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INSIDE BLOOD

IMMUNOBIOLOGY

IgM memory B cells: origin, mutation, and mobilization by polysaccharide vaccination

Alexander H. Lucas

View Articletitled, IgM memory B cells: origin, mutation, and mobilization by polysaccharide vaccination

CLINICAL OBSERVATIONS

Hodgkin disease: the sword of Damocles resheathed

Dan L. Longo

View Articletitled, Hodgkin disease: the sword of Damocles resheathed

GENE THERAPY

One step closer to gene therapy for hemoglobinopathies

Brian P. Sorrentino

View Articletitled, One step closer to gene therapy for hemoglobinopathies

CLINICAL OBSERVATIONS

Interfering with amyloidosis

David C. Seldin

View Articletitled, Interfering with amyloidosis

HEMATOPOIESIS

Blood and Runx1: got to have it, really need it

Stephen D. Nimer

View Articletitled, Blood and Runx1: got to have it, really need it

HEMATOPOIESIS

Time to end the stem cell wars?

Darwin J. Prockop

View Articletitled, Time to end the stem cell wars?

TRANSPLANTATION

Depletion of alloreactive T cells: which cell?

Sherif S. Farag

View Articletitled, Depletion of alloreactive T cells: which cell?

NEOPLASIA

Leukemia gene expression: MLL rearrangements in AML and ALL

Scott A. Armstrong

View Articletitled, Leukemia gene expression: MLL rearrangements in AML and ALL

NEOPLASIA

Genetic rearrangements beget genomic instability

Feyruz V. Rassool

View Articletitled, Genetic rearrangements beget genomic instability

RED CELLS

“Stress” and sickle red cell adhesion

Dhananjay K. Kaul

View Articletitled, “Stress” and sickle red cell adhesion

BLOOD WORK

Juvenile myelomonocytic leukemia

View Articletitled, Juvenile myelomonocytic leukemia

PLENARY PAPERS

Functional assessment and specific depletion of alloreactive human T cells using flow cytometry

Sergio L. R. Martins,Lisa S. St. John,Richard E. Champlin,Eric D. Wieder,John McMannis,Jeffrey J. Molldrem,Krishna V. Komanduri

View Articletitled, Functional assessment and specific depletion of alloreactive human T cells using flow cytometry

PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain

Wendy D. Cook,Benjamin J. McCaw,Christopher Herring,Deborah L. John,Simon J. Foote,Stephen L. Nutt,Jerry M. Adams

View Articletitled, PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain

Successful correction of the human β-thalassemia major phenotype using a lentiviral vector

Geetha Puthenveetil,Jessica Scholes,Denysha Carbonell,Naveen Qureshi,Ping Xia,Licheng Zeng,Shulian Li,Ying Yu,Alan L Hiti,Jiing-Kuan Yee,Punam Malik

View Articletitled, Successful correction of the human β-thalassemia major phenotype using a lentiviral vector

REVIEW ARTICLES

Mechanisms of WASp-mediated hematologic and immunologic disease

Siobhan Burns,Giles O. Cory,William Vainchenker,Adrian J. Thrasher

View Articletitled, Mechanisms of WASp-mediated hematologic and immunologic disease

CHEMOKINES

IL-8 responsiveness defines a subset of CD8 T cells poised to kill

Christoph Hess,Terry K. Means,Patrick Autissier,Tonia Woodberry,Marcus Altfeld,Marylyn M. Addo,Nicole Frahm,Christian Brander,Bruce D. Walker,Andrew D. Luster

View Articletitled, IL-8 responsiveness defines a subset of CD8 T cells poised to kill

SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells

Elena De Falco,Daniele Porcelli,Anna Rita Torella,Stefania Straino,Maria Grazia Iachininoto,Alessia Orlandi,Silvia Truffa,Paolo Biglioli,Monica Napolitano,Maurizio C. Capogrossi,Maurizio Pesce

View Articletitled, SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Results of a prospective randomized clinical trial of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by radiation therapy (RT) versus ABVD alone for stages I, II, and IIIA nonbulky Hodgkin disease
Clinical Trials & Observations

