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Lack of BCL-6 self-control fuels lymphomagenesis

Chi Van Dang

View Articletitled, Lack of BCL-6 self-control fuels lymphomagenesis

Toward gene therapy for β-thalassemia: new models, new approaches

Punam Malik

View Articletitled, Toward gene therapy for β-thalassemia: new models, new approaches

Heparin-induced thrombocytopenia in medical patients

Theodore E. Warkentin

View Articletitled, Heparin-induced thrombocytopenia in medical patients

Tentative progress in hemophilia B gene therapy

Jay Nelson Lozier

View Articletitled, Tentative progress in hemophilia B gene therapy

‘Les cytokinès responsables’ in osteosclerosis and myelofibrosis

Ayalew Tefferi

View Articletitled, ‘Les cytokinès responsables’ in osteosclerosis and myelofibrosis

INSIDE BLOOD

Stem cells take a shortcut to the bone marrow

John E. Dick,Tsvee Lapidot

View Articletitled, Stem cells take a shortcut to the bone marrow

The mystery of FXIII-A Val34Leu polymorphism

Laszlo Muszbek

View Articletitled, The mystery of FXIII-A Val34Leu polymorphism

PLENARY PAPERS

A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow

Takashi Yahata,Kiyoshi Ando,Tadayuki Sato,Hiroko Miyatake,Yoshihiko Nakamura,Yukari Muguruma,Shunichi Kato,Tomomitsu Hotta

View Articletitled, A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow

Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma

Laura Pasqualucci,Anna Migliazza,Katia Basso,Jane Houldsworth,R. S. K. Chaganti,Riccardo Dalla-Favera

View Articletitled, Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma

Supplemental data

SCID-repopulating cell activity of human cord blood–derived CD34⁻ cells assured by intra–bone marrow injection

Jianfeng Wang,Takafumi Kimura,Rumiko Asada,Sachio Harada,Shouhei Yokota,Yoshio Kawamoto,Yoshihiro Fujimura,Takashi Tsuji,Susumu Ikehara,Yoshiaki Sonoda

View Articletitled, SCID-repopulating cell activity of human cord blood–derived CD34− cells assured by intra–bone marrow injection

A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human β-globin gene transfer

Stefano Rivella,Chad May,Amy Chadburn,Isabelle Rivière,Michel Sadelain

View Articletitled, A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human β-globin gene transfer

REVIEW ARTICLES

Signal transducer and activator of transcription proteins in leukemias

Mustafa Benekli,Maria R. Baer,Heinz Baumann,Meir Wetzler

View Articletitled, Signal transducer and activator of transcription proteins in leukemias

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study
Clinical Trials & Observations

Bruno Girolami,Paolo Prandoni,Piero M. Stefani,Cinzia Tanduo,Paola Sabbion,Petra Eichler,Roberto Ramon,Giovannella Baggio,Fabrizio Fabris,Antonio Girolami

View Articletitled, The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study

Sustained complete hematologic remission after administration of the tyrosine kinase inhibitor imatinib mesylate in a patient with refractory, secondary AML
Clinical Trials & Observations Brief Report

Thomas Kindler,Frank Breitenbuecher,Andreas Marx,Georg Hess,Harald Gschaidmeier,Heinold Gamm,Charles J. Kirkpatrick,Christoph Huber,Thomas Fischer

View Articletitled, Sustained complete hematologic remission after administration of the tyrosine kinase inhibitor imatinib mesylate in a patient with refractory, secondary AML

GENE THERAPY

AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B
Clinical Trials & Observations

View Articletitled, AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B

HEMATOPOIESIS

Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition

Jalila Chagraoui,Adeline Lepage-Noll,Aurora Anjo,Georges Uzan,Pierre Charbord

View Articletitled, Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition

Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO

Hédia Chagraoui,Micheline Tulliez,Tarek Smayra,Emiko Komura,Stéphane Giraudier,Theodore Yun,Nathalie Lassau,William Vainchenker,Françoise Wendling

View Articletitled, Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO

Impaired neutrophil maturation in truncated murine G-CSF receptor–transgenic mice

Tetsuo Mitsui,Sumiko Watanabe,Yoshihiro Taniguchi,Sachiyo Hanada,Yasuhiro Ebihara,Takeshi Sato,Toshio Heike,Masao Mitsuyama,Tatsutoshi Nakahata,Kohichiro Tsuji

