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Volume 102, Issue 4

August 15 2003

In this Issue

INSIDE BLOOD
PERSPECTIVES
REVIEW IN TRANSLATIONAL HEMATOLOGY
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

Leukemic cell resistance: targeting needed beyond MDR-1

Peter Greenberg

View Articletitled, Leukemic cell resistance: targeting needed beyond MDR-1

Chronic graft-versus-host disease (cGVHD) is more frequent due to changes in the practice of stem cell transplantation (SCT)

Georgia B. Vogelsang

View Articletitled, Chronic graft-versus-host disease (cGVHD) is more frequent due to changes in the practice of stem cell transplantation (SCT)

Build it and they will come (or will they?)

James T. Casper

View Articletitled, Build it and they will come (or will they?)

Novel functional defect in factor V deficiency

William H. Kane

View Articletitled, Novel functional defect in factor V deficiency

What genes do Shiga toxins target?

Wayne L. Chandler

View Articletitled, What genes do Shiga toxins target?

Extending the repertoire of Epo action

Mitchell J. Weiss

View Articletitled, Extending the repertoire of Epo action

DAG signaling taught us a lesson: what diverges can converge

Marcelo G. Kazanietz

View Articletitled, DAG signaling taught us a lesson: what diverges can converge

Neutrophils and the protein C pathway

Jeffrey I. Weitz

View Articletitled, Neutrophils and the protein C pathway

PlGF: a link between inflammation and angiogenesis in sickle disease

Gregory M. Vercellotti

View Articletitled, PlGF: a link between inflammation and angiogenesis in sickle disease

PERSPECTIVES

New insights into the structural basis of integrin activation

Jian-Ping Xiong,Thilo Stehle,Simon L. Goodman,M. Amin Arnaout

View Articletitled, New insights into the structural basis of integrin activation

REVIEW IN TRANSLATIONAL HEMATOLOGY

Double jeopardy from a single translocation: deletions of the derivative chromosome 9 in chronic myeloid leukemia

Brian J. P. Huntly,Anthony Bench,Anthony R. Green

View Articletitled, Double jeopardy from a single translocation: deletions of the derivative chromosome 9 in chronic myeloid leukemia

CHEMOKINES

RANTES (CCL5) uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement

Branka Roscic-Mrkic,Marek Fischer,Christine Leemann,Amapola Manrique,Cynthia J. Gordon,John P. Moore,Amanda E. I. Proudfoot,Alexandra Trkola

View Articletitled, RANTES (CCL5) uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement

TGFβ inhibits LPS-induced chemokine mRNA stabilization

Yalei Dai,Shyamsree Datta,Michael Novotny,Thomas A. Hamilton

View Articletitled, TGFβ inhibits LPS-induced chemokine mRNA stabilization

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

Christian Hundhausen,Dominika Misztela,Theo A. Berkhout,Neil Broadway,Paul Saftig,Karina Reiss,Dieter Hartmann,Falk Fahrenholz,Rolf Postina,Vance Matthews,Karl-Josef Kallen,Stefan Rose-John,Andreas Ludwig

View Articletitled, The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Effect of antiviral treatment in patients with chronic HCV infection and t(14;18) translocation
Clinical Trials & Observations

Francesca Giannelli,Stefania Moscarella,Carlo Giannini,Patrizio Caini,Monica Monti,Laura Gragnani,Roberto Giulio Romanelli,Vera Solazzo,Giacomo Laffi,Giorgio La Villa,Paolo Gentilini,Anna Linda Zignego

View Articletitled, Effect of antiviral treatment in patients with chronic HCV infection and t(14;18) translocation

Quinine as a multidrug resistance inhibitor: a phase 3 multicentric randomized study in adult de novo acute myelogenous leukemia
Clinical Trials & Observations

Eric Solary,Bernard Drenou,Lydia Campos,Patricia de Crémoux,Francine Mugneret,Philippe Moreau,Bruno Lioure,Annie Falkenrodt,Brigitte Witz,Marc Bernard,Mathilde Hunault-Berger,Martine Delain,José Fernandes,Christiane Mounier,François Guilhot,Francine Garnache,Christian Berthou,Fawzi Kara-Slimane,Jean-Luc Harousseau,the Groupe Ouest Est Leucémies Aiguës Myéloblastiques (GOELAMS)

