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Issue Archive

Volume 104, Issue 13
December 15 2004
Issue Cover

Table of Contents

INSIDE BLOOD

RED CELLS
Is TfR2 the iron sensor?
Tomas Ganz
View Article
HEMOSTASIS
A CLEVER molecule that regulates lymphoctye trafficking
Edward M. Conway,Peter Carmeliet
View Article
CLINICAL OBSERVATIONS/HEMOSTASIS
APC: braking neutrophils to benefit patients?
Joseph P. Mizgerd
View Article
IMMUNOBIOLOGY
IL-7: a limited resource during thymopoiesis
Thomas R. Malek
View Article
NEOPLASIA
Adoptive immunotherapy of murine CML: navigating between Scylla and Charybdis
Michael W. N. Deininger
View Article
RED CELLS
Malaria parasites deck the holes in erythrocytes
Akhil B. Vaidya
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NEOPLASIA
Toward a rational combinaTORial therapy for multiple myeloma
Helena Jernberg-Wiklund,Kenneth Nilsson
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IMMUNOBIOLOGY
Dectin-1: unique appetite for yeast
Cees van Kooten
View Article
IMMUNOBIOLOGY
All B cells are not the same: a story of CD40 activation
John C. Byrd
View Article
TRANSPLANTATION
HSCs for muscular dystrophy: a paradigm shift, back
John F. Tisdale
View Article

PLENARY PAPERS

CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium
Marko Salmi,Kaisa Koskinen,Tiina Henttinen,Kati Elima,Sirpa Jalkanen
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Supplemental data

ERRATA

Erratum for vol. 104, p. 881
View Article
Erratum for vol. 101, p. 2405
View Article

REVIEW IN TRANSLATIONAL HEMATOLOGY

The use of recombinant factor VIIa in the treatment of bleeding disorders
Clinical Trials & Observations
Harold R. Roberts,Dougald M. Monroe,Gilbert C. White
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Outcomes after alemtuzumab-containing reduced-intensity allogeneic transplantation regimen for relapsed and refractory non-Hodgkin lymphoma
Clinical Trials & Observations
Emma Morris,Kirsty Thomson,Charles Craddock,Prem Mahendra,Donald Milligan,Gordon Cook,Graeme Murray Smith,Anne Parker,Steve Schey,Rajesh Chopra,Christopher Hatton,Jane Tighe,Anne Hunter,Karl Peggs,David Linch,Anthony Goldstone,Stephen Mackinnon
View Article
Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy
Clinical Trials & Observations
James M. Allan,Alexandra G. Smith,Keith Wheatley,Robert K. Hills,Lois B. Travis,Deirdre A. Hill,David M. Swirsky,Gareth J. Morgan,Christopher P. Wild
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Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis
Clinical Trials & Observations
Jerry A. Nick,Christopher D. Coldren,Mark W. Geraci,Katie R. Poch,Brian W. Fouty,James O'Brien,Michael Gruber,Simona Zarini,Robert C. Murphy,Katherine Kuhn,Don Richter,Kelly R. Kast,Edward Abraham
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GENE THERAPY

Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- γc-/- mice: functional inactivation of p53 in developing T cells
Ramon Gimeno,Kees Weijer,Arie Voordouw,Christel H. Uittenbogaart,Nicolas Legrand,Nuno L. Alves,Erwin Wijnands,Bianca Blom,Hergen Spits
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HEMATOPOIESIS

