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Volume 104, Issue 1

July 1 2004

In this Issue

INSIDE BLOOD
BLOOD WORK
PLENARY PAPERS
REVIEW ARTICLES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
ERRATA
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
RED CELLS
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

Mammalian primitive erythrocytes: neither fish nor fowl

Joel Anne Chasis

View Articletitled, Mammalian primitive erythrocytes: neither fish nor fowl

IMMUNOBIOLOGY

Neutropenia in systemic lupus erythematosus

W. Conrad Liles,Gordon Starkebaum,David C. Dale

View Articletitled, Neutropenia in systemic lupus erythematosus

INSIDE BLOOD

Atherogenic role of the type EIIIA fibronectin domain

Vicente Andrés

View Articletitled, Atherogenic role of the type EIIIA fibronectin domain

HEMOSTASIS, THROMBOSIS, & VASCULAR BIOLOGY

ADAMTS-13, VWF, inflammation, and thrombosis

David G. Motto

View Articletitled, ADAMTS-13, VWF, inflammation, and thrombosis

HEMATOPOIESIS

Blood cells: excitable at last

Richard Sullivan

View Articletitled, Blood cells: excitable at last

HEMOSTASIS, THROMBOSIS, & VASCULAR BIOLOGY

VEGF up-regulates DSCR1: more surprises

Michael Detmar

View Articletitled, VEGF up-regulates DSCR1: more surprises

HEMOSTASIS, THROMBOSIS, & VASCULAR BIOLOGY

A new mechanism for inherited factor XI deficiency

Uri Seligsohn

View Articletitled, A new mechanism for inherited factor XI deficiency

HEMOSTASIS, THROMBOSIS, & VASCULAR BIOLOGY

Quebec platelet syndrome: from the bench to the family

James N. George

View Articletitled, Quebec platelet syndrome: from the bench to the family

NEOPLASIA

Molecular monitoring of EBV-positive lymphoma

Jan J. Cornelissen

View Articletitled, Molecular monitoring of EBV-positive lymphoma

BLOOD WORK

Timely topic

View Articletitled, Timely topic

PLENARY PAPERS

Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis

Michelle H. Tan,Zhengwu Sun,Sarah L. Opitz,Tracy E. Schmidt,John H. Peters,Elizabeth L. George

View Articletitled, Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis

Yolk sac–derived primitive erythroblasts enucleate during mammalian embryogenesis

Paul D. Kingsley,Jeffrey Malik,Katherine A. Fantauzzo,James Palis

View Articletitled, Yolk sac–derived primitive erythroblasts enucleate during mammalian embryogenesis

REVIEW ARTICLES

Antigen-induced regulatory T cells

Stephane Vigouroux,Eric Yvon,Ettore Biagi,Malcolm K. Brenner

View Articletitled, Antigen-induced regulatory T cells

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Complications of β-thalassemia major in North America
Clinical Trials & Observations

Melody J. Cunningham,Eric A. Macklin,Ellis J. Neufeld,Alan R. Cohen,the Thalassemia Clinical Research Network

View Articletitled, Complications of β-thalassemia major in North America

Acquired Fanconi syndrome is an indolent disorder in the absence of overt multiple myeloma
Clinical Trials & Observations Brief Report

Cynthia X. Ma,Martha Q. Lacy,John F. Rompala,Angela Dispenzieri,S. Vincent Rajkumar,Philip R. Greipp,Rafael Fonseca,Robert A. Kyle,Morie A. Gertz

View Articletitled, Acquired Fanconi syndrome is an indolent disorder in the absence of overt multiple myeloma

ERRATA

Erratum for vol. 103, p. 2908

View Articletitled, Erratum for vol. 103, p. 2908

HEMATOPOIESIS

Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia

Hagir B. Suliman,Mervat Ali,Claude A. Piantadosi

View Articletitled, Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia

Activation of the MAP kinase pathway by c-Kit is PI-3 kinase dependent in hematopoietic progenitor/stem cell lines

