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INSIDE BLOOD

Thrombopoietin and the mysteries of plasmacytoid dendritic cells

Claudio Anasetti

View Articletitled, Thrombopoietin and the mysteries of plasmacytoid dendritic cells

Supple to stiff

Arthur R. Thompson

View Articletitled, Supple to stiff

Down syndrome and leukemia—it's in the cards

Jeffrey W. Taub

View Articletitled, Down syndrome and leukemia—it's in the cards

Fanconi anemia: now we are 11

Eric Nisbet-Brown

View Articletitled, Fanconi anemia: now we are 11

Does cGMP mediate platelet inhibition or stimulation?

Wolfgang Siess

View Articletitled, Does cGMP mediate platelet inhibition or stimulation?

Idiotype-mediated neutralization of factor VIII inhibitor antibodies

Kathleen P. Pratt

View Articletitled, Idiotype-mediated neutralization of factor VIII inhibitor antibodies

Wobbling with warfarin

Bruce Furie

View Articletitled, Wobbling with warfarin

Adults are not simply big children

Peter D. Aplan

View Articletitled, Adults are not simply big children

A new model of plasma cell proliferation

Teru Hideshima,Kenneth C. Anderson

View Articletitled, A new model of plasma cell proliferation

Another link in the chain

Richard Ajioka,James Kushner

View Articletitled, Another link in the chain

BLOOD WORK

Neuroblastoma

View Articletitled, Neuroblastoma

REVIEW ARTICLES

Vav1: an oncogene that regulates specific transcriptional activation of T cells

Shulamit Katzav

View Articletitled, Vav1: an oncogene that regulates specific transcriptional activation of T cells

CHEMOKINES

Differential processing of stromal-derived factor-1α and stromal-derived factor-1β explains functional diversity

Maria De La Luz Sierra,Fuquan Yang,Masashi Narazaki,Ombretta Salvucci,David Davis,Robert Yarchoan,Hongwei H. Zhang,Henry Fales,Giovanna Tosato

View Articletitled, Differential processing of stromal-derived factor-1α and stromal-derived factor-1β explains functional diversity

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

The epidemiology of chronic hepatitis C infection in survivors of childhood cancer: an update of the St Jude Children's Research Hospital hepatitis C seropositive cohort
Clinical Trials & Observations

Sharon Castellino,Shelly Lensing,Caroline Riely,Shesh N. Rai,Rene Davila,Randall T. Hayden,Jackie Fleckenstein,Mark Levstik,Shari Taylor,Patrick J. Dean,Sarah Kippenbrock,Jennifer Pope,Jeanne Carr,Donald K. Strickland,Melissa M. Hudson

View Articletitled, The epidemiology of chronic hepatitis C infection in survivors of childhood cancer: an update of the St Jude Children's Research Hospital hepatitis C seropositive cohort

Joint range-of-motion limitations among young males with hemophilia: prevalence and risk factors
Clinical Trials & Observations

J. Michael Soucie,Christy Cianfrini,Robert L. Janco,Roshni Kulkarni,Julie Hambleton,Bruce Evatt,Angela Forsyth,Sue Geraghty,Keith Hoots,Tom Abshire,Randall Curtis,Ann Forsberg,Heather Huszti,Margaret Wagner,Gilbert C. White, II

View Articletitled, Joint range-of-motion limitations among young males with hemophilia: prevalence and risk factors

Peripheral T-cell lymphoma unspecified (PTCL-U): a new prognostic model from a retrospective multicentric clinical study
Clinical Trials & Observations

Andrea Gallamini,Caterina Stelitano,Roberta Calvi,Monica Bellei,Daniele Mattei,Umberto Vitolo,Fortunato Morabito,Maurizio Martelli,Ercole Brusamolino,Emilio Iannitto,Francesco Zaja,Sergio Cortelazzo,Luigi Rigacci,Liliana Devizzi,Giuseppe Todeschini,Gino Santini,Maura Brugiatelli,Massimo Federico,for the Intergruppo Italiano Linfomi

View Articletitled, Peripheral T-cell lymphoma unspecified (PTCL-U): a new prognostic model from a retrospective multicentric clinical study

