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Volume 103, Issue 8

April 15 2004

In this Issue

INSIDE BLOOD
PLENARY PAPERS
REVIEW ARTICLES
ERRATA
REVIEW IN TRANSLATIONAL HEMATOLOGY
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
RED CELLS
CORRESPONDENCE

INSIDE BLOOD

Gas up and live!

Victoria L. Bautch

View Articletitled, Gas up and live!

Can we cure CML?

Brian J. Druker

View Articletitled, Can we cure CML?

A casein kinase making its case in granulopoiesis

Ivo P. Touw

View Articletitled, A casein kinase making its case in granulopoiesis

Fibrinogen faux pas

Victor J. Marder

View Articletitled, Fibrinogen faux pas

IgE-induced signaling: only the weak survive

Gerald Krystal

View Articletitled, IgE-induced signaling: only the weak survive

Bridging the bone marrow–thymus gap

Markus G. Manz

View Articletitled, Bridging the bone marrow–thymus gap

“Annexing” acute leukemias

Kevin S. Smith

View Articletitled, “Annexing” acute leukemias

MLL, Hox genes, and leukemia: the plot thickens

Jay L. Hess

View Articletitled, MLL, Hox genes, and leukemia: the plot thickens

Novel twin study implicates IL-6 in the etiology of young adult Hodgkin lymphoma

James R. Cerhan

View Articletitled, Novel twin study implicates IL-6 in the etiology of young adult Hodgkin lymphoma

Unique genetics of human embryonic stem cells

Dan S. Kaufman

View Articletitled, Unique genetics of human embryonic stem cells

PLENARY PAPERS

High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome–positive chronic phase chronic myeloid leukemia
Clinical Trials & Observations

Hagop Kantarjian,Moshe Talpaz,Susan O'Brien,Guillermo Garcia-Manero,Srdan Verstovsek,Francis Giles,Mary Beth Rios,Jianqin Shan,Laurie Letvak,Deborah Thomas,Stefan Faderl,Alessandra Ferrajoli,Jorge Cortes

View Articletitled, High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome–positive chronic phase chronic myeloid leukemia

REVIEW ARTICLES

The FIP1L1-PDGFRα fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management
Clinical Trials & Observations

Jason Gotlib,Jan Cools,James M. Malone, III,Stanley L. Schrier,D. Gary Gilliland,Steven E. Coutré

View Articletitled, The FIP1L1-PDGFRα fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management

ERRATA

Erratum for vol. 103, p. 2291

View Articletitled, Erratum for vol. 103, p. 2291

REVIEW IN TRANSLATIONAL HEMATOLOGY

Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm

Gregor Prindull,Dov Zipori

View Articletitled, Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm

CHEMOKINES

Unique SDF-1–induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling

Asaf Spiegel,Orit Kollet,Amnon Peled,Loya Abel,Arnon Nagler,Bella Bielorai,Gideon Rechavi,Josef Vormoor,Tsvee Lapidot

View Articletitled, Unique SDF-1–induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients
Clinical Trials & Observations

Gert J. Ossenkoppele,Wilfried J. Graveland,Pieter Sonneveld,Simon M. G. J. Daenen,Douwe H. Biesma,Leo F. Verdonck,M. Ron Schaafsma,Petra H. M. Westveer,Godefridus J. Peters,Paul Noordhuis,Petra Muus,Dominik Selleslag,Bronnie van der Holt,Michel Delforge,Bob Löwenberg,Gregor E. G. Verhoef,Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON)

View Articletitled, The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients

Hemochromatosis mutations in the general population: iron overload progression rate
Clinical Trials & Observations

Rolf Værn Andersen,Anne Tybjærg-Hansen,Merete Appleyard,Henrik Birgens,Børge Grønne Nordestgaard

View Articletitled, Hemochromatosis mutations in the general population: iron overload progression rate

A pilot study of alemtuzumab (anti-CD52 monoclonal antibody) therapy for patients with relapsed or chemotherapy-refractory peripheral T-cell lymphomas
Clinical Trials & Observations

