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Issue Archive

Volume 102, Issue 13
December 15 2003
Blood Cover Image for Volume 102, Issue 13

Table of Contents

INSIDE BLOOD

Gene therapy for sickle cell disease marches on
David M. Bodine
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Afibrinogenemia in a compound heterozygote: making sense out of missense
Michael W. Mosesson
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Multitalented embryonic endothelial cells: a new role in stem cell expansion
William H. Fleming
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Babies helping babies with leukemia
Donna Przepiorka
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Adult stem cells: can they transdifferentiate?
Donald Orlic
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ITP and pregnancy
Douglas B. Cines
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Overriding BCR/ABL mitotic signal by ICSBP-induced differentiation
Ruibao Ren
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Two signals that trigger NK cell aggression against tumors
Marco Colonna
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Turning terminal differentiation into proliferative responses
Ursula Klingmüller
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Killing 2 birds with 1 stone
Stephen Gottschalk
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Modeling human hematopoiesis: of mice and monkeys
John F. Tisdale
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Donor CMV serologic status and outcome of CMV-seropositive recipients after unrelated donor stem cell transplantation: an EBMT megafile analysis
Clinical Trials & Observations
Per Ljungman,Ronald Brand,Hermann Einsele,Francesco Frassoni,Dietger Niederwieser,Catherine Cordonnier
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Hepatosplenic γδ T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients
Clinical Trials & Observations
Karim Belhadj,Félix Reyes,Jean-Pierre Farcet,Hervé Tilly,Christian Bastard,Régis Angonin,Eric Deconinck,Frédéric Charlotte,Véronique Leblond,Eric Labouyrie,Pierre Lederlin,Jean-François Emile,Béatrice Delmas-Marsalet,Bertrand Arnulf,Elie-Serge Zafrani,Philippe Gaulard
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Cladribine therapy for systemic mastocytosis
Clinical Trials & Observations
Hanneke C. Kluin-Nelemans,J. Marja Oldhoff,Jasper J. van Doormaal,Jan W. van 't Wout,Gregor Verhoef,Wim B. J. Gerrits,O. Aart van Dobbenburgh,Suzanne G. Pasmans,Rob Fijnheer
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A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia
Clinical Trials & Observations
William J. Kell,Alan K. Burnett,Raj Chopra,John A. L. Yin,Richard E. Clark,Ama Rohatiner,Dominic Culligan,Ann Hunter,Archie G. Prentice,Donald W. Milligan
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Intensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma
Clinical Trials & Observations
Hervé Tilly,Eric Lepage,Bertrand Coiffier,Michel Blanc,Raoul Herbrecht,André Bosly,Michel Attal,Georges Fillet,Catherine Guettier,Thierry Jo Molina,Christian Gisselbrecht,Félix Reyes,for the Groupe d'Etude des Lymphomes de l'Adulte
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Unrelated cord blood transplantation for childhood acute myeloid leukemia: a Eurocord Group analysis
Clinical Trials & Observations
Gerard Michel,Vanderson Rocha,Sylvie Chevret,William Arcese,Kah-Wah Chan,Alexandra Filipovich,Tsuneo A. Takahashi,Marcus Vowels,Juan Ortega,Pierre Bordigoni,Peter J. Shaw,Isaac Yaniv,Alexandra Machado,Pedro Pimentel,Franca Fagioli,Amparo Verdeguer,Jean Pierre Jouet,Blanca Diez,Euripedes Ferreira,Ricardo Pasquini,Joseph Rosenthal,Eric Sievers,Chiara Messina,Anna Paola Iori,Federico Garnier,Irina Ionescu,Franco Locatelli,Eliane Gluckman,for the Eurocord Group
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Results of a prospective phase 2 study combining imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukemia in chronic phase
Clinical Trials & Observations
Martine Gardembas,Philippe Rousselot,Michel Tulliez,Magda Vigier,Agnès Buzyn,Françoise Rigal-Huguet,Laurence Legros,Mauricette Michallet,Christian Berthou,Nathalie Cheron,Frederic Maloisel,François-Xavier Mahon,Thierry Facon,Patrice Berthaud,Joëlle Guilhot,François Guilhot,for the CML French Group (FIϕLMC)
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A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura
Clinical Trials & Observations
Kathryn E. Webert,Richa Mittal,Christopher Sigouin,Nancy M. Heddle,John G. Kelton
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GENE THERAPY

