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Volume 102, Issue 3

August 1 2003

In this Issue

INSIDE BLOOD
BLOOD WORK
REVIEW ARTICLES
ERRATA
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

Unlocking the mysteries of iron homeostasis and of the anemia of chronic disease: is hepcidin the key?

Ernest Beutler

View Articletitled, Unlocking the mysteries of iron homeostasis and of the anemia of chronic disease: is hepcidin the key?

AML beyond the boundaries of daunomycin and cytarabine

Bob Löwenberg

View Articletitled, AML beyond the boundaries of daunomycin and cytarabine

Magnetic cells show the way home

Kevin M. Brindle

View Articletitled, Magnetic cells show the way home

ESCs and hematopoietic fate: mixing the perfect “cocktail”

Kimberly A Dooley,Leonard I. Zon

View Articletitled, ESCs and hematopoietic fate: mixing the perfect “cocktail”

Antithrombotic thrombocytes

William P. Fay

View Articletitled, Antithrombotic thrombocytes

Peptide decoys: cure for FVIII inhibitors?

Alexey Khrenov,Evgueni Saenko

View Articletitled, Peptide decoys: cure for FVIII inhibitors?

Radicals accused of causing MALT lymphomas

Thomas F. E. Barth,Peter Möller

View Articletitled, Radicals accused of causing MALT lymphomas

A profile of mycosis fungoides

David M. Dorfman

View Articletitled, A profile of mycosis fungoides

Prognostic staging in myeloma: in search of biology

A. K. Stewart

View Articletitled, Prognostic staging in myeloma: in search of biology

The MoAb reloaded? Is alemtuzumab the one?

Raymond L. Comenzo

View Articletitled, The MoAb reloaded? Is alemtuzumab the one?

A new von Hippel–Lindau disease

Peter J. Ratcliffe

View Articletitled, A new von Hippel–Lindau disease

BLOOD WORK

Peripheral smear and marrow biopsy of a patient with hairy cell leukemia

View Articletitled, Peripheral smear and marrow biopsy of a patient with hairy cell leukemia

REVIEW ARTICLES

Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation

Tomas Ganz

View Articletitled, Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation

ERRATA

Erratum for vol. 101, p. 2963

View Articletitled, Erratum for vol. 101, p. 2963

Erratum for vol. 101, p. 2089

View Articletitled, Erratum for vol. 101, p. 2089

CHEMOKINES

Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes

Patricia Ogilvie,Samantha Paoletti,Ian Clark-Lewis,Mariagrazia Uguccioni

View Articletitled, Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes
Clinical Trials & Observations

Francis J. Giles,Alison T. Stopeck,Lewis R. Silverman,Jeffrey E. Lancet,Maureen A. Cooper,Alison L. Hannah,Julie M. Cherrington,Anne-Marie O'Farrell,Helene A. Yuen,Sharianne G. Louie,Weiru Hong,Jorge E. Cortes,Srdan Verstovsek,Maher Albitar,Susan M. O'Brien,Hagop M. Kantarjian,Judith E. Karp

View Articletitled, SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes

Performance of a new clinical grading system for chronic graft-versus-host disease: a multicenter study
Clinical Trials & Observations

Görgün Akpek,Stephanie J. Lee,Mary E. Flowers,Steven Z. Pavletic,Mukta Arora,Shing Lee,Steven Piantadosi,Katherine A. Guthrie,James C. Lynch,Alessandra Takatu,Mary M. Horowitz,Joseph H. Antin,Daniel J. Weisdorf,Paul J. Martin,Georgia B. Vogelsang

View Articletitled, Performance of a new clinical grading system for chronic graft-versus-host disease: a multicenter study

Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell leukemia
Clinical Trials & Observations

Jorge Nieva,Kelly Bethel,Alan Saven

View Articletitled, Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell leukemia

Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors
Clinical Trials & Observations

