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Volume 102, Issue 1

July 1 2003

In this Issue

INSIDE BLOOD
BLOOD WORK
PLENARY PAPERS
PERSPECTIVES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

New insights from Fanconi anemia

Alan D'Andrea

View Articletitled, New insights from Fanconi anemia

Secondary leukemia or unfavorable leukemia?

Jacob M. Rowe

View Articletitled, Secondary leukemia or unfavorable leukemia?

Positron emission tomography predicts transplantation outcome

David James Inwards

View Articletitled, Positron emission tomography predicts transplantation outcome

A broader look at thrombotic microangiopathy and ADAMTS13

J. Evan Sadler

View Articletitled, A broader look at thrombotic microangiopathy and ADAMTS13

Thalidomide, age, and future use in multiple myeloma

Mohamad A. Hussein

View Articletitled, Thalidomide, age, and future use in multiple myeloma

Platelets are anticoagulants?

Charles T. Esmon

View Articletitled, Platelets are anticoagulants?

PECAM-1/CD31 provides survival signals to suppress apoptosis

Denise E. Jackson

View Articletitled, PECAM-1/CD31 provides survival signals to suppress apoptosis

γδ T cells in cancer immunotherapy

Jack F. Bukowski

View Articletitled, γδ T cells in cancer immunotherapy

Resistance to imatinib: more and more mutations

Charles L. Sawyers

View Articletitled, Resistance to imatinib: more and more mutations

New insight into myeloma lytic bone disease

Joshua Epstein

View Articletitled, New insight into myeloma lytic bone disease

BLOOD WORK

Mott cell

View Articletitled, Mott cell

PLENARY PAPERS

Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia

M. William Lensch,Marc Tischkowitz,Tracy A. Christianson,Carol A. Reifsteck,S. Ashley Speckhart,Petra M. Jakobs,Michael E. O'Dwyer,Susan B. Olson,Michelle M. Le Beau,Shirley V. Hodgson,Christopher G. Mathew,Richard A. Larson,Grover C. Bagby, Jr

View Articletitled, Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia

PERSPECTIVES

Role of deferiprone in chelation therapy for transfusional iron overload
Clinical Trials & Observations

A. Victor Hoffbrand,Alan Cohen,Chaim Hershko

View Articletitled, Role of deferiprone in chelation therapy for transfusional iron overload

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Genetic variants of coagulation factor XIII, postmenopausal estrogen therapy, and risk of nonfatal myocardial infarction
Clinical Trials & Observations

Alexander P. Reiner,Susan R. Heckbert,Hans L. Vos,Robert A. S. Ariëns,Rozenn N. Lemaitre,Nicholas L. Smith,Thomas Lumley,Thomas D. Rea,Lucia A. Hindorff,Gina D. Schellenbaum,Frits R. Rosendaal,David S. Siscovick,Bruce M. Psaty

View Articletitled, Genetic variants of coagulation factor XIII, postmenopausal estrogen therapy, and risk of nonfatal myocardial infarction

HLA-matched related hematopoietic cell transplantation for chronic-phase CML using a targeted busulfan and cyclophosphamide preparative regimen
Clinical Trials & Observations

Jerald P. Radich,Ted Gooley,William Bensinger,Thomas Chauncey,Reginald Clift,Mary Flowers,Paul Martin,John Slattery,Debbie Sultan,Frederick R. Appelbaum

View Articletitled, HLA-matched related hematopoietic cell transplantation for chronic-phase CML using a targeted busulfan and cyclophosphamide preparative regimen

Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigen
Clinical Trials & Observations

Michel Gilliet,Martin Kleinhans,Erica Lantelme,Dirk Schadendorf,Günter Burg,Frank O. Nestle

View Articletitled, Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigen

Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series
Clinical Trials & Observations

Sonali M. Smith,Michelle M. Le Beau,Dezheng Huo,Theodore Karrison,Ronald M. Sobecks,John Anastasi,James W. Vardiman,Janet D. Rowley,Richard A. Larson

View Articletitled, Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series

Prognostic value of pretransplantation positron emission tomography using fluorine 18-fluorodeoxyglucose in patients with aggressive lymphoma treated with high-dose chemotherapy and stem cell transplantation
Clinical Trials & Observations

