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INSIDE BLOOD

Is a complete response in CLL now a realistic goal?

Stephen H. Petersdorf

View Articletitled, Is a complete response in CLL now a realistic goal?

Thrombocytopenia induced by GPIIB/IIIA inhibitors

Richard Aster

View Articletitled, Thrombocytopenia induced by GPIIB/IIIA inhibitors

Thalassemic splice repair, delivered

John F. Tisdale

View Articletitled, Thalassemic splice repair, delivered

AML1-ETO contra PU.1: another way to block myeloid differentiation

Thomas Graf

View Articletitled, AML1-ETO contra PU.1: another way to block myeloid differentiation

BLOOD WORK

Spur-cell hemolytic anemia in severe alcoholic cirrhosis

View Articletitled, Spur-cell hemolytic anemia in severe alcoholic cirrhosis

EDITORIALS

A changing of the guard

Sanford J. Shattil, MD

View Articletitled, A changing of the guard

PLENARY PAPERS

Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712)

John C. Byrd,Bercedis L. Peterson,Vicki A. Morrison,Kathleen Park,Robert Jacobson,Eva Hoke,James W. Vardiman,Kanti Rai,Charles A. Schiffer,Richard A. Larson

View Articletitled, Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712)

PERSPECTIVE

Noninvasive measurement of iron: report of an NIDDK workshop
Clinical Trials & Observations

Gary M. Brittenham,David G. Badman

View Articletitled, Noninvasive measurement of iron: report of an NIDDK workshop

REVIEW ARTICLES

Factor V: a combination of Dr Jekyll and Mr Hyde

Kenneth G. Mann,Michael Kalafatis

View Articletitled, Factor V: a combination of Dr Jekyll and Mr Hyde

HOW I TREAT

How I treat heparin-induced thrombocytopenia and thrombosis
Clinical Trials & Observations

Barbara M. Alving

View Articletitled, How I treat heparin-induced thrombocytopenia and thrombosis

CHEMOKINES

CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway

Jens V. Stein,Silvia F. Soriano,Christine M'rini,César Nombela-Arrieta,Gonzalo González de Buitrago,José Miguel Rodrı́guez-Frade,Mario Mellado,Jean-Philippe Girard,Carlos Martı́nez-A.

View Articletitled, CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway

Heterologous cells cooperate to augment stem cell migration, homing, and engraftment

Gregor B. Adams,Karissa T. Chabner,Russell B. Foxall,Kathryn W. Weibrecht,Neil P. Rodrigues,David Dombkowski,Robert Fallon,Mark C. Poznansky,David T. Scadden

View Articletitled, Heterologous cells cooperate to augment stem cell migration, homing, and engraftment

Supplemental data

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Differential distribution and internal translation efficiency of hepatitis C virus quasispecies present in dendritic and liver cells
Clinical Trials & Observations

Julien Laporte,Christine Bain,Patrick Maurel,Genevieve Inchauspe,Henri Agut,Annie Cahour

View Articletitled, Differential distribution and internal translation efficiency of hepatitis C virus quasispecies present in dendritic and liver cells

Prospective testing for drug-dependent antibodies reduces the incidence of thrombocytopenia observed with the small molecule glycoprotein IIb/IIIa antagonist roxifiban: implications for the etiology of thrombocytopenia
Clinical Trials & Observations

Dietmar Seiffert,Andrew M. Stern,William Ebling,Richard J. Rossi,Yu Chen Barrett,Richard Wynn,Gregory F. Hollis,Bokang He,Cathy J. Kieras,Donna L. Pedicord,Debra A. Cromley,Tsushung A. Hua,Robert B. Stein,Robert N. Daly,Anthony Sferruzza,Henry J. Pieniaszek,Jeffrey T. Billheimer

View Articletitled, Prospective testing for drug-dependent antibodies reduces the incidence of thrombocytopenia observed with the small molecule glycoprotein IIb/IIIa antagonist roxifiban: implications for the etiology of thrombocytopenia

Early blast clearance by remission induction therapy is a major independent prognostic factor for both achievement of complete remission and long-term outcome in acute myeloid leukemia: data from the German AML Cooperative Group (AMLCG) 1992 Trial
Clinical Trials & Observations

Wolfgang Kern,Torsten Haferlach,Claudia Schoch,Helmut Löffler,Winfried Gassmann,Achim Heinecke,Maria Christina Sauerland,Wolfgang Berdel,Thomas Büchner,Wolfgang Hiddemann