David J. Straus,Carol S. Portlock,Jing Qin,Jane Myers,Andrew D. Zelenetz,Craig Moskowitz,Ariela Noy,André Goy,Joachim Yahalom

View Articletitled, Results of a prospective randomized clinical trial of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by radiation therapy (RT) versus ABVD alone for stages I, II, and IIIA nonbulky Hodgkin disease

All-trans retinoic acid and anthracycline monochemotherapy for the treatment of elderly patients with acute promyelocytic leukemia
Clinical Trials & Observations

Miguel A. Sanz,Edo Vellenga,Chelo Rayón,Joaquín Díaz-Mediavilla,Concha Rivas,Elena Amutio,Jesús Arias,Guillermo Debén,Andrés Novo,Juan Bergua,Javier de la Serna,Javier Bueno,Silvia Negri,José M. Beltrán de Heredia,Guillermo Martín

View Articletitled, All-trans retinoic acid and anthracycline monochemotherapy for the treatment of elderly patients with acute promyelocytic leukemia

Thirty years of hemophilia treatment in the Netherlands, 1972-2001
Clinical Trials & Observations

Iris Plug,Johanna G. van der Bom,Marjolein Peters,Evelien P. Mauser-Bunschoten,Arja de Goede-Bolder,Lily Heijnen,Cees Smit,Jeannette E. F. Zwart-van Rijkom,José Willemse,Frits R. Rosendaal

View Articletitled, Thirty years of hemophilia treatment in the Netherlands, 1972-2001

Duration of immunosuppressive treatment for chronic graft-versus-host disease
Clinical Trials & Observations

Betty L. Stewart,Barry Storer,Jan Storek,H. Joachim Deeg,Rainer Storb,John A. Hansen,Frederick R. Appelbaum,Paul A. Carpenter,Jean E. Sanders,Hans-Peter Kiem,Richard A. Nash,Effie W. Petersdorf,Carina Moravec,A. James Morton,Claudio Anasetti,Mary E. D. Flowers,Paul J. Martin

View Articletitled, Duration of immunosuppressive treatment for chronic graft-versus-host disease

Combination of intensive chemotherapy and imatinib can rapidly induce high-quality complete remission for a majority of patients with newly diagnosed BCR-ABL–positive acute lymphoblastic leukemia
Clinical Trials & Observations

Masayuki Towatari,Masamitsu Yanada,Noriko Usui,Jin Takeuchi,Isamu Sugiura,Makoto Takeuchi,Fumiharu Yagasaki,Yasukazu Kawai,Shuichi Miyawaki,Shigeki Ohtake,Itsuro Jinnai,Keitaro Matsuo,Tomoki Naoe,Ryuzo Ohno,for the Japan Adult Leukemia Study Group

View Articletitled, Combination of intensive chemotherapy and imatinib can rapidly induce high-quality complete remission for a majority of patients with newly diagnosed BCR-ABL–positive acute lymphoblastic leukemia

Establishment of the CD4⁺ T-cell pool in healthy children and untreated children infected with HIV-1
Clinical Trials & Observations

Mette D. Hazenberg,Sigrid A. Otto,Annemarie M.C. van Rossum,Henriëtte J. Scherpbier,Ronald de Groot,Taco W. Kuijpers,Joep M.A. Lange,Dörte Hamann,Rob J. de Boer,José A.M. Borghans,Frank Miedema

View Articletitled, Establishment of the CD4+ T-cell pool in healthy children and untreated children infected with HIV-1

Clinical efficacy of high-dose dexamethasone with maintenance dexamethasone/alpha interferon in patients with primary systemic amyloidosis: results of United States Intergroup Trial Southwest Oncology Group (SWOG) S9628
Clinical Trials & Observations

Madhav V. Dhodapkar,Mohamad A. Hussein,Erik Rasmussen,Alan Solomon,Richard A. Larson,John J. Crowley,Bart Barlogie

View Articletitled, Clinical efficacy of high-dose dexamethasone with maintenance dexamethasone/alpha interferon in patients with primary systemic amyloidosis: results of United States Intergroup Trial Southwest Oncology Group (SWOG) S9628

