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Volume 103, Issue 4

February 15 2004

In this Issue

INSIDE BLOOD
PLENARY PAPERS
REVIEW ARTICLES
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
RED CELLS
TRANSPLANTATION

INSIDE BLOOD

HFE, a putative hepatocyte iron sensor?

Surjit K. S. Srai

View Articletitled, HFE, a putative hepatocyte iron sensor?

Dimerize and die

Karin C. Straathof,Helen E. Heslop

View Articletitled, Dimerize and die

Anti-CD40L: biology and therapy in ITP

Joseph Schwartz,James B. Bussel

View Articletitled, Anti-CD40L: biology and therapy in ITP

And a final message from antithrombin

Robin Carrell

View Articletitled, And a final message from antithrombin

Thrombosis down to the vessel wall

Frits R. Rosendaal

View Articletitled, Thrombosis down to the vessel wall

Platelet collagen receptors play molecular ping-pong

Mark L. Kahn

View Articletitled, Platelet collagen receptors play molecular ping-pong

The myelodysplastic syndromes: heterogeneneity on many levels

Peter T. Curtin

View Articletitled, The myelodysplastic syndromes: heterogeneneity on many levels

Fungal infection in hemato-oncologic patients: better to prevent than to treat?

Jan W. van't Wout,Jaap T. van Dissel

View Articletitled, Fungal infection in hemato-oncologic patients: better to prevent than to treat?

Cell adhesion: a partner for many

Carl G. Gahmberg

View Articletitled, Cell adhesion: a partner for many

Swinging for the fences: persistent and efficient liver-directed gene therapy for hemophilia A

Terence R. Flotte

View Articletitled, Swinging for the fences: persistent and efficient liver-directed gene therapy for hemophilia A

PLENARY PAPERS

Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells

Weiqing Zhang,Yung-Jen Chuang,Richard Swanson,Juan Li,Kyunga Seo,Lawrence Leung,Lester F. Lau,Steven T. Olson

View Articletitled, Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells

REVIEW ARTICLES

Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S–C4b binding protein complex

Suely Meireles Rezende,Rachel Elizabeth Simmonds,David Anthony Lane

View Articletitled, Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S–C4b binding protein complex

Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL
Clinical Trials & Observations

Tait D. Shanafelt,Susan M. Geyer,Neil E. Kay

View Articletitled, Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL

CHEMOKINES

Specific inhibition of HIV-1 coreceptor activity by synthetic peptides corresponding to the predicted extracellular loops of CCR5

Lokesh Agrawal,Zainab VanHorn-Ali,Edward A. Berger,Ghalib Alkhatib

View Articletitled, Specific inhibition of HIV-1 coreceptor activity by synthetic peptides corresponding to the predicted extracellular loops of CCR5

CXCR4 engagement is required for HIV-1–induced L-selectin shedding
Brief Report

JiangFang Wang,Susanne Marschner,Terri H. Finkel

View Articletitled, CXCR4 engagement is required for HIV-1–induced L-selectin shedding

Supplemental data

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Second cancers and late toxicities after treatment of aggressive non-Hodgkin lymphoma with the ACVBP regimen: a GELA cohort study on 2837 patients
Clinical Trials & Observations

Marc André,Nicolas Mounier,Xavier Leleu,Anne Sonet,Pauline Brice,Michel Henry-Amar,Hervé Tilly,Bertrand Coiffier,André Bosly,Pierre Morel,Corinne Haioun,Philippe Gaulard,Felix Reyes,Christian Gisselbrecht,the Groupe d'Etude des Lymphomes de l'Adulte (GELA)

View Articletitled, Second cancers and late toxicities after treatment of aggressive non-Hodgkin lymphoma with the ACVBP regimen: a GELA cohort study on 2837 patients

Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura
Clinical Trials & Observations

Masataka Kuwana,Shosaku Nomura,Kingo Fujimura,Toshiro Nagasawa,Yoshitomo Muto,Yoshiyuki Kurata,Shigeru Tanaka,Yasuo Ikeda

View Articletitled, Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura

Risk-adapted treatment of acute promyelocytic leukemia with all-trans-retinoic acid and anthracycline monochemotherapy: a multicenter study by the PETHEMA group
Clinical Trials & Observations

Miguel A. Sanz,Guillermo Martín,Marcos González,Angel León,Chelo Rayón,Concha Rivas,Dolors Colomer,Elena Amutio,Francisco J. Capote,Gustavo A. Milone,Javier de la Serna,José Román,Eva Barragán,Juan Bergua,Lourdes Escoda,Ricardo Parody,Silvia Negri,María J. Calasanz,Pascual Bolufer

