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Volume 100, Issue 9

November 1 2002

In this Issue

INSIDE BLOOD
PLENARY PAPERS
REVIEW ARTICLES
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

Myeloma therapy: from the bench to the clinic

Mohamad A. Hussein

View Articletitled, Myeloma therapy: from the bench to the clinic

Curtailing BCR signaling

René A. W. van Lier,Marinus J. H. van Oers

View Articletitled, Curtailing BCR signaling

PLENARY PAPERS

Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
Clinical Trials & Observations

Paul G. Richardson,Robert L. Schlossman,Edie Weller,Teru Hideshima,Constantine Mitsiades,Faith Davies,Richard LeBlanc,Laurence P. Catley,Deborah Doss,Kathleen Kelly,Mary McKenney,Julie Mechlowicz,Andrea Freeman,Reggie Deocampo,Rebecca Rich,Joan J. Ryoo,Dharminder Chauhan,Kathe Balinski,Jerome Zeldis,Kenneth C. Anderson

View Articletitled, Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma

The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis

Mark S. Cragg,H. T. Claude Chan,Mathew D. Fox,Alison Tutt,Aimée Smith,David G. Oscier,Terry J. Hamblin,Martin J. Glennie

View Articletitled, The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis

REVIEW ARTICLES

Locus control regions

Qiliang Li,Kenneth R. Peterson,Xiangdong Fang,George Stamatoyannopoulos

View Articletitled, Locus control regions

CHEMOKINES

Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal–regulated kinase pathway but not by the phosphatidylinositol 3–kinase pathway

Eric Sulpice,Marijke Bryckaert,Julie Lacour,Jean-Olivier Contreres,Gerard Tobelem

View Articletitled, Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal–regulated kinase pathway but not by the phosphatidylinositol 3–kinase pathway

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Flow cytometric disease monitoring in multiple myeloma: the relationship between normal and neoplastic plasma cells predicts outcome after transplantation
Clinical Trials & Observations

Andy C. Rawstron,Faith E. Davies,Ranjit DasGupta,A. John Ashcroft,Russell Patmore,Mark T. Drayson,Roger G. Owen,Andrew S. Jack,J. Anthony Child,Gareth J. Morgan

View Articletitled, Flow cytometric disease monitoring in multiple myeloma: the relationship between normal and neoplastic plasma cells predicts outcome after transplantation

Phase 1 trial of the novel bispecific molecule H22xKi-4 in patients with refractory Hodgkin lymphoma
Clinical Trials & Observations

Peter Borchmann,Roland Schnell,Irene Fuss,Oliver Manzke,Thomas Davis,Lionel D. Lewis,Detlev Behnke,Claudia Wickenhauser,Petra Schiller,Volker Diehl,Andreas Engert

View Articletitled, Phase 1 trial of the novel bispecific molecule H22xKi-4 in patients with refractory Hodgkin lymphoma

The toxicity and efficacy of donor lymphocyte infusions given after reduced-intensity conditioning allogeneic stem cell transplantation
Clinical Trials & Observations

David I. Marks,Richard Lush,Jamie Cavenagh,Donald W. Milligan,Steven Schey,Anne Parker,Fiona J. Clark,Linda Hunt,John Yin,Steven Fuller,Elisabeth Vandenberghe,Judith Marsh,Timothy Littlewood,Graeme M. Smith,Dominic Culligan,Ann Hunter,Rajesh Chopra,Andrew Davies,Keiren Towlson,Catherine D. Williams

View Articletitled, The toxicity and efficacy of donor lymphocyte infusions given after reduced-intensity conditioning allogeneic stem cell transplantation

Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia
Clinical Trials & Observations

Holger Schulz,Saskia Karina Klein,Ute Rehwald,Marcel Reiser,Axel Hinke,Wolfgang-Ulrich Knauf,Walter-Erich Aulitzky,Manfred Hensel,Michael Herold,Dieter Huhn,Michael Hallek,Volker Diehl,Andreas Engert,on behalf of the German CLL Study Group (GCLLSG)

