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Volume 101, Issue 6

March 15 2003

In this Issue

INSIDE BLOOD
PLENARY PAPERS
ERRATA
PERSPECTIVE
REVIEW IN TRANSLATIONAL HEMATOLOGY
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

i to I and the eye

Ernest Beutler

View Articletitled, i to I and the eye

UCB allogeneic transplantation for hemoglobinopathies

Mary J. Laughlin

View Articletitled, UCB allogeneic transplantation for hemoglobinopathies

Platelet message and microarrays

Mortimer Poncz

View Articletitled, Platelet message and microarrays

Cytologic subtypes of grade 3 follicular lymphoma

William G. Finn

View Articletitled, Cytologic subtypes of grade 3 follicular lymphoma

Photochemical pathogen reduction: improved safety for the blood supply?

Edward L. Snyder

View Articletitled, Photochemical pathogen reduction: improved safety for the blood supply?

PLENARY PAPERS

The molecular genetics of the human I locus and molecular background explain the partial association of the adult i phenotype with congenital cataracts

Lung-Chih Yu,Yuh-Ching Twu,Ming-Lun Chou,Marion E. Reid,Alan R. Gray,Joann M. Moulds,Ching-Yi Chang,Marie Lin

View Articletitled, The molecular genetics of the human I locus and molecular background explain the partial association of the adult i phenotype with congenital cataracts

Supplemental data

ERRATA

PERSPECTIVE

Von Willebrand disease type 1: a diagnosis in search of a disease

J. Evan Sadler

View Articletitled, Von Willebrand disease type 1: a diagnosis in search of a disease

RANK ligand and osteoprotegerin in myeloma bone disease
Clinical Trials & Observations

Orhan Sezer,Ulrike Heider,Ivana Zavrski,Christian Alexander Kühne,Lorenz Christian Hofbauer

View Articletitled, RANK ligand and osteoprotegerin in myeloma bone disease

REVIEW IN TRANSLATIONAL HEMATOLOGY

Side effects of retroviral gene transfer into hematopoietic stem cells

Christopher Baum,Jochen Düllmann,Zhixiong Li,Boris Fehse,Johann Meyer,David A. Williams,Christof von Kalle

View Articletitled, Side effects of retroviral gene transfer into hematopoietic stem cells

CHEMOKINES

Differential regulation of CXCR2 trafficking by Rab GTPases

Guo-Huang Fan,Lynne A. Lapierre,James R. Goldenring,Ann Richmond

View Articletitled, Differential regulation of CXCR2 trafficking by Rab GTPases

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML): Presented in part at the 42nd annual meeting of the American Society of Hematology, San Francisco, CA, December 1-5, 2000.⁴⁶
Clinical Trials & Observations

Giovanni Del Poeta,Adriano Venditti,Maria Ilaria Del Principe,Luca Maurillo,Francesco Buccisano,Anna Tamburini,Maria Christina Cox,Annibale Franchi,Antonio Bruno,Carla Mazzone,Paola Panetta,Giovanna Suppo,Mario Masi,Sergio Amadori

View Articletitled, Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML): Presented in part at the 42nd annual meeting of the American Society of Hematology, San Francisco, CA, December 1-5, 2000.46

Cytomegalovirus seropositivity is significantly associated with mycosis fungoides and Sézary syndrome: Presented in part at the 43rd annual meeting of the American Society of Hematology, Orlando, FL, December 8-11, 2001, and at the annual meeting of the American Academy of Dermatology, New Orleans, LA, February 24-28, 2002.
Clinical Trials & Observations

Kelly L. Herne,Rakhshandra Talpur,Joan Breuer-McHam,Richard Champlin,Madeleine Duvic

View Articletitled, Cytomegalovirus seropositivity is significantly associated with mycosis fungoides and Sézary syndrome: Presented in part at the 43rd annual meeting of the American Society of Hematology, Orlando, FL, December 8-11, 2001, and at the annual meeting of the American Academy of Dermatology, New Orleans, LA, February 24-28, 2002.

Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease
Clinical Trials & Observations

Franco Locatelli,Vanderson Rocha,William Reed,Françoise Bernaudin,Mehmet Ertem,Stelios Grafakos,Benedicte Brichard,Xiaxin Li,Arnon Nagler,Giovanna Giorgiani,Paul R. Haut,Joel A. Brochstein,Diane J. Nugent,Julie Blatt,Paul Woodard,Joanne Kurtzberg,Charles M. Rubin,Roberto Miniero,Patrick Lutz,Thirumalairaj Raja,Irene Roberts,Andrew M. Will,Isaac Yaniv,Christiane Vermylen,Nunzia Tannoia,Federico Garnier,Irina Ionescu,Mark C. Walters,Bertram H. Lubin,Eliane Gluckman,for the Eurocord Transplant Group

View Articletitled, Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease

Overall and event-free survival are not improved by the use of myeloablative therapy following intensified chemotherapy in previously untreated patients with multiple myeloma: a prospective randomized phase 3 study
Clinical Trials & Observations

Christine M. Segeren,Pieter Sonneveld,Bronno van der Holt,Edo Vellenga,Alexandra J. Croockewit,Gregor E. G. Verhoef,Jan J. Cornelissen,Martijn R. Schaafsma,Marinus H. J. van Oers,Pierre W. Wijermans,Wim E. Fibbe,Shulamit Wittebol,Harry C. Schouten,Marinus van Marwijk Kooy,Douwe H. Biesma,Joke W. Baars,Rosalyn Slater,Monique M. C. Steijaert,Ivon Buijt,Henk M. Lokhorst

View Articletitled, Overall and event-free survival are not improved by the use of myeloablative therapy following intensified chemotherapy in previously untreated patients with multiple myeloma: a prospective randomized phase 3 study

High levels of BAX, low levels of MRP-1, and high platelets are independent predictors of response to imatinib in myeloid blast crisis of CML
Clinical Trials & Observations Brief Report

Thoralf Lange,Christine Günther,Thomas Köhler,Rainer Krahl,Scarlet Musiol,Sabine Leiblein,Haifa-Kathrin Al-Ali,Iris van Hoomissen,Dietger Niederwieser,Michael W. N. Deininger

View Articletitled, High levels of BAX, low levels of MRP-1, and high platelets are independent predictors of response to imatinib in myeloid blast crisis of CML

Antithymocyte globulin has limited efficacy and substantial toxicity in unselected anemic patients with myelodysplastic syndrome
Clinical Trials & Observations Brief Report

David P. Steensma,Angela Dispenzieri,S. Breanndan Moore,Georgene Schroeder,Ayalew Tefferi

View Articletitled, Antithymocyte globulin has limited efficacy and substantial toxicity in unselected anemic patients with myelodysplastic syndrome

GENE THERAPY

Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice

Christoph Klein,Deanna Nguyen,Ching-Hui Liu,Atsushi Mizoguchi,Atul K. Bhan,Hiroaki Miki,Tadaomi Takenawa,Fred S. Rosen,Fred W. Alt,Richard C. Mulligan,Scott B. Snapper

View Articletitled, Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice

IL-7 surface-engineered lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytes

Els Verhoeyen,Valerie Dardalhon,Odile Ducrey-Rundquist,Didier Trono,Naomi Taylor,François-Loı̈c Cosset

View Articletitled, IL-7 surface-engineered lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytes

The degree of phenotypic correction of murine β-thalassemia intermedia following lentiviral-mediated transfer of a human γ-globin gene is influenced by chromosomal position effects and vector copy number

Derek A. Persons,Phillip W. Hargrove,Esther R. Allay,Hideki Hanawa,Arthur W. Nienhuis

View Articletitled, The degree of phenotypic correction of murine β-thalassemia intermedia following lentiviral-mediated transfer of a human γ-globin gene is influenced by chromosomal position effects and vector copy number

Retrovirus-mediated IL-7 expression in leukemic dendritic cells generated from primary acute myelogenous leukemias enhances their functional properties
Clinical Trials & Observations

Concha Bello-Fernández,Jana Stasakova,Alexander Renner,Nicole Carballido-Perrig,Margit Koening,Martina Waclavicek,Otto Madjic,Leopold Oehler,Oskar Haas,José M. Carballido,Michael Buschle,Walter Knapp

View Articletitled, Retrovirus-mediated IL-7 expression in leukemic dendritic cells generated from primary acute myelogenous leukemias enhances their functional properties

Retroviral vector integration occurs in preferred genomic targets of human bone marrow–repopulating cells

Stephanie Laufs,Bernhard Gentner,K. Zsuzsanna Nagy,Anna Jauch,Axel Benner,Sonja Naundorf,Klaus Kuehlcke,Bernhard Schiedlmeier,Anthony D. Ho,W. Jens Zeller,Stefan Fruehauf

View Articletitled, Retroviral vector integration occurs in preferred genomic targets of human bone marrow–repopulating cells