Infant acute lymphoblastic leukemia with MLL gene rearrangements: outcome following intensive chemotherapy and hematopoietic stem cell transplantation
Clinical Trials & Observations

View Articletitled, Infant acute lymphoblastic leukemia with MLL gene rearrangements: outcome following intensive chemotherapy and hematopoietic stem cell transplantation

Allogeneic hematopoietic cell transplantation after fludarabine and 2 Gy total body irradiation for relapsed and refractory mantle cell lymphoma
Clinical Trials & Observations

Michael B. Maris,Brenda M. Sandmaier,Barry E. Storer,Thomas Chauncey,Monic Jain Stuart,Richard T. Maziarz,Edward Agura,Amelia A. Langston,Michael Pulsipher,Rainer Storb,David G. Maloney

View Articletitled, Allogeneic hematopoietic cell transplantation after fludarabine and 2 Gy total body irradiation for relapsed and refractory mantle cell lymphoma

GENE THERAPY

Tumor cells escape suicide gene therapy by genetic and epigenetic instability

Oliver Frank,Cornelia Rudolph,Christoph Heberlein,Nils von Neuhoff,Evelin Schröck,Axel Schambach,Brigitte Schlegelberger,Boris Fehse,Wolfram Ostertag,Carol Stocking,Christopher Baum

View Articletitled, Tumor cells escape suicide gene therapy by genetic and epigenetic instability

HEMATOPOIESIS

A GTPase-activating protein binds STAT3 and is required for IL-6–induced STAT3 activation and for differentiation of a leukemic cell line

Yukio Tonozuka,Yukinori Minoshima,Ying Chun Bao,Yuseok Moon,Yohei Tsubono,Tomonori Hatori,Hideaki Nakajima,Tetsuya Nosaka,Toshiyuki Kawashima,Toshio Kitamura

View Articletitled, A GTPase-activating protein binds STAT3 and is required for IL-6–induced STAT3 activation and for differentiation of a leukemic cell line

The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region

Susumu Goyama,Yuko Yamaguchi,Yoichi Imai,Masahito Kawazu,Masahiro Nakagawa,Takashi Asai,Keiki Kumano,Kinuko Mitani,Seishi Ogawa,Shigeru Chiba,Mineo Kurokawa,Hisamaru Hirai

View Articletitled, The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region

Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors

Weili Sun,James R. Downing

View Articletitled, Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors

Supplemental data

Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1^low mice

Lucia Centurione,Angela Di Baldassarre,Maria Zingariello,Domenico Bosco,Valentina Gatta,Rosa Alba Rana,Vincenzo Langella,Antonio Di Virgilio,Alessandro M. Vannucchi,Anna Rita Migliaccio

View Articletitled, Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1low mice

Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction

Hiroshi Kawada,Jun Fujita,Kentaro Kinjo,Yumi Matsuzaki,Mitsuyo Tsuma,Hiroko Miyatake,Yukari Muguruma,Kosuke Tsuboi,Yuji Itabashi,Yasuo Ikeda,Satoshi Ogawa,Hideyuki Okano,Tomomitsu Hotta,Kiyoshi Ando,Keiichi Fukuda

View Articletitled, Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction

Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome
Brief Report

Jill R. Woloszynek,Robert J. Rothbaum,Amy S. Rawls,Patrick J. Minx,Richard K. Wilson,Philip J. Mason,Monica Bessler,Daniel C. Link

View Articletitled, Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Antioxidative stress–associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress

Elisabeth Dernbach,Carmen Urbich,Ralf P. Brandes,Wolf K. Hofmann,Andreas M. Zeiher,Stefanie Dimmeler

View Articletitled, Antioxidative stress–associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress

β₂-glycoprotein I–dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome
Clinical Trials & Observations

H. Bas de Laat,Ronald H.W.M. Derksen,Rolf T. Urbanus,Mark Roest,Philip G. de Groot

View Articletitled, β2-glycoprotein I–dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome

The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage

Gabriele Jedlitschky,Konstanze Tirschmann,Lena E. Lubenow,Hendrik K. Nieuwenhuis,Jan W. N. Akkerman,Andreas Greinacher,Heyo K. Kroemer