View Articletitled, Impaired neutrophil maturation in truncated murine G-CSF receptor–transgenic mice

Hematopoietic capacity of connexin43 wild-type and knock-out fetal liver cells not different on wild-type stroma
Brief Report

Martin Rosendaal,Chris Jopling

View Articletitled, Hematopoietic capacity of connexin43 wild-type and knock-out fetal liver cells not different on wild-type stroma

Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates
Brief Report

Steven M. Devine,Carrington Cobbs,Matt Jennings,Amelia Bartholomew,Ron Hoffman

View Articletitled, Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Distinct dose-dependent effects of plasmin and TPA on coagulation and hemorrhage

Daphne Stewart,Mansze Kong,Valery Novokhatny,Gary Jesmok,Victor J. Marder

View Articletitled, Distinct dose-dependent effects of plasmin and TPA on coagulation and hemorrhage

Elevated prothrombin results in clots with an altered fiber structure: a possible mechanism of the increased thrombotic risk

Alisa S. Wolberg,Dougald M. Monroe,Harold R. Roberts,Maureane Hoffman

View Articletitled, Elevated prothrombin results in clots with an altered fiber structure: a possible mechanism of the increased thrombotic risk

The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo

Jian-Miao Liu,Françoise Lawrence,Milica Kovacevic,Jérôme Bignon,Evangelia Papadimitriou,Jean-Yves Lallemand,Panagiotis Katsoris,Pierre Potier,Yves Fromes,Joanna Wdzieczak-Bakala

View Articletitled, The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo

IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization

Valentina A. Schmidt,Lesley Scudder,Craig E. Devoe,André Bernards,Lisa D. Cupit,Wadie F. Bahou

View Articletitled, IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization

Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production

Akio Mizutani,Kenji Okajima,Mitsuhiro Uchiba,Hirotaka Isobe,Naoaki Harada,Sachiko Mizutani,Takayuki Noguchi

View Articletitled, Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production

Combined carrier status of prothrombin 20210A and factor XIII-A Leu34 alleles as a strong risk factor for myocardial infarction: evidence of a gene-gene interaction
Clinical Trials & Observations

Christopher Butt,Hong Zheng,Edward Randell,Desmond Robb,Patrick Parfrey,Ya-Gang Xie

View Articletitled, Combined carrier status of prothrombin 20210A and factor XIII-A Leu34 alleles as a strong risk factor for myocardial infarction: evidence of a gene-gene interaction

Direct binding of Nur77/NAK-1 to the plasminogen activator inhibitor 1 (PAI-1) promoter regulates TNFα-induced PAI-1 expression

Florian Gruber,Peter Hufnagl,Renate Hofer-Warbinek,Johannes A. Schmid,Johannes M. Breuss,Renate Huber-Beckmann,Markus Lucerna,Nikolina Papac,Hanna Harant,Ivan Lindley,Rainer de Martin,Bernd R. Binder

View Articletitled, Direct binding of Nur77/NAK-1 to the plasminogen activator inhibitor 1 (PAI-1) promoter regulates TNFα-induced PAI-1 expression

Central venous catheters and upper-extremity deep-vein thrombosis complicating immune heparin-induced thrombocytopenia
Clinical Trials & Observations Brief Report

Aaron P. Hong,Deborah J. Cook,Christopher S. Sigouin,Theodore E. Warkentin

View Articletitled, Central venous catheters and upper-extremity deep-vein thrombosis complicating immune heparin-induced thrombocytopenia

IMMUNOBIOLOGY

CD56^bright natural killer cells are present in human lymph nodes and are activated by T cell–derived IL-2: a potential new link between adaptive and innate immunity

Todd A. Fehniger,Megan A. Cooper,Gerard J. Nuovo,Marina Cella,Fabio Facchetti,Marco Colonna,Michael A. Caligiuri

View Articletitled, CD56bright natural killer cells are present in human lymph nodes and are activated by T cell–derived IL-2: a potential new link between adaptive and innate immunity

Regulation of human β₂-microglobulin transactivation in hematopoietic cells

Sam J. P. Gobin,Paula Biesta,Peter J. Van den Elsen

View Articletitled, Regulation of human β2-microglobulin transactivation in hematopoietic cells