Ewa Wandzioch,Charlotte E. Edling,Ruth H. Palmer,Leif Carlsson,Bengt Hallberg

View Articletitled, Activation of the MAP kinase pathway by c-Kit is PI-3 kinase dependent in hematopoietic progenitor/stem cell lines

Supplemental data

Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities

Koji Inagaki,Tomohiro Oda,Yuichi Naka,Hisashi Shinkai,Norio Komatsu,Hiroyuki Iwamura

View Articletitled, Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities

Characterization of hematopoietic progenitor mobilization in protease-deficient mice

Jean-Pierre Levesque,Fulu Liu,Paul J. Simmons,Tomoko Betsuyaku,Robert M. Senior,Christine Pham,Daniel C. Link

View Articletitled, Characterization of hematopoietic progenitor mobilization in protease-deficient mice

Erythropoietin regulation of Raf-1 and MEK: evidence for a Ras-independent mechanism

Changmin Chen,Arthur J. Sytkowski

View Articletitled, Erythropoietin regulation of Raf-1 and MEK: evidence for a Ras-independent mechanism

Primary human CD34⁺ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators

Ulrich Steidl,Simone Bork,Sebastian Schaub,Oliver Selbach,Janette Seres,Manuel Aivado,Thomas Schroeder,Ulrich-Peter Rohr,Roland Fenk,Slawomir Kliszewski,Christian Maercker,Peter Neubert,Stefan R. Bornstein,Helmut L. Haas,Guido Kobbe,Daniel G. Tenen,Rainer Haas,Ralf Kronenwett

View Articletitled, Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators

Deletion of the major GATA1 enhancer HS 1 does not affect eosinophil GATA1 expression and eosinophil differentiation
Brief Report

Boris Guyot,Veronica Valverde-Garduno,Catherine Porcher,Paresh Vyas

View Articletitled, Deletion of the major GATA1 enhancer HS 1 does not affect eosinophil GATA1 expression and eosinophil differentiation

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis

Marco Rusnati,Maura Camozzi,Emanuela Moroni,Barbara Bottazzi,Giuseppe Peri,Stefano Indraccolo,Alberto Amadori,Alberto Mantovani,Marco Presta

View Articletitled, Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis

Effects of inflammatory cytokines on the release and cleavage of the endothelial cell–derived ultralarge von Willebrand factor multimers under flow

Aubrey Bernardo,Chalmette Ball,Leticia Nolasco,Joel F. Moake,Jing-fei Dong

View Articletitled, Effects of inflammatory cytokines on the release and cleavage of the endothelial cell–derived ultralarge von Willebrand factor multimers under flow

Severe deficiency of glycoprotein VI in a patient with gray platelet syndrome

Paquita Nurden,Martine Jandrot-Perrus,Robert Combrié,Joelle Winckler,Veronique Arocas,Christelle Lecut,Jean-Max Pasquet,Thomas J. Kunicki,Alan T. Nurden

View Articletitled, Severe deficiency of glycoprotein VI in a patient with gray platelet syndrome

Preventing restimulation of memory B cells in hemophilia A: a potential new strategy for the treatment of antibody-dependent immune disorders

Christina Hausl,Rafi U. Ahmad,Hans Peter Schwarz,Eva M. Muchitsch,Peter L. Turecek,Friedrich Dorner,Birgit M. Reipert

View Articletitled, Preventing restimulation of memory B cells in hemophilia A: a potential new strategy for the treatment of antibody-dependent immune disorders

Platelet deposition inhibits tissue factor activity: in vitro clots are impermeable to factor X_a

James J. Hathcock,Yale Nemerson

View Articletitled, Platelet deposition inhibits tissue factor activity: in vitro clots are impermeable to factor Xa

Dominant factor XI deficiency caused by mutations in the factor XI catalytic domain
Clinical Trials & Observations

Dmitri V. Kravtsov,Wenman Wu,Joost C. M. Meijers,Mao-Fu Sun,Morey A. Blinder,Thao P. Dang,Hongli Wang,David Gailani