Natural history of GATA1 mutations in Down syndrome
Clinical Trials & Observations

Momin Ahmed,Alexander Sternberg,Georgina Hall,Angela Thomas,Owen Smith,Aengus O'Marcaigh,Robert Wynn,Richard Stevens,Michael Addison,Derek King,Barbara Stewart,Brenda Gibson,Irene Roberts,Paresh Vyas

View Articletitled, Natural history of GATA1 mutations in Down syndrome

Long-term outcome after bone marrow transplantation for severe aplastic anemia
Clinical Trials & Observations

Lionel Ades,Jean-Yves Mary,Marie Robin,Christèle Ferry,Raphael Porcher,Hélène Esperou,Patricia Ribaud,Agnès Devergie,Richard Traineau,Eliane Gluckman,Gérard Socié

View Articletitled, Long-term outcome after bone marrow transplantation for severe aplastic anemia

HEMATOPOIESIS

Heterogeneity in Fanconi anemia: evidence for 2 new genetic subtypes

Marieke Levitus,Martin A. Rooimans,Jûrgen Steltenpool,Nicolle F. C. Cool,Anneke B. Oostra,Christopher G. Mathew,Maureen E. Hoatlin,Quinten Waisfisz,Fré Arwert,Johan P. de Winter,Hans Joenje

View Articletitled, Heterogeneity in Fanconi anemia: evidence for 2 new genetic subtypes

VEGF-A₁₆₅ augments erythropoietic development from human embryonic stem cells

Chantal Cerdan,Anne Rouleau,Mickie Bhatia

View Articletitled, VEGF-A165 augments erythropoietic development from human embryonic stem cells

Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells

Cheng Cheng Zhang,Harvey F. Lodish

View Articletitled, Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells

Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression

Robert B. Lorsbach,Jennifer Moore,Sonny O. Ang,Weili Sun,Noel Lenny,James R. Downing

View Articletitled, Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression

Differential gene expression of human stem progenitor cells derived from early stages of in utero human hematopoiesis

Farbod Shojaei,Lisa Gallacher,Mickie Bhatia

View Articletitled, Differential gene expression of human stem progenitor cells derived from early stages of in utero human hematopoiesis

Multiparameter analysis of murine bone marrow side population cells

Daniel J. Pearce,Christopher M. Ridler,Catherine Simpson,Dominique Bonnet

View Articletitled, Multiparameter analysis of murine bone marrow side population cells

Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors

Wei Chen,Svetlana Antonenko,Joel M. Sederstrom,Xueqing Liang,Anissa S. H. Chan,Holger Kanzler,Bianca Blom,Bruce R. Blazar,Yong-Jun Liu

View Articletitled, Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors

Association of biallelic BRCA2/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood
Clinical Trials & Observations

Betsy Hirsch,Akiko Shimamura,Lisa Moreau,Shari Baldinger,Maha Hag-alshiekh,Bruce Bostrom,Susan Sencer,Alan D. D'Andrea

View Articletitled, Association of biallelic BRCA2/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood

Transgenic rescue of GATA-1–deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia

Ritsuko Shimizu,Kinuko Ohneda,James Douglas Engel,Cecelia D. Trainor,Masayuki Yamamoto

View Articletitled, Transgenic rescue of GATA-1–deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia

Raf-1 is not required for megakaryocytopoiesis or TPO-induced ERK phosphorylation
Brief Report

Tamihiro Kamata,Catrin A. Pritchard,Andrew D. Leavitt

View Articletitled, Raf-1 is not required for megakaryocytopoiesis or TPO-induced ERK phosphorylation

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Severe hypodysfibrinogenemia in compound heterozygotes of the fibrinogen AαIVS4 + 1G>T mutation and an AαGln328 truncation (fibrinogen Keokuk)
Clinical Trials & Observations

Phil Lefebvre,Pauline T. Velasco,Amy Dear,Karim C. Lounes,Susan T. Lord,Stephen O. Brennan,David Green,Laszlo Lorand

View Articletitled, Severe hypodysfibrinogenemia in compound heterozygotes of the fibrinogen AαIVS4 + 1G>T mutation and an AαGln328 truncation (fibrinogen Keokuk)