Intravenous immunoglobulins induce the in vitro differentiation of human B lymphocytes and the secretion of IgG

Marie Joëlle de Grandmont,Claudia Racine,Annie Roy,Réal Lemieux,Sonia Néron

View Articletitled, Intravenous immunoglobulins induce the in vitro differentiation of human B lymphocytes and the secretion of IgG

Degenerate specificity of HTLV-1–specific CD8⁺ T cells during viral replication in patients with HTLV-1–associated myelopathy (HAM/TSP)

Ryuji Kubota,Yoshitaka Furukawa,Shuji Izumo,Koichiro Usuku,Mitsuhiro Osame

View Articletitled, Degenerate specificity of HTLV-1–specific CD8+ T cells during viral replication in patients with HTLV-1–associated myelopathy (HAM/TSP)

Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire

Kathleen N. Potter,Jenny Orchard,Eustacia Critchley,C. Ian Mockridge,Annette Jose,Freda K. Stevenson

View Articletitled, Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire

Regulation of the cell-surface expression of an HTLV-I binding protein in human T cells during immune activation

Manisha D. Nath,Francis W. Ruscetti,Cari Petrow-Sadowski,Kathryn S. Jones

View Articletitled, Regulation of the cell-surface expression of an HTLV-I binding protein in human T cells during immune activation

Cell death induced by granzyme C

Hillary Johnson,Luca Scorrano,Stanley J. Korsmeyer,Timothy J. Ley

View Articletitled, Cell death induced by granzyme C

A nonsecreted variant of interleukin-4 is associated with apoptosis: implication for the T helper–2 polarization in HIV infection
Brief Report

Eric Ledru,Michèle Février,Hervé Lecoeur,Sylvie Garcia,Séverine Boullier,Marie-Lise Gougeon

View Articletitled, A nonsecreted variant of interleukin-4 is associated with apoptosis: implication for the T helper–2 polarization in HIV infection

Clonal expansion of CD8⁺ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia
Brief Report

Anna Maria Masci,Giovannella Palmieri,Laura Vitiello,Liliana Montella,Francesco Perna,Paola Orlandi,Gianfranco Abbate,Serafino Zappacosta,Raffaele De Palma,Luigi Racioppi

View Articletitled, Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia

NEOPLASIA

Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations
Clinical Trials & Observations

Jose A. Martinez-Climent,Ash A. Alizadeh,Richard Segraves,David Blesa,Fanny Rubio-Moscardo,Donna G. Albertson,Javier Garcia-Conde,Martin J. S. Dyer,Ronald Levy,Daniel Pinkel,Izidore S. Lossos

View Articletitled, Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations

Mitochondrial DNA mutations in patients with myelodysplastic syndromes

Myung Geun Shin,Sachiko Kajigaya,Barbara C. Levin,Neal S. Young

View Articletitled, Mitochondrial DNA mutations in patients with myelodysplastic syndromes

Downstream effectors of oncogenic ras in multiple myeloma cells

Liping Hu,Yijiang Shi,Jung-hsin Hsu,Joseph Gera,Brian Van Ness,Alan Lichtenstein

View Articletitled, Downstream effectors of oncogenic ras in multiple myeloma cells

Multiple myeloma tumor progression in the 5T2MM murine model is a multistage and dynamic process of differentiation, proliferation, invasion, and apoptosis

Kewal Asosingh,Hendrik De Raeve,Ivan Van Riet,Benjamin Van Camp,Karin Vanderkerken

View Articletitled, Multiple myeloma tumor progression in the 5T2MM murine model is a multistage and dynamic process of differentiation, proliferation, invasion, and apoptosis

Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML)

Yinghui Guan,Brigitte Gerhard,Donna E. Hogge

View Articletitled, Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML)

Therapeutic LMP1 polyepitope vaccine for EBV-associated Hodgkin disease and nasopharyngeal carcinoma

Jaikumar Duraiswamy,Martina Sherritt,Scott Thomson,Judy Tellam,Leanne Cooper,Geoff Connolly,Mandvi Bharadwaj,Rajiv Khanna

View Articletitled, Therapeutic LMP1 polyepitope vaccine for EBV-associated Hodgkin disease and nasopharyngeal carcinoma

AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells

Olaf Heidenreich,Jürgen Krauter,Heidemarie Riehle,Philipp Hadwiger,Matthias John,Gerhard Heil,Hans-Peter Vornlocher,Alfred Nordheim

View Articletitled, AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

Masao Mizuki,Joachim Schwäble,Claudia Steur,Chunaram Choudhary,Shuchi Agrawal,Bülent Sargin,Björn Steffen,Itaru Matsumura,Yuzuru Kanakura,Frank D. Böhmer,Carsten Müller-Tidow,Wolfgang E. Berdel,Hubert Serve

View Articletitled, Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis

Dylan T. Jones,Kanagasabai Ganeshaguru,Robert J. Anderson,Trevor R. Jackson,K. Richard Bruckdorfer,Sylvia Y. Low,Lars Palmqvist,H. Grant Prentice,A. Victor Hoffbrand,Atul B. Mehta,R. Gitendra Wickremasinghe

View Articletitled, Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis

Sequestration of p27^Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesis

Leticia Quintanilla-Martinez,Theresa Davies-Hill,Falko Fend,Julia Calzada-Wack,Lynn Sorbara,Elias Campo,Elaine S. Jaffe,Mark Raffeld

View Articletitled, Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesis

A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657

Jastinder Sohal,Vernon T. Phan,Philip V. Chan,Elizabeth M. Davis,Bhumi Patel,Louise M. Kelly,Tinya J. Abrams,Anne Marie O'Farrell,D. Gary Gilliland,Michelle M. Le Beau,Scott C. Kogan

View Articletitled, A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657

Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94:NKG2C/E and NKD2D killer cell receptors

Valérie Bigouret,Till Hoffmann,Lionel Arlettaz,Jean Villard,Marco Colonna,André Ticheli,Alois Gratwohl,Kaveh Samii,Bernard Chapuis,Nathalie Rufer,Eddy Roosnek

View Articletitled, Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94:NKG2C/E and NKD2D killer cell receptors

JunB gene expression is inactivated by methylation in chronic myeloid leukemia

Ming-Yu Yang,Ta-Chih Liu,Jan-Gowth Chang,Pai-Mei Lin,Sheng-Fung Lin

View Articletitled, JunB gene expression is inactivated by methylation in chronic myeloid leukemia

Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells

Adamantios Serafeim,Michelle J. Holder,Gillian Grafton,Anita Chamba,Mark T. Drayson,Quang T. Luong,Christopher M. Bunce,Christopher D. Gregory,Nicholas M. Barnes,John Gordon

View Articletitled, Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells

Enhancement of ATRA-induced cell differentiation by inhibition of calcium accumulation into the endoplasmic reticulum: cross-talk between RARα and calcium-dependent signaling

Sophie Launay,Maurizio Giannı̀,Luisa Diomede,Laura M. Machesky,Jocelyne Enouf,Béla Papp

View Articletitled, Enhancement of ATRA-induced cell differentiation by inhibition of calcium accumulation into the endoplasmic reticulum: cross-talk between RARα and calcium-dependent signaling

Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia

Jennifer J. Johnson,Weili Chen,Wendy Hudson,Qing Yao,Marnie Taylor,Terence H. Rabbitts,John H. Kersey

View Articletitled, Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia

Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl–positive human acute leukemia cells
Brief Report

Ramadevi Nimmanapalli,Lianne Fuino,Corinne Stobaugh,Victoria Richon,Kapil Bhalla

View Articletitled, Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl–positive human acute leukemia cells

PHAGOCYTES

Human neutrophils utilize a Rac/Cdc42-dependent MAPK pathway to direct intracellular granule mobilization toward ingested microbial pathogens

Bin Zhong,Kun Jiang,Danielle L. Gilvary,Pearlie K. Epling-Burnette,Connie Ritchey,Jinhong Liu,Rosalind J. Jackson,Elizabeth Hong-Geller,Sheng Wei

View Articletitled, Human neutrophils utilize a Rac/Cdc42-dependent MAPK pathway to direct intracellular granule mobilization toward ingested microbial pathogens

Recombinant P-selectin glycoprotein ligand–1 directly inhibits leukocyte rolling by all 3 selectins in vivo: complete inhibition of rolling is not required for anti-inflammatory effect