The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells
Hyung-Gyoon Kim,Cristina G. de Guzman,C. Scott Swindle,Claudiu V. Cotta,Larry Gartland,Edward W. Scott,Christopher A. Klug
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Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1
Kenneth W. Harder,Cathy Quilici,Edwina Naik,Melissa Inglese,Nicole Kountouri,Amanda Turner,Kristina Zlatic,David M. Tarlinton,Margaret L. Hibbs
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Supplemental data
Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes
Sigal Gery,Dorothy J. Park,Peter T. Vuong,Doris Y. Chih,Nathan Lemp,H. Phillip Koeffler
View Article
Molecular characterization of early human T/NK and B-lymphoid progenitor cells in umbilical cord blood
Rima Haddad,Philippe Guardiola,Brigitte Izac,Christelle Thibault,Jerry Radich,Anne-Lise Delezoide,Claude Baillou,François M. Lemoine,Jean Claude Gluckman,Françoise Pflumio,Bruno Canque
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Supplemental data
Telomere dynamics in Fancg-deficient mouse and human cells
Sonia Franco,Henri J. van de Vrugt,Piedad Fernández,Miguel Aracil,Fre Arwert,María A. Blasco
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Supplemental data
Heterozygous telomerase RNA mutations found in dyskeratosis congenita and aplastic anemia reduce telomerase activity via haploinsufficiency
Anna Marrone,David Stevens,Tom Vulliamy,Inderjeet Dokal,Philip J. Mason
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Platelets synthesize large amounts of active plasminogen activator inhibitor 1
Helén Brogren,Lena Karlsson,Maria Andersson,Lingwei Wang,David Erlinge,Sverker Jern
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Interactions between the megakaryocyte/platelet-specific β1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions
Harald Schulze,Manav Korpal,Wolfgang Bergmeier,Joseph E. Italiano, Jr,Sharon M. Wahl,Ramesh A. Shivdasani
View Article
Patients with severe sepsis vary markedly in their ability to generate activated protein C
Clinical Trials & Observations
Patricia C. Y. Liaw,Charles T. Esmon,Kamyar Kahnamoui,Shelley Schmidt,Sarah Kahnamoui,Gary Ferrell,Suzanne Beaudin,Jim A. Julian,Jeffrey I. Weitz,Mark Crowther,Mark Loeb,Deborah Cook
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Antithrombotic activity of dermatan sulfate in heparin cofactor II-deficient mice
Cristina P. Vicente,Li He,Mauro S. G. Pavão,Douglas M. Tollefsen
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The α1 helix-β13 strand spanning Leu214 to Val229 of platelet glycoprotein Ibα facilitates the interaction with von Willebrand factor: evidence from characterization of the epitope of monoclonal antibody AP1
Yuandong Peng,Michael C. Berndt,Miguel A. Cruz,José A. López
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Functional and structural correlations of individual αIIbβ3 molecules
Rustem I. Litvinov,Chandrasekaran Nagaswami,Gaston Vilaire,Henry Shuman,Joel S. Bennett,John W. Weisel
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Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism
Holger K. Eltzschig,Linda F. Thompson,Jorn Karhausen,Richard J. Cotta,Juan C. Ibla,Simon C. Robson,Sean P. Colgan
View Article
Induction of plasminogen activator inhibitor I gene expression by intracellular calcium via hypoxia-inducible factor-1
Qing Liu,Ulrike Möller,Daniela Flügel,Thomas Kietzmann
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IMMUNOBIOLOGY