Gunilla Enblad,Hans Hagberg,Martin Erlanson,Jeanette Lundin,Anja Porwit MacDonald,Roland Repp,Johannes Schetelig,Gernot Seipelt,Anders Österborg

View Articletitled, A pilot study of alemtuzumab (anti-CD52 monoclonal antibody) therapy for patients with relapsed or chemotherapy-refractory peripheral T-cell lymphomas

Rituximab for primary chronic cold agglutinin disease: a prospective study of 37 courses of therapy in 27 patients
Clinical Trials & Observations

Sigbjørn Berentsen,Elling Ulvestad,Bjørn Tore Gjertsen,Henrik Hjorth-Hansen,Ruth Langholm,Håvar Knutsen,Waleed Ghanima,Fuad Victor Shammas,Geir E. Tjønnfjord

View Articletitled, Rituximab for primary chronic cold agglutinin disease: a prospective study of 37 courses of therapy in 27 patients

Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib
Clinical Trials & Observations

Petri Bono,Andreas Krause,Margaret von Mehren,Michael C. Heinrich,Charles D. Blanke,Sasa Dimitrijevic,George D. Demetri,Heikki Joensuu

View Articletitled, Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib

Association of melphalan and high-dose dexamethasone is effective and well tolerated in patients with AL (primary) amyloidosis who are ineligible for stem cell transplantation
Clinical Trials & Observations Brief Report

Giovanni Palladini,Vittorio Perfetti,Laura Obici,Riccardo Caccialanza,Alessandra Semino,Fausto Adami,Giobatta Cavallero,Roberto Rustichelli,Giovambattista Virga,Giampaolo Merlini

View Articletitled, Association of melphalan and high-dose dexamethasone is effective and well tolerated in patients with AL (primary) amyloidosis who are ineligible for stem cell transplantation

Safety and efficacy of the monoclonal anti–interleukin-5 antibody SCH55700 in the treatment of patients with hypereosinophilic syndrome
Clinical Trials & Observations Brief Report

Amy D. Klion,Melissa A. Law,Pierre Noel,Yae-Jean Kim,Thomas P. Haverty,Thomas B. Nutman

View Articletitled, Safety and efficacy of the monoclonal anti–interleukin-5 antibody SCH55700 in the treatment of patients with hypereosinophilic syndrome

GENE THERAPY

Overexpression of CXCR4 on human CD34⁺ progenitors increases their proliferation, migration, and NOD/SCID repopulation

Joy Kahn,Tamara Byk,Lottie Jansson-Sjostrand,Isabelle Petit,Shoham Shivtiel,Arnon Nagler,Izhar Hardan,Varda Deutsch,Zulma Gazit,Dan Gazit,Stefan Karlsson,Tsvee Lapidot

View Articletitled, Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation

HEMATOPOIESIS

Dynamic reorganization of chromatin structure and selective DNA demethylation prior to stable enhancer complex formation during differentiation of primary hematopoietic cells in vitro

Hiromi Tagoh,Svitlana Melnik,Pascal Lefevre,Suyinn Chong,Arthur D. Riggs,Constanze Bonifer

View Articletitled, Dynamic reorganization of chromatin structure and selective DNA demethylation prior to stable enhancer complex formation during differentiation of primary hematopoietic cells in vitro

Gene expression in human embryonic stem cell lines: unique molecular signature

Bhaskar Bhattacharya,Takumi Miura,Ralph Brandenberger,Josef Mejido,Yongquan Luo,Amy X. Yang,Bharat H. Joshi,Irene Ginis,R. Scott Thies,Michal Amit,Ian Lyons,Brian G. Condie,Joseph Itskovitz-Eldor,Mahendra S. Rao,Raj K. Puri

View Articletitled, Gene expression in human embryonic stem cell lines: unique molecular signature

Supplemental data

Hematopoietic-repopulating defects from STAT5-deficient bone marrow are not fully accounted for by loss of thrombopoietin responsiveness