Correction of a mouse model of sickle cell disease: lentiviral/antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells
Dana N. Levasseur,Thomas M. Ryan,Kevin M. Pawlik,Tim M. Townes
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Supplemental data
Identification of a murine CD28 dileucine motif that suppresses single-chain chimeric T-cell receptor expression and function
Phuong Nguyen,Ioana Moisini,Terrence L. Geiger
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CD4+CD25+ regulatory T cells inhibit immune-mediated transgene rejection
Brief Report
David-Alexandre Gross,Marylène Leboeuf,Bernard Gjata,Olivier Danos,Jean Davoust
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HEMATOPOIESIS

Distinct hematopoietic stem/progenitor cell populations are responsible for repopulating NOD/SCID mice compared with nonhuman primates
Peter A. Horn,Bobbie M. Thomasson,Brent L. Wood,Robert G. Andrews,Julia C. Morris,Hans-Peter Kiem
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Lipid raft-associated protein sorting in exosomes
Aude de Gassart,Charles Géminard,Benoit Février,Graça Raposo,Michel Vidal
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Primary endothelial cells isolated from the yolk sac and para-aortic splanchnopleura support the expansion of adult marrow stem cells in vitro
Weiming Li,Scott A. Johnson,William C. Shelley,Michael Ferkowicz,Paul Morrison,Yanjun Li,Mervin C. Yoder
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PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells
Ming-jiang Xu,Xingwei Sui,Runxiang Zhao,Chunhua Dai,Sanford B. Krantz,Zhizhuang Joe Zhao
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Influence of mobilized stem cells on myocardial infarct repair in a nonhuman primate model
Françoise Norol,Pascal Merlet,Richard Isnard,Pascale Sebillon,Nicolas Bonnet,Christian Cailliot,Claire Carrion,Maria Ribeiro,Frédéric Charlotte,Pascal Pradeau,Jean-François Mayol,André Peinnequin,Michel Drouet,Karima Safsafi,Jean-Paul Vernant,Francis Herodin
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Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element
James C. Mulloy,Jorg Cammenga,Francisco J. Berguido,Kaida Wu,Ping Zhou,Raymond L. Comenzo,Suresh Jhanwar,Malcolm A. S. Moore,Stephen D. Nimer
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Monocyte-expressed urokinase inhibits vascular smooth muscle cell growth by activating Stat1
Sateesh Kunigal,Angelika Kusch,Natalia Tkachuk,Sergey Tkachuk,Uwe Jerke,Hermann Haller,Inna Dumler
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Selective targeted delivery of TNFα to tumor blood vessels
Laura Borsi,Enrica Balza,Barbara Carnemolla,Francesca Sassi,Patrizia Castellani,Alexander Berndt,Hartwig Kosmehl,Attila Birò,Annalisa Siri,Paola Orecchia,Jessica Grassi,Dario Neri,Luciano Zardi
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Reduced bleeding events with subcutaneous administration of recombinant human factor IX in immune-tolerant hemophilia B dogs
Karen E. Russell,Eva H. N. Olsen,Robin A. Raymer,Elizabeth P. Merricks,Dwight A. Bellinger,Marjorie S. Read,Bonita J. Rup,James C. Keith, Jr,Kyle P. McCarthy,Robert G. Schaub,Timothy C. Nichols
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Thrombospondin 1 as a scavenger for matrix-associated fibroblast growth factor 2
Barbara Margosio,Daniela Marchetti,Veronica Vergani,Raffaella Giavazzi,Marco Rusnati,Marco Presta,Giulia Taraboletti
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ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1
Brief Report
Amir Tadros,David P. Hughes,Benjamin J. Dunmore,Nicholas P. J. Brindle
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Factor XIII A subunit-deficient mice developed severe uterine bleeding events and subsequent spontaneous miscarriages
Brief Report
Shiori Koseki-Kuno,Mitsunori Yamakawa,Gerhard Dickneite,Akitada Ichinose
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Congenital afibrinogenemia: identification and expression of a missense mutation in FGB impairing fibrinogen secretion
Brief Report
Dung Vu,Paula H. B. Bolton-Maggs,Jeremy R. Parr,Michael A. Morris,Philippe de Moerloose,Marguerite Neerman-Arbez
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IMMUNOBIOLOGY