Karoline Spaepen,Sigrid Stroobants,Patrick Dupont,Peter Vandenberghe,Johan Maertens,Guy Bormans,José Thomas,Jan Balzarini,Christine De Wolf-Peeters,Luc Mortelmans,Gregor Verhoef

View Articletitled, Prognostic value of pretransplantation positron emission tomography using fluorine 18-fluorodeoxyglucose in patients with aggressive lymphoma treated with high-dose chemotherapy and stem cell transplantation

ADAMTS13 activity in thrombotic thrombocytopenic purpura–hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients
Clinical Trials & Observations

Sara K. Vesely,James N. George,Bernhard Lämmle,Jan-Dirk Studt,Lorenzo Alberio,Mayez A. El-Harake,Gary E. Raskob

View Articletitled, ADAMTS13 activity in thrombotic thrombocytopenic purpura–hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients

Multicenter phase 2 trial of thalidomide in relapsed/refractory multiple myeloma: adverse prognostic impact of advanced age
Clinical Trials & Observations

Linda Mileshkin,James J. Biagi,Paul Mitchell,Craig Underhill,Andrew Grigg,Richard Bell,Joe McKendrick,Peter Briggs,John F. Seymour,Kate Lillie,Jennifer G. Smith,Jerome B. Zeldis,H. Miles Prince

View Articletitled, Multicenter phase 2 trial of thalidomide in relapsed/refractory multiple myeloma: adverse prognostic impact of advanced age

A 6-month versus a 12-month surveillance for hepatocellular carcinoma in 559 hemophiliacs infected with the hepatitis C virus
Clinical Trials & Observations

Elena Santagostino,Massimo Colombo,Monica Rivi,Maria Grazia Rumi,Angiola Rocino,Silvia Linari,Pier Mannuccio Mannucci,for the the Study Group of the Association of Italian Hemophilia Centers

View Articletitled, A 6-month versus a 12-month surveillance for hepatocellular carcinoma in 559 hemophiliacs infected with the hepatitis C virus

Result of high-dose imatinib mesylate in patients with Philadelphia chromosome—positive chronic myeloid leukemia after failure of interferon-α
Clinical Trials & Observations

Jorge Cortes,Francis Giles,Susan O'Brien,Deborah Thomas,Guillermo Garcia-Manero,Mary Beth Rios,Stefan Faderl,Srdan Verstovsek,Alessandra Ferrajoli,Emil J. Freireich,Moshe Talpaz,Hagop Kantarjian

View Articletitled, Result of high-dose imatinib mesylate in patients with Philadelphia chromosome—positive chronic myeloid leukemia after failure of interferon-α

HEMATOPOIESIS

Stem cell factor protects erythroid precursor cells from chemotherapeutic agents via up-regulation of BCL-2 family proteins

Ann Zeuner,Francesca Pedini,Michele Signore,Ugo Testa,Elvira Pelosi,Cesare Peschle,Ruggero De Maria

View Articletitled, Stem cell factor protects erythroid precursor cells from chemotherapeutic agents via up-regulation of BCL-2 family proteins

Gene expression analysis of purified hematopoietic stem cells and committed progenitors

Alexey V. Terskikh,Toshihiro Miyamoto,Cynthia Chang,Luda Diatchenko,Irving L. Weissman

View Articletitled, Gene expression analysis of purified hematopoietic stem cells and committed progenitors

Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs

Debra D. Dahlen,Virginia C. Broudy,Jonathan G. Drachman

View Articletitled, Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs

Differential STAT3, STAT5, and NF-κB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules

Julien Giron-Michel,Anne Caignard,Manuela Fogli,Danièle Brouty-Boyé,Diane Briard,Marc van Dijk,Raffaella Meazza,Silvano Ferrini,Caroline Lebousse-Kerdilès,Denis Clay,Heidi Bompais,Salem Chouaib,Bruno Péault,Bruno Azzarone

View Articletitled, Differential STAT3, STAT5, and NF-κB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules

Human reconstituting hematopoietic stem cells up-regulate Fas expression upon active cell cycling but remain resistant to Fas-induced suppression