Human endothelial cells derived from circulating progenitors display specific functional properties compared with mature vessel wall endothelial cells

Heidi Bompais,Jalila Chagraoui,Xavier Canron,Mihaela Crisan,Xu Hui Liu,Aurora Anjo,Carine Tolla-Le Port,Marylene Leboeuf,Pierre Charbord,Andreas Bikfalvi,Georges Uzan

View Articletitled, Human endothelial cells derived from circulating progenitors display specific functional properties compared with mature vessel wall endothelial cells

The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y₁ and P2Y₁₂ receptors

Nadine Haserück,Wolfgang Erl,Dharmendra Pandey,Gabor Tigyi,Philippe Ohlmann,Catherine Ravanat,Christian Gachet,Wolfgang Siess

View Articletitled, The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors

Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase

Stepan Gambaryan,Jörg Geiger,Ulrike R. Schwarz,Elke Butt,Antonija Begonja,Achim Obergfell,Ulrich Walter

View Articletitled, Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase

GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase

Stuart J. Marshall,Yotis A. Senis,Jocelyn M. Auger,Robert Feil,Franz Hofmann,Gary Salmon,J. Thomas Peterson,Frank Burslem,Steve P. Watson

View Articletitled, GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase

Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice

Bing-Qiao Zhao,Yasuhiko Ikeda,Hayato Ihara,Tetsumei Urano,WenYing Fan,Sumiko Mikawa,Yasuhiro Suzuki,Kazunao Kondo,Kohji Sato,Nobuo Nagai,Kazuo Umemura

View Articletitled, Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice

In vivo neutralization of a C2 domain–specific human anti–Factor VIII inhibitor by an anti-idiotypic antibody

Jean Guy G. Gilles,Sabrina C. Grailly,Marc De Maeyer,Marc G. Jacquemin,Luc P. VanderElst,Jean-Marie R. Saint-Remy

View Articletitled, In vivo neutralization of a C2 domain–specific human anti–Factor VIII inhibitor by an anti-idiotypic antibody

Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice

Angela M. Devlin,Erland Arning,Teodoro Bottiglieri,Frank M. Faraci,Rima Rozen,Steven R. Lentz

View Articletitled, Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice

Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX, and X; proteins S and C; and γ-glutamyl carboxylase) gene variants with warfarin sensitivity

Eriko Shikata,Ichiro Ieiri,Shingo Ishiguro,Hironao Aono,Kazuko Inoue,Tomoko Koide,Shigetsugu Ohgi,Kenji Otsubo

View Articletitled, Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX, and X; proteins S and C; and γ-glutamyl carboxylase) gene variants with warfarin sensitivity

MEK1,2 response element mediates angiotensin II—stimulated plasminogen activator inhibitor-1 promoter activation

Hong-Chi Chen,Edward P. Feener

View Articletitled, MEK1,2 response element mediates angiotensin II—stimulated plasminogen activator inhibitor-1 promoter activation

Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response
Brief Report

Fotios P. Panitsas,Maria Theodoropoulou,Alexandra Kouraklis,Marina Karakantza,Georgios L. Theodorou,Nicholas C. Zoumbos,Alice Maniatis,Athanasia Mouzaki

View Articletitled, Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response

IMMUNOBIOLOGY

DC-SIGN promotes exogenous MHC-I–restricted HIV-1 antigen presentation

Arnaud Moris,Cinzia Nobile,Florence Buseyne,Françoise Porrot,Jean-Pierre Abastado,Olivier Schwartz

View Articletitled, DC-SIGN promotes exogenous MHC-I–restricted HIV-1 antigen presentation

In vivo exit of c-kit⁺/CD49d^hi/β7⁺ mucosal mast cell precursors from the bone marrow following infection with the intestinal nematode Trichinella spiralis

Joanne L. Pennock,Richard K. Grencis

View Articletitled, In vivo exit of c-kit+/CD49dhi/β7+ mucosal mast cell precursors from the bone marrow following infection with the intestinal nematode Trichinella spiralis

Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis

Sanjay Tiwari,Kyriacos Felekkis,Eun-Yi Moon,Amanda Flies,David H. Sherr,Adam Lerner