Differential regulation of gene expression following CD40 activation of leukemic compared to healthy B cells
Clair S. Gricks,David Zahrieh,A. Jason Zauls,Gullu Gorgun,Daniela Drandi,Katja Mauerer,Donna Neuberg,John G. Gribben
View Article
Supplemental data
Mutations of the Wiskott-Aldrich Syndrome Protein (WASP): hotspots, effect on transcription, and translation and phenotype/genotype correlation
Yinzhu Jin,Cinzia Mazza,Jacinda R. Christie,Silvia Giliani,Maurilia Fiorini,Patrizia Mella,Francesca Gandellini,Donn M. Stewart,Qili Zhu,David L. Nelson,Luigi D. Notarangelo,Hans D. Ochs
View Article
Are interleukin-16 and thrombopoietin new tools for the in vitro generation of dendritic cells?
Silvia Della Bella,Stefania Nicola,Inna Timofeeva,Maria Luisa Villa,Armando Santoro,Anna C. Berardi
View Article
Immature dendritic cell transdifferentiation into osteoclasts: a novel pathway sustained by the rheumatoid arthritis microenvironment
Aymeric Rivollier,Marlène Mazzorana,Jacques Tebib,Muriel Piperno,Tarik Aitsiselmi,Chantal Rabourdin-Combe,Pierre Jurdic,Christine Servet-Delprat
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Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages
Jurgen Herre,Andrew S. J. Marshall,Emmanuelle Caron,Alexander D. Edwards,David L. Williams,Edina Schweighoffer,Victor Tybulewicz,Caetano Reis e Sousa,Siamon Gordon,Gordon D. Brown
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Ligation of lymphocyte function-associated antigen-1 on monocytes decreases very late antigen-4-mediated adhesion through a reactive oxygen species-dependent pathway
Kuo-Pin Chuang,Ya-Fang Huang,Yi-Ling Hsu,Hsiao-Sheng Liu,Hong-Chen Chen,Chi-Chang Shieh
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Identification of talin head domain as an immunodominant epitope of the antiplatelet antibody response in patients with HIV-1-associated thrombocytopenia
Klaus Koefoed,Henrik J. Ditzel
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The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells
Svitlana V. Mikhalap,Larysa M. Shlapatska,Olga V. Yurchenko,Maria Y. Yurchenko,Ganna G. Berdova,Kim E. Nichols,Edward A. Clark,Svetlana P. Sidorenko
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Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock
Jérôme Pugin,Sabine Stern-Voeffray,Bruno Daubeuf,Michael A. Matthay,Greg Elson,Irène Dunn-Siegrist
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Lysophosphatidic acid accelerates the development of human mast cells
Savita Bagga,Kursteen S. Price,Debby A. Lin,Daniel S. Friend,K. Frank Austen,Joshua A. Boyce
View Article
Tracking CD40 signaling during germinal center development
Katia Basso,Ulf Klein,Huifeng Niu,Gustavo A. Stolovitzky,Yuhai Tu,Andrea Califano,Giorgio Cattoretti,Riccardo Dalla-Favera
View Article
Supplemental data
Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice
Yasuhito Ide,Daisuke Tsuchimoto,Yohei Tominaga,Manabu Nakashima,Takeshi Watanabe,Kunihiko Sakumi,Mizuki Ohno,Yusaku Nakabeppu
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Core 2 branching β1,6-N-acetylglucosaminyltransferase and high endothelial cell N-acetylglucosamine-6-sulfotransferase exert differential control over B- and T-lymphocyte homing to peripheral lymph nodes
Jean-Marc Gauguet,Steven D. Rosen,Jamey D. Marth,Ulrich H. von Andrian
View Article
Supplemental data
Evidence that genetic deletion of the TNF receptor p60 or p80 in macrophages modulates RANKL-induced signaling
Yasunari Takada,Bharat B. Aggarwal
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Phospholipase D1 regulates high-affinity IgE receptor-induced mast cell degranulation
Tomohiro Hitomi,Juan Zhang,Liliana M. Nicoletti,Ana Cristina G. Grodzki,Maria C. Jamur,Constance Oliver,Reuben P. Siraganian
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FTY720 suppresses humoral immunity by inhibiting germinal center reaction
Shuhua Han,Xuejun Zhang,Gangdou Wang,Hui Guan,Gabriela Garcia,Ping Li,Lili Feng,Biao Zheng
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Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice
Domenico Vittorio Delfino,Massimiliano Agostini,Stefania Spinicelli,Pasquale Vito,Carlo Riccardi
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Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15
Maria Wysocka,Bernice M. Benoit,Sarah Newton,Livio Azzoni,Luis J. Montaner,Alain H. Rook
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Distinct homeostatic requirements of CD4+ and CD4- subsets of Vα24-invariant natural killer T cells in humans
Denis V. Baev,Xiao-hui Peng,Liping Song,Jerry R. Barnhart,Gay M. Crooks,Kenneth I. Weinberg,Leonid S. Metelitsa
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p38 MAPK activation controls the TLR3-mediated up-regulation of cytotoxicity and cytokine production in human NK cells
Simona Pisegna,Gianluca Pirozzi,Mario Piccoli,Luigi Frati,Angela Santoni,Gabriella Palmieri
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Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis
Ivana Munitic,Joy A. Williams,Yili Yang,Bei Dong,Philip J. Lucas,Nahed El Kassar,Ronald E. Gress,Jonathan D. Ashwell
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NEOPLASIA