View Articletitled, Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia

Nonmyeloablative transplantation with or without alemtuzumab: comparison between 2 prospective studies in patients with lymphoproliferative disorders
Clinical Trials & Observations

José A. Pérez-Simón,Panagiotis D. Kottaridis,Rodrigo Martino,Charles Craddock,Dolores Caballero,Raj Chopra,Javier Garcı́a-Conde,Don W. Milligan,Stephen Schey,Alvaro Urbano-Ispizua,Anne Parker,Angel Leon,Kwee Yong,Ana Sureda,Ann Hunter,Jordi Sierra,Anthony H. Goldstone,David C. Linch,Jesus F. San Miguel,Stephen Mackinnon,for the Spanish and United Kingdom Collaborative Groups for Nonmyeloablative Transplantation

View Articletitled, Nonmyeloablative transplantation with or without alemtuzumab: comparison between 2 prospective studies in patients with lymphoproliferative disorders

Chronic graft-versus-host disease after allogeneic blood stem cell transplantation: long-term results of a randomized study
Clinical Trials & Observations

Mohamad Mohty,Mathieu Kuentz,Mauricette Michallet,Jean-Henri Bourhis,Noël Milpied,Laurent Sutton,Jean-Pierre Jouet,Michel Attal,Pierre Bordigoni,Jean-Yves Cahn,Jean-Michel Boiron,Didier Blaise,for the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)

View Articletitled, Chronic graft-versus-host disease after allogeneic blood stem cell transplantation: long-term results of a randomized study

Hematopoietic stem cell transplantation for de novo erythroleukemia: a study of the European Group for Blood and Marrow Transplantation (EBMT)
Clinical Trials & Observations

Loı̈c Fouillard,Myriam Labopin,Norbert-Claude Gorin,Emmanuelle Polge,Hugh Grant Prentice,Giovanna Meloni,Josy Reiffers,Arnaud Pigneux,Roel Willemze,Anton Schattenberg,Simona Sica,Monique Lagrange,Odile Fenneteau,Christine Perot,Francesco Frassoni,for the Acute Leukemia Working Party of the EBMT

View Articletitled, Hematopoietic stem cell transplantation for de novo erythroleukemia: a study of the European Group for Blood and Marrow Transplantation (EBMT)

Induction therapy with idarubicin alone significantly influences event-free survival duration in patients with newly diagnosed hypergranular acute promyelocytic leukemia: final results of the GIMEMA randomized study LAP 0389 with 7 years of minimal follow-up
Clinical Trials & Observations

Giuseppe Avvisati,Maria Concetta Petti,Francesco Lo-Coco,Maria Luce Vegna,Sergio Amadori,Michele Baccarani,Nicola Cantore,Eros Di Bona,Felicetto Ferrara,Giuseppe Fioritoni,Eugenio Gallo,Rosangela Invernizzi,Mario Lazzarino,Vincenzo Liso,Guglielmo Mariani,Francesco Ricciuti,Carmine Selleri,Simona Sica,Dino Veneri,Franco Mandelli,for the Italian Cooperative Group GIMEMA (Gruppo Italiano Malattie Ematologiche dell'Adulto)

View Articletitled, Induction therapy with idarubicin alone significantly influences event-free survival duration in patients with newly diagnosed hypergranular acute promyelocytic leukemia: final results of the GIMEMA randomized study LAP 0389 with 7 years of minimal follow-up

GENE THERAPY

Transduction of donor hematopoietic stem-progenitor cells with Fas ligand enhanced short-term engraftment in a murine model of allogeneic bone marrow transplantation

Katharine A. Whartenby,Erin E. Straley,Heeje Kim,Frederick Racke,Vivek Tanavde,Kevin S. Gorski,Linzhao Cheng,Drew M. Pardoll,Curt I. Civin

View Articletitled, Transduction of donor hematopoietic stem-progenitor cells with Fas ligand enhanced short-term engraftment in a murine model of allogeneic bone marrow transplantation

