Issue Archive

INSIDE BLOOD

Blood or marrow stem cells?

Patrick G. Beatty

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Adenovirus infections after BMT

Richard Champlin

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In vivo gene transfer moves one step closer to success

Katherine A. High

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PLENARY PAPERS

A randomized multicenter comparison of bone marrow and peripheral blood in recipients of matched sibling allogeneic transplants for myeloid malignancies

Clinical Trials & Observations

Stephen Couban,David R. Simpson,Michael J. Barnett,Christopher Bredeson,Lothar Hubesch,Kang Howson-Jan,Tsiporah B. Shore,Irwin R. Walker,Peter Browett,Hans A. Messner,Tony Panzarella,Jeffrey H. Lipton,for the Canadian Bone Marrow Transplant Group

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ERRATA

Erratum for vol. 99, p. 1986

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REVIEW ARTICLES

The roles of FLT3 in hematopoiesis and leukemia

D. Gary Gilliland,James D. Griffin

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CHEMOKINES

Characterization of the binding site on heparan sulfate for macrophage inflammatory protein 1α

Sally E. Stringer,Mark J. Forster,Barbara Mulloy,Christopher R. Bishop,Gerard J. Graham,John T. Gallagher

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Efficacious immunomodulatory activity of the chemokine stromal cell–derived factor 1 (SDF-1): local secretion of SDF-1 at the tumor site serves as T-cell chemoattractant and mediates T-cell–dependent antitumor responses

Kyriaki Dunussi-Joannopoulos,Krystyna Zuberek,Kathlene Runyon,Robert G. Hawley,Anthony Wong,Jamie Erickson,Steve Herrmann,John P. Leonard

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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

High rate of clinical and molecular remissions in follicular lymphoma patients receiving high-dose sequential chemotherapy and autografting at diagnosis: a multicenter, prospective study by the Gruppo Italiano Trapianto Midollo Osseo (GITMO)

Clinical Trials & Observations

Marco Ladetto,Paolo Corradini,Sonia Vallet,Fabio Benedetti,Umberto Vitolo,Maurizio Martelli,Maura Brugiatelli,Paolo Coser,Alessio Perrotti,Ignazio Majolino,Giuseppe Fioritoni,Sergio Morandi,Maurizio Musso,Renato Zambello,Teodoro Chisesi,Nicola Di Renzo,Paolo Vivaldi,Alberto De Crescenzo,Andrea Gallamini,Flavia Salvi,Gino Santini,Carola Boccomini,Marco Sorio,Monica Astolfi,Daniela Drandi,Alessandro Pileri,Corrado Tarella

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Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia

Clinical Trials & Observations

Ian R. Wanless,George Sweeney,Amar P. Dhillon,Maria Guido,Antonio Piga,Renzo Galanello,M. Rita Gamberini,Elias Schwartz,Alan R. Cohen

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HLA-DR15 (DR2) is overrepresented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome

Clinical Trials & Observations

Yogen Saunthararajah,Ryotaro Nakamura,Jun-Mo Nam,Jamie Robyn,Fausto Loberiza,Jaroslaw P. Maciejewski,Toni Simonis,Jeffrey Molldrem,Neal S. Young,A. John Barrett

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Retrospective analysis of HHV-8 viremia and cellular viral load in HIV-seropositive patients receiving interleukin 2 in combination with antiretroviral therapy

Clinical Trials & Observations

Mauro Malnati,Francesco Broccolo,Silvia Nozza,Loredana Sarmati,Silvia Ghezzi,Giuseppe Locatelli,Fanny Delfanti,Brunella Capiluppi,Anna Careddu,Massimo Andreoni,Paolo Monini,Guido Poli,Adriano Lazzarin,Paolo Lusso,Giuseppe Tambussi

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Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy

Clinical Trials & Observations

Philippe Moreau,Thierry Facon,Xavier Leleu,Nadine Morineau,Pauline Huyghe,Jean-Luc Harousseau,Régis Bataille,Hervé Avet-Loiseau,for the Intergroupe Francophone du Myélome

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End-stage liver disease in persons with hemophilia and transfusion-associated infections

Clinical Trials & Observations

James J. Goedert,M. Elaine Eyster,Michael M. Lederman,Titica Mandalaki,Philippe de Moerloose,Gilbert C. White, II,Anne L. Angiolillo,Naomi L. C. Luban,Kenneth E. Sherman,Marilyn Manco-Johnson,Liliana Preiss,Cindy Leissinger,Craig M. Kessler,Alan R. Cohen,Donna DiMichele,Margaret W. Hilgartner,Louis M. Aledort,Barbara L. Kroner,Philip S. Rosenberg,Angelos Hatzakis,for the Multicenter Hemophilia Cohort Study

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Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia

Clinical Trials & Observations

Hagop M. Kantarjian,Susan O'Brien,Jorge E. Cortes,Sergio A. Giralt,Mary Beth Rios,Jianqin Shan,Francis J. Giles,Deborah A. Thomas,Stefan Faderl,Marcos De Lima,Guillermo Garcia-Manero,Richard Champlin,Ralph Arlinghaus,Moshe Talpaz