Sebastian Giebel,Franco Locatelli,Teresa Lamparelli,Andrea Velardi,Stella Davies,Guido Frumento,Rita Maccario,Federico Bonetti,Jerzy Wojnar,Miryam Martinetti,Francesco Frassoni,Giovanna Giorgiani,Andrea Bacigalupo,Jerzy Holowiecki

View Articletitled, Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors

Conditioning with fludarabine and targeted busulfan for transplantation of allogeneic hematopoietic stem cells
Clinical Trials & Observations

Martin Bornhäuser,Barry Storer,John T. Slattery,Frederick R. Appelbaum,H. Joachim Deeg,John Hansen,Paul J. Martin,George B. McDonald,W. Garrett Nichols,Jerald Radich,Ann Woolfrey,Andreas Jenke,Eberhard Schleyer,Christian Thiede,Gerhard Ehninger,Claudio Anasetti

View Articletitled, Conditioning with fludarabine and targeted busulfan for transplantation of allogeneic hematopoietic stem cells

Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning
Clinical Trials & Observations

Takahiro Fukuda,Michael Boeckh,Rachel A. Carter,Brenda M. Sandmaier,Michael B. Maris,David G. Maloney,Paul J. Martin,Rainer F. Storb,Kieren A. Marr

View Articletitled, Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning

Effect of a comprehensive clinical care program on disease course in severely ill children with sickle cell anemia in a sub-Saharan African setting
Clinical Trials & Observations

Mohamed Cherif Rahimy,Annick Gangbo,Gilbert Ahouignan,Roselyn Adjou,Chantal Deguenon,Stephanie Goussanou,Eusebe Alihonou

View Articletitled, Effect of a comprehensive clinical care program on disease course in severely ill children with sickle cell anemia in a sub-Saharan African setting

Reconstitution of the Epstein-Barr virus–specific cytotoxic T-lymphocyte response following T-cell–depleted myeloablative and nonmyeloablative allogeneic stem cell transplantation
Clinical Trials & Observations Brief Report

Suparno Chakrabarti,Donald W. Milligan,Deenan Pillay,Stephen Mackinnon,Kathleen Holder,Narinder Kaur,Dorothy McDonald,Christopher D. Fegan,Herman Waldmann,Geoff Hale,Alan Rickinson,Neil Steven

View Articletitled, Reconstitution of the Epstein-Barr virus–specific cytotoxic T-lymphocyte response following T-cell–depleted myeloablative and nonmyeloablative allogeneic stem cell transplantation

GENE THERAPY

In vivo retroviral gene transfer by direct intrafemoral injection results in correction of the SCID phenotype in Jak3 knock-out animals

Christine S. McCauslin,John Wine,Linzhao Cheng,Kim D. Klarmann,Fabio Candotti,Peter A. Clausen,Sally E. Spence,Jonathan R. Keller

View Articletitled, In vivo retroviral gene transfer by direct intrafemoral injection results in correction of the SCID phenotype in Jak3 knock-out animals

Telomerase levels control the lifespan of human T lymphocytes

Alexander Röth,Hans Yssel,Jérôme Pène,Elizabeth A. Chavez,Mike Schertzer,Peter M. Lansdorp,Hergen Spits,Rosalie M. Luiten

View Articletitled, Telomerase levels control the lifespan of human T lymphocytes

HEMATOPOIESIS

Impaired hematopoiesis in mice lacking the transcription factor Sp3

Pieter Fokko van Loo,Peter Bouwman,Kam-Wing Ling,Sabine Middendorp,Guntram Suske,Frank Grosveld,Elaine Dzierzak,Sjaak Philipsen,Rudolf W. Hendriks

View Articletitled, Impaired hematopoiesis in mice lacking the transcription factor Sp3

Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells

Kathleen A. Hinds,Jonathan M. Hill,Erik M. Shapiro,Mikko O. Laukkanen,Alfonso C. Silva,Christian A. Combs,Timothy R. Varney,Robert S. Balaban,Alan P. Koretsky,Cynthia E. Dunbar