Retroviral transduction efficiency of G-CSF+SCF–mobilized peripheral blood CD34⁺ cells is superior to G-CSF or G-CSF+Flt3-L–mobilized cells in nonhuman primates

Peiman Hematti,Stephanie E. Sellers,Brian A. Agricola,Mark E. Metzger,Robert E. Donahue,Cynthia E. Dunbar

View Articletitled, Retroviral transduction efficiency of G-CSF+SCF–mobilized peripheral blood CD34+ cells is superior to G-CSF or G-CSF+Flt3-L–mobilized cells in nonhuman primates

HEMATOPOIESIS

Induction of C/EBPα activity alters gene expression and differentiation of human CD34⁺ cells

Jörg Cammenga,James C. Mulloy,Francisco J. Berguido,Donal MacGrogan,Agnes Viale,Stephen D. Nimer

View Articletitled, Induction of C/EBPα activity alters gene expression and differentiation of human CD34+ cells

Hematopoietic origin of glomerular mesangial cells

Masahiro Masuya,Christopher J. Drake,Paul A. Fleming,Christopher M. Reilly,Haiqun Zeng,William D. Hill,Angeline Martin-Studdard,David C. Hess,Makio Ogawa

View Articletitled, Hematopoietic origin of glomerular mesangial cells

Ikaros regulates neutrophil differentiation

Alexis Dumortier,Peggy Kirstetter,Philippe Kastner,Susan Chan

View Articletitled, Ikaros regulates neutrophil differentiation

Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells

Takayuki Yamada,Hidetoshi Yamazaki,Toshiyuki Yamane,Miya Yoshino,Hiromi Okuyama,Motokazu Tsuneto,Tomomi Kurino,Shin-Ichi Hayashi,Seiji Sakano

View Articletitled, Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells

The function of the bcl-x promoter in erythroid progenitor cells

Cuixia Tian,Paul Gregoli,Maurice Bondurant

View Articletitled, The function of the bcl-x promoter in erythroid progenitor cells

Identification of an MIP-1α–binding heparan sulfate oligosaccharide that supports long-term in vitro maintenance of human LTC-ICs
Brief Report

Sally E. Stringer,Matthew S. Nelson,Pankaj Gupta

View Articletitled, Identification of an MIP-1α–binding heparan sulfate oligosaccharide that supports long-term in vitro maintenance of human LTC-ICs

Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region
Brief Report

Claudia Orelio,Elaine Dzierzak

View Articletitled, Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region

Supplemental data

Hematologic effects of inactivating the Ras processing enzymeRce1
Brief Report

Abigail L. Aiyagari,Brigit R. Taylor,Vikas Aurora,Stephen G. Young,Kevin M. Shannon

View Articletitled, Hematologic effects of inactivating the Ras processing enzymeRce1

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Cellular response to hypoxia involves signaling via Smad proteins

Hong Zhang,Hasan O. Akman,Eric L. P. Smith,Jin Zhao,Joanne E. Murphy-Ullrich, M. A. Q. Siddiqui,Olcay A. Batuman

View Articletitled, Cellular response to hypoxia involves signaling via Smad proteins

A chemically defined culture of VEGFR2⁺ cells derived from embryonic stem cells reveals the role of VEGFR1 in tuning the threshold for VEGF in developing endothelial cells

Masanori Hirashima,Minetaro Ogawa,Satomi Nishikawa,Kazuyoshi Matsumura,Kotomi Kawasaki,Masabumi Shibuya,Shin-Ichi Nishikawa

View Articletitled, A chemically defined culture of VEGFR2+ cells derived from embryonic stem cells reveals the role of VEGFR1 in tuning the threshold for VEGF in developing endothelial cells

Two novel mutations in the αIIb calcium-binding domains identify hydrophobic regions essential for αIIbβ3 biogenesis

W. Beau Mitchell,Ji Hong Li,Fiza Singh,Alan D. Michelson,James Bussel,Barry S. Coller,Deborah L. French

View Articletitled, Two novel mutations in the αIIb calcium-binding domains identify hydrophobic regions essential for αIIbβ3 biogenesis

Gla domain–mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding

Yong-Hui Sun,Lei Shen,Björn Dahlbäck

View Articletitled, Gla domain–mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding

Transcript profiling of human platelets using microarray and serial analysis of gene expression

Dmitri V. Gnatenko,John J. Dunn,Sean R. McCorkle,David Weissmann,Peter L. Perrotta,Wadie F. Bahou