View Articletitled, Risk-adapted treatment of acute promyelocytic leukemia with all-trans-retinoic acid and anthracycline monochemotherapy: a multicenter study by the PETHEMA group

Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturation
Clinical Trials & Observations

Harutaka Katano,Mir A. Ali,Andriani C. Patera,Marta Catalfamo,Elaine S. Jaffe,Hiroshi Kimura,Janet K. Dale,Stephen E. Straus,Jeffrey I. Cohen

View Articletitled, Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturation

GENE THERAPY

Total correction of hemophilia A mice with canine FVIII using an AAV 8 serotype

Rita Sarkar,Renee Tetreault,Guangping Gao,Lili Wang,Peter Bell,Randy Chandler,James M. Wilson,Haig H. Kazazian, Jr

View Articletitled, Total correction of hemophilia A mice with canine FVIII using an AAV 8 serotype

Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate model

Carolina Berger,C. Anthony Blau,Meei-Li Huang,John D. Iuliucci,David C. Dalgarno,Joëlle Gaschet,Shelly Heimfeld,Tim Clackson,Stanley R. Riddell

View Articletitled, Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate model

HEMATOPOIESIS

Allergen exposure–induced differences in CD34⁺ cell phenotype: relationship to eosinophilopoietic responses in different compartments

Svetlana Sergejeva,Anna-Karin Johansson,Carina Malmhäll,Jan Lötvall

View Articletitled, Allergen exposure–induced differences in CD34+ cell phenotype: relationship to eosinophilopoietic responses in different compartments

BUBR1 deficiency results in abnormal megakaryopoiesis

Qi Wang,Tongyi Liu,Yuqiang Fang,Suqing Xie,Xuan Huang,Radma Mahmood,Gita Ramaswamy,Kathleen M. Sakamoto,Zbigniew Darzynkiewicz,Ming Xu,Wei Dai

View Articletitled, BUBR1 deficiency results in abnormal megakaryopoiesis

Identification of the molecular requirements for an RARα-mediated cell cycle arrest during granulocytic differentiation

Carl R. Walkley,Louise E. Purton,Hayley J. Snelling,Yang-Dar Yuan,Hideaki Nakajima,Pierre Chambon,Roshantha A. S. Chandraratna,Grant A. McArthur

View Articletitled, Identification of the molecular requirements for an RARα-mediated cell cycle arrest during granulocytic differentiation

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Chemokine receptor–8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion

Nasreen S. Haque,John T. Fallon,Jiang Jin Pan,Mark B. Taubman,Peter C. Harpel

View Articletitled, Chemokine receptor–8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion

Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome
Clinical Trials & Observations

Masanori Matsumoto,Koichi Kokame,Kenji Soejima,Masayoshi Miura,Syuhei Hayashi,Yasuhiko Fujii,Asayuki Iwai,Etsuro Ito,Yoichiro Tsuji,Mayuko Takeda-Shitaka,Mitsuo Iwadate,Hideaki Umeyama,Hideo Yagi,Hiromichi Ishizashi,Fumiaki Banno,Tomohiro Nakagaki,Toshiyuki Miyata,Yoshihiro Fujimura

View Articletitled, Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome

A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis

Beatrice Saposnik,Jean-Luc Reny,Pascale Gaussem,Joseph Emmerich,Martine Aiach,Sophie Gandrille

View Articletitled, A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis

Thymosin β4 induces the synthesis of plasminogen activator inhibitor 1 in cultured endothelial cells and increases its extracellular expression

Khalid N. I. Al-Nedawi,Malgorzata Czyz,Radoslaw Bednarek,Janusz Szemraj,Maria Swiatkowska,Aleksandra Cierniewska-Cieslak,Janina Wyczolkowska,Czeslaw S. Cierniewski

View Articletitled, Thymosin β4 induces the synthesis of plasminogen activator inhibitor 1 in cultured endothelial cells and increases its extracellular expression

Functional endothelial cells derived from rhesus monkey embryonic stem cells

Dan S. Kaufman,Rachel L. Lewis,Eric T. Hanson,Robert Auerbach,Johanna Plendl,James A. Thomson

View Articletitled, Functional endothelial cells derived from rhesus monkey embryonic stem cells

Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood

Pia R.-M. Siljander,Imke C. A. Munnix,Peter A. Smethurst,Hans Deckmyn,Theo Lindhout,Willem H. Ouwehand,Richard W. Farndale,Johan W. M. Heemskerk