View Articletitled, Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells

Complete reconstitution of human lymphocytes from cord blood CD34⁺ cells using the NOD/SCID/γ_c^null mice model

Hidefumi Hiramatsu,Ryuta Nishikomori,Toshio Heike,Mamoru Ito,Kimio Kobayashi,Kenji Katamura,Tatsutoshi Nakahata

View Articletitled, Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/γcnull mice model

Human CD34⁺ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells

Ewa Sitnicka,Natalija Buza-Vidas,Staffan Larsson,Jens M. Nygren,Karina Liuba,Sten Erik W. Jacobsen

View Articletitled, Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells

Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro

Mei Chang,Peggy A. Nakagawa,Shirley A. Williams,Michael R. Schwartz,Karen L. Imfeld,Jeffrey S. Buzby,Diane J. Nugent

View Articletitled, Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro

Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos

Naoko Minegishi,Norio Suzuki,Tomomasa Yokomizo,Xiaoqing Pan,Tetsuhiro Fujimoto,Satoru Takahashi,Takahiko Hara,Atsushi Miyajima,Shin-ichi Nishikawa,Masayuki Yamamoto

View Articletitled, Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos

Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells

Kristin Chadwick,Lisheng Wang,Li Li,Pablo Menendez,Barbara Murdoch,Anne Rouleau,Mickie Bhatia

View Articletitled, Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells

Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome
Brief Report

Hiroki Yamaguchi,Gabriela M. Baerlocher,Peter M. Lansdorp,Stephen J. Chanock,Olga Nunez,Elaine Sloand,Neal S. Young

View Articletitled, Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Antithrombin Phe229Leu: a new homozygous variant leading to spontaneous antithrombin polymerization in vivo associated with severe childhood thrombosis
Clinical Trials & Observations

Véronique Picard,Marie-Dominique Dautzenberg,Bruno O. Villoutreix,Gilles Orliaguet,Martine Alhenc-Gelas,Martine Aiach

View Articletitled, Antithrombin Phe229Leu: a new homozygous variant leading to spontaneous antithrombin polymerization in vivo associated with severe childhood thrombosis

Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets

Dubravka Kufrin,Don E. Eslin,Khalil Bdeir,Juan-Carlos Murciano,Alice Kuo,M. Anna Kowalska,Jay L. Degen,Bruce S. Sachais,Douglas B. Cines,Mortimer Poncz

View Articletitled, Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets

Plasminogen activator inhibitor type–1 deficiency does not influence the outcome of murine pneumococcal pneumonia

Anita W. Rijneveld,Sandrine Florquin,Paul Bresser,Marcel Levi,Vivian de Waard,Roger Lijnen,Jaring S. Van der Zee,Peter Speelman,Peter Carmeliet,Tom van der Poll

View Articletitled, Plasminogen activator inhibitor type–1 deficiency does not influence the outcome of murine pneumococcal pneumonia

SHIP-2 forms a tetrameric complex with filamin, actin, and GPIb-IX-V: localization of SHIP-2 to the activated platelet actin cytoskeleton

Jennifer M. Dyson,Adam D. Munday,Anne M. Kong,Richard D. Huysmans,Maria Matzaris,Meredith J. Layton,Harshal H. Nandurkar,Michael C. Berndt,Christina A. Mitchell

View Articletitled, SHIP-2 forms a tetrameric complex with filamin, actin, and GPIb-IX-V: localization of SHIP-2 to the activated platelet actin cytoskeleton

Peptide decoys selected by phage display block in vitro and in vivo activity of a human anti-FVIII inhibitor
Brief Report

Sylvie Villard,Sébastien Lacroix-Desmazes,Thomas Kieber-Emmons,Dominique Piquer,Sabrina Grailly,Abdellah Benhida,Srini V. Kaveri,Jean-Marie Saint-Remy,Claude Granier