View Articletitled, Dominant factor XI deficiency caused by mutations in the factor XI catalytic domain

TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death

I-Shing Yu,Shu-Rung Lin,Chin-Chin Huang,Hui-Yu Tseng,Pei-Hsing Huang,Guey-Yueh Shi,Hua-Lin Wu,Chi-Lu Tang,Pao-Hsien Chu,Lee-Ho Wang,Kenneth K. Wu,Shu-Wha Lin

View Articletitled, TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death

The contribution of inherited and acquired thrombophilic defects, alone or combined with antiphospholipid antibodies, to venous and arterial thromboembolism in patients with systemic lupus erythematosus
Clinical Trials & Observations

Jan-Leendert P. Brouwer,Marc Bijl,Nic J. G. M. Veeger,Hanneke C. Kluin-Nelemans,Jan van der Meer

View Articletitled, The contribution of inherited and acquired thrombophilic defects, alone or combined with antiphospholipid antibodies, to venous and arterial thromboembolism in patients with systemic lupus erythematosus

Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells

Boris A. Hesser,Xiao Huan Liang,Gieri Camenisch,Suya Yang,David A. Lewin,Richard Scheller,Napoleone Ferrara,Hans-Peter Gerber

View Articletitled, Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells

Bleeding risks associated with inheritance of the Quebec platelet disorder
Clinical Trials & Observations

Heather McKay,Francine Derome,M. Anwar Haq,Susan Whittaker,Emmy Arnold,Frédéric Adam,Nancy M. Heddle,Georges E. Rivard,Catherine P. M. Hayward

View Articletitled, Bleeding risks associated with inheritance of the Quebec platelet disorder

Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells
Brief Report

Yasuhiro Suzuki,Yusuke Komi,Hiromi Ashino,Jun Yamashita,Jun Inoue,Atsushi Yoshiki,Anne Eichmann,Hiroshi Amanuma,Soichi Kojima

View Articletitled, Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells

IMMUNOBIOLOGY

Enhanced cytotoxicity of allogeneic NK cells with killer immunoglobulin-like receptor ligand incompatibility against melanoma and renal cell carcinoma cells

Takehito Igarashi,Jason Wynberg,Ramprasad Srinivasan,Brian Becknell,J. Phillip McCoy, Jr,Yoshiyuki Takahashi,Dante A. Suffredini,W. Marston Linehan,Michael A. Caligiuri,Richard W. Childs

View Articletitled, Enhanced cytotoxicity of allogeneic NK cells with killer immunoglobulin-like receptor ligand incompatibility against melanoma and renal cell carcinoma cells

An anti-CD19 antibody inhibits the interaction between P-glycoprotein (P-gp) and CD19, causes P-gp to translocate out of lipid rafts, and chemosensitizes a multidrug-resistant (MDR) lymphoma cell line

Maria-Ana Ghetie,Radu Marches,Stephanie Kufert,Ellen S. Vitetta

View Articletitled, An anti-CD19 antibody inhibits the interaction between P-glycoprotein (P-gp) and CD19, causes P-gp to translocate out of lipid rafts, and chemosensitizes a multidrug-resistant (MDR) lymphoma cell line

TNF-related apoptosis-inducing ligand is involved in neutropenia of systemic lupus erythematosus
Clinical Trials & Observations

Wataru Matsuyama,Masuki Yamamoto,Ikkou Higashimoto,Ken-ichi Oonakahara,Masaki Watanabe,Kentarou Machida,Teizo Yoshimura,Nobutaka Eiraku,Masaharu Kawabata,Mitsuhiro Osame,Kimiyoshi Arimura

View Articletitled, TNF-related apoptosis-inducing ligand is involved in neutropenia of systemic lupus erythematosus

Human B cells that hyperexpress a triad of costimulatory molecules via avipox-vector infection: an alternative source of efficient antigen-presenting cells

Claudia Palena,MingZhu Zhu,Jeffrey Schlom,Kwong-Yok Tsang

View Articletitled, Human B cells that hyperexpress a triad of costimulatory molecules via avipox-vector infection: an alternative source of efficient antigen-presenting cells