Heath L. Bradley,Christine Couldrey,Kevin D. Bunting

View Articletitled, Hematopoietic-repopulating defects from STAT5-deficient bone marrow are not fully accounted for by loss of thrombopoietin responsiveness

Reprogramming of human postmitotic neutrophils into macrophages by growth factors

Hiroto Araki,Naoyuki Katayama,Yoshihiro Yamashita,Hiroyuki Mano,Atsushi Fujieda,Eiji Usui,Hidetsugu Mitani,Kohshi Ohishi,Kazuhiro Nishii,Masahiro Masuya,Nobuyuki Minami,Tsutomu Nobori,Hiroshi Shiku

View Articletitled, Reprogramming of human postmitotic neutrophils into macrophages by growth factors

CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34⁺ stem/progenitor cells to bone marrow

Abraham Avigdor,Polina Goichberg,Shoham Shivtiel,Ayelet Dar,Amnon Peled,Sarit Samira,Orit Kollet,Rami Hershkoviz,Ronen Alon,Izhar Hardan,Herzl Ben-Hur,David Naor,Arnon Nagler,Tsvee Lapidot

View Articletitled, CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow

Supplemental data

L-selectin defines a bone marrow analog to the thymic early T-lineage progenitor

S. Scott Perry,Hongfang Wang,L. Jeanne Pierce,Anne Marie Yang,Schickwann Tsai,Gerald J. Spangrude

View Articletitled, L-selectin defines a bone marrow analog to the thymic early T-lineage progenitor

Involvement of casein kinase Iϵ in cytokine-induced granulocytic differentiation

Atsuo Okamura,Nobuko Iwata,Aki Nagata,Akira Tamekane,Manabu Shimoyama,Hiroshi Gomyo,Kimikazu Yakushijin,Norinaga Urahama,Miyuki Hamaguchi,Chie Fukui,Kazuo Chihara,Mitsuhiro Ito,Toshimitsu Matsui

View Articletitled, Involvement of casein kinase Iϵ in cytokine-induced granulocytic differentiation

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Gas1 is induced by VE-cadherin and vascular endothelial growth factor and inhibits endothelial cell apoptosis

Raffaella Spagnuolo,Monica Corada,Fabrizio Orsenigo,Lucia Zanetta,Ulrich Deuschle,Peter Sandy,Claudio Schneider,Christopher J. Drake,Ferruccio Breviario,Elisabetta Dejana

View Articletitled, Gas1 is induced by VE-cadherin and vascular endothelial growth factor and inhibits endothelial cell apoptosis

EWI-2 modulates lymphocyte integrin α4β1 functions

Tatiana V. Kolesnikova,Christopher S. Stipp,Ravi M. Rao,William S. Lane,Francis W. Luscinskas,Martin E. Hemler

View Articletitled, EWI-2 modulates lymphocyte integrin α4β1 functions

Supplemental data

Membrane type 1–matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1–phosphate to induce endothelial cell migration and morphogenic differentiation

Stéphanie Langlois,Denis Gingras,Richard Béliveau

View Articletitled, Membrane type 1–matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1–phosphate to induce endothelial cell migration and morphogenic differentiation

Tissue factor-factor VIIa–specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration

Gertrud M. Hjortoe,Lars C. Petersen,Tatjana Albrektsen,Brit B. Sorensen,Peder L. Norby,Samir K. Mandal,Usha R. Pendurthi,L. Vijaya Mohan Rao

View Articletitled, Tissue factor-factor VIIa–specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration

Lipid rafts are necessary for tonic inhibition of cellular tissue factor procoagulant activity

Dennis J. Dietzen,Keith L. Page,Tina A. Tetzloff

View Articletitled, Lipid rafts are necessary for tonic inhibition of cellular tissue factor procoagulant activity