View Articletitled, Peptide decoys selected by phage display block in vitro and in vivo activity of a human anti-FVIII inhibitor

Factor XI–dependence of surface- and tissue factor–initiated thrombus propagation in primates
Brief Report

András Gruber,Stephen R. Hanson

View Articletitled, Factor XI–dependence of surface- and tissue factor–initiated thrombus propagation in primates

IMMUNOBIOLOGY

The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells

Emer Bourke,Daniela Bosisio,Josée Golay,Nadia Polentarutti,Alberto Mantovani

View Articletitled, The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells

Synergy between tumor immunotherapy and antiangiogenic therapy

Smita Nair,David Boczkowski,Benjamin Moeller,Mark Dewhirst,Johannes Vieweg,Eli Gilboa

View Articletitled, Synergy between tumor immunotherapy and antiangiogenic therapy

NEOPLASIA

Survival of acute myeloid leukemia cells requires PI3 kinase activation

Qing Xu,Serge-Emile Simpson,Timothy J. Scialla,Adam Bagg,Martin Carroll

View Articletitled, Survival of acute myeloid leukemia cells requires PI3 kinase activation

Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21
Clinical Trials & Observations

Liat Rainis,Dan Bercovich,Sabine Strehl,Andrea Teigler-Schlegel,Batia Stark,Jan Trka,Ninette Amariglio,Andrea Biondi,Inna Muler,Gideon Rechavi,Helena Kempski,Oskar A. Haas,Shai Izraeli

View Articletitled, Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21

Resveratrol blocks interleukin-1β–induced activation of the nuclear transcription factor NF-κB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells

Zeev Estrov,Shishir Shishodia,Stefan Faderl,David Harris,Quin Van,Hagop M. Kantarjian,Moshe Talpaz,Bharat B. Aggarwal

View Articletitled, Resveratrol blocks interleukin-1β–induced activation of the nuclear transcription factor NF-κB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells

Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study
Clinical Trials & Observations

Alfonso Mele,Alessandro Pulsoni,Elvira Bianco,Pellegrino Musto,Andrè Szklo,Maria Grazia Sanpaolo,Emilio Iannitto,Amalia De Renzo,Bruno Martino,Vincenzo Liso,Cristina Andrizzi,Simona Pusterla,Fausto Dore,Maddalena Maresca,Maria Rapicetta,Fabrizio Marcucci,Franco Mandelli,Silvia Franceschi

View Articletitled, Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study

CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRγδ lineage
Clinical Trials & Observations

Vahid Asnafi,Isabelle Radford-Weiss,Nicole Dastugue,Chantal Bayle,Daniel Leboeuf,Christiane Charrin,Richard Garand,Marina Lafage-Pochitaloff,Eric Delabesse,Agnès Buzyn,Xavier Troussard,Elizabeth Macintyre

View Articletitled, CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRγδ lineage

Gastric marginal zone lymphoma is associated with polymorphisms in genes involved in inflammatory response and antioxidative capacity
Clinical Trials & Observations

Sara Rollinson,Adam P. Levene,Fiona K. Mensah,Philippa L. Roddam,James M. Allan,Tim C. Diss,Eve Roman,Andrew Jack,Kenneth MacLennan,Michael F. Dixon,Gareth J. Morgan

View Articletitled, Gastric marginal zone lymphoma is associated with polymorphisms in genes involved in inflammatory response and antioxidative capacity

Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma
Clinical Trials & Observations

Hongtao Ye,Hongxiang Liu,Ayoma Attygalle,Andrew C. Wotherspoon,Andrew G. Nicholson,Frédéric Charlotte,Veronique Leblond,Paul Speight,John Goodlad,Anne Lavergne-Slove,Jose Ignacio Martin-Subero,Reiner Siebert,Ahmet Dogan,Peter G. Isaacson,Ming-Qing Du