View Articletitled, The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage

Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase

Elizabeth E. Gardiner,Jane F. Arthur,Mark L. Kahn,Michael C. Berndt,Robert K. Andrews

View Articletitled, Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase

Expression and analysis of a split premature termination codon in FGG responsible for congenital afibrinogenemia: escape from RNA surveillance mechanisms in transfected cells

Marguerite Neerman-Arbez,Myrna Germanos-Haddad,Konstantinos Tzanidakis,Dung Vu,Samuel Deutsch,Armelle David,Michael A. Morris,Philippe de Moerloose

View Articletitled, Expression and analysis of a split premature termination codon in FGG responsible for congenital afibrinogenemia: escape from RNA surveillance mechanisms in transfected cells

Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance

Kristin M. Seré,Jan Rosing,Tilman M. Hackeng

View Articletitled, Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance

A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism
Clinical Trials & Observations

Armando Tripodi,Veena Chantarangkul,Ida Martinelli,Paolo Bucciarelli,Pier Mannuccio Mannucci

View Articletitled, A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism

Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires α_vβ₃

Abha Sahni,Charles W. Francis

View Articletitled, Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires αvβ3

RNAi-mediated silencing of CD40 prevents leukocyte adhesion on CD154-activated endothelial cells
Brief Report

Raquel Pluvinet,Jordi Pétriz,Joan Torras,Inmaculada Herrero-Fresneda,Josep M. Cruzado,Josep M. Grinyó,Josep M. Aran

View Articletitled, RNAi-mediated silencing of CD40 prevents leukocyte adhesion on CD154-activated endothelial cells

IMMUNOBIOLOGY

Human blood IgM “memory” B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

Sandra Weller,Moritz C. Braun,Bruce K. Tan,Andreas Rosenwald,Corinne Cordier,Mary Ellen Conley,Alessandro Plebani,Dinakhanta S. Kumararatne,Damien Bonnet,Olivier Tournilhac,Gil Tchernia,Birte Steiniger,Louis M. Staudt,Jean-Laurent Casanova,Claude-Agnès Reynaud,Jean-Claude Weill

View Articletitled, Human blood IgM “memory” B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

Supplemental data

RelB regulates human dendritic cell subset development by promoting monocyte intermediates

Barbara Platzer,Almut Jörgl,Sabine Taschner,Bernhard Höcher,Herbert Strobl

View Articletitled, RelB regulates human dendritic cell subset development by promoting monocyte intermediates

Imprint of human cytomegalovirus infection on the NK cell receptor repertoire

Mónica Gumá,Ana Angulo,Carlos Vilches,Natalia Gómez-Lozano,Núria Malats,Miguel López-Botet

View Articletitled, Imprint of human cytomegalovirus infection on the NK cell receptor repertoire

Expansion of CD7^low and CD7^negative CD8 T-cell effector subsets in HIV-1 infection: correlation with antigenic load and reversion by antiretroviral treatment

Einar M. Aandahl,Máire F. Quigley,Walter J. Moretto,Markus Moll,Veronica D. Gonzalez,Anders Sönnerborg,Stefan Lindbäck,Frederick M. Hecht,Steven G. Deeks,Michael G. Rosenberg,Douglas F. Nixon,Johan K. Sandberg

View Articletitled, Expansion of CD7low and CD7negative CD8 T-cell effector subsets in HIV-1 infection: correlation with antigenic load and reversion by antiretroviral treatment

NEOPLASIA

Gene expression profiling of pediatric acute myelogenous leukemia

Mary E. Ross,Rami Mahfouz,Mihaela Onciu,Hsi-Che Liu,Xiaodong Zhou,Guangchun Song,Sheila A. Shurtleff,Stanley Pounds,Cheng Cheng,Jing Ma,Raul C. Ribeiro,Jeffrey E. Rubnitz,Kevin Girtman,W. Kent Williams,Susana C. Raimondi,Der-Cherng Liang,Lee-Yung Shih,Ching-Hon Pui,James R. Downing

View Articletitled, Gene expression profiling of pediatric acute myelogenous leukemia