Identification of an HLA-A*0201–restricted CD8⁺ T-cell epitope SSp-1 of SARS-CoV spike protein

Baomei Wang,Huabiao Chen,Xiaodong Jiang,Minghui Zhang,Tao Wan,Nan Li,Xiangyang Zhou,Yanfeng Wu,Feng Yang,Yizhi Yu,Xiaoning Wang,Ruifu Yang,Xuetao Cao

View Articletitled, Identification of an HLA-A*0201–restricted CD8+ T-cell epitope SSp-1 of SARS-CoV spike protein

NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and FcϵRI aggregation

Christine Tkaczyk,Vaclav Horejsi,Shoko Iwaki,Petr Draber,Lawrence E. Samelson,Anne B. Satterthwaite,Dong-Ho Nahm,Dean D. Metcalfe,Alasdair M. Gilfillan

View Articletitled, NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and FcϵRI aggregation

GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal–induced apoptosis

Marie-Liesse Asselin-Labat,Muriel David,Armelle Biola-Vidamment,Damiana Lecoeuche,Maria-Christina Zennaro,Jacques Bertoglio,Marc Pallardy

View Articletitled, GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal–induced apoptosis

Artificial antigen-presenting constructs efficiently stimulate minor histocompatibility antigen–specific cytotoxic T lymphocytes
Brief Report

Liesbeth E. M. Oosten,Els Blokland,Astrid G. S. van Halteren,Julie Curtsinger,Matthew F. Mescher,J. H. Frederik Falkenburg,Tuna Mutis,Els Goulmy

View Articletitled, Artificial antigen-presenting constructs efficiently stimulate minor histocompatibility antigen–specific cytotoxic T lymphocytes

Supplemental data

NEOPLASIA

Phase 1 trial of a novel anti-CD20 fusion protein in pretargeted radioimmunotherapy for B-cell non-Hodgkin lymphoma
Clinical Trials & Observations

Andres Forero,Paul L. Weiden,Julie M. Vose,Susan J. Knox,Albert F. LoBuglio,Jordan Hankins,Michael L. Goris,Vincent J. Picozzi,Don B. Axworthy,Hazel B. Breitz,Robert B. Sims,Richard G. Ghalie,Sui Shen,Ruby F. Meredith

View Articletitled, Phase 1 trial of a novel anti-CD20 fusion protein in pretargeted radioimmunotherapy for B-cell non-Hodgkin lymphoma

Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells

Takayuki Ikezoe,Sakae Tanosaki,Utz Krug,Bingrong Liu,Pinchas Cohen,Hirokuni Taguchi,H. Phillip Koeffler

View Articletitled, Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells

Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients
Clinical Trials & Observations

Wing-Yan Au,Annie Pang,Carolyn Choy,Chor-Sang Chim,Yok-Lam Kwong

View Articletitled, Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients

Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature

Vera Vanhentenrijk,Chris De Wolf-Peeters,Iwona Wlodarska

View Articletitled, Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signature

MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription

Elisa Benasciutti,Gilles Pagès,Olga Kenzior,William Folk,Francesco Blasi,Massimo P. Crippa

View Articletitled, MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription

RED CELLS

Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major
Clinical Trials & Observations

Bernard A. Davis,Caoimhe O'Sullivan,Peter H. Jarritt,John B. Porter

View Articletitled, Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major

Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease

Maria L. Jison,Peter J. Munson,Jennifer J. Barb,Anthony F. Suffredini,Shefali Talwar,Carolea Logun,Nalini Raghavachari,John H. Beigel,James H. Shelhamer,Robert L. Danner,Mark T. Gladwin

View Articletitled, Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease

Supplemental data

TRANSPLANTATION

Reconstitution dynamics of plasmacytoid and myeloid dendritic cell precursors after allogeneic myeloablative hematopoietic stem cell transplantation