View Articletitled, Early blast clearance by remission induction therapy is a major independent prognostic factor for both achievement of complete remission and long-term outcome in acute myeloid leukemia: data from the German AML Cooperative Group (AMLCG) 1992 Trial

High-dose cyclophosphamide with autologous lymphocyte–depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia
Clinical Trials & Observations

Richard D. Huhn,Patrick F. Fogarty,Ryotaro Nakamura,Elizabeth J. Read,Susan F. Leitman,Margaret E. Rick,Janice Kimball,Adeira Greene,Kristin Hansmann,Alois Gratwohl,Neal Young,A. John Barrett,Cynthia E. Dunbar

View Articletitled, High-dose cyclophosphamide with autologous lymphocyte–depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia

Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma
Clinical Trials & Observations

Lluı́s Colomo,Armando López-Guillermo,Marı́a Perales,Susana Rives,Antonio Martı́nez,Francesc Bosch,Dolors Colomer,Brunangelo Falini,Emili Montserrat,Elı́as Campo

View Articletitled, Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma

Early minimal residual disease (MRD) analysis during treatment of Philadelphia chromosome/Bcr-Abl–positive acute lymphoblastic leukemia with the Abl-tyrosine kinase inhibitor imatinib (STI571)
Clinical Trials & Observations

Urban J. Scheuring,Heike Pfeifer,Barbara Wassmann,Patrick Brück,Johannes Atta,Eduard K. Petershofen,Brigitte Gehrke,Harald Gschaidmeier,Dieter Hoelzer,Oliver G. Ottmann

View Articletitled, Early minimal residual disease (MRD) analysis during treatment of Philadelphia chromosome/Bcr-Abl–positive acute lymphoblastic leukemia with the Abl-tyrosine kinase inhibitor imatinib (STI571)

Relationship between hepatocellular injury and transfusional iron overload prior to and during iron chelation with desferrioxamine: a study in adult patients with acquired anemias
Clinical Trials & Observations

Peter D. Jensen,Finn T. Jensen,Thorkil Christensen,Johan L. Nielsen,Joergen Ellegaard

View Articletitled, Relationship between hepatocellular injury and transfusional iron overload prior to and during iron chelation with desferrioxamine: a study in adult patients with acquired anemias

Imatinib mesylate therapy in newly diagnosed patients with Philadelphia chromosome–positive chronic myelogenous leukemia: high incidence of early complete and major cytogenetic responses
Clinical Trials & Observations Brief Report

Hagop M. Kantarjian,Jorge E. Cortes,Susan O'Brien,Francis Giles,Guillermo Garcia-Manero,Stefan Faderl,Deborah Thomas,Sima Jeha,Mary Beth Rios,Laurie Letvak,Kathy Bochinski,Ralph Arlinghaus,Moshe Talpaz

View Articletitled, Imatinib mesylate therapy in newly diagnosed patients with Philadelphia chromosome–positive chronic myelogenous leukemia: high incidence of early complete and major cytogenetic responses

Acute sickle cell hepatopathy represents a potential contraindication for percutaneous liver biopsy
Clinical Trials & Observations Brief Report

Nada Zakaria,Alex Knisely,Bernard Portmann,Giorgina Mieli-Vergani,Julia Wendon,Roopen Arya,John Devlin

View Articletitled, Acute sickle cell hepatopathy represents a potential contraindication for percutaneous liver biopsy

GENE THERAPY

High-level expression of hemoglobin A in human thalassemic erythroid progenitor cells following lentiviral vector delivery of an antisense snRNA

Marla M. Vacek,Hong Ma,Federica Gemignani,Giuseppina Lacerra,Tal Kafri,Ryszard Kole

View Articletitled, High-level expression of hemoglobin A in human thalassemic erythroid progenitor cells following lentiviral vector delivery of an antisense snRNA

HEMATOPOIESIS

Reversibility of CD34 expression on human hematopoietic stem cells that retain the capacity for secondary reconstitution

Mo A. Dao,Jesusa Arevalo,Jan A. Nolta

View Articletitled, Reversibility of CD34 expression on human hematopoietic stem cells that retain the capacity for secondary reconstitution

An intrinsic thyrotropin-mediated pathway of TNF-α production by bone marrow cells

Heuy-Ching Wang,Jolene Dragoo,Qin Zhou,John R. Klein

View Articletitled, An intrinsic thyrotropin-mediated pathway of TNF-α production by bone marrow cells

Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis

Bing Liu,Yanxun Sun,Feizi Jiang,Shuangxi Zhang,Ying Wu,Yu Lan,Xiao Yang,Ning Mao

View Articletitled, Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis

Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood–derived CD34⁺ cells

Miranda Buitenhuis,Belinda Baltus,Jan-Willem J. Lammers,Paul J. Coffer,Leo Koenderman

View Articletitled, Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood–derived CD34+ cells

Interferon-γ switches monocyte differentiation from dendritic cells to macrophages

Yves Delneste,Peggy Charbonnier,Nathalie Herbault,Giovanni Magistrelli,Gersende Caron,Jean-Yves Bonnefoy,Pascale Jeannin

View Articletitled, Interferon-γ switches monocyte differentiation from dendritic cells to macrophages

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

An Arg760Cys mutation in the consensus sequence of the von Willebrand factor propeptide cleavage site is responsible for a new von Willebrand disease variant

Alessandra Casonato,Francesca Sartorello,Maria Grazia Cattini,Elena Pontara,Carmen Soldera,Antonella Bertomoro,Antonio Girolami

View Articletitled, An Arg760Cys mutation in the consensus sequence of the von Willebrand factor propeptide cleavage site is responsible for a new von Willebrand disease variant

Thrombogenicity of β₂-glycoprotein I–dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster

Milosz Jankowski,Ingrid Vreys,Christine Wittevrongel,Doris Boon,Jos Vermylen,Marc. F. Hoylaerts,Jef Arnout

View Articletitled, Thrombogenicity of β2-glycoprotein I–dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster

A new locus on chromosome 18 that influences normal variation in activated protein C resistance phenotype and factor VIII activity and its relation to thrombosis susceptibility

José Manuel Soria,Laura Almasy,Joan Carles Souto,Alfonso Buil,Elisabeth Martı́nez-Sánchez,José Mateo,Montserrat Borrell,William H. Stone,Mark Lathrop,Jordi Fontcuberta,John Blangero

View Articletitled, A new locus on chromosome 18 that influences normal variation in activated protein C resistance phenotype and factor VIII activity and its relation to thrombosis susceptibility

VEGFR-3 and CD133 identify a population of CD34⁺ lymphatic/vascular endothelial precursor cells

Petri Salven,Satu Mustjoki,Riitta Alitalo,Kari Alitalo,Shahin Rafii

View Articletitled, VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells

Arg2074Cys missense mutation in the C2 domain of factor V causing moderately severe factor V deficiency: molecular characterization by expression of the recombinant protein

Stefano Duga,Maria Claudia Montefusco,Rosanna Asselta,Massimo Malcovati,Flora Peyvandi,Elena Santagostino,Pier Mannuccio Mannucci,Maria Luisa Tenchini

View Articletitled, Arg2074Cys missense mutation in the C2 domain of factor V causing moderately severe factor V deficiency: molecular characterization by expression of the recombinant protein

IMMUNOBIOLOGY

T lymphocytes constitutively produce an interferonlike cytokine limitin characterized as a heat- and acid-stable and heparin-binding glycoprotein

Kenji Oritani,Seiichi Hirota,Taishirou Nakagawa,Isao Takahashi,Shin-ichiro Kawamoto,Masahide Yamada,Naoko Ishida,Toshihiko Kadoya,Yoshiaki Tomiyama,Paul W. Kincade,Yuji Matsuzawa

View Articletitled, T lymphocytes constitutively produce an interferonlike cytokine limitin characterized as a heat- and acid-stable and heparin-binding glycoprotein

Transendothelial migration leads to protection from starvation-induced apoptosis in CD34⁺CD14⁺circulating precursors: evidence for PECAM-1 involvement through Akt/PKB activation

Elisabetta Ferrero,Daniela Belloni,Paola Contini,Chiara Foglieni,Maria Elena Ferrero,Monica Fabbri,Alessandro Poggi,Maria Raffaella Zocchi

View Articletitled, Transendothelial migration leads to protection from starvation-induced apoptosis in CD34+CD14+circulating precursors: evidence for PECAM-1 involvement through Akt/PKB activation

LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level

Patrick Ducoroy,Olivier Micheau,Sylvain Perruche,Laurence Dubrez-Daloz,Daniel de Fornel,Patrick Dutartre,Philippe Saas,Eric Solary

View Articletitled, LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level

CTLA-4 is not restricted to the lymphoid cell lineage and can function as a target molecule for apoptosis induction of leukemic cells