Thrombophilic dysfibrinogen Tokyo V with the amino acid substitution of γ Ala327Thr: formation of fragile but fibrinolysis-resistant fibrin clots and its relevance to arterial thromboembolism
Clinical Trials & Observations

Akiei Hamano,Jun Mimuro,Motonori Aoshima,Takeyoshi Itoh,Noboru Kitamura,Susumu Nishinarita,Katsuhiro Takano,Akira Ishiwata,Yuji Kashiwakura,Kazuki Niwa,Tomoko Ono,Seiji Madoiwa,Teruko Sugo,Michio Matsuda,Yoichi Sakata

View Articletitled, Thrombophilic dysfibrinogen Tokyo V with the amino acid substitution of γ Ala327Thr: formation of fragile but fibrinolysis-resistant fibrin clots and its relevance to arterial thromboembolism

Missense or splicing mutation? The case of a fibrinogen Bβ-chain mutation causing severe hypofibrinogenemia
Clinical Trials & Observations Brief Report

Rosanna Asselta,Stefano Duga,Silvia Spena,Flora Peyvandi,Giancarlo Castaman,Massimo Malcovati,Pier Mannuccio Mannucci,Maria Luisa Tenchini

View Articletitled, Missense or splicing mutation? The case of a fibrinogen Bβ-chain mutation causing severe hypofibrinogenemia

5′-Flanking region polymorphisms of CYP2C9 and their relationship to S-warfarin metabolism in white and Japanese patients
Brief Report

Harumi Takahashi,Ichiro Ieiri,Grant R. Wilkinson,Gail Mayo,Toshitaka Kashima,Sosuke Kimura,Kenji Otsubo,Hirotoshi Echizen

View Articletitled, 5′-Flanking region polymorphisms of CYP2C9 and their relationship to S-warfarin metabolism in white and Japanese patients

IMMUNOBIOLOGY

Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help

Hendrik Poeck,Moritz Wagner,Julia Battiany,Simon Rothenfusser,Daniela Wellisch,Veit Hornung,Bernd Jahrsdorfer,Thomas Giese,Stefan Endres,Gunther Hartmann

View Articletitled, Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help

Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8⁺ T cells

Michael R. Verneris,Mobin Karami,Jeanette Baker,Anishka Jayaswal,Robert S. Negrin

View Articletitled, Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells

Unexpectedly, induction of cytotoxic T lymphocytes enhances the humoral response after DNA immunization

Christopher M. Dyer,Yifan Zhan,Jamie L. Brady,Francis R. Carbone,Mark J. Smyth,Andrew M. Lew

View Articletitled, Unexpectedly, induction of cytotoxic T lymphocytes enhances the humoral response after DNA immunization

Identification and in vitro expansion of CD4⁺ and CD8⁺ T cells specific for human neutrophil elastase

Hiroshi Fujiwara,Frank El Ouriaghli,Matthias Grube,David A. Price,Katayoun Rezvani,Emma Gostick,Giuseppe Sconocchia,Jos Melenhorst,Nancy Hensel,Daniel C. Douek,A. John Barrett

View Articletitled, Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase

Uninfected erythrocytes inhibit Plasmodium falciparum–induced cellular immune responses in whole-blood assays

Siske S. Struik,Fakhreldin M. Omer,Katerina Artavanis-Tsakonas,Eleanor M. Riley

View Articletitled, Uninfected erythrocytes inhibit Plasmodium falciparum–induced cellular immune responses in whole-blood assays

The quantity and duration of FcRγ signals determine mast cell degranulation and survival

Sho Yamasaki,Eri Ishikawa,Masayuki Kohno,Takashi Saito

View Articletitled, The quantity and duration of FcRγ signals determine mast cell degranulation and survival

Do thymically and strictly extrathymically developing T cells generate similar immune responses?

Marie-Ève Blais,Gwladys Gérard,Marianne M. Martinic,Guillaume Roy-Proulx,Rolf M. Zinkernagel,Claude Perreault

View Articletitled, Do thymically and strictly extrathymically developing T cells generate similar immune responses?