Supplemental data

Cytotoxic activity of the maytansinoid immunoconjugate B-B4–DM1 against CD138⁺ multiple myeloma cells

Pierfrancesco Tassone,Victor S. Goldmacher,Paola Neri,Antonella Gozzini,Masood A. Shammas,Kathleen R. Whiteman,Linda L. Hylander-Gans,Daniel R. Carrasco,Teru Hideshima,Reshma Shringarpure,Jialan Shi,Charles K. Allam,John Wijdenes,Salvatore Venuta,Nikhil C. Munshi,Kenneth C. Anderson

View Articletitled, Cytotoxic activity of the maytansinoid immunoconjugate B-B4–DM1 against CD138+ multiple myeloma cells

Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines

Christiane Houde,Yulin Li,Lynda Song,Kevin Barton,Qing Zhang,John Godwin,Sucha Nand,Amir Toor,Serhan Alkan,N. Veronique Smadja,Hervé Avet-Loiseau,Carmen S. Lima,Lucio Miele,Lionel J. Coignet

View Articletitled, Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines

Antiproliferative activity of a humanized anti-CD74 monoclonal antibody, hLL1, on B-cell malignancies

Rhona Stein,Zhengxing Qu,Thomas M. Cardillo,Susan Chen,Adriane Rosario,Ivan D. Horak,Hans J. Hansen,David M. Goldenberg

View Articletitled, Antiproliferative activity of a humanized anti-CD74 monoclonal antibody, hLL1, on B-cell malignancies

Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells

Manik Chatterjee,Thorsten Stühmer,Pia Herrmann,Kurt Bommert,Bernd Dörken,Ralf C. Bargou

View Articletitled, Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells

T cells support osteoclastogenesis in an in vitro model derived from human multiple myeloma bone disease: the role of the OPG/TRAIL interaction

Silvia Colucci,Giacomina Brunetti,Rita Rizzi,Antonia Zonno,Giorgio Mori,Graziana Colaianni,Davide Del Prete,Roberta Faccio,Arcangelo Liso,Silvana Capalbo,Vincenzo Liso,Alberta Zallone,Maria Grano

View Articletitled, T cells support osteoclastogenesis in an in vitro model derived from human multiple myeloma bone disease: the role of the OPG/TRAIL interaction

Protein kinase Cδ mediates retinoic acid and phorbol myristate acetate–induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation

Ke-Wen Zhao,Xi Li,Qian Zhao,Ying Huang,Dong Li,Zhen-Gang Peng,Wu-Zhong Shen,Ji Zhao,Quansheng Zhou,Zhu Chen,Peter J. Sims,Therese Wiedmer,Guo-Qiang Chen

View Articletitled, Protein kinase Cδ mediates retinoic acid and phorbol myristate acetate–induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation

Active transport of imatinib into and out of cells: implications for drug resistance

Julia Thomas,Lihui Wang,Richard E. Clark,Munir Pirmohamed

View Articletitled, Active transport of imatinib into and out of cells: implications for drug resistance

BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species–dependent DNA double-strand breaks

Michal O. Nowicki,Rafal Falinski,Mateusz Koptyra,Artur Slupianek,Tomasz Stoklosa,Ewa Gloc,Margaret Nieborowska-Skorska,Janusz Blasiak,Tomasz Skorski

View Articletitled, BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species–dependent DNA double-strand breaks

Sensitivity of oncogenic KIT mutants to the kinase inhibitors MLN518 and PD180970
Brief Report

Amie S. Corbin,Ian J. Griswold,Paul La Rosée,Kevin W. H. Yee,Michael C. Heinrich,Corinne L. Reimer,Brian J. Druker,Michael W. N. Deininger

View Articletitled, Sensitivity of oncogenic KIT mutants to the kinase inhibitors MLN518 and PD180970

PHAGOCYTES

Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass

Chun Xiang Sun,Gregory P. Downey,Fei Zhu,Adeline L. Y. Koh,Herman Thang,Michael Glogauer

View Articletitled, Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass

A down-regulatable E-selectin ligand is functionally important for PSGL-1–independent leukocyte–endothelial cell interactions