View Articletitled, Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis

Dendritic cell differentiation potential of mouse monocytes: monocytes represent immediate precursors of CD8^- and CD8⁺ splenic dendritic cells

Beatriz León,Gloria Martínez del Hoyo,Verónica Parrillas,Héctor Hernández Vargas,Paloma Sánchez-Mateos,Natividad Longo,María López-Bravo,Carlos Ardavín

View Articletitled, Dendritic cell differentiation potential of mouse monocytes: monocytes represent immediate precursors of CD8- and CD8+ splenic dendritic cells

New CFSE-based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population

Inge Jedema,Nicole M. van der Werff,Renée M. Y. Barge,Roel Willemze,J. H. Frederik Falkenburg

View Articletitled, New CFSE-based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population

Defective B-cell-negative selection and terminal differentiation in the ICF syndrome

Carla E. Blanco-Betancourt,Anne Moncla,Michèle Milili,Yun Liang Jiang,Evani M. Viegas-Péquignot,Bertrand Roquelaure,Isabelle Thuret,Claudine Schiff

View Articletitled, Defective B-cell-negative selection and terminal differentiation in the ICF syndrome

CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance

Michael D. Rosenblum,Edit Olasz,Jeffery E. Woodliff,Bryon D. Johnson,Marja C. Konkol,Kimberly A. Gerber,Rimas J. Orentas,Gordon Sandford,Robert L. Truitt

View Articletitled, CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance

Mature dendritic cells can enhance CD8⁺ cell noncytotoxic anti-HIV responses: the role of IL-15

JoAnn Castelli,Elaine K. Thomas,Michel Gilliet,Yong-Jun Liu,Jay A. Levy

View Articletitled, Mature dendritic cells can enhance CD8+ cell noncytotoxic anti-HIV responses: the role of IL-15

IgG antiplatelet immunity is dependent on an early innate natural killer cell–derived interferon-γ response that is regulated by CD8⁺ T cells

Ebrahim Sayeh,Katherine Sterling,Edwin Speck,John Freedman,John W. Semple

View Articletitled, IgG antiplatelet immunity is dependent on an early innate natural killer cell–derived interferon-γ response that is regulated by CD8+ T cells

Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with β-tryptase monomers

Merel C. M. Strik,Angela Wolbink,Dorine Wouters,Bellinda A. Bladergroen,Angelique R. Verlaan,Inge S. van Houdt,Sanne Hijlkema,C. Erik Hack,J. Alain Kummer

View Articletitled, Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with β-tryptase monomers

NEOPLASIA

Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins

Thomas Decker,Madlene Oelsner,Robert J. Kreitman,Giuliana Salvatore,Qing-cheng Wang,Ira Pastan,Christian Peschel,Thomas Licht

View Articletitled, Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins

Small lymphocytic lymphoma, marginal zone B-cell lymphoma, and mantle cell lymphoma exhibit distinct gene-expression profiles allowing molecular diagnosis

View Articletitled, Small lymphocytic lymphoma, marginal zone B-cell lymphoma, and mantle cell lymphoma exhibit distinct gene-expression profiles allowing molecular diagnosis

Supplemental data

Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents

Mark S. Cragg,Martin J. Glennie

View Articletitled, Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents

A dominant-negative mutant of C/EBPα, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse

Maike Schwieger,Jürgen Löhler,Meike Fischer,Uwe Herwig,Daniel G. Tenen,Carol Stocking

View Articletitled, A dominant-negative mutant of C/EBPα, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse

Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells

Mika Yoshida,Kisato Nosaka,Jun-ichirou Yasunaga,Ichiro Nishikata,Kazuhiro Morishita,Masao Matsuoka

View Articletitled, Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells

Interruption of the NF-κB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells

Yun Dai,Xin-Yan Pei,Mohamed Rahmani,Daniel H. Conrad,Paul Dent,Steven Grant

View Articletitled, Interruption of the NF-κB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells

Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival
Clinical Trials & Observations

Sabina Chiaretti,Xiaochun Li,Robert Gentleman,Antonella Vitale,Marco Vignetti,Franco Mandelli,Jerome Ritz,Robin Foa