View Articletitled, Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood

Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia

Rafal Pawlinski,Brian Pedersen,Gernot Schabbauer,Michael Tencati,Todd Holscher,William Boisvert,Patricia Andrade-Gordon,Rolf Dario Frank,Nigel Mackman

View Articletitled, Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia

Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation, platelet adhesion, and aggregation via effector pathways that do not require phosphorylation of ephrinB1

Nicolas Prévost,Donna S. Woulfe,Massimiliano Tognolini,Takako Tanaka,Wenying Jian,Ryan R. Fortna,Hong Jiang,Lawrence F. Brass

View Articletitled, Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation, platelet adhesion, and aggregation via effector pathways that do not require phosphorylation of ephrinB1

Novel concatameric heparin-binding peptides reverse heparin and low-molecular-weight heparin anticoagulant activities in patient plasma in vitro and in rats in vivo

Barbara P. Schick,David Maslow,Adrianna Moshinski,James D. San Antonio

View Articletitled, Novel concatameric heparin-binding peptides reverse heparin and low-molecular-weight heparin anticoagulant activities in patient plasma in vitro and in rats in vivo

Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP

Robert McMillan,Lei Wang,Aaron Tomer,Janet Nichol,Jeanne Pistillo

View Articletitled, Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP

Dual roles of the C-terminal Src kinase (Csk) during developmental vascularization
Brief Report

Li-Juan Duan,Akira Imamoto,Guo-Hua Fong

View Articletitled, Dual roles of the C-terminal Src kinase (Csk) during developmental vascularization

Endothelial progenitor cells in infantile hemangioma
Brief Report

Ying Yu,Alan F. Flint,John B. Mulliken,June K. Wu,Joyce Bischoff

View Articletitled, Endothelial progenitor cells in infantile hemangioma

IMMUNOBIOLOGY

High levels of osteopontin associated with polymorphisms in its gene are a risk factor for development of autoimmunity/lymphoproliferation

Annalisa Chiocchetti,Manuela Indelicato,Thea Bensi,Riccardo Mesturini,Mara Giordano,Selina Sametti,Luca Castelli,Flavia Bottarel,Maria Clorinda Mazzarino,Letizia Garbarini,Francesca Giacopelli,Guido Valesini,Claudio Santoro,Irma Dianzani,Ugo Ramenghi,Umberto Dianzani

View Articletitled, High levels of osteopontin associated with polymorphisms in its gene are a risk factor for development of autoimmunity/lymphoproliferation

In vitro and in vivo evidence of PNH cell sensitivity to immune attack after nonmyeloablative allogeneic hematopoietic cell transplantation
Clinical Trials & Observations

Yoshiyuki Takahashi,J. Philip McCoy, Jr,Cristian Carvallo,Candido Rivera,Takehito Igarashi,Ramaprasad Srinivasan,Neal S. Young,Richard W. Childs

View Articletitled, In vitro and in vivo evidence of PNH cell sensitivity to immune attack after nonmyeloablative allogeneic hematopoietic cell transplantation

Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells

Max Schnurr,Tracey Toy,Amanda Shin,Gunther Hartmann,Simon Rothenfusser,Julia Soellner,Ian D. Davis,Jonathan Cebon,Eugene Maraskovsky

View Articletitled, Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells

A novel SHP-1/Grb2–dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling

Parham Minoo,Maryam Mohsen Zadeh,Robert Rottapel,Jean-Jacques Lebrun,Suhad Ali

View Articletitled, A novel SHP-1/Grb2–dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling

Direct killing of Epstein-Barr virus (EBV)–infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1

Elise Landais,Xavier Saulquin,Emmanuel Scotet,Lydie Trautmann,Marie-Alix Peyrat,John L. Yates,William W. Kwok,Marc Bonneville,Elisabeth Houssaint

View Articletitled, Direct killing of Epstein-Barr virus (EBV)–infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1

A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation

Elisabetta Zino,Guido Frumento,Sarah Marktel,Maria Pia Sormani,Francesca Ficara,Simona Di Terlizzi,Anna Maria Parodi,Ruhena Sergeant,Miryam Martinetti,Andrea Bontadini,Francesca Bonifazi,Daniela Lisini,Benedetta Mazzi,Silvano Rossini,Paolo Servida,Fabio Ciceri,Chiara Bonini,Edoardo Lanino,Giuseppe Bandini,Franco Locatelli,Jane Apperley,Andrea Bacigalupo,Giovanni Battista Ferrara,Claudio Bordignon,Katharina Fleischhauer