Maria Pia Pistillo,Pier Luigi Tazzari,Giulio Lelio Palmisano,Ivana Pierri,Andrea Bolognesi,Francesca Ferlito,Paolo Capanni,Letizia Polito,Marina Ratta,Stefano Pileri,Milena Piccioli,Giuseppe Basso,Laura Rissotto,Roberto Conte,Marco Gobbi,Fiorenzo Stirpe,Giovanni Battista Ferrara

View Articletitled, CTLA-4 is not restricted to the lymphoid cell lineage and can function as a target molecule for apoptosis induction of leukemic cells

Early macrophage influx to sites of cutaneous granuloma formation is dependent on MIP-1α/β released from neutrophils recruited by mast cell–derived TNFα

Esther von Stebut,Martin Metz,Genevieve Milon,Jürgen Knop,Marcus Maurer

View Articletitled, Early macrophage influx to sites of cutaneous granuloma formation is dependent on MIP-1α/β released from neutrophils recruited by mast cell–derived TNFα

Differential chemokine expression profiles in human peripheral blood T lymphocytes: dependence on T-cell coreceptor and calcineurin signaling

Anthony D. Cristillo,Mirtha J. Macri,Barbara E. Bierer

View Articletitled, Differential chemokine expression profiles in human peripheral blood T lymphocytes: dependence on T-cell coreceptor and calcineurin signaling

Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic

Dong Zhang,Premlata Shankar,Zhan Xu,Brooke Harnisch,Gang Chen,Christoph Lange,Sandra J. Lee,Hernan Valdez,Michael M. Lederman,Judy Lieberman

View Articletitled, Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic

Regulation of Akt-dependent cell survival by Syk and Rac

Kun Jiang,Bin Zhong,Connie Ritchey,Danielle L. Gilvary,Elizabeth Hong-Geller,Sheng Wei,Julie Y. Djeu

View Articletitled, Regulation of Akt-dependent cell survival by Syk and Rac

Exogenous stress proteins enhance the immunogenicity of apoptotic tumor cells and stimulate antitumor immunity

Hanping Feng,Yi Zeng,Michael W. Graner,Anna Likhacheva,Emmanuel Katsanis

View Articletitled, Exogenous stress proteins enhance the immunogenicity of apoptotic tumor cells and stimulate antitumor immunity

Mac-1 (CD11b/CD18) is crucial for effective Fc receptor–mediated immunity to melanoma

Annemiek B. van Spriel,Heidi H. van Ojik,Annie Bakker,Marco J. H. Jansen,Jan G. J. van de Winkel

View Articletitled, Mac-1 (CD11b/CD18) is crucial for effective Fc receptor–mediated immunity to melanoma

NEOPLASIA

Interferon-α, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia

Andreas Burchert,Stefan Wölfl,Manuel Schmidt,Cornelia Brendel,Barbara Denecke,Dali Cai,Larissa Odyvanova,Tanja Lahaye,Martin C. Müller,Thomas Berg,Harald Gschaidmeier,Burghardt Wittig,Rüdiger Hehlmann,Andreas Hochhaus,Andreas Neubauer

View Articletitled, Interferon-α, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia

Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells

Marika Sarfati,Véronique Mateo,Sylvie Baudet,Manuel Rubio,Christine Fernandez,Fréderic Davi,Jacques-Louis Binet,Jozo Delic,Hélène Merle-Béral

View Articletitled, Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

Rajani K. Vangala,Marion S. Heiss-Neumann,Janki S. Rangatia,Sheo M. Singh,Claudia Schoch,Daniel G. Tenen,Wolfgang Hiddemann,Gerhard Behre

View Articletitled, The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

Rapamycin-induced G₁ arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin

Thomas Decker,Susanne Hipp,Ingo Ringshausen,Christian Bogner,Madlene Oelsner,Folker Schneller,Christian Peschel

View Articletitled, Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin

Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3)
Clinical Trials & Observations Brief Report

Géraldine Guasch,Cornel Popovici,Francine Mugneret,Max Chaffanet,Pierre Pontarotti,Daniel Birnbaum,Marie-Josèphe Pébusque

View Articletitled, Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3)

Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile
Brief Report

Kai Neben,Christian Giesecke,Silja Schweizer,Anthony D. Ho,Alwin Krämer

View Articletitled, Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile

Monoglycerides induce apoptosis in human leukemic cells while sparing normal peripheral blood mononuclear cells
Brief Report

Fabianne Philippoussis,Chantal Arguin,Véronique Mateo,Ann-Muriel Steff,Patrice Hugo