Renata C. O. Zanardo,Claudine S. Bonder,John M. Hwang,Graciela Andonegui,Lixin Liu,Dietmar Vestweber,Lori Zbytnuik,Paul Kubes

View Articletitled, A down-regulatable E-selectin ligand is functionally important for PSGL-1–independent leukocyte–endothelial cell interactions

RED CELLS

Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-αvβ3 interactions

Rahima Zennadi,Patrick C. Hines,Laura M. De Castro,Jean-Pierre Cartron,Leslie V. Parise,Marilyn J. Telen

View Articletitled, Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-αvβ3 interactions

TRANSFUSION MEDICINE

Transfer of glycosylphosphatidylinositol-anchored proteins to deficient cells after erythrocyte transfusion in paroxysmal nocturnal hemoglobinuria

Elaine M. Sloand,Lori Mainwaring,Keyvan Keyvanfar,Jichun Chen,Jaroslaw Maciejewski,Harvey G. Klein,Neal S. Young

View Articletitled, Transfer of glycosylphosphatidylinositol-anchored proteins to deficient cells after erythrocyte transfusion in paroxysmal nocturnal hemoglobinuria

TRANSPLANTATION

Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease

Masashi Tanaka,Susumu Nakae,Raya D. Terry,Golnaz K. Mokhtari,Feny Gunawan,Leora B. Balsam,Hideaki Kaneda,Theo Kofidis,Philip S. Tsao,Robert C. Robbins

View Articletitled, Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease

Myeloablative allogeneic hematopoietic stem cell transplantation in patients who experience relapse after autologous stem cell transplantation for lymphoma: a report of the International Bone Marrow Transplant Registry
Clinical Trials & Observations

View Articletitled, Myeloablative allogeneic hematopoietic stem cell transplantation in patients who experience relapse after autologous stem cell transplantation for lymphoma: a report of the International Bone Marrow Transplant Registry

L-Selectin^hi but not the L-selectin^lo CD4⁺25⁺ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection

Patricia A. Taylor,Angela Panoskaltsis-Mortari,Jessica M. Swedin,Philip J. Lucas,Ronald E. Gress,Bruce L. Levine,Carl H. June,Jonathan S. Serody,Bruce R. Blazar

View Articletitled, L-Selectinhi but not the L-selectinlo CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection

Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies
Clinical Trials & Observations

Satoshi Takahashi,Tohru Iseki,Jun Ooi,Akira Tomonari,Kashiya Takasugi,Yoko Shimohakamada,Toshiki Yamada,Kaoru Uchimaru,Arinobu Tojo,Naoki Shirafuji,Hideki Kodo,Kenzaburo Tani,Tsuneo Takahashi,Takuhiro Yamaguchi,Shigetaka Asano

View Articletitled, Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies

Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)–mismatched family members linked with long-term fetomaternal microchimerism
Clinical Trials & Observations

View Articletitled, Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)–mismatched family members linked with long-term fetomaternal microchimerism

Absence of clinical GVHD and the in vivo induction of regulatory T cells after transplantation of facilitating cells

Yolonda L. Colson,Kenneth Christopher,Jonathan Glickman,Kendra N. Taylor,Renee Wright,David L. Perkins

View Articletitled, Absence of clinical GVHD and the in vivo induction of regulatory T cells after transplantation of facilitating cells

CORRESPONDENCE

Eosinophilic leukemia and idiopathic hypereosinophilic syndrome are mutually exclusive diagnoses

Barbara J. Bain

View Articletitled, Eosinophilic leukemia and idiopathic hypereosinophilic syndrome are mutually exclusive diagnoses

Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

PLENARY PAPERS

REVIEW ARTICLES

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Results of a prospective randomized clinical trial of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by radiation therapy (RT) versus ABVD alone for stages I, II, and IIIA nonbulky Hodgkin disease Clinical Trials & Observations

All-trans retinoic acid and anthracycline monochemotherapy for the treatment of elderly patients with acute promyelocytic leukemia Clinical Trials & Observations

Thirty years of hemophilia treatment in the Netherlands, 1972-2001 Clinical Trials & Observations