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

Nicole M. Haynes,Joseph A. Trapani,Michèle W. L. Teng,Jacob T. Jackson,Loretta Cerruti,Stephen M. Jane,Michael H. Kershaw,Mark J. Smyth,Phillip K. Darcy

View Articletitled, Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

HEMATOPOIESIS

Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors

Caroline A. Evans,Shahrul Ariffin,Andrew Pierce,Anthony D. Whetton

View Articletitled, Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors

NOD/SCID/γ $_{c}^{null}$ mouse: an excellent recipient mouse model for engraftment of human cells

Mamoru Ito,Hidefumi Hiramatsu,Kimio Kobayashi,Kazutomo Suzue,Mariko Kawahata,Kyoji Hioki,Yoshito Ueyama,Yoshio Koyanagi,Kazuo Sugamura,Kohichiro Tsuji,Toshio Heike,Tatsutoshi Nakahata

View Articletitled, NOD/SCID/γ<math xmlns="http://www.w3.org/1998/Math/MathML"><msubsup xmlns=""><mrow></mrow><mrow><mtext>c</mtext></mrow><mrow><mtext>null</mtext></mrow></msubsup></math> mouse: an excellent recipient mouse model for engraftment of human cells

Activation of Rac-1, Rac-2, and Cdc42 by hemopoietic growth factors or cross-linking of the B-lymphocyte receptor for antigen

Brock Grill,John W. Schrader

View Articletitled, Activation of Rac-1, Rac-2, and Cdc42 by hemopoietic growth factors or cross-linking of the B-lymphocyte receptor for antigen

Emergence of muscle and neural hematopoiesis in humans

Karen E. Jay,Lisa Gallacher,Mickie Bhatia

View Articletitled, Emergence of muscle and neural hematopoiesis in humans

Identification of the hemangioblast in postnatal life

Elvira Pelosi,Mauro Valtieri,Simona Coppola,Rosanna Botta,Marco Gabbianelli,Valentina Lulli,Giovanna Marziali,Barbara Masella,Robert Müller,Cecilia Sgadari,Ugo Testa,Giuseppina Bonanno,Cesare Peschle

View Articletitled, Identification of the hemangioblast in postnatal life

Genomic and proteomic analysis of the myeloid differentiation program: global analysis of gene expression during induced differentiation in the MPRO cell line

Zheng Lian,Yuval Kluger,Dov S. Greenbaum,David Tuck,Mark Gerstein,Nancy Berliner,Sherman M. Weissman,Peter E. Newburger

View Articletitled, Genomic and proteomic analysis of the myeloid differentiation program: global analysis of gene expression during induced differentiation in the MPRO cell line

Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis

David S. Grenda,Sonja E. Johnson,Jill R. Mayer,Morgan L. McLemore,Kathleen F. Benson,Marshall Horwitz,Daniel C. Link

View Articletitled, Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K–dependent clotting factors to the centromeric region of chromosome 16

Andreas Fregin,Simone Rost,Werner Wolz,Alice Krebsova,Clemens R. Muller,Johannes Oldenburg

View Articletitled, Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K–dependent clotting factors to the centromeric region of chromosome 16

LPS-induced platelet response and rapid shock in mice: contribution of O-antigen region of LPS and involvement of the lectin pathway of the complement system

Lijuan Zhao,Yuko Ohtaki,Kouji Yamaguchi,Misao Matsushita,Teizo Fujita,Takashi Yokochi,Haruhiko Takada,Yasuo Endo

View Articletitled, LPS-induced platelet response and rapid shock in mice: contribution of O-antigen region of LPS and involvement of the lectin pathway of the complement system

Protection against thrombosis in mice lacking PAR3

Ethan J. Weiss,Justin R. Hamilton,Katy E. Lease,Shaun R. Coughlin

View Articletitled, Protection against thrombosis in mice lacking PAR3

Kallistatin is a new inhibitor of angiogenesis and tumor growth

Robert Q. Miao,Jun Agata,Lee Chao,Julie Chao

View Articletitled, Kallistatin is a new inhibitor of angiogenesis and tumor growth