View Articletitled, Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival

Supplemental data

Targeted overexpression of Bcl-X_L in B-lymphoid cells results in lymphoproliferative disease and plasma cell malignancies

Michael Linden,Nicole Kirchhof,Cathy Carlson,Brian Van Ness

View Articletitled, Targeted overexpression of Bcl-XL in B-lymphoid cells results in lymphoproliferative disease and plasma cell malignancies

Bcl-X_L down-regulation suppresses the tumorigenic potential of NPM/ALK in vitro and in vivo

Addolorata Maria Luce Coluccia,Silvia Perego,Loredana Cleris,Rosalind Helen Gunby,Lorena Passoni,Edoardo Marchesi,Franca Formelli,Carlo Gambacorti-Passerini

View Articletitled, Bcl-XL down-regulation suppresses the tumorigenic potential of NPM/ALK in vitro and in vivo

Mantle cell lymphoma with t(11;14) and unmutated or mutated V_H genes expresses AID and undergoes isotype switch events
Brief Report

Gavin Babbage,Richard Garand,Nelly Robillard,Niklas Zojer,Freda K. Stevenson,Surinder S. Sahota

View Articletitled, Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events

Relative increase in leukemia-specific DNA in peripheral blood plasma from patients with acute myeloid leukemia and myelodysplasia
Clinical Trials & Observations Brief Report

Anna Rogers,Youngson Joe,Taghi Manshouri,Amanda Dey,Iman Jilani,Francis Giles,Elihu Estey,Emil Freireich,Michael Keating,Hagop Kantarjian,Maher Albitar

View Articletitled, Relative increase in leukemia-specific DNA in peripheral blood plasma from patients with acute myeloid leukemia and myelodysplasia

The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA–positive chronic eosinophilic leukemia
Brief Report

Jan Cools,Hilmar Quentmeier,Brian J. P. Huntly,Peter Marynen,James D. Griffin,Hans G. Drexler,D. Gary Gilliland

View Articletitled, The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA–positive chronic eosinophilic leukemia

Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL
Brief Report

Nicola E. Annels,Annemieke J. Willemze,Vincent H. J. van der Velden,Claudia M. J. M. Faaij,Elisabeth van Wering,Daisy M. D. S. Sie-Go,R. Maarten Egeler,Maarten J. D. van Tol,Tom Révész

View Articletitled, Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL

PHAGOCYTES

Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU

Bénédicte Neven,Isabelle Callebaut,Anne-Marie Prieur,Jérôme Feldmann,Christine Bodemer,Loredana Lepore,Beata Derfalvi,Suata Benjaponpitak,Richard Vesely,Marie Jose Sauvain,Stefan Oertle,Roger Allen,Gareth Morgan,Arndt Borkhardt,Clare Hill,Janet Gardner-Medwin,Alain Fischer,Geneviève de Saint Basile

View Articletitled, Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU

RED CELLS

Functional differences between hepcidin 1 and 2 in transgenic mice

Dan-Qing Lou,Gaël Nicolas,Jeanne-Claire Lesbordes,Lydie Viatte,Gisèle Grimber,Marie-France Szajnert,Axel Kahn,Sophie Vaulont

View Articletitled, Functional differences between hepcidin 1 and 2 in transgenic mice

Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP study
Clinical Trials & Observations

Miguel R. Abboud,Joel Cure,Suzanne Granger,Dianne Gallagher,Lewis Hsu,Winfred Wang,Gerald Woods,Brian Berman,Don Brambilla,Charles Pegelow,Jonathan Lewin,Robert A. Zimmermann,Robert J. Adams

View Articletitled, Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP study

A novel mechanism of complement-independent clearance of red cells deficient in glycosyl phosphatidylinositol–linked proteins

Marek Jasinski,Panagiotis Pantazopoulos,Russell P. Rother,Nico van Rooijen,Wen-Chao Song,Hector Molina,Monica Bessler

View Articletitled, A novel mechanism of complement-independent clearance of red cells deficient in glycosyl phosphatidylinositol–linked proteins

HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype

Sandrine Jacolot,Gerald Le Gac,Virginie Scotet,Isabelle Quere,Catherine Mura,Claude Ferec

View Articletitled, HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype

Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice
Brief Report

Gaël Nicolas,Nancy C. Andrews,Axel Kahn,Sophie Vaulont

View Articletitled, Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice

Correction of hypercoagulability and amelioration of pulmonary arterial hypertension by chronic blood transfusion in an asplenic hemoglobin E/β-thalassemia patient
Brief Report

Vichai Atichartakarn,Suporn Chuncharunee,Pakorn Chandanamattha,Khanchit Likittanasombat,Katcharin Aryurachai

View Articletitled, Correction of hypercoagulability and amelioration of pulmonary arterial hypertension by chronic blood transfusion in an asplenic hemoglobin E/β-thalassemia patient

Contributions of β2-microglobulin–dependent molecules and lymphocytes to iron regulation: insights from HfeRag1^-/- and β2mRag1^-/- double knock-out mice
Brief Report

Carlos J. Miranda,Hortence Makui,Nancy C. Andrews,Manuela M. Santos

View Articletitled, Contributions of β2-microglobulin–dependent molecules and lymphocytes to iron regulation: insights from HfeRag1-/- and β2mRag1-/- double knock-out mice

TRANSPLANTATION

The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukemia: a risk-matched analysis based on the V_H gene mutational status
Clinical Trials & Observations

Peter Dreger,Stephan Stilgenbauer,Axel Benner,Matthias Ritgen,Alexander Kröber,Michael Kneba,Norbert Schmitz,Hartmut Döhner

View Articletitled, The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukemia: a risk-matched analysis based on the VH gene mutational status

CORRESPONDENCE

The balance among immune suppression, stem cell ablation, competition, and engraftment

Ronald van Os,Gerald de Haan

View Articletitled, The balance among immune suppression, stem cell ablation, competition, and engraftment

Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors

Martin Bornhäuser,Rainer Schwerdtfeger,Hilmar Martin,Karl-Heinz Frank,Catrin Theuser,Gerhard Ehninger

View Articletitled, Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors

Oral vitamin B₁₂ therapy: a cautionary note

Lawrence R. Solomon

View Articletitled, Oral vitamin B12 therapy: a cautionary note

Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

REVIEW ARTICLES

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

The epidemiology of chronic hepatitis C infection in survivors of childhood cancer: an update of the St Jude Children's Research Hospital hepatitis C seropositive cohort Clinical Trials & Observations

Joint range-of-motion limitations among young males with hemophilia: prevalence and risk factors Clinical Trials & Observations

Peripheral T-cell lymphoma unspecified (PTCL-U): a new prognostic model from a retrospective multicentric clinical study Clinical Trials & Observations

Natural history of GATA1 mutations in Down syndrome Clinical Trials & Observations

Long-term outcome after bone marrow transplantation for severe aplastic anemia Clinical Trials & Observations

HEMATOPOIESIS

Association of biallelic BRCA2/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood Clinical Trials & Observations

Raf-1 is not required for megakaryocytopoiesis or TPO-induced ERK phosphorylation Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Severe hypodysfibrinogenemia in compound heterozygotes of the fibrinogen AαIVS4 + 1G>T mutation and an AαGln328 truncation (fibrinogen Keokuk) Clinical Trials & Observations

Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response Brief Report

IMMUNOBIOLOGY

NEOPLASIA

Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival Clinical Trials & Observations

Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events Brief Report

Relative increase in leukemia-specific DNA in peripheral blood plasma from patients with acute myeloid leukemia and myelodysplasia Clinical Trials & Observations Brief Report

The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA–positive chronic eosinophilic leukemia Brief Report

Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL Brief Report

PHAGOCYTES

RED CELLS

Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP study Clinical Trials & Observations

Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice Brief Report

Correction of hypercoagulability and amelioration of pulmonary arterial hypertension by chronic blood transfusion in an asplenic hemoglobin E/β-thalassemia patient Brief Report

Contributions of β2-microglobulin–dependent molecules and lymphocytes to iron regulation: insights from HfeRag1-/- and β2mRag1-/- double knock-out mice Brief Report