Ingunn Dybedal,Liping Yang,David Bryder,Ingbritt Aastrand-Grundstrom,Karin Leandersson,Sten Eirik W. Jacobsen

View Articletitled, Human reconstituting hematopoietic stem cells up-regulate Fas expression upon active cell cycling but remain resistant to Fas-induced suppression

Human NK cell development in NOD/SCID mice receiving grafts of cord blood CD34⁺ cells

Christian P. Kalberer,Uwe Siegler,Aleksandra Wodnar-Filipowicz

View Articletitled, Human NK cell development in NOD/SCID mice receiving grafts of cord blood CD34+ cells

Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems

Susan M. Gordon,Manuel Buchwald

View Articletitled, Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems

Functional p85α gene is required for normal murine fetal erythropoiesis
Brief Report

Hannah Huddleston,Bailin Tan,Feng-Chun Yang,Hilary White,Mary Jo Wenning,Attilio Orazi,Mervin C. Yoder,Reuben Kapur,David A. Ingram

View Articletitled, Functional p85α gene is required for normal murine fetal erythropoiesis

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Platelet factor 4 enhances generation of activated protein C in vitro and in vivo

Arne Slungaard,Jose A. Fernandez,John H. Griffin,Nigel S. Key,Janel R. Long,Donald J. Piegors,Steven R. Lentz

View Articletitled, Platelet factor 4 enhances generation of activated protein C in vitro and in vivo

Alterations in the intrinsic properties of the GPIbα–VWF tether bond define the kinetics of the platelet-type von Willebrand disease mutation, Gly233Val

Teresa A. Doggett,Gaurav Girdhar,Avril Lawshe,Jonathan L. Miller,Ian J. Laurenzi,Scott L. Diamond,Thomas G. Diacovo

View Articletitled, Alterations in the intrinsic properties of the GPIbα–VWF tether bond define the kinetics of the platelet-type von Willebrand disease mutation, Gly233Val

Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis

Yu-Ping Xia,Baosheng Li,Donna Hylton,Michael Detmar,George D. Yancopoulos,John S. Rudge

View Articletitled, Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis

PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis

Cunji Gao,Weiyong Sun,Melpo Christofidou-Solomidou,Motoshi Sawada,Debra K. Newman,Carmen Bergom,Steven M. Albelda,Shigemi Matsuyama,Peter J. Newman

View Articletitled, PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis

IMMUNOBIOLOGY

Lack of the CD8⁺ cell anti-HIV factor in CD8⁺ cell granules

Carl E. Mackewicz,Baikun Wang,Sunil Metkar,Matthew Richey,Christopher J. Froelich,Jay A. Levy

View Articletitled, Lack of the CD8+ cell anti-HIV factor in CD8+ cell granules

A novel anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis and tumor growth

Xiyun Yan,Yun Lin,Dongling Yang,Yi Shen,Mei Yuan,Zhiqiang Zhang,Peiyu Li,Hongtian Xia,Li Li,Dandan Luo,Qin Liu,Karlheinz Mann,Bernhard L. Bader

View Articletitled, A novel anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis and tumor growth

GMCSF activates NF-κB via direct interaction of the GMCSF receptor with IκB kinase β

Karin Ebner,Alexander Bandion,Bernd R. Binder,Rainer de Martin,Johannes A. Schmid

View Articletitled, GMCSF activates NF-κB via direct interaction of the GMCSF receptor with IκB kinase β

γδ T cells for immune therapy of patients with lymphoid malignancies
Clinical Trials & Observations

Martin Wilhelm,Volker Kunzmann,Susanne Eckstein,Peter Reimer,Florian Weissinger,Thomas Ruediger,Hans-Peter Tony

View Articletitled, γδ T cells for immune therapy of patients with lymphoid malignancies

IL-4 synergistically enhances both IL-2– and IL-12–induced IFN-γ expression in murine NK cells

Jay H. Bream,Rafael E. Curiel,Cheng-Rong Yu,Charles E. Egwuagu,Michael J. Grusby,Thomas M. Aune,Howard A. Young

View Articletitled, IL-4 synergistically enhances both IL-2– and IL-12–induced IFN-γ expression in murine NK cells

