Issue Archive

INSIDE BLOOD

Dealing with acquired hemophilia

Craig S. Kitchens

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Is there a bench at the bedside?

Richard A. Cooper

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Erythroblast renewal: new roles for RON and Gab1 in EpoR signaling

Hartmut Beug

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Hyper-CVADinib for Ph⁺ ALL

Mark A. Weiss

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Myeloproliferation or dysplasia: a matter of PIP₃ levels?

Hanno Glimm

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Mix 'n' match metalloproteins

Paul L. Fox

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VEGF receptors branch into new areas

Steven A. Stacker,Marc G. Achen

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Antibodies redux

Douglas B. Cines

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Generating CTL by HLA transplant

Moniek A. de Witte,Ton N. M. Schumacher

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SMRT interactions, repression, and Flt3-ITD

Leonidas C. Platanias

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PERSPECTIVES

Subspeciality training in hematology and oncology, 2003: results of a survey of training program directors conducted by the American Society of Hematology

Robert F. Todd, III,Scott D. Gitlin,Linda J. Burns,the Committee on Training Programs

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ERRATA

Erratum for vol. 102, p. 1340

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Erratum for vol. 102, p. 2173

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REVIEW IN TRANSLATIONAL HEMATOLOGY

Chronic lymphocytic leukemia: revelations from the B-cell receptor

Clinical Trials & Observations

Freda K. Stevenson,Federico Caligaris-Cappio

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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Treatment of Philadelphia chromosome–positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate

Clinical Trials & Observations

Deborah A. Thomas,Stefan Faderl,Jorge Cortes,Susan O'Brien,Francis J. Giles,Steven M. Kornblau,Guillermo Garcia-Manero,Michael J. Keating,Michael Andreeff,Sima Jeha,Miloslav Beran,Srdan Verstovsek,Sherry Pierce,Laurie Letvak,August Salvado,Richard Champlin,Moshe Talpaz,Hagop Kantarjian

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Randomized comparison of low-dose versus high-dose interferon-alfa in chronic myeloid leukemia: prospective collaboration of 3 joint trials by the MRC and HOVON groups

Clinical Trials & Observations

Hanneke C. Kluin-Nelemans,Georgina Buck,Saskia le Cessie,Sue Richards,H. Berna Beverloo,J. H. Frederik Falkenburg,Tim Littlewood,Petra Muus,David Bareford,Hans van der Lelie,Anthony R. Green,Klaas J. Roozendaal,Alison E. Milne,Claire S. Chapman,Patricia Shepherd,for the UK CML Working Group of NCRI and the HOVON trials group

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Prolonged treatment with rituximab in patients with follicular lymphoma significantly increases event-free survival and response duration compared with the standard weekly × 4 schedule

Clinical Trials & Observations

Michele Ghielmini,Shu-Fang Hsu Schmitz,Sergio B. Cogliatti,Gabriella Pichert,Jörg Hummerjohann,Ursula Waltzer,Martin F. Fey,Daniel C. Betticher,Giovanni Martinelli,Fedro Peccatori,Urs Hess,Emanuele Zucca,Roger Stupp,Tibor Kovacsovics,Claudine Helg,Andreas Lohri,Mario Bargetzi,Daniel Vorobiof,Thomas Cerny,for the Swiss Group for Clinical Cancer Research (SAKK)

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Selective B-cell depletion with rituximab for the treatment of patients with acquired hemophilia

Clinical Trials & Observations

Roberto Stasi,Maurizio Brunetti,Elisa Stipa,Sergio Amadori

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Durable responses after ibritumomab tiuxetan radioimmunotherapy for CD20⁺ B-cell lymphoma: long-term follow-up of a phase 1/2 study

Clinical Trials & Observations Brief Report

Leo I. Gordon,Arturo Molina,Thomas Witzig,Christos Emmanouilides,Andrew Raubtischek,Mohamed Darif,Russell J. Schilder,Greg Wiseman,Christine A. White

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GENE THERAPY

Modulating erythrocyte chimerism in a mouse model of pyruvate kinase deficiency

Robert E. Richard,Michael Weinreich,Kai-Hsin Chang,Jessica Ieremia,Mary M. Stevenson,C. Anthony Blau

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Supplemental data

HEMATOPOIESIS

Elevated telomerase activity and minimal telomere loss in cord blood long-term cultures with extensive stem cell replication

Loretta Gammaitoni,Katja C. Weisel,Monica Gunetti,Kai-Da Wu,Stefania Bruno,Silvana Pinelli,Antonio Bonati,Massimo Aglietta,Malcolm A. S. Moore,Wanda Piacibello

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Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages

Yong Jun Liu,Shi Hong Lu,Bin Xu,Ren Chi Yang,Qian Ren,Bin Liu,Bin Li,Min Lu,Feng Ying Yan,Zhi Bo Han,Zhong Chao Han

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Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors

Emile van den Akker,Thamar van Dijk,Martine Parren-van Amelsvoort,Katja S. Grossmann,Ute Schaeper,Kenya Toney-Earley,Susan E. Waltz,Bob Löwenberg,Marieke von Lindern

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Mitochondrial DNA sequence heterogeneity in circulating normal human CD34 cells and granulocytes

Myung Geun Shin,Sachiko Kajigaya,Magdalena Tarnowka,J. Philip McCoy, Jr,Barbara C. Levin,Neal S. Young

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The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34⁺ progenitor cells

Takafumi Kimura,Andreas M. Boehmler,Gabriele Seitz,Selim Kuçi,Tina Wiesner,Volker Brinkmann,Lothar Kanz,Robert Möhle

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ABC transporter activities of murine hematopoietic stem cells vary according to their developmental and activation status

Naoyuki Uchida,Brad Dykstra,Kristin Lyons,Frank Leung,Merete Kristiansen,Connie Eaves

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Human marrow stromal cells activate monocytes to secrete osteopontin, which down-regulates Notch1 gene expression in CD34⁺ cells

Mineo Iwata,Norihiro Awaya,Lynn Graf,Christoph Kahl,Beverly Torok-Storb

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Supplemental data

Anemia, thrombocytopenia, leukocytosis, extramedullary hematopoiesis, and impaired progenitor function in Pten^+/-SHIP^-/- mice: a novel model of myelodysplasia

Jennifer L. Moody,Lixin Xu,Cheryl D. Helgason,Frank R. Jirik

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Gene silencing by lentivirus-mediated delivery of siRNA in human CD34⁺ cells

Brief Report

Tibor Schomber,Christian P. Kalberer,Aleksandra Wodnar-Filipowicz,Radek C. Skoda

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura

Clinical Trials & Observations

Christoph Klaus,Barbara Plaimauer,Jan-Dirk Studt,Friedrich Dorner,Bernhard Lämmle,Pier Mannuccio Mannucci,Friedrich Scheiflinger

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Lipopolysaccharide initiates a TRAF6-mediated endothelial survival signal

Fred Wong,Christopher Hull,Rachel Zhande,Jennifer Law,Aly Karsan

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The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis

Joseph B. Kearney,Nicholas C. Kappas,Catharina Ellerstrom,Frank W. DiPaola,Victoria L. Bautch

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Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro

Alessio Zippo,Alessandra De Robertis,Monia Bardelli,Federico Galvagni,Salvatore Oliviero

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Supplemental data

Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia

Omer Aras,Arun Shet,Ronald R. Bach,Jessica L. Hysjulien,Arne Slungaard,Robert P. Hebbel,Gines Escolar,Bernd Jilma,Nigel S. Key

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Recombinant prolylcarboxypeptidase activates plasma prekallikrein

Zia Shariat-Madar,Fakhri Mahdi,Alvin H. Schmaier

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Platelet-associated autoantibodies as detected by a solid-phase modified antigen capture ELISA test (MACE) are a useful prognostic factor in idiopathic thrombocytopenic purpura

Clinical Trials & Observations Brief Report

Fabrizio Fabris,Raffaella Scandellari,Elisabetta Ruzzon,Maria Luigia Randi,Guido Luzzatto,Antonio Girolami

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IMMUNOBIOLOGY

X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival

Clinical Trials & Observations

Ryuta Nishikomori,Hiroshi Akutagawa,Kyoko Maruyama,Mami Nakata-Hizume,Katsuyuki Ohmori,Kazunori Mizuno,Akihiro Yachie,Takahiro Yasumi,Takashi Kusunoki,Toshio Heike,Tatsutoshi Nakahata

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Combined deficiency in IκBα and IκBϵ reveals a critical window of NF-κB activity in natural killer cell differentiation

Sandrine I. Samson,Sylvie Mémet,Christian A. J. Vosshenrich,Francesco Colucci,Odile Richard,Delphine Ndiaye,Alain Israël,James P. Di Santo

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Dynamics of cytokine expression in HIV productively infected primary CD4⁺ T cells

Bouchaib Bahbouhi,Alan Landay,Lena Al-Harthi

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Analysis of T-cell repertoire in hepatitis-associated aplastic anemia

Jun Lu,Atanu Basu,J. Joseph Melenhorst,Neal S. Young,Kevin E. Brown

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CD28 disruption exacerbates inflammation in Tgf-β1^-/- mice: in vivo suppression by CD4⁺CD25⁺ regulatory T cells independent of autocrine TGF-β1

Mizuko Mamura,WoonKyu Lee,Timothy J. Sullivan,Angelina Felici,Anastasia L. Sowers,James P. Allison,John J. Letterio

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Utilization of Ig heavy chain variable, diversity, and joining gene segments in children with B-lineage acute lymphoblastic leukemia: implications for the mechanisms of VDJ recombination and for pathogenesis