View Articletitled, Monoglycerides induce apoptosis in human leukemic cells while sparing normal peripheral blood mononuclear cells

PHAGOCYTES

Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-α–stimulated neutrophils

Chien-Ying Liu,Akihiro Takemasa,W. Conrad Liles,Richard B. Goodman,Mechthild Jonas,Henry Rosen,Emil Chi,Robert K. Winn,John M. Harlan,Peter I. Chuang

View Articletitled, Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-α–stimulated neutrophils

Essential role for ICSBP in the in vivo development of murine CD8α⁺ dendritic cells

Julio Aliberti,Oliver Schulz,Daniel J. Pennington,Hideki Tsujimura,Caetano Reis e Sousa,Keiko Ozato,Alan Sher

View Articletitled, Essential role for ICSBP in the in vivo development of murine CD8α+ dendritic cells

GA-binding protein (GABP) and Sp1 are required, along with retinoid receptors, to mediate retinoic acid responsiveness of CD18 (β₂ leukocyte integrin): a novel mechanism of transcriptional regulation in myeloid cells

Thomas S. Bush,Michele St. Coeur,Karen K. Resendes,Alan G. Rosmarin

View Articletitled, GA-binding protein (GABP) and Sp1 are required, along with retinoid receptors, to mediate retinoic acid responsiveness of CD18 (β2 leukocyte integrin): a novel mechanism of transcriptional regulation in myeloid cells

RED CELLS

Ribosomal protein S19 expression during erythroid differentiation

Lydie Da Costa,Goutham Narla,Thiébaut-Noel Willig,Luanne L. Peters,Marilyn Parra,Jason Fixler,Gil Tchernia,Narla Mohandas

View Articletitled, Ribosomal protein S19 expression during erythroid differentiation

Mutations in the murine erythroid α-spectrin gene alter spectrin mRNA and protein levels and spectrin incorporation into the red blood cell membrane skeleton

Nancy J. Wandersee,Connie S. Birkenmeier,David M. Bodine,Narla Mohandas,Jane E. Barker

View Articletitled, Mutations in the murine erythroid α-spectrin gene alter spectrin mRNA and protein levels and spectrin incorporation into the red blood cell membrane skeleton

Recombinant PfEMP1 peptide inhibits and reverses cytoadherence of clinical Plasmodium falciparum isolates in vivo

Bryan G. Yipp,Dror I. Baruch,Ciaran Brady,Allan G. Murray,Sornchai Looareesuwan,Paul Kubes,May Ho

View Articletitled, Recombinant PfEMP1 peptide inhibits and reverses cytoadherence of clinical Plasmodium falciparum isolates in vivo

Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47: Presented in part at the 43rd Annual Meeting of the American Society of Hematology, Orlando, FL, December 7-11, 2001.⁴⁶

Isabelle Mouro-Chanteloup,Jean Delaunay,Pierre Gane,Virginie Nicolas,Mette Johansen,Eric J. Brown,Luanne L. Peters,Caroline Le Van Kim,Jean Pierre Cartron,Yves Colin

View Articletitled, Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47: Presented in part at the 43rd Annual Meeting of the American Society of Hematology, Orlando, FL, December 7-11, 2001.46

HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia
Brief Report

Richard van Wijk,Gert Rijksen,Eric G. Huizinga,Hendrik K. Nieuwenhuis,Wouter W. van Solinge

View Articletitled, HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia

Hypoxic up-regulation of erythroid 5-aminolevulinate synthase
Brief Report

Thomas Hofer,Roland H. Wenger,Marianne F. Kramer,Gloria C. Ferreira,Max Gassmann

View Articletitled, Hypoxic up-regulation of erythroid 5-aminolevulinate synthase

TRANSPLANTATION

Comprehensive banking of sibling donor cord blood for children with malignant and nonmalignant disease

William Reed,Renée Smith,Florinna Dekovic,Joanna Y. Lee,Julie D. Saba,Elizabeth Trachtenberg,Joanna Epstein,Steffany Haaz,Mark C. Walters,Bertram H. Lubin

View Articletitled, Comprehensive banking of sibling donor cord blood for children with malignant and nonmalignant disease

Homeostasis of telomere length rather than telomere shortening after allogeneic peripheral blood stem cell transplantation

Helene Roelofs,Elmar S. D. de Pauw,Aeilko H. Zwinderman,Sonja M. Opdam,Roel Willemze,Hans J. Tanke,Willem E. Fibbe

View Articletitled, Homeostasis of telomere length rather than telomere shortening after allogeneic peripheral blood stem cell transplantation