Membrane cholesterol regulates LFA-1 function and lipid raft heterogeneity

Muhammad Reza Marwali,Jose Rey-Ladino,Lisa Dreolini,Douglas Shaw,Fumio Takei

View Articletitled, Membrane cholesterol regulates LFA-1 function and lipid raft heterogeneity

Immunogenicity and protective efficacy of orally administered recombinant Lactococcus lactis expressing surface-bound HIV Env

Ke-Qin Xin,Yuka Hoshino,Yoshihiko Toda,Shizunobu Igimi,Yoshitsugu Kojima,Nao Jounai,Kenji Ohba,Akira Kushiro,Mayumi Kiwaki,Kenji Hamajima,Dennis Klinman,Kenji Okuda

View Articletitled, Immunogenicity and protective efficacy of orally administered recombinant Lactococcus lactis expressing surface-bound HIV Env

Tolerance induction to a mammalian blood group—like carbohydrate antigen by syngeneic lymphocytes expressing the antigen, II: tolerance induction on memory B cells

Muhammad M. Mohiuddin,Haruko Ogawa,Deng-Ping Yin,Uri Galili

View Articletitled, Tolerance induction to a mammalian blood group—like carbohydrate antigen by syngeneic lymphocytes expressing the antigen, II: tolerance induction on memory B cells

NEOPLASIA

Synergy between all-trans retinoic acid and tumor necrosis factor pathways in acute leukemia cells

Michael Witcher,Douglas T. Ross,Caroline Rousseau,Leslie Deluca,Wilson H. Miller, Jr

View Articletitled, Synergy between all-trans retinoic acid and tumor necrosis factor pathways in acute leukemia cells

Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia

Ulrike Schroeder,Kathrin M. Bernt,Björn Lange,Jens Wenkel,Jiang Jikai,Doron Shabat,Roey Amir,Nicole Huebener,Andreas G. Niethammer,Christian Hagemeier,Lüder Wiebusch,Gerhard Gaedicke,Wolfgang Wrasidlo,Ralph A. Reisfeld,Holger N. Lode

View Articletitled, Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia

Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27^Kip1 associated with ATRA-induced G₀/G₁ arrest of U-937 cells

Anna Dimberg,Inger Karlberg,Kenneth Nilsson,Fredrik Öberg

View Articletitled, Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

Adolfo A. Ferrando,Scott A. Armstrong,Donna S. Neuberg,Stephen E. Sallan,Lewis B. Silverman,Stanley J. Korsmeyer,A. Thomas Look

View Articletitled, Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

Supplemental data

Regulation of 17-AAG—induced apoptosis: role of Bcl-2, Bcl-x_L, and Bax downstream of 17-AAG—mediated down-regulation of Akt, Raf-1, and Src kinases

Ramadevi Nimmanapalli,Erica O'Bryan,Deborah Kuhn,Hirohito Yamaguchi,Hong-Gang Wang,Kapil N. Bhalla

View Articletitled, Regulation of 17-AAG—induced apoptosis: role of Bcl-2, Bcl-xL, and Bax downstream of 17-AAG—mediated down-regulation of Akt, Raf-1, and Src kinases

Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
Clinical Trials & Observations

Susan Branford,Zbigniew Rudzki,Sonya Walsh,Ian Parkinson,Andrew Grigg,Jeff Szer,Kerry Taylor,Richard Herrmann,John F. Seymour,Chris Arthur,David Joske,Kevin Lynch,Tim Hughes

View Articletitled, Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis

Effective therapy for a murine model of adult T-cell leukemia with the humanized anti-CD2 monoclonal antibody, MEDI-507

Zhuo Zhang,Meili Zhang,Jeffrey V. Ravetch,Carolyn Goldman,Thomas A. Waldmann

View Articletitled, Effective therapy for a murine model of adult T-cell leukemia with the humanized anti-CD2 monoclonal antibody, MEDI-507

2-Methoxyestradiol alters cell motility, migration, and adhesion

Martin Sattler,Laura R. Quinnan,Yuri B. Pride,Jessica L. Gramlich,Stephanie C. Chu,Gaelle C. Even,Stine-Katherin Kraeft,Lan Bo Chen,Ravi Salgia