View Articletitled, Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma

MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival

Bei Zheng,Paolo Fiumara,Yang V. Li,Georgios Georgakis,Virginia Snell,Mamoun Younes,Jean Nicolas Vauthey,Antonino Carbone,Anas Younes

View Articletitled, MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival

Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis

Stephan Mathas,Andreas Lietz,Martin Janz,Michael Hinz,Franziska Jundt,Claus Scheidereit,Kurt Bommert,Bernd Dörken

View Articletitled, Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis

Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features
Clinical Trials & Observations

Anna Guarini,Gianluca Gaidano,Francesca Romana Mauro,Daniela Capello,Francesca Mancini,Maria Stefania De Propris,Marco Mancini,Enrica Orsini,Massimo Gentile,Massimo Breccia,Antonio Cuneo,Gianluigi Castoldi,Robert Foa

View Articletitled, Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features

Mycosis fungoides shows concurrent deregulation of multiple genes involved in the TNF signaling pathway: an expression profile study

Lorraine Tracey,Raquel Villuendas,Ana Maria Dotor,Inmaculada Spiteri,Pablo Ortiz,Juan F. García,Jose Luis Rodríguez Peralto,Mark Lawler,Miguel A. Piris

View Articletitled, Mycosis fungoides shows concurrent deregulation of multiple genes involved in the TNF signaling pathway: an expression profile study

The role of autocrine FGF-2 in the distinctive bone marrow fibrosis of hairy-cell leukemia (HCL)

Khalil A. Aziz,Kathleen J. Till,Haijuan Chen,Joseph R. Slupsky,Fiona Campbell,John C. Cawley,Mirko Zuzel

View Articletitled, The role of autocrine FGF-2 in the distinctive bone marrow fibrosis of hairy-cell leukemia (HCL)

Expansion of CMV-specific CD8⁺CD45RA⁺CD27^- T cells in B-cell chronic lymphocytic leukemia

Wendelina J. M. Mackus,Florine N. J. Frakking,Annette Grummels,Laila E. Gamadia,Godelieve J. de Bree,Dörte Hamann,René A. W. van Lier,Marinus H. J. van Oers

View Articletitled, Expansion of CMV-specific CD8+CD45RA+CD27- T cells in B-cell chronic lymphocytic leukemia

Soluble receptor activator of nuclear factor κB ligand–osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index
Clinical Trials & Observations

Evangelos Terpos,Richard Szydlo,Jane F. Apperley,Evdoxia Hatjiharissi,Marianna Politou,John Meletis,Nora Viniou,Xenophon Yataganas,John M. Goldman,Amin Rahemtulla

View Articletitled, Soluble receptor activator of nuclear factor κB ligand–osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index

CD20 is associated with a small mature plasma cell morphology and t(11;14) in multiple myeloma
Brief Report

Nelly Robillard,Hervé Avet-Loiseau,Richard Garand,Philippe Moreau,Danielle Pineau,Marie-Josée Rapp,Jean-Luc Harousseau,Régis Bataille

View Articletitled, CD20 is associated with a small mature plasma cell morphology and t(11;14) in multiple myeloma

Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia
Brief Report

Michelle M. Le Beau,Elizabeth M. Davis,Bhumi Patel,Vernon T. Phan,Jastinder Sohal,Scott C. Kogan

View Articletitled, Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia

Expression of CD52 on plasma cells in plasma cell proliferative disorders
Brief Report

Shaji Kumar,Teresa K. Kimlinger,John A. Lust,Kathleen Donovan,Thomas E. Witzig

View Articletitled, Expression of CD52 on plasma cells in plasma cell proliferative disorders

PHAGOCYTES

IL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: irreversible inhibition of the differentiation program activated by RANKL

Jose L. Moreno,Michele Kaczmarek,Achsah D. Keegan,Mehrdad Tondravi

View Articletitled, IL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: irreversible inhibition of the differentiation program activated by RANKL

RED CELLS

Inhaled nitric oxide protects transgenic SAD mice from sickle cell disease–specific lung injury induced by hypoxia/reoxygenation