Induction of cytotoxic T-cell responses against the oncofetal antigen-immature laminin receptor for the treatment of hematologic malignancies
Sandra Siegel,Andreas Wagner,Dieter Kabelitz,Matthias Marget,Joseph Coggin, Jr,Adel Barsoum,James Rohrer,Norbert Schmitz,Matthias Zeis
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Novel antimalarial antibodies highlight the importance of the antibody Fc region in mediating protection
Richard J. Pleass,Solabomi A. Ogun,David H. McGuinness,Jan G. J. van de Winkel,Anthony A. Holder,Jenny M. Woof
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Human dendritic cells express neuronal Eph receptor tyrosine kinases: role of EphA2 in regulating adhesion to fibronectin
Blandine de Saint-Vis,Caroline Bouchet,Grégory Gautier,Jenny Valladeau,Christophe Caux,Pierre Garrone
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Fas ligation induces IL-1β-dependent maturation and IL-1β-independent survival of dendritic cells: different roles of ERK and NF-κB signaling pathways
Zhenhong Guo,Minghui Zhang,Huazhang An,Weilin Chen,Shuxun Liu,Jun Guo,Yizhi Yu,Xuetao Cao
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Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells
Jean Francois Fonteneau,Daniel G. Kavanagh,Margareta Lirvall,Catherine Sanders,Timothy L. Cover,Nina Bhardwaj,Marie Larsson
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Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells
Jian-Xin Gao,Xingluo Liu,Jing Wen,Michael A. Caligiuri,Iwona Stroynowski,Pan Zheng,Yang Liu
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Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE
Bradley E. Theien,Carol L. Vanderlugt,Cheryl Nickerson-Nutter,Mark Cornebise,Daniel M. Scott,Stuart J. Perper,Eric T. Whalley,Stephen D. Miller
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Differential requirement for A2a and A3 adenosine receptors for the protective effect of inosine in vivo
Gregorio Gomez,Michail V. Sitkovsky
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HIV-1 preferentially binds receptors copatched with cell-surface elastase
Cynthia L. Bristow,Danielle R. Mercatante,Ryszard Kole
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IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences
Omar Duramad,Karen L. Fearon,Jean H. Chan,Holger Kanzler,Jason D. Marshall,Robert L. Coffman,Franck J. Barrat
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NEOPLASIA

The multidrug resistance-associated protein 3 (MRP3) is associated with a poor outcome in childhood ALL and may account for the worse prognosis in male patients and T-cell immunophenotype
Clinical Trials & Observations
Daniel Steinbach,Susann Wittig,Gunnar Cario,Susanne Viehmann,Angelika Mueller,Bernd Gruhn,Ralf Haefer,Felix Zintl,Axel Sauerbrey
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Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro
Petranel T. Ferrao,Michelle J. Frost,Shoo-Peng Siah,Leonie K. Ashman
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Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis
Faith E. Davies,Ann M. Dring,Cheng Li,Andrew C. Rawstron,Masood A. Shammas,Sheila M. O'Connor,James A.L. Fenton,Teru Hideshima,Dharminder Chauhan,Isabella T. Tai,Elizabeth Robinson,Daniel Auclair,Karen Rees,David Gonzalez,A. John Ashcroft,Ranjit Dasgupta,Constantine Mitsiades,Nicholas Mitsiades,Lan B. Chen,Wing H. Wong,Nikhil C. Munshi,Gareth J. Morgan,Kenneth C. Anderson
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Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells
Joya Chandra,Jennifer Hackbarth,Son Le,David Loegering,Nancy Bone,Laura M. Bruzek,Ven L. Narayanan,Alex A. Adjei,Neil E. Kay,Ayalew Tefferi,Judith E. Karp,Edward A. Sausville,Scott H. Kaufmann
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Sequence analysis of clonal immunoglobulin and T-cell receptor gene rearrangements in children with acute lymphoblastic leukemia at diagnosis and at relapse: implications for pathogenesis and for the clinical utility of PCR-based methods of minimal residual disease detection
Clinical Trials & Observations
Aihong Li,Jianbiao Zhou,David Zuckerman,Montse Rue,Virginia Dalton,Cheryl Lyons,Lewis B. Silverman,Stephen E. Sallan,John G. Gribben
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Farnesyltransferase inhibitor R115777 in myelodysplastic syndrome: clinical and biologic activities in the phase 1 setting
Razelle Kurzrock,Hagop M. Kantarjian,Jorge E. Cortes,Neil Singhania,Deborah A. Thomas,Edward F. Wilson,John J. Wright,Emil J. Freireich,Moshe Talpaz,Saïd M. Sebti
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Proteasomal targeting of a viral oncogene abrogates oncogenic phenotype and enhances immunogenicity
Judy Tellam,Geoff Connolly,Natasha Webb,Jaikumar Duraiswamy,Rajiv Khanna
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Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia
Amy Holleman,Monique L. den Boer,Karin M. Kazemier,Gritta E. Janka-Schaub,Rob Pieters
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ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells
Tomohiko Tamura,Hee Jeong Kong,Chainarong Tunyaplin,Hideki Tsujimura,Kathryn Calame,Keiko Ozato
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Up-regulation of SLAP in FLI-1-transformed erythroblasts interferes with EpoR signaling
Ingrid Lebigot,Paola Gardellin,Laurent Lefebvre,Hartmut Beug,Jacques Ghysdael,Christine Tran Quang
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RED CELLS