Francesco F. Fagnoni,Barbara Oliviero,Giovanna Giorgiani,Piero De Stefano,Anna Dehò,Carlo Zibera,Nadia Gibelli,Rita Maccario,GianAntonio Da Prada,Marco Zecca,Franco Locatelli

View Articletitled, Reconstitution dynamics of plasmacytoid and myeloid dendritic cell precursors after allogeneic myeloablative hematopoietic stem cell transplantation

Myogenic fusion of human bone marrow stromal cells, but not hematopoietic cells

Daqing Shi,Hans Reinecke,Charles E. Murry,Beverly Torok-Storb

View Articletitled, Myogenic fusion of human bone marrow stromal cells, but not hematopoietic cells

Supplemental data

CORRESPONDENCE

Donor lymphocyte infusions after reduced intensity conditioning allogeneic transplantation: what we need to know

David I. Marks,Anne Parker,Stephen P. Robinson

View Articletitled, Donor lymphocyte infusions after reduced intensity conditioning allogeneic transplantation: what we need to know

HIV Env reduction postreceptor binding: a new target for AIDS treatment?

Emmanuel Fenouillet,Rym Barbouche,Ian M. Jones

View Articletitled, HIV Env reduction postreceptor binding: a new target for AIDS treatment?

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Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

PLENARY PAPERS

REVIEW ARTICLES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Complications of β-thalassemia major in North America Clinical Trials & Observations

Acquired Fanconi syndrome is an indolent disorder in the absence of overt multiple myeloma Clinical Trials & Observations Brief Report

ERRATA

HEMATOPOIESIS

Deletion of the major GATA1 enhancer HS 1 does not affect eosinophil GATA1 expression and eosinophil differentiation Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Dominant factor XI deficiency caused by mutations in the factor XI catalytic domain Clinical Trials & Observations

The contribution of inherited and acquired thrombophilic defects, alone or combined with antiphospholipid antibodies, to venous and arterial thromboembolism in patients with systemic lupus erythematosus Clinical Trials & Observations

Bleeding risks associated with inheritance of the Quebec platelet disorder Clinical Trials & Observations

Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells Brief Report

IMMUNOBIOLOGY

TNF-related apoptosis-inducing ligand is involved in neutropenia of systemic lupus erythematosus Clinical Trials & Observations

Artificial antigen-presenting constructs efficiently stimulate minor histocompatibility antigen–specific cytotoxic T lymphocytes Brief Report

NEOPLASIA

Phase 1 trial of a novel anti-CD20 fusion protein in pretargeted radioimmunotherapy for B-cell non-Hodgkin lymphoma Clinical Trials & Observations

Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients Clinical Trials & Observations

RED CELLS

Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major Clinical Trials & Observations

TRANSPLANTATION

CORRESPONDENCE

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American Society of Hematology

This Feature Is Available To Subscribers Only

Complications of β-thalassemia major in North America
Clinical Trials & Observations

Acquired Fanconi syndrome is an indolent disorder in the absence of overt multiple myeloma
Clinical Trials & Observations Brief Report

Deletion of the major GATA1 enhancer HS 1 does not affect eosinophil GATA1 expression and eosinophil differentiation
Brief Report

Dominant factor XI deficiency caused by mutations in the factor XI catalytic domain
Clinical Trials & Observations

The contribution of inherited and acquired thrombophilic defects, alone or combined with antiphospholipid antibodies, to venous and arterial thromboembolism in patients with systemic lupus erythematosus
Clinical Trials & Observations

Bleeding risks associated with inheritance of the Quebec platelet disorder
Clinical Trials & Observations

Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells
Brief Report

TNF-related apoptosis-inducing ligand is involved in neutropenia of systemic lupus erythematosus
Clinical Trials & Observations

Artificial antigen-presenting constructs efficiently stimulate minor histocompatibility antigen–specific cytotoxic T lymphocytes
Brief Report

Phase 1 trial of a novel anti-CD20 fusion protein in pretargeted radioimmunotherapy for B-cell non-Hodgkin lymphoma
Clinical Trials & Observations

Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients
Clinical Trials & Observations

Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major
Clinical Trials & Observations