Duration of immunosuppressive treatment for chronic graft-versus-host disease Clinical Trials & Observations

Combination of intensive chemotherapy and imatinib can rapidly induce high-quality complete remission for a majority of patients with newly diagnosed BCR-ABL–positive acute lymphoblastic leukemia Clinical Trials & Observations

Establishment of the CD4+ T-cell pool in healthy children and untreated children infected with HIV-1 Clinical Trials & Observations

Clinical efficacy of high-dose dexamethasone with maintenance dexamethasone/alpha interferon in patients with primary systemic amyloidosis: results of United States Intergroup Trial Southwest Oncology Group (SWOG) S9628 Clinical Trials & Observations

Infant acute lymphoblastic leukemia with MLL gene rearrangements: outcome following intensive chemotherapy and hematopoietic stem cell transplantation Clinical Trials & Observations

Allogeneic hematopoietic cell transplantation after fludarabine and 2 Gy total body irradiation for relapsed and refractory mantle cell lymphoma Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

β2-glycoprotein I–dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome Clinical Trials & Observations

A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism Clinical Trials & Observations

RNAi-mediated silencing of CD40 prevents leukocyte adhesion on CD154-activated endothelial cells Brief Report

IMMUNOBIOLOGY

NEOPLASIA

Sensitivity of oncogenic KIT mutants to the kinase inhibitors MLN518 and PD180970 Brief Report

PHAGOCYTES

RED CELLS

TRANSFUSION MEDICINE

TRANSPLANTATION

Myeloablative allogeneic hematopoietic stem cell transplantation in patients who experience relapse after autologous stem cell transplantation for lymphoma: a report of the International Bone Marrow Transplant Registry Clinical Trials & Observations

Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies Clinical Trials & Observations

Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)–mismatched family members linked with long-term fetomaternal microchimerism Clinical Trials & Observations

CORRESPONDENCE

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Results of a prospective randomized clinical trial of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by radiation therapy (RT) versus ABVD alone for stages I, II, and IIIA nonbulky Hodgkin disease
Clinical Trials & Observations

All-trans retinoic acid and anthracycline monochemotherapy for the treatment of elderly patients with acute promyelocytic leukemia
Clinical Trials & Observations

Thirty years of hemophilia treatment in the Netherlands, 1972-2001
Clinical Trials & Observations

Duration of immunosuppressive treatment for chronic graft-versus-host disease
Clinical Trials & Observations

Combination of intensive chemotherapy and imatinib can rapidly induce high-quality complete remission for a majority of patients with newly diagnosed BCR-ABL–positive acute lymphoblastic leukemia
Clinical Trials & Observations

Establishment of the CD4⁺ T-cell pool in healthy children and untreated children infected with HIV-1
Clinical Trials & Observations

Clinical efficacy of high-dose dexamethasone with maintenance dexamethasone/alpha interferon in patients with primary systemic amyloidosis: results of United States Intergroup Trial Southwest Oncology Group (SWOG) S9628
Clinical Trials & Observations

Infant acute lymphoblastic leukemia with MLL gene rearrangements: outcome following intensive chemotherapy and hematopoietic stem cell transplantation
Clinical Trials & Observations

Allogeneic hematopoietic cell transplantation after fludarabine and 2 Gy total body irradiation for relapsed and refractory mantle cell lymphoma
Clinical Trials & Observations

Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome
Brief Report

β₂-glycoprotein I–dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome
Clinical Trials & Observations

A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism
Clinical Trials & Observations

RNAi-mediated silencing of CD40 prevents leukocyte adhesion on CD154-activated endothelial cells
Brief Report

Sensitivity of oncogenic KIT mutants to the kinase inhibitors MLN518 and PD180970
Brief Report

Myeloablative allogeneic hematopoietic stem cell transplantation in patients who experience relapse after autologous stem cell transplantation for lymphoma: a report of the International Bone Marrow Transplant Registry
Clinical Trials & Observations

Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies
Clinical Trials & Observations

Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)–mismatched family members linked with long-term fetomaternal microchimerism
Clinical Trials & Observations