View Articletitled, Quinine as a multidrug resistance inhibitor: a phase 3 multicentric randomized study in adult de novo acute myelogenous leukemia

Polyclonal hematopoiesis maintained in patients with bone marrow failure harboring a minor population of paroxysmal nocturnal hemoglobinuria–type cells
Clinical Trials & Observations

Ken Ishiyama,Tatsuya Chuhjo,Hongbo Wang,Akihiro Yachie,Mitsuhiro Omine,Shinji Nakao

View Articletitled, Polyclonal hematopoiesis maintained in patients with bone marrow failure harboring a minor population of paroxysmal nocturnal hemoglobinuria–type cells

Influence of extracorporeal photopheresis on clinical and laboratory parameters in chronic graft-versus-host disease and analysis of predictors of response
Clinical Trials & Observations

Edward D. Seaton,Richard M. Szydlo,Edward Kanfer,Jane F. Apperley,Robin Russell-Jones

View Articletitled, Influence of extracorporeal photopheresis on clinical and laboratory parameters in chronic graft-versus-host disease and analysis of predictors of response

Stem cell transplantation for chronic myeloid leukemia in children
Clinical Trials & Observations

Kate Cwynarski,Irene A. G. Roberts,Simona Iacobelli,Anja van Biezen,Ronald Brand,Agnes Devergie,Jaak M. Vossen,Mahmoud Aljurf,William Arcese,Franco Locatelli,Giorgio Dini,Dietrich Niethammer,Dietger Niederwieser,Jane F. Apperley,for the Paediatric and Chronic Leukaemia Working Parties of the European Group for Blood and Marrow Transplantation

View Articletitled, Stem cell transplantation for chronic myeloid leukemia in children

Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia (AML) in first complete remission (CR1): an intention-to-treat analysis of the EORTC/GIMEMAAML-10 trial
Clinical Trials & Observations

Stefan Suciu,Franco Mandelli,Theo de Witte,Robert Zittoun,Eugenio Gallo,Boris Labar,Gennaro De Rosa,Amine Belhabri,Rosario Giustolisi,Richard Delarue,Vincenzo Liso,Salvatore Mirto,Giuseppe Leone,Jean-Henri Bourhis,Giuseppe Fioritoni,Ulrich Jehn,Sergio Amadori,Paola Fazi,Anne Hagemeijer,Roel Willemze,the EORTC and GIMEMA Leukemia Groups

View Articletitled, Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia (AML) in first complete remission (CR1): an intention-to-treat analysis of the EORTC/GIMEMAAML-10 trial

GENE THERAPY

Retrovirus-mediated gene transfer in polyclonal T cells results in lower apoptosis and enhanced ex vivo cell expansion of CMV-reactive CD8 T cells as compared with EBV-reactive CD8 T cells

Delphine Sauce,Nathalie Rufer,Patricia Mercier,Marie Bodinier,Jean-Paul Rémy-Martin,Anne Duperrier,Christophe Ferrand,Patrick Hervé,Pedro Romero,François Lang,Pierre Tiberghien,Eric Robinet

View Articletitled, Retrovirus-mediated gene transfer in polyclonal T cells results in lower apoptosis and enhanced ex vivo cell expansion of CMV-reactive CD8 T cells as compared with EBV-reactive CD8 T cells

HEMATOPOIESIS

Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure

Janis L. Abkowitz,Abigail E. Robinson,Sujata Kale,Michael W. Long,Jing Chen

View Articletitled, Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure

NMDA receptor–mediated regulation of human megakaryocytopoiesis

Ian S. Hitchcock,Timothy M. Skerry,Martin R. Howard,Paul G. Genever

View Articletitled, NMDA receptor–mediated regulation of human megakaryocytopoiesis

Ex vivo targeting of p21^Cip1/Waf1 permits relative expansion of human hematopoietic stem cells

Sebastian Stier,Tao Cheng,Randolf Forkert,Christoph Lutz,David M. Dombkowski,Jie Lin Zhang,David T. Scadden

View Articletitled, Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells

Transcription activation function of C/EBPα is required for induction of granulocytic differentiation

Karen Keeshan,Giorgia Santilli,Francesca Corradini,Danilo Perrotti,Bruno Calabretta

View Articletitled, Transcription activation function of C/EBPα is required for induction of granulocytic differentiation

Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells

Eitan Fibach,Nicoletta Bianchi,Monica Borgatti,Eugenia Prus,Roberto Gambari

View Articletitled, Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells

A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome

Catherine Lacout,Elie Haddad,Siham Sabri,Fedor Svinarchouk,Loic Garçon,Claude Capron,Adlen Foudi,Rym Mzali,Scott B. Snapper,Fawzia Louache,William Vainchenker,Dominique Duménil

View Articletitled, A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome

Stat5 expression is critical for mast cell development and survival

Christopher P. Shelburne,Margaret E. McCoy,Roland Piekorz,Veronica Sexl,Kwan-Ho Roh,Sarah M. Jacobs-Helber,Sheila R. Gillespie,Daniel P. Bailey,Paria Mirmonsef,Meredith N. Mann,Mohit Kashyap,Harry V. Wright,Hey Jin Chong,L. Andrew Bouton,Brian Barnstein,Carlos D. Ramirez,Kevin D. Bunting,Steven Sawyer,Chris S. Lantz,John J. Ryan

View Articletitled, Stat5 expression is critical for mast cell development and survival

Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation

Michael J. Nemeth,David J. Curtis,Martha R. Kirby,Lisa J. Garrett-Beal,Nancy E. Seidel,Amanda P. Cline,David M. Bodine

View Articletitled, Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Platelet α₂β₁ integrin activation: contribution of ligand internalization and the α₂-cytoplasmic domain

Zhengyan Wang,Tina M. Leisner,Leslie V. Parise

View Articletitled, Platelet α2β1 integrin activation: contribution of ligand internalization and the α2-cytoplasmic domain

Factor V New Brunswick: Ala221Val associated with FV deficiency reproduced in vitro and functionally characterized

Mårten Steen,Maria Miteva,Bruno O. Villoutreix,Tomio Yamazaki,Björn Dahlbäck

View Articletitled, Factor V New Brunswick: Ala221Val associated with FV deficiency reproduced in vitro and functionally characterized

Molecular and functional analysis of Shiga toxin–induced response patterns in human vascular endothelial cells

Andreas Matussek,Joerg Lauber,Anna Bergau,Wiebke Hansen,Manfred Rohde,Kurt E. J. Dittmar,Matthias Gunzer,Michael Mengel,Patricia Gatzlaff,Maike Hartmann,Jan Buer,Florian Gunzer

View Articletitled, Molecular and functional analysis of Shiga toxin–induced response patterns in human vascular endothelial cells

The vitamin K–dependent γ-glutamyl carboxylase gene contains a TATA-less promoter with a novel upstream regulatory element

Elizabeth E. Romero,Umaima Marvi,Zachary E. Niman,David A. Roth

View Articletitled, The vitamin K–dependent γ-glutamyl carboxylase gene contains a TATA-less promoter with a novel upstream regulatory element

Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization

Christopher Heeschen,Alexandra Aicher,Ralf Lehmann,Stephan Fichtlscherer,Mariuca Vasa,Carmen Urbich,Christiane Mildner-Rihm,Hans Martin,Andreas M. Zeiher,Stefanie Dimmeler

View Articletitled, Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization

The nonenzymatic subunit of pseutarin C, a prothrombin activator from eastern brown snake (Pseudonaja textilis) venom, shows structural similarity to mammalian coagulation factor V

Veena S. Rao,Sanjay Swarup,R. Manjunatha Kini

View Articletitled, The nonenzymatic subunit of pseutarin C, a prothrombin activator from eastern brown snake (Pseudonaja textilis) venom, shows structural similarity to mammalian coagulation factor V

Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen

Ulhas P. Naik,Meghna U. Naik

View Articletitled, Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen

Hyperhomocysteinemia in cerebral vein thrombosis
Clinical Trials & Observations

Ida Martinelli,Tullia Battaglioli,Paola Pedotti,Marco Cattaneo,Pier M. Mannucci

View Articletitled, Hyperhomocysteinemia in cerebral vein thrombosis

Murine GPVI stimulates weak integrin activation in PLCγ2^–^/^– platelets: involvement of PLCγ1 and PI3-kinase

Katsue Suzuki-Inoue,Osamu Inoue,Jon Frampton,Steve P. Watson

View Articletitled, Murine GPVI stimulates weak integrin activation in PLCγ2–/– platelets: involvement of PLCγ1 and PI3-kinase