View Articletitled, 2-Methoxyestradiol alters cell motility, migration, and adhesion

Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies

Bo Shi,Hsin-Ling Hsu,Andy M. Evens,Leo I. Gordon,Ronald B. Gartenhaus

View Articletitled, Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies

The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP

Thomas J. Sayers,Alan D. Brooks,Crystal Y. Koh,Weihong Ma,Naoko Seki,Arati Raziuddin,Bruce R. Blazar,Xia Zhang,Peter J. Elliott,William J. Murphy

View Articletitled, The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP

Dual effects of macrophage inflammatory protein-1α on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease

Babatunde O. Oyajobi,Giovanni Franchin,Paul J. Williams,Donna Pulkrabek,Anjana Gupta,Steve Munoz,Barry Grubbs,Ming Zhao,Di Chen,Barbara Sherry,Gregory R. Mundy

View Articletitled, Dual effects of macrophage inflammatory protein-1α on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease

Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis
Brief Report

Koiti Inokuchi,Kazuo Dan,Miyuki Takatori,Hidemasa Takahuji,Naoya Uchida,Mitsuharu Inami,Koichi Miyake,Hiroaki Honda,Hisamaru Hirai,Takashi Shimada

View Articletitled, Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis

Very late relapse in diffuse large B-cell lymphoma represents clonally related disease and is marked by germinal center cell features
Clinical Trials & Observations Brief Report

Daphne de Jong,Annuska M. Glas,Lucie Boerrigter,Marie-Christine Hermus,Otilia Dalesio,Els Willemse,Petra M. Nederlof,Marie José Kersten

View Articletitled, Very late relapse in diffuse large B-cell lymphoma represents clonally related disease and is marked by germinal center cell features

PHAGOCYTES

Rapid recruitment of inflammatory monocytes is independent of neutrophil migration

Robert B. Henderson,Josie A. R. Hobbs,Meg Mathies,Nancy Hogg

View Articletitled, Rapid recruitment of inflammatory monocytes is independent of neutrophil migration

Supplemental data

Vitamin C inhibits FAS-induced apoptosis in monocytes and U937 cells

Isabel Perez-Cruz,Juan M. Carcamo,David W. Golde

View Articletitled, Vitamin C inhibits FAS-induced apoptosis in monocytes and U937 cells

Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival

Hongtao Liu,Yingyu Ma,Shawn M. Cole,Christopher Zander,Kun-Hung Chen,Jim Karras,Richard M. Pope

View Articletitled, Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival

RED CELLS

Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia
Clinical Trials & Observations

Joan-Lluis Vives Corrons,Estefania Garcia,Joan J. Tusell,Kottayil I. Varughese,Carol West,Ernest Beutler

View Articletitled, Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia

Fluorescence measurements of the labile iron pool of sickle erythrocytes

Deepika Darbari,Mark Loyevsky,Victor Gordeuk,John A. Kark,Oswaldo Castro,Sohail Rana,Victor Apprey,Joseph Kurantsin-Mills

View Articletitled, Fluorescence measurements of the labile iron pool of sickle erythrocytes

Phosphatidylserine externalization in sickle red blood cells: associations with cell age, density, and hemoglobin F

Zahida Yasin,Scott Witting,Mary B. Palascak,Clinton H. Joiner,Donald L. Rucknagel,Robert S. Franco

View Articletitled, Phosphatidylserine externalization in sickle red blood cells: associations with cell age, density, and hemoglobin F

Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron

Sven G. Gehrke,Hasan Kulaksiz,Thomas Herrmann,Hans-Dieter Riedel,Karin Bents,Claudia Veltkamp,Wolfgang Stremmel

View Articletitled, Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron

TRANSPLANTATION

Reovirus oncolysis as a novel purging strategy for autologous stem cell transplantation

Chandini M. Thirukkumaran,Joanne M. Luider,Douglas A. Stewart,Tina Cheng,Sasha M. Lupichuk,Michael J. Nodwell,James A. Russell,Iwona A. Auer,Donald G. Morris

View Articletitled, Reovirus oncolysis as a novel purging strategy for autologous stem cell transplantation

Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans

Edward James,Jian-Guo Chai,Hamlata Dewchand,Eugenio Macchiarulo,Francesco Dazzi,Elizabeth Simpson

View Articletitled, Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans

Myeloid and monocytic dyspoiesis as determined by flow cytometric scoring in myelodysplastic syndrome correlates with the IPSS and with outcome after hematopoietic stem cell transplantation

Denise A. Wells,Martin Benesch,Michael R. Loken,Carlos Vallejo,David Myerson,Wendy M. Leisenring,H. Joachim Deeg

View Articletitled, Myeloid and monocytic dyspoiesis as determined by flow cytometric scoring in myelodysplastic syndrome correlates with the IPSS and with outcome after hematopoietic stem cell transplantation

Pharmacokinetics of alemtuzumab used for in vivo and in vitro T-cell depletion in allogeneic transplantations: relevance for early adoptive immunotherapy and infectious complications
Brief Report

Emma C. Morris,Peppy Rebello,Kirsty J. Thomson,Karl S. Peggs,Charalampia Kyriakou,Anthony H. Goldstone,Stephen Mackinnon,Geoff Hale

View Articletitled, Pharmacokinetics of alemtuzumab used for in vivo and in vitro T-cell depletion in allogeneic transplantations: relevance for early adoptive immunotherapy and infectious complications

CORRESPONDENCE

Oral arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia

Wing-Yan Au,Cyrus R. Kumana,Maybelle Kou,Raymond Mak,Godfrey C. F. Chan,Ching-Wan Lam,Yok-Lam Kwong

View Articletitled, Oral arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia

No clinical evidence for CD4⁺ cell depletion caused by rituximab

M. Wayne Saville,Mark C. Benyunes,Pratik S. Multani

View Articletitled, No clinical evidence for CD4+ cell depletion caused by rituximab

Allogenic bone marrow transplantation: not a treatment yet for familial Mediterranean fever

Isabelle Touitou,Eldad Ben-Chetrit,Ruth Gershoni-Baruch,Gilles Grateau,Daniel L. Kastner,Isabelle Kone-Paut,Avi Livneh,Raffaele Manna,Issam Mansour,Huri Ozdogan,Seza Ozen,Tamara Sarkisian,Mehmet Tunca,Fatos Yalcinkaya

View Articletitled, Allogenic bone marrow transplantation: not a treatment yet for familial Mediterranean fever

S-nitrosohemoglobin is distinguished from other nitrosovasodilators by unique oxygen-dependent responses that support an allosteric mechanism of action

Timothy J. McMahon,John R. Pawloski,Douglas T. Hess,Claude A. Piantadosi,Benjamin P. Luchsinger,David J. Singel,Jonathan S. Stamler

View Articletitled, S-nitrosohemoglobin is distinguished from other nitrosovasodilators by unique oxygen-dependent responses that support an allosteric mechanism of action

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Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

PLENARY PAPERS

PERSPECTIVES

Role of deferiprone in chelation therapy for transfusional iron overload Clinical Trials & Observations

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Genetic variants of coagulation factor XIII, postmenopausal estrogen therapy, and risk of nonfatal myocardial infarction Clinical Trials & Observations

HLA-matched related hematopoietic cell transplantation for chronic-phase CML using a targeted busulfan and cyclophosphamide preparative regimen Clinical Trials & Observations

Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigen Clinical Trials & Observations

Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series Clinical Trials & Observations

Prognostic value of pretransplantation positron emission tomography using fluorine 18-fluorodeoxyglucose in patients with aggressive lymphoma treated with high-dose chemotherapy and stem cell transplantation Clinical Trials & Observations

ADAMTS13 activity in thrombotic thrombocytopenic purpura–hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients Clinical Trials & Observations

Multicenter phase 2 trial of thalidomide in relapsed/refractory multiple myeloma: adverse prognostic impact of advanced age Clinical Trials & Observations

A 6-month versus a 12-month surveillance for hepatocellular carcinoma in 559 hemophiliacs infected with the hepatitis C virus Clinical Trials & Observations

Result of high-dose imatinib mesylate in patients with Philadelphia chromosome—positive chronic myeloid leukemia after failure of interferon-α Clinical Trials & Observations