View Articletitled, A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation

Dynamic regulation of Src-family kinases by CD45 in B cells

Punya Shrivastava,Tatsuo Katagiri,Mami Ogimoto,Kazuya Mizuno,Hidetaka Yakura

View Articletitled, Dynamic regulation of Src-family kinases by CD45 in B cells

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9

Anne Krug,Gary D. Luker,Winfried Barchet,David A. Leib,Shizuo Akira,Marco Colonna

View Articletitled, Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9

Regulation of MHC class II expression in human T-cell malignancies

Tjadine M. Holling,Erik Schooten,Anton W. Langerak,Peter J. van den Elsen

View Articletitled, Regulation of MHC class II expression in human T-cell malignancies

NEOPLASIA

Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein

Judy Wai Ping Yam,Dong-Yan Jin,Chi Wai So,Li Chong Chan

View Articletitled, Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein

ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein

Nathalie Chevallier,Connie M. Corcoran,Christine Lennon,Elizabeth Hyjek,Amy Chadburn,Vivian J. Bardwell,Jonathan D. Licht,Ari Melnick

View Articletitled, ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein

Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60^c-src to mediate its mitogenicity

Daniel Cussac,Catherine Greenland,Serge Roche,Ren-Yuan Bai,Justus Duyster,Stephan W. Morris,Georges Delsol,Michèle Allouche,Bernard Payrastre

View Articletitled, Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity

FcγRIIIa and FcγRIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia

Sherif S. Farag,Ian W. Flinn,Rama Modali,Teresa A. Lehman,Donn Young,John C. Byrd

View Articletitled, FcγRIIIa and FcγRIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia

Eμ-BRD2 transgenic mice develop B-cell lymphoma and leukemia

Rebecca J. Greenwald,Joseph R. Tumang,Anupama Sinha,Nicolas Currier,Robert D. Cardiff,Thomas L. Rothstein,Douglas V. Faller,Gerald V. Denis

View Articletitled, Eμ-BRD2 transgenic mice develop B-cell lymphoma and leukemia

Antibody-induced intracellular signaling works in combination with radiation to eradicate lymphoma in radioimmunotherapy

Yong Du,Jamie Honeychurch,Mark S. Cragg,Mike Bayne,Martin J. Glennie,Peter W. M. Johnson,Tim M. Illidge

View Articletitled, Antibody-induced intracellular signaling works in combination with radiation to eradicate lymphoma in radioimmunotherapy

Early prediction of response in patients with relapsed or refractory Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph⁺ALL) treated with imatinib
Clinical Trials & Observations Brief Report

Barbara Wassmann,Heike Pfeifer,Urban J. Scheuring,Anja Binckebanck,Nicola Gökbuget,Johannes Atta,Patrick Brück,Harald Rieder,Claudia Schoch,Lothar Leimer,Rainer Schwerdtfeger,Gerhard Ehninger,Thomas Lipp,Jolanta Perz,Matthias Stelljes,Harald Gschaidmeier,Dieter Hoelzer,Oliver G. Ottmann

View Articletitled, Early prediction of response in patients with relapsed or refractory Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ALL) treated with imatinib

Ineffective hematopoiesis linked with a mitochondrial tRNA mutation (G3242A) in a patient with myelodysplastic syndrome
Brief Report

Norbert Gattermann,Michael Wulfert,Bärbel Junge,Ulrich Germing,Rainer Haas,Götz Hofhaus

View Articletitled, Ineffective hematopoiesis linked with a mitochondrial tRNA mutation (G3242A) in a patient with myelodysplastic syndrome

RED CELLS

Identification of critical amino-acid residues on the erythroid intercellular adhesion molecule-4 (ICAM-4) mediating adhesion to α_V integrins

Tosti J. Mankelow,Frances A. Spring,Stephen F. Parsons,R. Leo Brady,Narla Mohandas,Joel A. Chasis,David J. Anstee

View Articletitled, Identification of critical amino-acid residues on the erythroid intercellular adhesion molecule-4 (ICAM-4) mediating adhesion to αV integrins

Localization of iron metabolism–related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes

An-Sheng Zhang,Shigang Xiong,Hidekazu Tsukamoto,Caroline A. Enns

View Articletitled, Localization of iron metabolism–related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes

Identification of a 4-base deletion in the gene in inherited intrinsic factor deficiency
Clinical Trials & Observations Brief Report

Fawwaz Yassin,Sheldon P. Rothenberg,Sreedhar Rao,Marilyn M. Gordon,David H. Alpers,Edward V. Quadros

View Articletitled, Identification of a 4-base deletion in the gene in inherited intrinsic factor deficiency