IMMUNOBIOLOGY

CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes

Norihito Yazawa,Manabu Fujimoto,Shinichi Sato,Kensuke Miyake,Noriko Asano,Yoshinori Nagai,Osamu Takeuchi,Kiyoshi Takeda,Hitoshi Okochi,Shizuo Akira,Thomas F. Tedder,Kunihiko Tamaki

View Articletitled, CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes

Impaired germinal center formation and recall T-cell–dependent immune responses in mice lacking the costimulatory ligand B7-H2

Siew-Cheng Wong,Edwin Oh,Chee-Hoe Ng,Kong-Peng Lam

View Articletitled, Impaired germinal center formation and recall T-cell–dependent immune responses in mice lacking the costimulatory ligand B7-H2

Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia

Helmut Rainer Salih,Holger Antropius,Friederike Gieseke,Stefan Zoltan Lutz,Lothar Kanz,Hans-Georg Rammensee,Alexander Steinle

View Articletitled, Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia

Changes in the lymph node microenvironment induced by oncostatin M

Isabelle Louis,Gaël Dulude,Sophie Corneau,Sylvie Brochu,Catherine Boileau,Caroline Meunier,Caroline Côté,Nathalie Labrecque,Claude Perreault

View Articletitled, Changes in the lymph node microenvironment induced by oncostatin M

IgE alone stimulates mast cell adhesion to fibronectin via pathways similar to those used by IgE + antigen but distinct from those used by Steel factor

Vivian Lam,Janet Kalesnikoff,Corinna W. K. Lee,Valerie Hernandez-Hansen,Bridget S. Wilson,Janet M. Oliver,Gerald Krystal

View Articletitled, IgE alone stimulates mast cell adhesion to fibronectin via pathways similar to those used by IgE + antigen but distinct from those used by Steel factor

Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3

Christine Teixeira,Stacey L. Stang,Yong Zheng,Naomi S. Beswick,James C. Stone

View Articletitled, Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3

The immunoglobulin heavy-chain locus hs3b and hs4 3′ enhancers are dispensable for VDJ assembly and somatic hypermutation

Caroline Le Morvan,Eric Pinaud,Catherine Decourt,Armelle Cuvillier,Michel Cogné

View Articletitled, The immunoglobulin heavy-chain locus hs3b and hs4 3′ enhancers are dispensable for VDJ assembly and somatic hypermutation

Homeostatic control of T-cell generation in neonates

Stefan O. Schönland,Julia K. Zimmer,Consuelo M. Lopez-Benitez,Thomas Widmann,Kirk D. Ramin,Jörg J. Goronzy,Cornelia M. Weyand

View Articletitled, Homeostatic control of T-cell generation in neonates

Ex vivo induction of multiple myeloma–specific cytotoxic T lymphocytes

Toshiaki Hayashi,Teru Hideshima,Masaharu Akiyama,Noopur Raje,Paul Richardson,Dharminder Chauhan,Kenneth C. Anderson

View Articletitled, Ex vivo induction of multiple myeloma–specific cytotoxic T lymphocytes

NEOPLASIA

BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma
Clinical Trials & Observations

Takashi Akasaka,Izidore S. Lossos,Ronald Levy

View Articletitled, BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma

Anti-CD40 monoclonal antibody therapy in combination with irradiation results in a CD8 T-cell–dependent immunity to B-cell lymphoma

Jamie Honeychurch,Martin J. Glennie,Peter W. M. Johnson,Timothy M. Illidge

View Articletitled, Anti-CD40 monoclonal antibody therapy in combination with irradiation results in a CD8 T-cell–dependent immunity to B-cell lymphoma

cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activity

Joseph A. Francisco,Charles G. Cerveny,Damon L. Meyer,Bruce J. Mixan,Kerry Klussman,Dana F. Chace,Starr X. Rejniak,Kristine A. Gordon,Ron DeBlanc,Brian E. Toki,Che-Leung Law,Svetlana O. Doronina,Clay B. Siegall,Peter D. Senter,Alan F. Wahl

View Articletitled, cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activity

Multidrug resistance protein attenuates gemtuzumab ozogamicin–induced cytotoxicity in acute myeloid leukemia cells

Roland B. Walter,Brian W. Raden,Tom C. Hong,David A. Flowers,Irwin D. Bernstein,Michael L. Linenberger