Anne E. R. Hicks,Sarah L. Nolan,Victoria C. Ridger,Paul G. Hellewell,Keith E. Norman

View Articletitled, Recombinant P-selectin glycoprotein ligand–1 directly inhibits leukocyte rolling by all 3 selectins in vivo: complete inhibition of rolling is not required for anti-inflammatory effect

Supplemental data

Roles of neutrophil β2 integrins in kinetics of bacteremia, extravasation, and tick acquisition of Anaplasma phagocytophila in mice

Dori L. Borjesson,Scott I. Simon,Emir Hodzic,Hilde E. V. DeCock,Christie M. Ballantyne,Stephen W. Barthold

View Articletitled, Roles of neutrophil β2 integrins in kinetics of bacteremia, extravasation, and tick acquisition of Anaplasma phagocytophila in mice

Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBPε and PU.1

Adrian F. Gombart,Scott H. Kwok,Karen L. Anderson,Yuji Yamaguchi,Bruce E. Torbett,H. Phillip Koeffler

View Articletitled, Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBPε and PU.1

RED CELLS

Involvement of ABC7 in the biosynthesis of heme in erythroid cells: interaction of ABC7 with ferrochelatase

Shigeru Taketani,Kazuhiro Kakimoto,Hiromi Ueta,Ryuichi Masaki,Takako Furukawa

View Articletitled, Involvement of ABC7 in the biosynthesis of heme in erythroid cells: interaction of ABC7 with ferrochelatase

Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion

Patrick C. Hines,Qin Zen,Sharran N. Burney,Deborah A. Shea,Kenneth I. Ataga,Eugene P. Orringer,Marilyn J. Telen,Leslie V. Parise

View Articletitled, Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion

UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis

Sven G. Gehrke,Hans-Dieter Riedel,Thomas Herrmann,Boris Hadaschik,Karin Bents,Claudia Veltkamp,Wolfgang Stremmel

View Articletitled, UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis

Discrimination of polycythemias and thrombocytoses by novel, simple, accurate clonality assays and comparison with PRV-1 expression and BFU-E response to erythropoietin
Clinical Trials & Observations

Enli Liu,Jaroslav Jelinek,Yves D. Pastore,Yongli Guan,Jaroslav F. Prchal,Josef T. Prchal

View Articletitled, Discrimination of polycythemias and thrombocytoses by novel, simple, accurate clonality assays and comparison with PRV-1 expression and BFU-E response to erythropoietin

Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism: Presented in preliminary form at the 44th Annual Meeting of the American Society of Hematology, Philadelphia, PA, December 7, 2002.

Ralph Carmel,Stepan Melnyk,S. Jill James

View Articletitled, Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism: Presented in preliminary form at the 44th Annual Meeting of the American Society of Hematology, Philadelphia, PA, December 7, 2002.

Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous state
Clinical Trials & Observations

Rick M. Fairhurst,Hisashi Fujioka,Karen Hayton,Kathleen F. Collins,Thomas E. Wellems

View Articletitled, Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous state

Duodenal nonheme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out
Brief Report

Robert J. Simpson,Edward S. Debnam,Abas H. Laftah,Nita Solanky,Nick Beaumont,Seiamak Bahram,Klaus Schümann,S. Kaila S. Srai

View Articletitled, Duodenal nonheme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out

TRANSPLANTATION

Factors affecting antibody levels after allogeneic hematopoietic cell transplantation
Clinical Trials & Observations

Jan Storek,Federico Viganego,Monja A. Dawson,M. M. P. Tineke Herremans,Michael Boeckh,Mary E. D. Flowers,Barry Storer,William I. Bensinger,Robert P. Witherspoon,David G. Maloney

View Articletitled, Factors affecting antibody levels after allogeneic hematopoietic cell transplantation

Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival by CTLA4Ig

Cécile Guillot,Séverine Ménoret,Carole Guillonneau,Cécile Braudeau,Maria G. Castro,Pedro Lowenstein,Ignacio Anegon

View Articletitled, Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival by CTLA4Ig

Non–T-cell–depleted HLA haploidentical stem cell transplantation in advanced hematologic malignancies based on the feto-maternal michrochimerism
Brief Report