Lucia de Franceschi,Antonella Baron,Aldo Scarpa,Christophe Adrie,Anne Janin,Stefano Barbi,Jean Kister,Philippe Rouyer-Fessard,Roberto Corrocher,Philippe Leboulch,Yves Beuzard

View Articletitled, Inhaled nitric oxide protects transgenic SAD mice from sickle cell disease–specific lung injury induced by hypoxia/reoxygenation

Chuvash-type congenital polycythemia in 4 families of Asian and Western European ancestry
Clinical Trials & Observations Brief Report

Melanie J. Percy,Mary Frances McMullin,Simon N. Jowitt,Michael Potter,Marilyn Treacy,William H. Watson,Terence R. J. Lappin

View Articletitled, Chuvash-type congenital polycythemia in 4 families of Asian and Western European ancestry

TRANSFUSION MEDICINE

Transforming growth factor–β1 in supernatants from stored red blood cells inhibits neutrophil locomotion

Massimo Ghio,Luciano Ottonello,Paola Contini,Massimo Amelotti,Clemente Mazzei,Francesco Indiveri,Francesco Puppo,Franco Dallegri

View Articletitled, Transforming growth factor–β1 in supernatants from stored red blood cells inhibits neutrophil locomotion

TRANSPLANTATION

Impact of CD34⁺ cell dose on the outcome of patients undergoing reduced-intensity-conditioning allogeneic peripheral blood stem cell transplantation

José A. Pérez-Simón,María Díez-Campelo,Rodrigo Martino,Anna Sureda,Dolores Caballero,Consuelo Cañizo,Salut Brunet,Albert Altes,Lourdes Vazquez,Jordi Sierra,Jesús F. San Miguel

View Articletitled, Impact of CD34+ cell dose on the outcome of patients undergoing reduced-intensity-conditioning allogeneic peripheral blood stem cell transplantation

Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease
Clinical Trials & Observations

Thomas Lion,Rosi Baumgartinger,Franz Watzinger,Susanne Matthes-Martin,Magdalena Suda,Sandra Preuner,Barbara Futterknecht,Anita Lawitschka,Christina Peters,Ulrike Pötschger,Helmut Gadner

View Articletitled, Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease

Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients
Clinical Trials & Observations

M. Louise Markert,Marcella Sarzotti,Daniel A. Ozaki,Gregory D. Sempowski,Maria E. Rhein,Laura P. Hale,Francoise Le Deist,Marilyn J. Alexieff,Jie Li,Elizabeth R. Hauser,Barton F. Haynes,Henry E. Rice,Michael A. Skinner,Samuel M. Mahaffey,James Jaggers,Leonard D. Stein,Michael R. Mill

View Articletitled, Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients

Hematopoietic stem cell transplantation: contrasting the outcome of transplantations from HLA-identical siblings, partially HLA-mismatched related donors, and HLA-matched unrelated donors
Clinical Trials & Observations

Hellmut D. Ottinger,Stanislav Ferencik,Dietrich W. Beelen,Monika Lindemann,Rudolf Peceny,Ahmed H. Elmaagacli,Johannes Hüsing,Hans Grosse-Wilde

View Articletitled, Hematopoietic stem cell transplantation: contrasting the outcome of transplantations from HLA-identical siblings, partially HLA-mismatched related donors, and HLA-matched unrelated donors

Cord blood transplantation provides better reconstitution of hematopoietic reservoir compared with bone marrow transplantation

Francesco Frassoni,Marina Podestà,Rita Maccario,Giovanna Giorgiani,Gabriele Rossi,Marco Zecca,Andrea Bacigalupo,Giovanna Piaggio,Franco Locatelli

View Articletitled, Cord blood transplantation provides better reconstitution of hematopoietic reservoir compared with bone marrow transplantation

CORRESPONDENCE

Functional consequence of MDR1 expression on imatinib intracellular concentrations