IMMUNOBIOLOGY

Role of 4-1BB (CD137) in the functional activation of cord blood CD28⁻CD8⁺ T cells

Young-June Kim,Randy R. Brutkiewicz,Hal E. Broxmeyer

View Articletitled, Role of 4-1BB (CD137) in the functional activation of cord blood CD28−CD8+ T cells

Anti-μ-opioid-receptor IgG antibodies are commonly present in serum from healthy blood donors: evidence for a role in apoptotic immune cell death

Gaëtane Macé,Martial Jaume,Catherine Blanpied,Lionel Stephan,Jérôme D. Coudert,Philippe Druet,Gilles Dietrich

View Articletitled, Anti-μ-opioid-receptor IgG antibodies are commonly present in serum from healthy blood donors: evidence for a role in apoptotic immune cell death

Regulation of thymic epithelium by keratinocyte growth factor

Matthew Erickson,Stanislaw Morkowski,Sophie Lehar,Geoffrey Gillard,Courtney Beers,James Dooley,Jeffrey S. Rubin,Alexander Rudensky,Andrew G. Farr

View Articletitled, Regulation of thymic epithelium by keratinocyte growth factor

Mouse T cells receive costimulatory signals from LIGHT, a TNF family member

Guixiu Shi,Hongyu Luo,Xiaochun Wan,Theodora W. Salcedo,Jun Zhang,Jiangping Wu

View Articletitled, Mouse T cells receive costimulatory signals from LIGHT, a TNF family member

Sézary syndrome patients demonstrate a defect in dendritic cell populations: effects of CD40 ligand and treatment with GM-CSF on dendritic cell numbers and the production of cytokines

Maria Wysocka,Mohamed H. Zaki,Lars E. French,Jihed Chehimi,Michael Shapiro,Suzanne E. Everetts,Karen S. McGinnis,Luis Montaner,Alain H. Rook

View Articletitled, Sézary syndrome patients demonstrate a defect in dendritic cell populations: effects of CD40 ligand and treatment with GM-CSF on dendritic cell numbers and the production of cytokines

Subtractive hybridization reveals the expression of immunoglobulinlike transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells

Marie-Clotilde Rissoan,Thomas Duhen,Jean-Michel Bridon,Nathalie Bendriss-Vermare,Catherine Péronne,Blandine de Saint Vis,Francine Brière,Elizabeth E. M. Bates

View Articletitled, Subtractive hybridization reveals the expression of immunoglobulinlike transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells

Expression of rat complement control protein Crry on tumor cells inhibits rat natural killer cell–mediated cytotoxicity

Theresa A. Caragine,Masaki Imai,Alan B. Frey,Stephen Tomlinson

View Articletitled, Expression of rat complement control protein Crry on tumor cells inhibits rat natural killer cell–mediated cytotoxicity

NEOPLASIA

In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway

Manik Chatterjee,Dirk Hönemann,Suzanne Lentzsch,Kurt Bommert,Christine Sers,Pia Herrmann,Stephan Mathas,Bernd Dörken,Ralf C. Bargou

View Articletitled, In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway

The histone deacetylase inhibitor AN-9 has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines

Ayse Batova,Li-en Shao,Mitchell B. Diccianni,Alice L.Yu, Tetsuya Tanaka,Ada Rephaeli,Abraham Nudelman,John Yu

View Articletitled, The histone deacetylase inhibitor AN-9 has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines

Binding of Sp1 to the proximal promoter links constitutive expression of the human uPA gene and invasive potential of PC3 cells

Inés Ibañez-Tallon,Carmelo Ferrai,Elena Longobardi,Ileana Facetti,Francesco Blasi,Massimo P. Crippa

View Articletitled, Binding of Sp1 to the proximal promoter links constitutive expression of the human uPA gene and invasive potential of PC3 cells

Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6–independent mechanism

Yun Dai,Terry H. Landowski,Steven T. Rosen,Paul Dent,Steven Grant

View Articletitled, Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6–independent mechanism

Prognostic value of enhanced bone marrow angiogenesis in early B-cell chronic lymphocytic leukemia