Mixture distribution analysis of phenotypic markers reflecting HFE gene mutations
Clinical Trials & Observations
Christine E. McLaren,Kuo-Tung Li,Chad P. Garner,Ernest Beutler,Victor R. Gordeuk
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Autoantibodies frequently detected in patients with aplastic anemia
Naoto Hirano,Marcus O. Butler,Michael S. von Bergwelt-Baildon,Britta Maecker,Joachim L. Schultze,Kevin C. O'Connor,Peter H. Schur,Seiji Kojima,Eva C. Guinan,Lee M. Nadler
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Congenital dyserythropoietic anemia type II: epidemiology, clinical appearance, and prognosis based on long-term observation
Clinical Trials & Observations
Hermann Heimpel,Volker Anselstetter,Ladislav Chrobak,Jonas Denecke,Beate Einsiedler,Kerstin Gallmeier,Antje Griesshammer,Thorsten Marquardt,Gritta Janka-Schaub,Martina Kron,Elisabeth Kohne
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Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease
Leslie S. Kean,Elizabeth A. Manci,Jennifer Perry,Can Balkan,Shana Coley,David Holtzclaw,Andrew B. Adams,Christian P. Larsen,Lewis L. Hsu,David R. Archer
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TRANSFUSION MEDICINE

Desmopressin antagonizes the in vitro platelet dysfunction induced by GPIIb/IIIa inhibitors and aspirin
Rosemarie A. Reiter,Florian Mayr,Hannes Blazicek,Elisabeth Galehr,Petra Jilma-Stohlawetz,Hans Domanovits,Bernd Jilma
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TRANSPLANTATION

Evidence for adequate thymic function but impaired naive T-cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease
Jean-François Poulin,Myriam Sylvestre,Patrick Champagne,Marie-Lise Dion,Nadia Kettaf,Alain Dumont,Maryse Lainesse,Pierre Fontaine,Denis-Claude Roy,Claude Perreault,Rafick-Pierre Sékaly,Rémi Cheynier
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Reduced expression of NFAT-associated genes in UCB versus adult CD4+ T lymphocytes during primary stimulation
Beth A. Kaminski,Suzanne Kadereit,Robin E. Miller,Patrick Leahy,Kevin R. Stein,David A. Topa,Tomas Radivoyevitch,Martina L. Veigl,Mary J. Laughlin
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CORRESPONDENCE

Plasma D-dimer measurement as a predictor of venous thrombosis
Muttuswamy Sivakumaran,Neil Malton
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c-kit is not expressed in Hodgkin disease and anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma
George Z. Rassidakis,Georgios V. Georgakis,Anas Younes,L. Jeffrey Medeiros
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All Issues

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