Cognate recognition of the endothelium induces HY-specific CD8⁺ T-lymphocyte transendothelial migration (diapedesis) in vivo

Federica M. Marelli-Berg,Martha J. James,John Dangerfield,Julian Dyson,Maggie Millrain,Diane Scott,Elizabeth Simpson,Sussan Nourshargh,Robert I. Lechler

View Articletitled, Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo

Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25⁺ regulatory thymocytes because of their responsiveness to different cytokines

Lorenzo Cosmi,Francesco Liotta,Roberta Angeli,Benedetta Mazzinghi,Veronica Santarlasci,Roberto Manetti,Laura Lasagni,Vittorio Vanini,Paola Romagnani,Enrico Maggi,Francesco Annunziato,Sergio Romagnani

View Articletitled, Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines

NEOPLASIA

Down-regulation of HLA-A and HLA-Bw6, but not HLA-Bw4, allospecificities in leukemic cells: an escape mechanism from CTL and NK attack?

Christian Demanet,Arend Mulder,Veronique Deneys,Maria J. Worsham,Piet Maes,Frans H. Claas,Soldano Ferrone

View Articletitled, Down-regulation of HLA-A and HLA-Bw6, but not HLA-Bw4, allospecificities in leukemic cells: an escape mechanism from CTL and NK attack?

Angiogenic switch during 5T2MM murine myeloma tumorigenesis: role of CD45 heterogeneity

Kewal Asosingh,Hendrik De Raeve,Eline Menu,Ivan Van Riet,Eric Van Marck,Benjamin Van Camp,Karin Vanderkerken

View Articletitled, Angiogenic switch during 5T2MM murine myeloma tumorigenesis: role of CD45 heterogeneity

Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone

Thomas Strömberg,Anna Dimberg,Anna Hammarberg,Kristina Carlson,Anders Österborg,Kenneth Nilsson,Helena Jernberg-Wiklund

View Articletitled, Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone

BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone

Jérôme Moreaux,Eric Legouffe,Eric Jourdan,Philippe Quittet,Thierry Rème,Cécile Lugagne,Philippe Moine,Jean-François Rossi,Bernard Klein,Karin Tarte

View Articletitled, BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone

The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti–multiple myeloma (MM) activity and overcome bortezomib resistance

Dharminder Chauhan,Guilan Li,Klaus Podar,Teru Hideshima,Reshma Shringarpure,Laurence Catley,Constantine Mitsiades,Nikhil Munshi,Yu Tzu Tai,Nanjoo Suh,Gordon W. Gribble,Tadashi Honda,Robert Schlossman,Paul Richardson,Michael B. Sporn,Kenneth C. Anderson

View Articletitled, The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti–multiple myeloma (MM) activity and overcome bortezomib resistance

BCR/ABL kinase inhibition by imatinib mesylate enhances MAP kinase activity in chronic myelogenous leukemia CD34⁺ cells

Su Chu,Melissa Holtz,Mamta Gupta,Ravi Bhatia

View Articletitled, BCR/ABL kinase inhibition by imatinib mesylate enhances MAP kinase activity in chronic myelogenous leukemia CD34+ cells

Nuclear factor–κB and STAT3 are constitutively active in CD138⁺ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis
Clinical Trials & Observations

Alok C. Bharti,Shishir Shishodia,James M. Reuben,Donna Weber,Raymond Alexanian,Saroj Raj-Vadhan,Zeev Estrov,Moshe Talpaz,Bharat B. Aggarwal

View Articletitled, Nuclear factor–κB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis

Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein

Takayuki Matsunaga,Toshiya Inaba,Hirotaka Matsui,Mayuko Okuya,Atsushi Miyajima,Takeshi Inukai,Tetsunori Funabiki,Mikiya Endo,A. Thomas Look,Hidemitsu Kurosawa