Stefano Molica,Angelo Vacca,Domenico Ribatti,Antonio Cuneo,Francesco Cavazzini,Domenico Levato,Gaetano Vitelli,Luigi Tucci,Aldo M. Roccaro,Franco Dammacco

View Articletitled, Prognostic value of enhanced bone marrow angiogenesis in early B-cell chronic lymphocytic leukemia

Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities

Christian M. Zwaan,Gertjan J. L. Kaspers,Rob Pieters,Karel Hählen,Dieuwke R. Huismans,Martin Zimmermann,Jochen Harbott,Rosalyn M. Slater,Ursala Creutzig,Anjo J. P. Veerman

View Articletitled, Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities

Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model

William W. Spurbeck,Catherine Y. C. Ng,Ted S. Strom,Elio F. Vanin,Andrew M. Davidoff

View Articletitled, Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model

Clonal heterogeneity in mycosis fungoides and its relationship to clinical course

Francisco Vega,Rajyalakshmi Luthra,L. Jeffrey Medeiros,Valerie Dunmire,Sang-Joon Lee,Madeleine Duvic,Dan Jones

View Articletitled, Clonal heterogeneity in mycosis fungoides and its relationship to clinical course

PHAGOCYTES

The Src homology 2 domain–containing inositol 5-phosphatase negatively regulates Fcγ receptor–mediated phagocytosis through immunoreceptor tyrosine-based activation motif–bearing phagocytic receptors

Koji Nakamura,Alexander Malykhin,K. Mark Coggeshall

View Articletitled, The Src homology 2 domain–containing inositol 5-phosphatase negatively regulates Fcγ receptor–mediated phagocytosis through immunoreceptor tyrosine-based activation motif–bearing phagocytic receptors

Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis

Raymond J. Coakley,Clifford Taggart,Noel G. McElvaney,Shane J. O'Neill

View Articletitled, Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis

RED CELLS

Phorbol ester stimulates a protein kinase C–mediated agatoxin-TK–sensitive calcium permeability pathway in human red blood cells

Dina A. Andrews,Lu Yang,Philip S. Low

View Articletitled, Phorbol ester stimulates a protein kinase C–mediated agatoxin-TK–sensitive calcium permeability pathway in human red blood cells

TRANSPLANTATION

Combined effects of calcineurin inhibitors or sirolimus with anti-CD40L mAb on alloengraftment under nonmyeloablative conditions

Patricia A. Taylor,Christopher J. Lees,Jessica M. Wilson,Michael J. Ehrhardt,Matthew T. Campbell,Randolph J. Noelle,Bruce R. Blazar

View Articletitled, Combined effects of calcineurin inhibitors or sirolimus with anti-CD40L mAb on alloengraftment under nonmyeloablative conditions

Donor-lymphocyte infusion induces transplantation tolerance by activating systemic and graft-infiltrating double-negative regulatory T cells

Kevin J. Young,Liming Yang,M. James Phillips,Li Zhang

View Articletitled, Donor-lymphocyte infusion induces transplantation tolerance by activating systemic and graft-infiltrating double-negative regulatory T cells

BRIEF REPORTS

KSHV- and EBV-associated germinotropic lymphoproliferative disorder
Brief Report

Ming-Qing Du,Tim C. Diss,Hongxiang Liu,Hongtao Ye,Rifat A. Hamoudi,José Cabeçadas,Henry Y. Dong,Nancy Lee Harris,John K. C. Chan,John W. Rees,Ahmet Dogan,Peter G. Isaacson

View Articletitled, KSHV- and EBV-associated germinotropic lymphoproliferative disorder

Chronic lymphocytic leukemia preceded by cold agglutinin disease: intraclonal immunoglobulin light-chain diversity inV_H4-34 expressing single leukemic B cells
Brief Report

Sarka Ruzickova,Axel Pruss,Marcus Odendahl,Karsten Wolbart,Gerd-Rüdiger Burmester,Jürgen Scholze,Thomas Dörner,Arne Hansen