View Articletitled, Multidrug resistance protein attenuates gemtuzumab ozogamicin–induced cytotoxicity in acute myeloid leukemia cells

Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia
Clinical Trials & Observations

Soheil Meshinchi,Derek L. Stirewalt,Todd A. Alonzo,Quangeng Zhang,David A. Sweetser,William G. Woods,Irwin D. Bernstein,Robert J. Arceci,Jerald P. Radich

View Articletitled, Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia

The coupling of TEL/PDGFβR to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases

Helen Wheadon,Melanie J. Welham

View Articletitled, The coupling of TEL/PDGFβR to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases

Involvement of nitric oxide in farnesyltransferase inhibitor–mediated apoptosis in chronic myeloid leukemia cells

Carmine Selleri,Jaroslaw P. Maciejewski,Nunzia Montuori,Patrizia Ricci,Valeria Visconte,Bianca Serio,Luigiana Luciano,Bruno Rotoli

View Articletitled, Involvement of nitric oxide in farnesyltransferase inhibitor–mediated apoptosis in chronic myeloid leukemia cells

PHAGOCYTES

Expression and function of the endothelial protein C receptor in human neutrophils

Daniel H. Sturn,Nicole C. Kaneider,Clemens Feistritzer,Angela Djanani,Kenji Fukudome,Christian J. Wiedermann

View Articletitled, Expression and function of the endothelial protein C receptor in human neutrophils

RED CELLS

Placenta growth factor activates monocytes and correlates with sickle cell disease severity

Natalya Perelman,Suresh K. Selvaraj,Sandeep Batra,Lori R. Luck,Anat Erdreich-Epstein,Thomas D. Coates,Vijay K. Kalra,Punam Malik

View Articletitled, Placenta growth factor activates monocytes and correlates with sickle cell disease severity

Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor

Suresh K. Selvaraj,Ranjit K. Giri,Natalya Perelman,Cage Johnson,Punam Malik,Vijay K. Kalra

View Articletitled, Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor

Hemoglobin metabolites mimic benzodiazepines and are possible mediators of hepatic encephalopathy

Brian J. Ruscito,Neil L. Harrison

View Articletitled, Hemoglobin metabolites mimic benzodiazepines and are possible mediators of hepatic encephalopathy

Hydroxyurea can eliminate transfusion requirements in children with severe β-thalassemia
Clinical Trials & Observations Brief Report

Mohamed Bradai,Mohand Tayeb Abad,Serge Pissard,Fatima Lamraoui,Laurent Skopinski,Mariane de Montalembert

View Articletitled, Hydroxyurea can eliminate transfusion requirements in children with severe β-thalassemia

Long targeting arms do not increase the efficiency of homologous recombination in the β-globin locus of murine embryonic stem cells
Brief Report

Zhi Hong Lu,Jason T. Books,Richard M. Kaufman,Timothy J. Ley

View Articletitled, Long targeting arms do not increase the efficiency of homologous recombination in the β-globin locus of murine embryonic stem cells

TRANSPLANTATION

Interleukin-7 improves T-cell recovery after experimental T-cell–depleted bone marrow transplantation in T-cell–deficient mice by strong expansion of recent thymic emigrants

Annoek E. C. Broers,Sandra J. Posthumus-van Sluijs,Hergen Spits,Bronno van der Holt,Bob Löwenberg,Eric Braakman,Jan J. Cornelissen

View Articletitled, Interleukin-7 improves T-cell recovery after experimental T-cell–depleted bone marrow transplantation in T-cell–deficient mice by strong expansion of recent thymic emigrants

Allogeneic hematopoietic stem cell transplantation from family members other than HLA-identical siblings over the last decade (1991-2000)
Clinical Trials & Observations

Yoshinobu Kanda,Shigeru Chiba,Hisamaru Hirai,Hisashi Sakamaki,Tohru Iseki,Yoshihisa Kodera,Takahiro Karasuno,Shinichiro Okamoto,Noriyuki Hirabayashi,Koji Iwato,Atsuo Maruta,Yoshihiro Fujimori,Tatsuo Furukawa,Shin Mineishi,Keitaro Matsuo,Nobuyuki Hamajima,Masahiro Imamura

View Articletitled, Allogeneic hematopoietic stem cell transplantation from family members other than HLA-identical siblings over the last decade (1991-2000)