View Articletitled, Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein

Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9

Chi Wai So,Holger Karsunky,Piu Wong,Irving L. Weissman,Michael L. Cleary

View Articletitled, Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9

Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimera

Gang Huang,Katsuya Shigesada,Hee-Jun Wee,P. Paul Liu,Motomi Osato,Yoshiaki Ito

View Articletitled, Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimera

Clonality analysis of alveolar B lymphocytes contributes to the diagnostic strategy in clinical suspicion of pulmonary lymphoma
Clinical Trials & Observations

Simona Zompi,Louis-Jean Couderc,Jacques Cadranel,Martine Antoine,Bernard Epardeau,Jocelyne Fleury-Feith,Natalia Popa,François Santoli,Jean-Pierre Farcet,Marie-Hélène Delfau-Larue

View Articletitled, Clonality analysis of alveolar B lymphocytes contributes to the diagnostic strategy in clinical suspicion of pulmonary lymphoma

IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma
Clinical Trials & Observations

Wendy Cozen,Parkash S. Gill,Sue Ann Ingles,Rizwan Masood,Otoniel Martínez-Maza,Myles G. Cockburn,W. James Gauderman,Malcolm C. Pike,Leslie Bernstein,Bharat N. Nathwani,Muhammad T. Salam,Kathleen Lackerdas Danley,Wei Wang,Julia Gage,Susan Gundell-Miller,Thomas M. Mack

View Articletitled, IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma

A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib
Clinical Trials & Observations

Cem Akin,Gerard Fumo,Akif S. Yavuz,Peter E. Lipsky,Len Neckers,Dean D. Metcalfe

View Articletitled, A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib

Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia
Clinical Trials & Observations

John E. Wagner,Jakub Tolar,Orna Levran,Thomas Scholl,Amie Deffenbaugh,Jaya Satagopan,Leah Ben-Porat,Katherine Mah,Sat Dev Batish,David I. Kutler,Margaret L. MacMillan,Helmut Hanenberg,Arleen D. Auerbach

View Articletitled, Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia

Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells
Brief Report

Ira Jakupovic,Victoria L. Grandage,David C. Linch,Asim Khwaja

View Articletitled, Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells

RED CELLS

Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency

Luanne L. Peters,Rebecca A. Swearingen,Sabra G. Andersen,Babette Gwynn,Amy J. Lambert,Renhua Li,Samuel E. Lux,Gary A. Churchill

View Articletitled, Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency

CORRESPONDENCE

Imatinib mesylate in polycythemia vera

Jerry L. Spivak,Richard T. Silver

View Articletitled, Imatinib mesylate in polycythemia vera

The GATA1 mutation in an adult patient with acute megakaryoblastic leukemia not accompanying Down syndrome

Hideo Harigae,Gang Xu,Tomohiro Sugawara,Izumi Ishikawa,Tsutomu Toki,Etsuro Ito

View Articletitled, The GATA1 mutation in an adult patient with acute megakaryoblastic leukemia not accompanying Down syndrome

RELevant gene amplification in B-cell lymphomas?

Thomas D. Gilmore,Daniel T. Starczynowski,Demetrios Kalaitzidis

View Articletitled, RELevant gene amplification in B-cell lymphomas?

BCR-ABL–specific T cells can be detected in healthy donors and in chronic myeloid leukemia patients following allogeneic stem cell transplantation

Nauman M. Butt,Lihui Wang,Hazem M. Abu-Eisha,Steve E. Christmas,Richard E. Clark

View Articletitled, BCR-ABL–specific T cells can be detected in healthy donors and in chronic myeloid leukemia patients following allogeneic stem cell transplantation

Increased susceptibility of von Willebrand factor to proteolysis by ADAMTS13: should the multimer profile be normal or type 2A?

Derrick J. Bowen

View Articletitled, Increased susceptibility of von Willebrand factor to proteolysis by ADAMTS13: should the multimer profile be normal or type 2A?