View Articletitled, Chronic lymphocytic leukemia preceded by cold agglutinin disease: intraclonal immunoglobulin light-chain diversity inVH4-34 expressing single leukemic B cells

A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia
Brief Report

Karsten Spiekermann,Ksenia Bagrintseva,Claudia Schoch,Torsten Haferlach,Wolfgang Hiddemann,Susanne Schnittger

View Articletitled, A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia

Rituximab in the treatment of acquired factor VIII inhibitors
Clinical Trials & Observations Brief Report

Adrian Wiestner,Hearn J. Cho,Adam S. Asch,Mary Ann Michelis,Jack A. Zeller,Ellinor I. B. Peerschke,Babette B. Weksler,Geraldine P. Schechter

View Articletitled, Rituximab in the treatment of acquired factor VIII inhibitors

Interleukin 18 preserves a perforin-dependent graft-versus-leukemia effect after allogeneic bone marrow transplantation
Brief Report

Pavan Reddy,Takanori Teshima,Gerhard Hildebrandt,Ulrich Duffner,Yoshinobu Maeda,Kenneth R. Cooke,James L. M. Ferrara

View Articletitled, Interleukin 18 preserves a perforin-dependent graft-versus-leukemia effect after allogeneic bone marrow transplantation

CORRESPONDENCE

Intron 1 factor VIII gene inversion in a population of Italian hemophilia A patients

Federica Riccardi,Annarita Tagliaferri,Cesare Manotti,Corrado Pattacini,Tauro Maria Neri

View Articletitled, Intron 1 factor VIII gene inversion in a population of Italian hemophilia A patients

Lack of p21^CIP1 DNA methylation in acute lymphocytic leukemia

LanLan Shen,Yutaka Kondo,Jean-Pierre Issa,Guillermo Garcia-Manero

View Articletitled, Lack of p21CIP1 DNA methylation in acute lymphocytic leukemia

Managing cutaneous reactions to imatinib therapy

Simon A. J. Rule,Stephen G. O'Brien,Lucy C. Crossman

View Articletitled, Managing cutaneous reactions to imatinib therapy

Cytogenetic characterization reveals that the SAM-1 erythroid cell line is derived from K-562 cells

Sara Alvarez,Donal MacGrogan,Sandra Rodriguez-Perales,Angel Martinez-Ramirez,Miguel Urioste,Javier Benitez,Stephen D. Nimer,Juan C. Cigudosa

View Articletitled, Cytogenetic characterization reveals that the SAM-1 erythroid cell line is derived from K-562 cells

Adult acute myeloid leukemia cells do not express nonfunctional Ikaros isoforms

Kazuhiro Nishii,Naoyuki Katayama,Hiroshi Shiku

View Articletitled, Adult acute myeloid leukemia cells do not express nonfunctional Ikaros isoforms

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma Clinical Trials & Observations

REVIEW ARTICLES

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Flow cytometric disease monitoring in multiple myeloma: the relationship between normal and neoplastic plasma cells predicts outcome after transplantation Clinical Trials & Observations

Phase 1 trial of the novel bispecific molecule H22xKi-4 in patients with refractory Hodgkin lymphoma Clinical Trials & Observations

The toxicity and efficacy of donor lymphocyte infusions given after reduced-intensity conditioning allogeneic stem cell transplantation Clinical Trials & Observations

Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia Clinical Trials & Observations

Nonmyeloablative transplantation with or without alemtuzumab: comparison between 2 prospective studies in patients with lymphoproliferative disorders Clinical Trials & Observations

Chronic graft-versus-host disease after allogeneic blood stem cell transplantation: long-term results of a randomized study Clinical Trials & Observations

Hematopoietic stem cell transplantation for de novo erythroleukemia: a study of the European Group for Blood and Marrow Transplantation (EBMT) Clinical Trials & Observations

Induction therapy with idarubicin alone significantly influences event-free survival duration in patients with newly diagnosed hypergranular acute promyelocytic leukemia: final results of the GIMEMA randomized study LAP 0389 with 7 years of minimal follow-up Clinical Trials & Observations