View Articletitled, Transcript profiling of human platelets using microarray and serial analysis of gene expression

IMMUNOBIOLOGY

IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates

Terry J. Fry,Marcin Moniuszko,Stephen Creekmore,Susan J. Donohue,Daniel C. Douek,Steven Giardina,Toby T. Hecht,Brenna J. Hill,Kristen Komschlies,Joseph Tomaszewski,Genoveffa Franchini,Crystal L. Mackall

View Articletitled, IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates

T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites

Shigeto Yoshida,Tominari Kobayashi,Hiroyuki Matsuoka,Chisato Seki,William L. Gosnell,Sandra P. Chang,Akira Ishii

View Articletitled, T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites

CD44-stimulated human B cells express transcripts specifically involved in immunomodulation and inflammation as analyzed by DNA microarrays

Carl-Magnus Högerkorp,Sven Bilke,Thomas Breslin,Sigurdur Ingvarsson,Carl A. K. Borrebaeck

View Articletitled, CD44-stimulated human B cells express transcripts specifically involved in immunomodulation and inflammation as analyzed by DNA microarrays

Granulocyte-colony stimulating factor increases CD123^hi blood dendritic cells with altered CD62L and CCR7 expression
Clinical Trials & Observations Brief Report

Slavica Vuckovic,Min Kim,Dailal Khalil,Cameron J. Turtle,Georgina V. Crosbie,Noel Williams,Len Brown,Katrina Williams,Cathryn Kelly,Penny Stravos,Robyn Rodwell,Geoff R. Hill,Susan Wright,Kerry Taylor,Devinder Gill,Paula Marlton,Ken Bradstock,Derek N. J. Hart

View Articletitled, Granulocyte-colony stimulating factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expression

Tolerance induction to a mammalian blood group–like carbohydrate antigen by syngeneic lymphocytes expressing the antigen
Brief Report

Haruko Ogawa,Deng-Ping Yin,Jikun Shen,Uri Galili

View Articletitled, Tolerance induction to a mammalian blood group–like carbohydrate antigen by syngeneic lymphocytes expressing the antigen

NEOPLASIA

Potentiation of TRAIL-induced apoptosis in primary effusion lymphoma through azidothymidine-mediated inhibition of NF-κB
Clinical Trials & Observations

Subrata K. Ghosh,Charles Wood,Lawrence H. Boise,Abdul M. Mian,Vadim V. Deyev,Gerold Feuer,Ngoc L. Toomey,Nicole C. Shank,Lisa Cabral,Glen N. Barber,William J. Harrington, Jr

View Articletitled, Potentiation of TRAIL-induced apoptosis in primary effusion lymphoma through azidothymidine-mediated inhibition of NF-κB

Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia
Clinical Trials & Observations

Mı́riam Molina-Arcas,Beatriz Bellosillo,F. Javier Casado,Emili Montserrat,Joan Gil,Dolors Colomer,Marçal Pastor-Anglada

View Articletitled, Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia

T(14;18)(q32;q21) involving IGH andMALT1 is a frequent chromosomal aberration in MALT lymphoma
Clinical Trials & Observations

Berthold Streubel,Andrea Lamprecht,Judith Dierlamm,Lorenzo Cerroni,Manfred Stolte,German Ott,Markus Raderer,Andreas Chott

View Articletitled, T(14;18)(q32;q21) involving IGH andMALT1 is a frequent chromosomal aberration in MALT lymphoma

Comparison of anti-CD20 and anti-CD45 antibodies for conventional and pretargeted radioimmunotherapy of B-cell lymphomas

John M. Pagel,Nathan Hedin,Krishnan Subbiah,Damon Meyer,Robert Mallet,Donald Axworthy,Louis J. Theodore,D. Scott Wilbur,Dana C. Matthews,Oliver W. Press

View Articletitled, Comparison of anti-CD20 and anti-CD45 antibodies for conventional and pretargeted radioimmunotherapy of B-cell lymphomas

Low-penetrance genetic susceptibility and resistance loci implicated in the relative risk for radiation-induced acute myeloid leukemia in mice

Emma Boulton,Clare Cole,Abigail Knight,Helen Cleary,Roger Snowden,Mark Plumb

View Articletitled, Low-penetrance genetic susceptibility and resistance loci implicated in the relative risk for radiation-induced acute myeloid leukemia in mice

ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties

Federico Simone,Roger T. Luo,Paul E. Polak,Joseph J. Kaberlein,Michael J. Thirman