Nicolas Widmer,Sara Colombo,Thierry Buclin,Laurent A. Decosterd

View Articletitled, Functional consequence of MDR1 expression on imatinib intracellular concentrations

Molecular monitoring in chronic myeloid leukemia patients who achieve complete cytogenetic remission on imatinib

Feng Lin,Mark Drummond,Stephen O'Brien,Francisco Cervantes,John Goldman,Jaspal Kaeda

View Articletitled, Molecular monitoring in chronic myeloid leukemia patients who achieve complete cytogenetic remission on imatinib

Quantitative tissue stem cell modeling

Ingo Roeder,Markus Loeffler

View Articletitled, Quantitative tissue stem cell modeling

High frequency of p53 dysfunction and low level of V_H mutation in chronic lymphocytic leukemia patients using the V_H3-21 gene segment

Ke Lin,Sameer Manocha,Robert J. Harris,Zoltan Matrai,Paul D. Sherrington,Andrew R. Pettitt

View Articletitled, High frequency of p53 dysfunction and low level of VH mutation in chronic lymphocytic leukemia patients using the VH3-21 gene segment

BCL-3 overexpression in anaplastic lymphoma kinase–positive anaplastic large cell lymphoma

George Z. Rassidakis,Mauricio P. Oyarzo,L. Jeffrey Medeiros

View Articletitled, BCL-3 overexpression in anaplastic lymphoma kinase–positive anaplastic large cell lymphoma

Discrepant activity levels of von Willebrand factor–cleaving protease (ADAMTS-13) in congenital thrombotic thrombocytopenic purpura

Jan-Dirk Studt,Johanna A. Kremer Hovinga,Miha Furlan,Bernhard Lämmle

View Articletitled, Discrepant activity levels of von Willebrand factor–cleaving protease (ADAMTS-13) in congenital thrombotic thrombocytopenic purpura

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Infectious Neutrophil deployment is regulated by Resolvin D4

Macrophage checkpoint for iron absorption

Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

REVIEW ARTICLES

ERRATA

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes Clinical Trials & Observations

Performance of a new clinical grading system for chronic graft-versus-host disease: a multicenter study Clinical Trials & Observations

Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell leukemia Clinical Trials & Observations

Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors Clinical Trials & Observations

Conditioning with fludarabine and targeted busulfan for transplantation of allogeneic hematopoietic stem cells Clinical Trials & Observations

Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning Clinical Trials & Observations

Effect of a comprehensive clinical care program on disease course in severely ill children with sickle cell anemia in a sub-Saharan African setting Clinical Trials & Observations

Reconstitution of the Epstein-Barr virus–specific cytotoxic T-lymphocyte response following T-cell–depleted myeloablative and nonmyeloablative allogeneic stem cell transplantation Clinical Trials & Observations Brief Report

GENE THERAPY

HEMATOPOIESIS

Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Antithrombin Phe229Leu: a new homozygous variant leading to spontaneous antithrombin polymerization in vivo associated with severe childhood thrombosis Clinical Trials & Observations

Peptide decoys selected by phage display block in vitro and in vivo activity of a human anti-FVIII inhibitor Brief Report

Factor XI–dependence of surface- and tissue factor–initiated thrombus propagation in primates Brief Report

IMMUNOBIOLOGY

NEOPLASIA

Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21 Clinical Trials & Observations

Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study Clinical Trials & Observations

CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRγδ lineage Clinical Trials & Observations

Gastric marginal zone lymphoma is associated with polymorphisms in genes involved in inflammatory response and antioxidative capacity Clinical Trials & Observations

Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma Clinical Trials & Observations

Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features Clinical Trials & Observations

Soluble receptor activator of nuclear factor κB ligand–osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index Clinical Trials & Observations

CD20 is associated with a small mature plasma cell morphology and t(11;14) in multiple myeloma Brief Report

Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia Brief Report

Expression of CD52 on plasma cells in plasma cell proliferative disorders Brief Report