioles by angiotensin II
Ángeles Álvarez,Miguel Cerdá-Nicolás,Yafa Naim Abu Nabah,Manuel Mata,Andrew C. Issekutz,Julián Panés,Roy R. Lobb,Maria-Jesus Sanz
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Interleukin-1β but not IL-1α binds to fibrinogen and fibrin and has enhanced activity in the bound form
Abha Sahni,Min Guo,Sanjeev K. Sahni,Charles W. Francis
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A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury
Kyuhwan Shim,Hongfa Zhu,Lisa A. Westfield,J. Evan Sadler
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Identification of a novel 14-3-3ζ binding site within the cytoplasmic tail of platelet glycoprotein Ibα
Pierre Mangin,Tovo David,Vincent Lavaud,Susan L. Cranmer,Inna Pikovski,Shaun P. Jackson,Michael C. Berndt,Jean-Pierre Cazenave,Christian Gachet,François Lanza
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The prothrombin 3′end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations
Sven Danckwardt,Niels H. Gehring,Gabriele Neu-Yilik,Patrick Hundsdoerfer,Margit Pforsich,Ute Frede,Matthias W. Hentze,Andreas E. Kulozik
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IMMUNOBIOLOGY

Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect
Clinical Trials & Observations
Angela Gismondi,Loredana Cifaldi,Cinzia Mazza,Silvia Giliani,Silvia Parolini,Stefania Morrone,Jordan Jacobelli,Elisabetta Bandiera,Luigi Notarangelo,Angela Santoni
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Altered leukocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome
Clinical Trials & Observations
Anna Virginia Gulino,Daniele Moratto,Silvano Sozzani,Patrizia Cavadini,Karel Otero,Laura Tassone,Luisa Imberti,Silvia Pirovano,Lucia D. Notarangelo,Roberta Soresina,Evelina Mazzolari,David L. Nelson,Luigi D. Notarangelo,Raffaele Badolato
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In vitro–expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell–stimulated MLR cultures
Wayne R. Godfrey,Ying G. Ge,Darrin J. Spoden,Bruce L. Levine,Carl H. June,Bruce R. Blazar,Stephen B. Porter
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Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene production
Mark Gilchrist,Scott D. McCauley,A. Dean Befus
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De novo T-cell generation in patients at different ages and stages of HIV-1 disease
Massimo Nobile,Rafael Correa,José A. M. Borghans,Claudia D'Agostino,Philippe Schneider,Rob J. de Boer,Giuseppe Pantaleo,for the Swiss HIV Cohort Study
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Peripheral CD4+CD8+ T cells are differentiated effector memory cells with antiviral functions
Michelina Nascimbeni,Eui-Cheol Shin,Luis Chiriboga,David E. Kleiner,Barbara Rehermann
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HIV-1–specific cytotoxicity is preferentially mediated by a subset of CD8+ T cells producing both interferon-γ and tumor necrosis factor–α
Mathias Lichterfeld,Xu G. Yu,Michael T. Waring,Stanley K. Mui,Mary N. Johnston,Daniel Cohen,Marylyn M. Addo,John Zaunders,Galit Alter,Eunice Pae,Daryld Strick,Todd M. Allen,Eric S. Rosenberg,Bruce D. Walker,Marcus Altfeld
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NEOPLASIA

Imatinib mesylate (STI571) decreases the vascular endothelial growth factor plasma concentration in patients with chronic myeloid leukemia
Laurence Legros,Christine Bourcier,Arnaud Jacquel,François-Xavier Mahon,Jill-Patrice Cassuto,Patrick Auberger,Gilles Pagès
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Homeostatic chemokines drive migration of malignant B cells in patients with non-Hodgkin lymphomas
Livio Trentin,Anna Cabrelle,Monica Facco,Davide Carollo,Marta Miorin,Alicia Tosoni,Paola Pizzo,Gianni Binotto,Linda Nicolardi,Renato Zambello,Fausto Adami,Carlo Agostini,Gianpietro Semenzato
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Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms
Yun Dai,Mohamed Rahmani,Xin-Yan Pei,Paul Dent,Steven Grant
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Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells
Paolo Lunghi,Antonio Costanzo,Massimo Levrero,Antonio Bonati
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The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner
Meritxell Alberich Jordà,Nazik Rayman,Marjolein Tas,Sandra E. Verbakel,Natalia Battista,Kirsten van Lom,Bob Löwenberg,Mauro Maccarrone,Ruud Delwel
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Positive and negative regulatory roles of the WW-like domain in TEL-PDGFβR transformation
Jing Chen,Ifor R. Williams,Jeffery L. Kutok,Nicole Duclos,Ema Anastasiadou,Shane C. Masters,Haian Fu,D. Gary Gilliland
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Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma
Chrystelle Guiter,Isabelle Dusanter-Fourt,Christiane Copie-Bergman,Marie-Laure Boulland,Sabine le Gouvello,Philippe Gaulard,Karen Leroy,Flavia Castellano
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Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia
Clinical Trials & Observations
Elwin J. C. Rombouts,Biljana Pavic,Bob Löwenberg,Rob E. Ploemacher
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Activating FLT3 mutations in CD117/KIT+ T-cell acute lymphoblastic leukemias
Brief Report
Elisabeth Paietta,Adolfo A. Ferrando,Donna Neuberg,John M. Bennett,Janis Racevskis,Hillard Lazarus,Gordon Dewald,Jacob M. Rowe,Peter H. Wiernik,Martin S. Tallman,A. Thomas Look
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Complete remission of TEL-PDGFRB–induced myeloproliferative disease in mice by receptor tyrosine kinase inhibitor SU11657
Brief Report
Jennifer A. Cain,Jay L. Grisolano,A. Douglas Laird,Michael H. Tomasson
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PHAGOCYTES

Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis
Benjamin T. Suratt,Joseph M. Petty,Scott K. Young,Kenneth C. Malcolm,Jonathan G. Lieber,Jerry A. Nick,Jose-Angel Gonzalo,Peter M. Henson,G. Scott Worthen
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TRANSPLANTATION

Bone marrow transplantation restores immune system function and prevents lymphoma in Atm-deficient mice
Jessamyn Bagley,Maria L. Cortes,Xandra O. Breakefield,John Iacomini
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A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: delayed transplantation for low-risk myelodysplasia is associated with improved outcome
Clinical Trials & Observations
Corey S. Cutler,Stephanie J. Lee,Peter Greenberg,H. Joachim Deeg,Waleska S. Pérez,Claudio Anasetti,Brian J. Bolwell,Mitchell S. Cairo,Robert Peter Gale,John P. Klein,Hillard M. Lazarus,Jane L. Liesveld,Philip L. McCarthy,Gustavo A. Milone,J. Douglas Rizzo,Kirk R. Schultz,Michael E. Trigg,Armand Keating,Daniel J. Weisdorf,Joseph H. Antin,Mary M. Horowitz
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Donor-derived TNF-α regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation
Gerhard C. Hildebrandt,Krystyna M. Olkiewicz,Leigh A. Corrion,Yayi Chang,Shawn G. Clouthier,Chen Liu,Kenneth R. Cooke
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CORRESPONDENCE

Helicobacter pylori and chronic ITP: the discrepancy in the clinical responses to eradication therapy might be due to differences in the bacterial strains
Toru Takahashi,Toshiaki Yujiri,Yukio Tanizawa
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All Issues

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