View Articletitled, ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties

A significant diffuse component predicts for inferior survival in grade 3 follicular lymphoma, but cytologic subtypes do not predict survival
Clinical Trials & Observations

Christine P. Hans,Dennis D. Weisenburger,Julie M. Vose,Lynette M. Hock,James C. Lynch,Patricia Aoun,Timothy C. Greiner,Wing C. Chan,Robert G. Bociek,Philip J. Bierman,James O. Armitage

View Articletitled, A significant diffuse component predicts for inferior survival in grade 3 follicular lymphoma, but cytologic subtypes do not predict survival

MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models

François-Xavier Mahon,Francis Belloc,Valérie Lagarde,Claudine Chollet,François Moreau-Gaudry,Josy Reiffers,John M. Goldman,Junia V. Melo

View Articletitled, MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models

A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains anIGH/MMSET fusion transcript
Clinical Trials & Observations Brief Report

Madhumita Santra,Fenghuang Zhan,Erming Tian,Bart Barlogie,John Shaughnessy, Jr

View Articletitled, A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains anIGH/MMSET fusion transcript

The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications
Brief Report

Nicholas Mitsiades,Constantine S. Mitsiades,Paul G. Richardson,Vassiliki Poulaki,Yu-Tzu Tai,Dharminder Chauhan,Galinos Fanourakis,Xuesong Gu,Charles Bailey,Marie Joseph,Towia A. Libermann,Robert Schlossman,Nikhil C. Munshi,Teru Hideshima,Kenneth C. Anderson

View Articletitled, The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications

PHAGOCYTES

Inhibition of microsomal glucose-6-phosphate transport in human neutrophils results in apoptosis: a potential explanation for neutrophil dysfunction in glycogen storage disease type 1b

Rosanna Leuzzi,Gábor Bánhegyi,Tamás Kardon,Paola Marcolongo,Piero-Leopoldo Capecchi,Hans-Joerg Burger,Angelo Benedetti,Rosella Fulceri

View Articletitled, Inhibition of microsomal glucose-6-phosphate transport in human neutrophils results in apoptosis: a potential explanation for neutrophil dysfunction in glycogen storage disease type 1b

Increased inflammation in lysozyme M–deficient mice in response to Micrococcus luteus and its peptidoglycan

Tomas Ganz,Victoria Gabayan,Hsiang-I Liao,Lide Liu,Ami Oren,Thomas Graf,Alexander M. Cole

View Articletitled, Increased inflammation in lysozyme M–deficient mice in response to Micrococcus luteus and its peptidoglycan

Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival

Andreas Villunger,Clare Scott,Philippe Bouillet,Andreas Strasser

View Articletitled, Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival

RED CELLS

Stroke risk in siblings with sickle cell anemia
Clinical Trials & Observations

M. Catherine Driscoll,Anne Hurlet,Lori Styles,Virgil McKie,Beatrice Files,Nancy Olivieri,Charles Pegelow,Brian Berman,Richard Drachtman,Kantilal Patel,Donald Brambilla

View Articletitled, Stroke risk in siblings with sickle cell anemia

Heparan sulfate on endothelial cells mediates the binding ofPlasmodium falciparum–infected erythrocytes via the DBL1α domain of PfEMP1

Anna M. Vogt,Antonio Barragan,Qijun Chen,Fred Kironde,Dorothe Spillmann,Mats Wahlgren

View Articletitled, Heparan sulfate on endothelial cells mediates the binding ofPlasmodium falciparum–infected erythrocytes via the DBL1α domain of PfEMP1

ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice

Jonathan W. Stocker,Lucia De Franceschi,Grant A. McNaughton-Smith,Roberto Corrocher,Yves Beuzard,Carlo Brugnara

View Articletitled, ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice

TRANSFUSION MEDICINE

The risk of hepatitis B virus infection by transfusion in Kumasi, Ghana
Clinical Trials & Observations

Jean-Pierre Allain,Daniel Candotti,Kate Soldan,Francis Sarkodie,Bruce Phelps,Cristina Giachetti,Venkatakrishna Shyamala,Francis Yeboah,Margaret Anokwa,Shirley Owusu-Ofori,Ohene Opare-Sem

View Articletitled, The risk of hepatitis B virus infection by transfusion in Kumasi, Ghana

Transfusion of pooled buffy coat platelet components prepared with photochemical pathogen inactivation treatment: the euroSPRITE trial
Clinical Trials & Observations

