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Issue Archive

Volume 102, Issue 12
December 1 2003
Blood Cover Image for Volume 102, Issue 12

Table of Contents

INSIDE BLOOD

Mediastinal B-cell lymphoma, classical Hodgkin disease, and the winds of change
Peter Möller
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Hypomethylation therapy for hemoglobin disorders is back at center stage
George F. Atweh
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Microvillar loss: when your pERM won't hold
Janis K. Burkhardt
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Transplantation for myelofibrosis: yes! But for whom?
Koen van Besien
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Novel therapies for hemophilia A
Katherine Parker Ponder
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Ras signaling in erythropoiesis: going with the flow
Robert T. Means, Jr
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Platelets made to order
Mark K. Larson,Leslie V. Parise
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Where have all the T cells gone?
Alain H. Rook,Maria Wysocka
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“Out damned spot”: ex vivo purging revisited
Mark W. Lowdell
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The rhythm of blood
Peter D. Aplan
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Virus as master of the house
Richard F. Ambinder
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BLOOD WORK

Chronic myelomonocytic leukemia
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PLENARY PAPERS

Effects of 5-aza-2′-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease
Clinical Trials & Observations
Yogen Saunthararajah,Cheryl A. Hillery,Don Lavelle,Robert Molokie,Louise Dorn,Linda Bressler,Stefana Gavazova,Yi-Hsiang Chen,Ronald Hoffman,Joseph DeSimone
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The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma
Kerry J. Savage,Stefano Monti,Jeffery L. Kutok,Giorgio Cattoretti,Donna Neuberg,Laurence de Leval,Paul Kurtin,Paola Dal Cin,Christine Ladd,Friedrich Feuerhake,Ricardo C. T. Aguiar,Sigui Li,Gilles Salles,Francoise Berger,Wen Jing,Geraldine S. Pinkus,Thomas Habermann,Riccardo Dalla-Favera,Nancy Lee Harris,Jon C. Aster,Todd R. Golub,Margaret A. Shipp
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Supplemental data

REVIEW IN TRANSLATIONAL HEMATOLOGY

Farnesyltransferase inhibitors in hematologic malignancies: new horizons in therapy
Clinical Trials & Observations
Jeffrey E. Lancet,Judith E. Karp
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CHEMOKINES

Chemokine stimulation of human peripheral blood T lymphocytes induces rapid dephosphorylation of ERM proteins, which facilitates loss of microvilli and polarization
Martin J. Brown,Ruchika Nijhara,John A. Hallam,Michelle Gignac,Kenneth M. Yamada,Stanley L. Erlandsen,Jérôme Delon,Michael Kruhlak,Stephen Shaw
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Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis
Lei Yao,Ombretta Salvucci,Adela R. Cardones,Sam T. Hwang,Yoshiyasu Aoki,Maria De La Luz Sierra,Agatha Sajewicz,Stefania Pittaluga,Robert Yarchoan,Giovanna Tosato
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Rituximab in relapsed or refractory hairy cell leukemia
Clinical Trials & Observations
Deborah A. Thomas,Susan O'Brien,Carlos Bueso-Ramos,Stefan Faderl,Michael J. Keating,Francis J. Giles,Jorge Cortes,Hagop M. Kantarjian
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Allogeneic hematopoietic stem cell transplantation for myelofibrosis
Clinical Trials & Observations
H. Joachim Deeg,Theodore A. Gooley,Mary E. D. Flowers,George E. Sale,John T. Slattery,Claudio Anasetti,Thomas R. Chauncey,Kristine Doney,George E. Georges,Hans-Peter Kiem,Paul J. Martin,Effie W. Petersdorf,Jerald Radich,Jean E. Sanders,Brenda M. Sandmaier,E. Houston Warren,Robert P. Witherspoon,Rainer Storb,Frederick R. Appelbaum
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GENE THERAPY

Phenotypic correction of a mouse model of hemophilia A using AAV2 vectors encoding the heavy and light chains of FVIII
Ciaran D. Scallan,Tongyao Liu,Amy E. Parker,Susannah L. Patarroyo-White,Haifeng Chen,Haiyan Jiang,Joseph Vargas,Dea Nagy,Sharon K. Powell,J. Fraser Wright,Rita Sarkar,Haig H. Kazazian,Alan McClelland,Linda B. Couto
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α5β1 integrin as a cellular coreceptor for human parvovirus B19: requirement of functional activation of β1 integrin for viral entry
Kirsten A. Weigel-Kelley,Mervin C. Yoder,Arun Srivastava
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Dose finding with retroviral vectors: correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population
Brief Report
Olga S. Kustikova,Anke Wahlers,Klaus Kühlcke,Birgit Stähle,Axel R. Zander,Christopher Baum,Boris Fehse
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HEMATOPOIESIS

Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry–based novel culture system
Jing Zhang,Merav Socolovsky,Alec W. Gross,Harvey F. Lodish
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BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis
Peter T. Tsai,Robert A. Lee,Hong Wu
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Kit regulatory elements required for expression in developing hematopoietic and germ cell lineages
Linda A. Cairns,Emanuela Moroni,Elena Levantini,Alessandra Giorgetti,Francesca G. Klinger,Simona Ronzoni,Laura Tatangelo,Cecilia Tiveron,Massimo De Felici,Susanna Dolci,Maria Cristina Magli,Barbara Giglioni,Sergio Ottolenghi
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HTLV-1 Rex is required for viral spread and persistence in vivo but is dispensable for cellular immortalization in vitro
Jianxin Ye,Lee Silverman,Michael D. Lairmore,Patrick L. Green
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A role for Rab27b in NF-E2-dependent pathways of platelet formation
Sanjay Tiwari,Joseph E. Italiano, Jr,Duarte C. Barral,Emilie H. Mules,Edward K. Novak,Richard T. Swank,Miguel C. Seabra,Ramesh A. Shivdasani
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Notch signaling is necessary but not sufficient for differentiation of dendritic cells
Pingyan Cheng,Yulia Nefedova,Lucio Miele,Barbara A. Osborne,Dmitry Gabrilovich
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Developmental stage–specific epigenetic control of human β-globin gene expression is potentiated in hematopoietic progenitor cells prior to their transcriptional activation
Stefania Bottardi,Angélique Aumont,Frank Grosveld,Eric Milot
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Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation
Andrea Dorfleutner,Wolfram Ruf
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Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment
Helen V. Yarovoi,Dubravka Kufrin,Don E. Eslin,Michael A. Thornton,Sandra L. Haberichter,Qizhen Shi,Hua Zhu,Rodney Camire,Steve S. Fakharzadeh,M. Anna Kowalska,David A. Wilcox,Bruce S. Sachais,Robert R. Montgomery,Mortimer Poncz
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Coinheritance of Factor V (FV) Leiden enhances thrombin formation and is associated with a mild bleeding phenotype in patients homozygous for the FVII 9726+5G>A (FVII Lazio) mutation
Clinical Trials & Observations
Elisabetta Castoldi,José W. P. Govers-Riemslag,Mirko Pinotti,Debora Bindini,Guido Tans,Mauro Berrettini,Maria Gabriella Mazzucconi,Francesco Bernardi,Jan Rosing
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Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo
Sabine Grüner,Miroslava Prostredna,Valerie Schulte,Thomas Krieg,Beate Eckes,Cord Brakebusch,Bernhard Nieswandt
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Heparin-induced substrate behavior of antithrombin Cambridge II
Alec Mushunje,Aiwu Zhou,Robin W. Carrell,James A. Huntington
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Matrix-fibrinogen enhances wound closure by increasing both cell proliferation and migration
Brian J. Rybarczyk,Sarah O. Lawrence,Patricia J. Simpson-Haidaris
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Production of functional platelets by differentiated embryonic stem (ES) cells in vitro
Tetsuro-Takahiro Fujimoto,Satoshi Kohata,Hidenori Suzuki,Hiroshi Miyazaki,Kingo Fujimura
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Specific abrogation of transforming growth factor-β signaling in T cells alters atherosclerotic lesion size and composition in mice
Andrea Gojova,Valérie Brun,Bruno Esposito,Françoise Cottrez,Pierre Gourdy,Patrice Ardouin,Alain Tedgui,Ziad Mallat,Hervé Groux
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IMMUNOBIOLOGY

Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma
Nikhil Yawalkar,Katalin Ferenczi,David A. Jones,Keiichi Yamanaka,Ki-Young Suh,Sarah Sadat,Thomas S. Kupper
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NK-cell purging of leukemia: superior antitumor effects of NK cells H2 allogeneic to the tumor and augmentation with inhibitory receptor blockade
Crystal Y. Koh,John R. Ortaldo,Bruce R. Blazar,Michael Bennett,William J. Murphy
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Complexity within the plasma cell compartment of mice deficient in both E- and P-selectin: implications for plasma cell differentiation
Gregory H. Underhill,K. Pallav Kolli,Geoffrey S. Kansas
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In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment
Deniz Durali,Marie-Ghislaine de Goër de Herve,Julien Giron-Michel,Bruno Azzarone,Jean-François Delfraissy,Yassine Taoufik
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Interleukin-21 inhibits dendritic cell activation and maturation
Katja Brandt,Silvia Bulfone-Paus,Donald C. Foster,René Rückert
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Functional defects of dendritic cells in patients with CD40 deficiency
Clinical Trials & Observations
Stefania Fontana,Daniele Moratto,Surinder Mangal,Maria De Francesco,William Vermi,Simona Ferrari,Fabio Facchetti,Necil Kutukculer,Claudia Fiorini,Marzia Duse,Pranab K. Das,Luigi D. Notarangelo,Alessandro Plebani,Raffaele Badolato
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Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes
Lorenzo Cosmi,Francesco Liotta,Elena Lazzeri,Michela Francalanci,Roberta Angeli,Benedetta Mazzinghi,Veronica Santarlasci,Roberto Manetti,Vittorio Vanini,Paola Romagnani,Enrico Maggi,Sergio Romagnani,Francesco Annunziato
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Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes
Subburaj Ilangumaran,Sheela Ramanathan,Terry Ning,Jose La Rose,Brandon Reinhart,Philippe Poussier,Robert Rottapel
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IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages
Hirotaka Kuwata,Yasuyuki Watanabe,Hiroyuki Miyoshi,Masahiro Yamamoto,Tsuneyasu Kaisho,Kiyoshi Takeda,Shizuo Akira
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Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell lines
Hye-Kyung Chung,Howard A. Young,Peter K. C. Goon,Gisela Heidecker,Gerald L. Princler,Osamu Shimozato,Graham P. Taylor,Charles R. M. Bangham,David Derse
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Inhibition of invariant chain expression in dendritic cells presenting endogenous antigens stimulates CD4+ T-cell responses and tumor immunity
Yangbing Zhao,David Boczkowski,Smita K. Nair,Eli Gilboa
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Circadian clock genes oscillate in human peripheral blood mononuclear cells
Clinical Trials & Observations Brief Report
Diane B. Boivin,Francine O. James,Aibin Wu,Park F. Cho-Park,Huabao Xiong,Zhong S. Sun
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NEOPLASIA

Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis
Brian Freie,Xiaxin Li,Samantha L. M. Ciccone,Kathy Nawa,Scott Cooper,Catherine Vogelweid,Laurel Schantz,Laura S. Haneline,Attilio Orazi,Hal E. Broxmeyer,Suk-Hee Lee,D. Wade Clapp
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Inhibition of acute lymphoblastic and myeloid leukemias by a novel kinase inhibitor
Thomas Grunberger,Peter Demin,Olga Rounova,Nigel Sharfe,Lorand Cimpean,Harjit Dadi,Andrew Freywald,Zeev Estrov,Chaim M. Roifman
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JunB inhibits proliferation and transformation in B-lymphoid cells
Agnieszka P. Szremska,Lukas Kenner,Eva Weisz,Rene G. Ott,Emmanuelle Passegué,Michaela Artwohl,Michael Freissmuth,Renate Stoxreiter,Hans-Christian Theussl,Sabina Baumgartner Parzer,Richard Moriggl,Erwin F. Wagner,Veronika Sexl
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Epstein-Barr Virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphoma
Toni Portis,Patricia Dyck,Richard Longnecker
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Supplemental data
Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis
Clinical Trials & Observations
Bing Z. Carter,Steven M. Kornblau,Twee Tsao,Rui-Yu Wang,Wendy D. Schober,Michele Milella,Hsi-Guang Sung,John C. Reed,Michael Andreeff
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Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib
Clinical Trials & Observations Brief Report
Kathryn Wilkinson,Elvira R. P. Velloso,Luiz Fernando Lopes,Charles Lee,Jon C. Aster,Margaret A. Shipp,Ricardo C. T. Aguiar
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PHAGOCYTES

Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages
Mitchell D. Knutson,Mohammad R. Vafa,David J. Haile,Marianne Wessling-Resnick
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RED CELLS

Erythroid pyrimidine 5′-nucleotidase: cloning, developmental expression, and regulation by cAMP and in vivo hypoxia
Markus Mass,Erika Simo,Stefanie Dragon
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Distribution of plasma membrane Ca2+ pump activity in normal human red blood cells
Virgilio L. Lew,Nuala Daw,Deisy Perdomo,Zipora Etzion,Robert M. Bookchin,Teresa Tiffert
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Induction of an embryonic globin gene promoter by short-chain fatty acids
Nancy J. Dempsey,Laureen S. Ojalvo,Davina W. Wu,Jane A. Little
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Role of AP1/NFE2 binding sites in endogenous α-globin gene transcription
Melanie R. Loyd,Yasuhiro Okamoto,Mindy S. Randall,Paul A. Ney
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TRANSFUSION MEDICINE

Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro–aged or –injured mouse platelets
Wolfgang Bergmeier,Peter C. Burger,Crystal L. Piffath,Karin M. Hoffmeister,John H. Hartwig,Bernhard Nieswandt,Denisa D. Wagner
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TRANSPLANTATION

Late-onset noninfectious pulmonary complications after allogeneic stem cell transplantation are significantly associated with chronic graft-versus-host disease and with the graft-versus-leukemia effect
Clinical Trials & Observations
Emiko Sakaida,Chiaki Nakaseko,Akane Harima,Akira Yokota,Ryuko Cho,Yasushi Saito,Miki Nishimura
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CORRESPONDENCE

EBV-positive cutaneous B-cell lymphoproliferative disease after imatinib mesylate
Marcel W. Bekkenk,Maarten H. Vermeer,Chris J. L. M. Meijer,Patty M. Jansen,Jaap M. Middeldorp,Servi J. C. Stevens,Rein Willemze
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Epstein-Barr virus infection in Western European pediatric non-Hodgkin lymphomas
Matthias A. Karajannis,Michael Hummel,Ilske Oschlies,Ioannis Anagnostopoulos,Martin Zimmermann,Harald Stein,Reza Parwaresch,Alfred Reiter
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Relevance of cyclin D1 level in the pathogenesis of multiple myeloma
Brigitte Sola,Xavier Troussard
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All Issues

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