Age-related phenotypic and oncogenic differences in T-cell acute lymphoblastic leukemias may reflect thymic atrophy
Vahid Asnafi,Kheira Beldjord,Marta Libura,Patrick Villarese,Corrine Millien,Paola Ballerini,Emilienne Kuhlein,Marina Lafage-Pochitaloff,Eric Delabesse,Olivier Bernard,Elizabeth Macintyre
View Article
In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model
Patrick Frost,Farhad Moatamed,Bao Hoang,Yijiang Shi,Joseph Gera,Huajun Yan,Philip Frost,Jay Gibbons,Alan Lichtenstein
View Article
Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma
Noopur Raje,Shaji Kumar,Teru Hideshima,Kenji Ishitsuka,Dharminder Chauhan,Constantine Mitsiades,Klaus Podar,Steven Le Gouill,Paul Richardson,Nikhil C. Munshi,David I. Stirling,Joseph H. Antin,Kenneth C. Anderson
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Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy
Kambiz Fotoohi,Gerrit Jansen,Yehuda G. Assaraf,Lilah Rothem,Michal Stark,Ietje Kathmann,Jacek Gregorczyk,Godefridus J. Peters,Freidoun Albertioni
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Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD–positive leukemic cells
Kevin W. H. Yee,Marcus Schittenhelm,Anne-Marie O'Farrell,Ajia R. Town,Laura McGreevey,Troy Bainbridge,Julie M. Cherrington,Michael C. Heinrich
View Article
Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities
Guibin Chen,Weihua Zeng,Akira Miyazato,Eric Billings,Jaroslaw P. Maciejewski,Sachiko Kajigaya,Elaine M. Sloand,Neal S. Young
View Article
Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein
Tong Yin,Ying-Li Wu,Hui-Ping Sun,Guan-Lin Sun,Yan-Zhi Du,Kan-Kan Wang,Ji Zhang,Guo-Qiang Chen,Sai-Juan Chen,Zhu Chen
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Expression of SMRTβ promotes ligand-induced activation of mutated and wild-type retinoid receptors
Sylvie Côté,Suzan McNamara,Daria Brambilla,Andrea Bianchini,Giovanni Rizzo,Sonia Victoria del Rincón,Francesco Grignani,Clara Nervi,Wilson H. Miller, Jr
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Adoptive immunotherapy of BCR-ABL–induced chronic myeloid leukemia–like myeloproliferative disease in a murine model
Daniela S. Krause,Richard A. Van Etten
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Imatinib and pegylated human recombinant interferon-α2b in early chronic-phase chronic myeloid leukemia
Clinical Trials & Observations
Michele Baccarani,Giovanni Martinelli,Gianantonio Rosti,Elena Trabacchi,Nicoletta Testoni,Simona Bassi,Marilina Amabile,Simona Soverini,Fausto Castagnetti,Daniela Cilloni,Barbara Izzo,Antonio de Vivo,Emanuela Messa,Francesca Bonifazi,Angela Poerio,Simona Luatti,Emilia Giugliano,Daniele Alberti,Gianluca Fincato,Domenico Russo,Fabrizio Pane,Giuseppe Saglio,for the GIMEMA Working Party on Chronic Myeloid Leukemia
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Mycoplasma fermentans infection promotes immortalization of human peripheral blood mononuclear cells in culture
Shimin Zhang,Shien Tsai,Timothy T. Wu,Bingjie Li,James W.-K. Shih,Shyh-Ching Lo
View Article

PHAGOCYTES

MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes
Thomas Vogl,Stephan Ludwig,Matthias Goebeler,Anke Strey,Irmgard S. Thorey,Rudolf Reichelt,Dirk Foell,Volker Gerke,Marie P. Manitz,Wolfgang Nacken,Sabine Werner,Clemens Sorg,Johannes Roth
View Article
CD157 is an important mediator of neutrophil adhesion and migration
Ada Funaro,Erika Ortolan,Bruna Ferranti,Lucia Gargiulo,Rosario Notaro,Lucio Luzzatto,Fabio Malavasi
View Article

RED CELLS

Plasmodium falciparum likely encodes the principal anion channel on infected human erythrocytes
Abdulnaser Alkhalil,Jamieson V. Cohn,Marissa A. Wagner,Jennifer S. Cabrera,Thavamani Rajapandi,Sanjay A. Desai
View Article
Diferric transferrin regulates transferrin receptor 2 protein stability
Martha B. Johnson,Caroline A. Enns
View Article
Regulation of transferrin receptor 2 protein levels by transferrin
Aeisha Robb,Marianne Wessling-Resnick
View Article
Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease
Yoko Nakano,Shigehiko Imagawa,Ken Matsumoto,Christian Stockmann,Naoshi Obara,Norio Suzuki,Takeshi Doi,Tatsuhiko Kodama,Satoru Takahashi,Toshiro Nagasawa,Masayuki Yamamoto
View Article
Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin
Brief Report
Jan Krijt,Martin Vokurka,Ko-Tung Chang,Emanuel Nečas
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TRANSPLANTATION

Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs
Chiara Dell'Agnola,Zejing Wang,Rainer Storb,Stephen J. Tapscott,Christian S. Kuhr,Stephen D. Hauschka,Richard S. Lee,George E. Sale,Eustacia Zellmer,Serina Gisburne,Janet Bogan,Joe N. Kornegay,Barry J. Cooper,Theodore A. Gooley,Marie-Térèse Little
View Article
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CXCR4 signaling controls dendritic cell location and activation at steady-state and in inflammation
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On ignoring instead of chasing after coagulation factor VII during warfarin management; an interrupted time series study
A Phase 3 Double-Blind Study of the Addition of Tocilizumab versus Placebo to Cyclosporin/Methotrexate GvHD Prophylaxis

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