Clinical Trials & Observations

Aihong Li,Montse Rue,Jianbiao Zhou,Hongjun Wang,Meredith A. Goldwasser,Donna Neuberg,Virginia Dalton,David Zuckerman,Cheryl Lyons,Lewis B. Silverman,Stephen E. Sallan,John G. Gribben,for the Dana-Farber Cancer Institute ALL Consortium

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Atypical features of familial hemophagocytic lymphohistiocytosis

Clinical Trials & Observations Brief Report

Rosanna Busiello,Marsilio Adriani,Franco Locatelli,Mario Galgani,Giorgia Fimiani,Rita Clementi,Matilde Valeria Ursini,Luigi Racioppi,Claudio Pignata

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Use of B cell–bound HLA-A2 class I monomers to generate high-avidity, allo-restricted CTLs against the leukemia-associated protein Wilms tumor antigen

Brief Report

Philip Savage,Liquan Gao,Kevin Vento,Pam Cowburn,Stephen Man,Neil Steven,Graham Ogg,Andrew McMichael,Agamemnon Epenetos,Els Goulmy,Hans J. Stauss

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Complete protection from relapsing experimental autoimmune encephalomyelitis induced by syngeneic B cells expressing the autoantigen

Brief Report

Chiann-Chyi Chen,Amariliz Rivera,Joseph P. Dougherty,Yacov Ron

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Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase–mediated tryptophan degradation

Brief Report

Roland Meisel,Andree Zibert,Maurice Laryea,Ulrich Göbel,Walter Däubener,Dagmar Dilloo

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NEOPLASIA

NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a

Ting-Lei Gu,Zuzana Tothova,Blanca Scheijen,James D. Griffin,D. Gary Gilliland,David W. Sternberg

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SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway

Chor-Sang Chim,Tsz-Kin Fung,Wai-Chung Cheung,Raymond Liang,Yok-Lam Kwong

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T-cell lymphoma as a model for the use of histone deacetylase inhibitors in cancer therapy: impact of depsipeptide on molecular markers, therapeutic targets, and mechanisms of resistance

Richard L. Piekarz,Robert W. Robey,Zhirong Zhan,Ganesh Kayastha,Anousheh Sayah,Amina H. Abdeldaim,Sonia Torrico,Susan E. Bates

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Telomere length correlates with histopathogenesis according to the germinal center in mature B-cell lymphoproliferative disorders

Clinical Trials & Observations

Marco Ladetto,Mara Compagno,Irene Ricca,Marco Pagano,Alberto Rocci,Monica Astolfi,Daniela Drandi,Paola Francia di Celle,Maria Dell'Aquila,Barbara Mantoan,Sonia Vallet,Gloria Pagliano,Federica De Marco,Roberto Francese,Loredana Santo,Alessandra Cuttica,Carlo Marinone,Mario Boccadoro,Corrado Tarella

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The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT

Shinichiro Takahashi,Melanie J. McConnell,Hideo Harigae,Mitsuo Kaku,Takeshi Sasaki,Ari M. Melnick,Jonathan D. Licht

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A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

Elaine Willmore,Sarah de Caux,Nicola J. Sunter,Michael J. Tilby,Graham H. Jackson,Caroline A. Austin,Barbara W. Durkacz

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Imatinib and plasmacytoid dendritic cell function in patients with chronic myeloid leukemia

Clinical Trials & Observations Brief Report

Mohamad Mohty,Eric Jourdan,Naira Ben Mami,Norbert Vey,Ghandi Damaj,Didier Blaise,Daniel Isnardon,Daniel Olive,Béatrice Gaugler

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RED CELLS

Genetic abnormalities and juvenile hemochromatosis: mutations of the HJV gene encoding hemojuvelin

Clinical Trials & Observations

Pauline L. Lee,Ernest Beutler,Sreenivas V. Rao,James C. Barton

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Supplemental data

A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia

Brief Report

Z. Leah Harris,Sandra R. Davis-Kaplan,Jonathan D. Gitlin,Jerry Kaplan

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Supplemental data

TRANSPLANTATION

Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: donor type matters

Clinical Trials & Observations

Maha El-Zimaity,Rima Saliba,Kawah Chan,Munir Shahjahan,Antonio Carrasco,Ola Khorshid,Humberto Caldera,Daniel Couriel,Sergio Giralt,Issa Khouri,Cindy Ippoliti,Richard Champlin,Marcos de Lima

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Pericapillary hemorrhage as criterion of severe human digestive graft-versus-host disease

Clinical Trials & Observations Brief Report

Marjan Ertault-Daneshpouy,Christophe Leboeuf,Marc Lemann,Fatiha Bouhidel,Lionel Ades,Eliane Gluckman,Gérard Socié,Anne Janin

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CORRESPONDENCE

Direct vascular delivery of primitive hematopoietic cells to bone marrow improves localization but not engraftment

Karissa T. Chabner,Gregor B. Adams,Jianhua Qiu,Michael Moskowitz,Emily S. Marsters,George P. Topulos,David T. Scadden

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