A novel rapid single nucleotide polymorphism (SNP)–based method for assessment of hematopoietic chimerism after allogeneic stem cell transplantation

Ephraim P. Hochberg,David B. Miklos,Donna Neuberg,Daniel A. Eichner,Stephen F. McLaughlin,Alex Mattes-Ritz,Edwin P. Alyea,Joseph H. Antin,Robert J. Soiffer,Jerome Ritz

View Articletitled, A novel rapid single nucleotide polymorphism (SNP)–based method for assessment of hematopoietic chimerism after allogeneic stem cell transplantation

CORRESPONDENCE

Leukocyte reduction and HTLV-I: is the glass half empty or half full?

Barry Wenz,Girolamo A. Ortolano

View Articletitled, Leukocyte reduction and HTLV-I: is the glass half empty or half full?

Factor XIII activation by thrombin depends on FXIIIVal34Leu genotype

Verena Schroeder,Hans P. Kohler

View Articletitled, Factor XIII activation by thrombin depends on FXIIIVal34Leu genotype

Iron status indicators: hello new, goodbye old?

Ivor A. Cavill

View Articletitled, Iron status indicators: hello new, goodbye old?

Donor lymphocyte infusions as primary therapy for neoplasms

Vittorio Montefusco

View Articletitled, Donor lymphocyte infusions as primary therapy for neoplasms

p14^ARF,p15^INK4b, and p16^INK4amethylation status in chronic myelogenous leukemia

Sophie Kusy,Marie Cividin,Nathalie Sorel,Françoise Brizard,François Guilhot,André Brizard,Christian Larsen,Joëlle Roche

View Articletitled, p14ARF,p15INK4b, and p16INK4amethylation status in chronic myelogenous leukemia

Telomere length in peripheral blood granulocytes reflects response to treatment with imatinib in patients with chronic myeloid leukemia

Tim H. Brümmendorf,Inci Ersöz,Ulrike Hartmann,Kerol Bartolovic,Stefan Balabanov,Alexandra Wahl,Peter Paschka,Sebastian Kreil,Tanja Lahaye,Ute Berger,Harald Gschaidmeier,Carsten Bokemeyer,Rüdiger Hehlmann,Klaus Dietz,Peter M. Lansdorp,Lothar Kanz,Andreas Hochhaus

View Articletitled, Telomere length in peripheral blood granulocytes reflects response to treatment with imatinib in patients with chronic myeloid leukemia

The role of interleukin-3 and stem cell factor in classical Hodgkin disease

Donatella Aldinucci,Valter Gattei

View Articletitled, The role of interleukin-3 and stem cell factor in classical Hodgkin disease

Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

EDITORIALS

PLENARY PAPERS

PERSPECTIVE

Noninvasive measurement of iron: report of an NIDDK workshop Clinical Trials & Observations

REVIEW ARTICLES

HOW I TREAT

How I treat heparin-induced thrombocytopenia and thrombosis Clinical Trials & Observations

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Differential distribution and internal translation efficiency of hepatitis C virus quasispecies present in dendritic and liver cells Clinical Trials & Observations

Prospective testing for drug-dependent antibodies reduces the incidence of thrombocytopenia observed with the small molecule glycoprotein IIb/IIIa antagonist roxifiban: implications for the etiology of thrombocytopenia Clinical Trials & Observations

Early blast clearance by remission induction therapy is a major independent prognostic factor for both achievement of complete remission and long-term outcome in acute myeloid leukemia: data from the German AML Cooperative Group (AMLCG) 1992 Trial Clinical Trials & Observations

High-dose cyclophosphamide with autologous lymphocyte–depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia Clinical Trials & Observations

Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma Clinical Trials & Observations

Early minimal residual disease (MRD) analysis during treatment of Philadelphia chromosome/Bcr-Abl–positive acute lymphoblastic leukemia with the Abl-tyrosine kinase inhibitor imatinib (STI571) Clinical Trials & Observations

Relationship between hepatocellular injury and transfusional iron overload prior to and during iron chelation with desferrioxamine: a study in adult patients with acquired anemias Clinical Trials & Observations

Imatinib mesylate therapy in newly diagnosed patients with Philadelphia chromosome–positive chronic myelogenous leukemia: high incidence of early complete and major cytogenetic responses Clinical Trials & Observations Brief Report

Acute sickle cell hepatopathy represents a potential contraindication for percutaneous liver biopsy Clinical Trials & Observations Brief Report