CORRESPONDENCE

Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation

Pieternella S. in `t Anker,Sicco A. Scherjon,Carin Kleijburg-van der Keur,Willy A. Noort,Frans H. J. Claas,Roelof Willemze,Willem E. Fibbe,Humphrey H. H. Kanhai

View Articletitled, Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation

In B-cell chronic lymphocytic leukemias, 7q21 translocations lead to overexpression of the CDK6 gene

Sandrine Hayette,Isabelle Tigaud,Evelyne Callet-Bauchu,Martine Ffrench,Sophie Gazzo,Kamal Wahbi,Mary Callanan,Pascale Felman,Charles Dumontet,Jean-Pierre Magaud,Ruth Rimokh

View Articletitled, In B-cell chronic lymphocytic leukemias, 7q21 translocations lead to overexpression of the CDK6 gene

Evaluating the relevance of the platelet transcriptome

Andrew S. Weyrich,Guy A. Zimmerman

View Articletitled, Evaluating the relevance of the platelet transcriptome

Does cytogenetic mosaicism in CD34⁺CD38^low cells reflect the persistence of normal primitive hematopoietic progenitors in myeloid metaplasia with myelofibrosis?

Chrystèle Bilhou-Nabéra,Christophe Brigaudeau,Denis Clay,Joris Andrieux,Jean-Luc Lai,Danielle Brouty-Boyé,Christine Vignon,Marie-Josée Gharbi,Marie-Caroline Le Bousse-Kerdilès,Vincent Praloran,the members of the French INSERM Network on Myeloid Metaplasia with Myelofibrosis

View Articletitled, Does cytogenetic mosaicism in CD34+CD38low cells reflect the persistence of normal primitive hematopoietic progenitors in myeloid metaplasia with myelofibrosis?

Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma

Lijun Shen,Anthony C. T. Liang,Liwei Lu,Wing Y. Au,Kai-Yau Wong,Pui-Chi Tin,Kwok-Wah Chan,King-Hung Ko,Yun-Wen Chen,Swan-Lip Beh,Norio Shimizu,Junjiro Tsuchiyama,Johnny C. O. Tang,Yok-Lam Kwong,Raymond H. S. Liang,Gopesh Srivastava

View Articletitled, Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma

Silencing of the SOCS-1 gene by CpG methylation?

Ingo Melzner,Peter Möller

View Articletitled, Silencing of the SOCS-1 gene by CpG methylation?

Acute chest syndrome, transfusion, and neurologic events in children with sickle cell disease

Scott T. Miller,Sreedhar P. Rao

View Articletitled, Acute chest syndrome, transfusion, and neurologic events in children with sickle cell disease

Rituximab-associated immune myelopathy

Theodora Papadaki,Kostas Stamatopoulos,Achilles Anagnostopoulos,Athanasios Fassas

View Articletitled, Rituximab-associated immune myelopathy

Vagaries of genetic association studies in myocardial infarction

Pier M. Mannucci,Diego Ardissino,Piera A. Merlini,Flora Peyvandi

View Articletitled, Vagaries of genetic association studies in myocardial infarction

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Issue Archive

Table of Contents

INSIDE BLOOD

PERSPECTIVES

REVIEW IN TRANSLATIONAL HEMATOLOGY

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Effect of antiviral treatment in patients with chronic HCV infection and t(14;18) translocation Clinical Trials & Observations

Quinine as a multidrug resistance inhibitor: a phase 3 multicentric randomized study in adult de novo acute myelogenous leukemia Clinical Trials & Observations

Polyclonal hematopoiesis maintained in patients with bone marrow failure harboring a minor population of paroxysmal nocturnal hemoglobinuria–type cells Clinical Trials & Observations

Influence of extracorporeal photopheresis on clinical and laboratory parameters in chronic graft-versus-host disease and analysis of predictors of response Clinical Trials & Observations

Stem cell transplantation for chronic myeloid leukemia in children Clinical Trials & Observations

Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia (AML) in first complete remission (CR1): an intention-to-treat analysis of the EORTC/GIMEMAAML-10 trial Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Hyperhomocysteinemia in cerebral vein thrombosis Clinical Trials & Observations

IMMUNOBIOLOGY

NEOPLASIA

BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma Clinical Trials & Observations

Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia Clinical Trials & Observations