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome–positive chronic phase chronic myeloid leukemia Clinical Trials & Observations

REVIEW ARTICLES

The FIP1L1-PDGFRα fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management Clinical Trials & Observations

ERRATA

REVIEW IN TRANSLATIONAL HEMATOLOGY

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients Clinical Trials & Observations

Hemochromatosis mutations in the general population: iron overload progression rate Clinical Trials & Observations

A pilot study of alemtuzumab (anti-CD52 monoclonal antibody) therapy for patients with relapsed or chemotherapy-refractory peripheral T-cell lymphomas Clinical Trials & Observations

Rituximab for primary chronic cold agglutinin disease: a prospective study of 37 courses of therapy in 27 patients Clinical Trials & Observations

Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib Clinical Trials & Observations

Association of melphalan and high-dose dexamethasone is effective and well tolerated in patients with AL (primary) amyloidosis who are ineligible for stem cell transplantation Clinical Trials & Observations Brief Report

Safety and efficacy of the monoclonal anti–interleukin-5 antibody SCH55700 in the treatment of patients with hypereosinophilic syndrome Clinical Trials & Observations Brief Report

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Thrombophilic dysfibrinogen Tokyo V with the amino acid substitution of γ Ala327Thr: formation of fragile but fibrinolysis-resistant fibrin clots and its relevance to arterial thromboembolism Clinical Trials & Observations

Missense or splicing mutation? The case of a fibrinogen Bβ-chain mutation causing severe hypofibrinogenemia Clinical Trials & Observations Brief Report

5′-Flanking region polymorphisms of CYP2C9 and their relationship to S-warfarin metabolism in white and Japanese patients Brief Report

IMMUNOBIOLOGY

NEOPLASIA

Nuclear factor–κB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis Clinical Trials & Observations

Clonality analysis of alveolar B lymphocytes contributes to the diagnostic strategy in clinical suspicion of pulmonary lymphoma Clinical Trials & Observations

IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma Clinical Trials & Observations

A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib Clinical Trials & Observations

Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia Clinical Trials & Observations

Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells Brief Report

RED CELLS

CORRESPONDENCE

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American Society of Hematology

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High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome–positive chronic phase chronic myeloid leukemia
Clinical Trials & Observations

The FIP1L1-PDGFRα fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management
Clinical Trials & Observations

The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients
Clinical Trials & Observations

Hemochromatosis mutations in the general population: iron overload progression rate
Clinical Trials & Observations

A pilot study of alemtuzumab (anti-CD52 monoclonal antibody) therapy for patients with relapsed or chemotherapy-refractory peripheral T-cell lymphomas
Clinical Trials & Observations

Rituximab for primary chronic cold agglutinin disease: a prospective study of 37 courses of therapy in 27 patients
Clinical Trials & Observations

Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib
Clinical Trials & Observations

Association of melphalan and high-dose dexamethasone is effective and well tolerated in patients with AL (primary) amyloidosis who are ineligible for stem cell transplantation
Clinical Trials & Observations Brief Report

Safety and efficacy of the monoclonal anti–interleukin-5 antibody SCH55700 in the treatment of patients with hypereosinophilic syndrome
Clinical Trials & Observations Brief Report

Thrombophilic dysfibrinogen Tokyo V with the amino acid substitution of γ Ala327Thr: formation of fragile but fibrinolysis-resistant fibrin clots and its relevance to arterial thromboembolism
Clinical Trials & Observations

Missense or splicing mutation? The case of a fibrinogen Bβ-chain mutation causing severe hypofibrinogenemia
Clinical Trials & Observations Brief Report

5′-Flanking region polymorphisms of CYP2C9 and their relationship to S-warfarin metabolism in white and Japanese patients
Brief Report

Nuclear factor–κB and STAT3 are constitutively active in CD138⁺ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis
Clinical Trials & Observations

Clonality analysis of alveolar B lymphocytes contributes to the diagnostic strategy in clinical suspicion of pulmonary lymphoma
Clinical Trials & Observations

IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma
Clinical Trials & Observations

A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib
Clinical Trials & Observations

Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia
Clinical Trials & Observations

Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells
Brief Report