Chihiro Shimazaki,Naoya Ochiai,Ryo Uchida,Akira Okano,Shin-ichi Fuchida,Eishi Ashihara,Tohru Inaba,Naohisa Fujita,Etsuko Maruya,Masao Nakagawa

View Articletitled, Non–T-cell–depleted HLA haploidentical stem cell transplantation in advanced hematologic malignancies based on the feto-maternal michrochimerism

CORRESPONDENCE

Association between p47^phox pseudogenes and inflammatory bowel disease

Marcus Harbord,Andrea Hankin,Stuart Bloom,Hannah Mitchison

View Articletitled, Association between p47phox pseudogenes and inflammatory bowel disease

The liver sieve and gene therapy

Robin Fraser,David G. Le Couteur,Alessandra Warren,Victoria C. Cogger,Patrick Bertolino,Mark Smith

View Articletitled, The liver sieve and gene therapy

Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

REVIEW ARTICLES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study Clinical Trials & Observations

Sustained complete hematologic remission after administration of the tyrosine kinase inhibitor imatinib mesylate in a patient with refractory, secondary AML Clinical Trials & Observations Brief Report

GENE THERAPY

AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B Clinical Trials & Observations

HEMATOPOIESIS

Hematopoietic capacity of connexin43 wild-type and knock-out fetal liver cells not different on wild-type stroma Brief Report

Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Combined carrier status of prothrombin 20210A and factor XIII-A Leu34 alleles as a strong risk factor for myocardial infarction: evidence of a gene-gene interaction Clinical Trials & Observations

Central venous catheters and upper-extremity deep-vein thrombosis complicating immune heparin-induced thrombocytopenia Clinical Trials & Observations Brief Report

IMMUNOBIOLOGY

A nonsecreted variant of interleukin-4 is associated with apoptosis: implication for the T helper–2 polarization in HIV infection Brief Report

Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia Brief Report

NEOPLASIA

Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations Clinical Trials & Observations

Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl–positive human acute leukemia cells Brief Report

PHAGOCYTES

RED CELLS

Discrimination of polycythemias and thrombocytoses by novel, simple, accurate clonality assays and comparison with PRV-1 expression and BFU-E response to erythropoietin Clinical Trials & Observations

Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous state Clinical Trials & Observations

Duodenal nonheme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out Brief Report

TRANSPLANTATION

Factors affecting antibody levels after allogeneic hematopoietic cell transplantation Clinical Trials & Observations

Non–T-cell–depleted HLA haploidentical stem cell transplantation in advanced hematologic malignancies based on the feto-maternal michrochimerism Brief Report

CORRESPONDENCE

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American Society of Hematology

This Feature Is Available To Subscribers Only

The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study
Clinical Trials & Observations

Sustained complete hematologic remission after administration of the tyrosine kinase inhibitor imatinib mesylate in a patient with refractory, secondary AML
Clinical Trials & Observations Brief Report

AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B
Clinical Trials & Observations

Hematopoietic capacity of connexin43 wild-type and knock-out fetal liver cells not different on wild-type stroma
Brief Report

Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates
Brief Report

Combined carrier status of prothrombin 20210A and factor XIII-A Leu34 alleles as a strong risk factor for myocardial infarction: evidence of a gene-gene interaction
Clinical Trials & Observations

Central venous catheters and upper-extremity deep-vein thrombosis complicating immune heparin-induced thrombocytopenia
Clinical Trials & Observations Brief Report

A nonsecreted variant of interleukin-4 is associated with apoptosis: implication for the T helper–2 polarization in HIV infection
Brief Report

Clonal expansion of CD8⁺ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia
Brief Report

Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations
Clinical Trials & Observations

Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl–positive human acute leukemia cells
Brief Report

Discrimination of polycythemias and thrombocytoses by novel, simple, accurate clonality assays and comparison with PRV-1 expression and BFU-E response to erythropoietin
Clinical Trials & Observations

Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous state
Clinical Trials & Observations

Duodenal nonheme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out
Brief Report

Factors affecting antibody levels after allogeneic hematopoietic cell transplantation
Clinical Trials & Observations

Non–T-cell–depleted HLA haploidentical stem cell transplantation in advanced hematologic malignancies based on the feto-maternal michrochimerism
Brief Report