Dick van Rhenen,Hans Gulliksson,Jean-Pierre Cazenave,Derwood Pamphilon,Per Ljungman,Harald Klüter,Hans Vermeij,Mies Kappers-Klunne,Georgine de Greef,Michel Laforet,Bruno Lioure,Kathryn Davis,Stephane Marblie,Veronique Mayaudon,Jocelyne Flament,Maureen Conlan,Lily Lin,Peyton Metzel,Don Buchholz,Laurence Corash

View Articletitled, Transfusion of pooled buffy coat platelet components prepared with photochemical pathogen inactivation treatment: the euroSPRITE trial

TRANSPLANTATION

Anti-CD45–mediated cytoreduction to facilitate allogeneic stem cell transplantation

Gerald G. Wulf,Kang-Li Luo,Margaret A. Goodell,Malcolm K. Brenner

View Articletitled, Anti-CD45–mediated cytoreduction to facilitate allogeneic stem cell transplantation

Donor T cell–derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantation

Cornelius Schmaltz,Onder Alpdogan,Stephanie J. Muriglan,Barry J. Kappel,Jimmy A. Rotolo,Eric T. Ricchetti,Andrew S. Greenberg,Lucy M. Willis,George F. Murphy,James M. Crawford,Marcel R. M. van den Brink

View Articletitled, Donor T cell–derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantation

CORRESPONDENCE

Severe skin reaction to imatinib in a case of Philadelphia-positive acute lymphoblastic leukemia

Blanca Sanchez-Gonzalez,Jose C. Pascual-Ramirez,Pascual Fernandez-Abellan,Isabel Belinchon-Romero,Concepcion Rivas,Gloria Vegara-Aguilera

View Articletitled, Severe skin reaction to imatinib in a case of Philadelphia-positive acute lymphoblastic leukemia

No effect of fasting plasma total homocysteine on protein C activity in vitro

GianMarco Podda,Elena M. Faioni,Maddalena L. Zighetti,Marco Cattaneo

View Articletitled, No effect of fasting plasma total homocysteine on protein C activity in vitro

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Loss of BCL7A Permits IRF4 Transcriptional Activity and Cellular Growth in Multiple Myeloma

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Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement

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Safety and efficacy of rilzabrutinib vs placebo in adults with immune thrombocytopenia: the phase 3 LUNA3 study

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

ERRATA

PERSPECTIVE

RANK ligand and osteoprotegerin in myeloma bone disease Clinical Trials & Observations

REVIEW IN TRANSLATIONAL HEMATOLOGY

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML): Presented in part at the 42nd annual meeting of the American Society of Hematology, San Francisco, CA, December 1-5, 2000.46 Clinical Trials & Observations

Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease Clinical Trials & Observations

Overall and event-free survival are not improved by the use of myeloablative therapy following intensified chemotherapy in previously untreated patients with multiple myeloma: a prospective randomized phase 3 study Clinical Trials & Observations

High levels of BAX, low levels of MRP-1, and high platelets are independent predictors of response to imatinib in myeloid blast crisis of CML Clinical Trials & Observations Brief Report

Antithymocyte globulin has limited efficacy and substantial toxicity in unselected anemic patients with myelodysplastic syndrome Clinical Trials & Observations Brief Report

GENE THERAPY

Retrovirus-mediated IL-7 expression in leukemic dendritic cells generated from primary acute myelogenous leukemias enhances their functional properties Clinical Trials & Observations

HEMATOPOIESIS

Identification of an MIP-1α–binding heparan sulfate oligosaccharide that supports long-term in vitro maintenance of human LTC-ICs Brief Report

Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region Brief Report

Hematologic effects of inactivating the Ras processing enzymeRce1 Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

Granulocyte-colony stimulating factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expression Clinical Trials & Observations Brief Report

Tolerance induction to a mammalian blood group–like carbohydrate antigen by syngeneic lymphocytes expressing the antigen Brief Report

NEOPLASIA

Potentiation of TRAIL-induced apoptosis in primary effusion lymphoma through azidothymidine-mediated inhibition of NF-κB Clinical Trials & Observations

Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia Clinical Trials & Observations

T(14;18)(q32;q21) involving IGH andMALT1 is a frequent chromosomal aberration in MALT lymphoma Clinical Trials & Observations

A significant diffuse component predicts for inferior survival in grade 3 follicular lymphoma, but cytologic subtypes do not predict survival Clinical Trials & Observations

A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains anIGH/MMSET fusion transcript Clinical Trials & Observations Brief Report

The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications Brief Report