Deletion of the α-globin gene cluster as a cause of acquired α-thalassemia in myelodysplastic syndrome
Brief Report

David P. Steensma,Vip Viprakasit,Alex Hendrick,David K. Goff,Joanne Leach,Richard J. Gibbons,Douglas R. Higgs

View Articletitled, Deletion of the α-globin gene cluster as a cause of acquired α-thalassemia in myelodysplastic syndrome

TRANSPLANTATION

The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia

Mark A. Cook,Donald W. Milligan,Christopher D. Fegan,Philip J. Darbyshire,Premini Mahendra,Charles F. Craddock,Paul A. H. Moss,David C. Briggs

View Articletitled, The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia

Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants
Clinical Trials & Observations

Kieren A. Marr,Fulvio Crippa,Wendy Leisenring,Maggie Hoyle,Michael Boeckh,S. Arunmozhi Balajee,W. Garrett Nichols,Benjamin Musher,Lawrence Corey

View Articletitled, Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants

Transfer of allogeneic CD62L^– memory T cells without graft-versus-host disease

Benny J. Chen,Xiuyu Cui,Gregory D. Sempowski,Congxiao Liu,Nelson J. Chao

View Articletitled, Transfer of allogeneic CD62L– memory T cells without graft-versus-host disease

LPAM (α₄β₇ integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease

Aleksandra Petrovic,Onder Alpdogan,Lucy M. Willis,Jeffrey M. Eng,Andrew S. Greenberg,Barry J. Kappel,Chen Liu,George J. Murphy,Glenn Heller,Marcel R. M. van den Brink

View Articletitled, LPAM (α4β7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease

Dose-escalated donor lymphocyte infusions following reduced intensity transplantation: toxicity, chimerism, and disease responses
Clinical Trials & Observations

Karl S. Peggs,Kirsty Thomson,Daniel P. Hart,Johanne Geary,Emma C. Morris,Kwee Yong,Anthony H. Goldstone,David C. Linch,Stephen Mackinnon

View Articletitled, Dose-escalated donor lymphocyte infusions following reduced intensity transplantation: toxicity, chimerism, and disease responses

Cyclophosphamide metabolism is affected by azole antifungals
Brief Report

Kieren A. Marr,Wendy Leisenring,Fulvio Crippa,John T. Slattery,Lawrence Corey,Michael Boeckh,George B. McDonald

View Articletitled, Cyclophosphamide metabolism is affected by azole antifungals

Prior chemotherapy and allograft CD34⁺ dose impact donor engraftment following nonmyeloablative allogeneic stem cell transplantation in patients with solid tumors
Clinical Trials & Observations Brief Report

Cristian Carvallo,Nancy Geller,Roger Kurlander,Ramaprasad Srinivasan,Othon Mena,Takehito Igarashi,Linda M. Griffith,W. Marston Linehan,Richard W. Childs

View Articletitled, Prior chemotherapy and allograft CD34+ dose impact donor engraftment following nonmyeloablative allogeneic stem cell transplantation in patients with solid tumors

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

REVIEW ARTICLES

Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL Clinical Trials & Observations

CHEMOKINES

CXCR4 engagement is required for HIV-1–induced L-selectin shedding Brief Report

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Second cancers and late toxicities after treatment of aggressive non-Hodgkin lymphoma with the ACVBP regimen: a GELA cohort study on 2837 patients Clinical Trials & Observations

Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura Clinical Trials & Observations

Risk-adapted treatment of acute promyelocytic leukemia with all-trans-retinoic acid and anthracycline monochemotherapy: a multicenter study by the PETHEMA group Clinical Trials & Observations

Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturation Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome Clinical Trials & Observations

Dual roles of the C-terminal Src kinase (Csk) during developmental vascularization Brief Report

Endothelial progenitor cells in infantile hemangioma Brief Report

IMMUNOBIOLOGY

In vitro and in vivo evidence of PNH cell sensitivity to immune attack after nonmyeloablative allogeneic hematopoietic cell transplantation Clinical Trials & Observations

NEOPLASIA

Early prediction of response in patients with relapsed or refractory Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ALL) treated with imatinib Clinical Trials & Observations Brief Report

Ineffective hematopoiesis linked with a mitochondrial tRNA mutation (G3242A) in a patient with myelodysplastic syndrome Brief Report

RED CELLS

Identification of a 4-base deletion in the gene in inherited intrinsic factor deficiency Clinical Trials & Observations Brief Report

Deletion of the α-globin gene cluster as a cause of acquired α-thalassemia in myelodysplastic syndrome Brief Report