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Predictive values of X-chromosome inactivation patterns and clinicohematologic parameters for vascular complications in female patients with essential thrombocythemia

Clinical Trials & Observations

Lee-Yung Shih,Tung-Liang Lin,Chang-Liang Lai,Po Dunn,Jin-Hou Wu,Po-Nan Wang,Ming-Chung Kuo,Lai-Chu Lee

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High-dose immunosuppressive therapy for severe systemic sclerosis: initial outcomes

Clinical Trials & Observations

Peter A. McSweeney,Richard A. Nash,Keith M. Sullivan,Jan Storek,Leslie J. Crofford,Roger Dansey,Maureen D. Mayes,Kevin T. McDonagh,J. Lee Nelson,Theodore A. Gooley,Leona A. Holmberg,C. S. Chen,Mark H. Wener,Katherine Ryan,Julie Sunderhaus,Ken Russell,John Rambharose,Rainer Storb,Daniel E. Furst

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Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival

Clinical Trials & Observations

John E. Wagner,Juliet N. Barker,Todd E. DeFor,K. Scott Baker,Bruce R. Blazar,Cindy Eide,Anne Goldman,John Kersey,William Krivit,Margaret L. MacMillan,Paul J. Orchard,Charles Peters,Daniel J. Weisdorf,Norma K. C. Ramsay,Stella M. Davies

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Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery

Clinical Trials & Observations

Suparno Chakrabarti,Vivien Mautner,Husam Osman,Kathryn E. Collingham,Chris D. Fegan,Paul E. Klapper,Paul A. H. Moss,Donald W. Milligan

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The impact of clonal evolution on response to imatinib mesylate (STI571) in accelerated phase CML

Clinical Trials & Observations

Michael E. O'Dwyer,Michael J. Mauro,Gwen Kurilik,Motomi Mori,Suzanne Balleisen,Susan Olson,Ellen Magenis,Renaud Capdeville,Brian J. Druker

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Phase 2 trial of infusional cyclophosphamide, doxorubicin, and etoposide in patients with poor-prognosis, intermediate-grade non-Hodgkin lymphoma: an Eastern Cooperative Oncology Group trial (E3493)

Clinical Trials & Observations

Joseph A. Sparano,Edie Weller,Tipu Nazeer,Thomas Habermann,Ann E. Traynor,Jane Manalo,Peter Cassileth

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The role of posttransplantation maintenance chemotherapy in improving the outcome of autotransplantation in adult acute lymphoblastic leukemia

Clinical Trials & Observations

Ray Powles,Bhawna Sirohi,Jennifer Treleaven,Samar Kulkarni,Diana Tait,Seema Singhal,Jayesh Mehta

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Splenic marginal zone lymphoma: clinical characteristics and prognostic factors in a series of 60 patients

Clinical Trials & Observations

Jose I. Chacón,Manuela Mollejo,Enriqueta Muñoz,Patricia Algara,Marisol Mateo,Luis Lopez,Jesús Andrade,Iciar Garcı́a Carbonero,Beatriz Martı́nez,Miguel A. Piris,Miguel A. Cruz

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GENE THERAPY

Efficient gene transfer of CD40 ligand into primary B-CLL cells using recombinant adeno-associated virus (rAAV) vectors

Clemens-Martin Wendtner,David M. Kofler,Hans D. Theiss,Christian Kurzeder,Raymund Buhmann,Carmen Schweighofer,Luca Perabo,Susanne Danhauser-Riedl,Jens Baumert,Wolfgang Hiddemann,Michael Hallek,Hildegard Büning

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Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques

Amit C. Nathwani,Andrew M. Davidoff,Hideki Hanawa,Yunyu Hu,Fredric A. Hoffer,Alexander Nikanorov,Clive Slaughter,Catherine Y. C. Ng,Junfang Zhou,Jay N. Lozier,Timothy D. Mandrell,Elio F. Vanin,Arthur W. Nienhuis

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HEMATOPOIESIS

BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation

Yulia Kaluzhny,Guangyao Yu,Shishinn Sun,Paul A. Toselli,Bernhard Nieswandt,Carl W. Jackson,Katya Ravid

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The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization

Wen Tao,Marie-Dominique Filippi,Jeffrey R. Bailey,Simon J. Atkinson,Bret Connors,Andrew Evan,David A. Williams

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2)

Rob J. Dekker,Simone van Soest,Ruud D. Fontijn,Sonia Salamanca,Philip G. de Groot,Ed VanBavel,Hans Pannekoek,Anton J. G. Horrevoets

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The role of the D1 domain of the von Willebrand factor propeptide in multimerization of VWF

Jonathan B. Rosenberg,Sandra L. Haberichter,Mary A. Jozwiak,Elizabeth A. Vokac,Philip A. Kroner,Scot A. Fahs,Yohko Kawai,Robert R. Montgomery

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The small proteoglycan decorin supports adhesion and activation of human platelets

Gianni Guidetti,Alessandra Bertoni,Manuela Viola,Enrica Tira,Cesare Balduini,Mauro Torti

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IMMUNOBIOLOGY

Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab

Andrea G. S. Buggins,Ghulam J. Mufti,Jonathan Salisbury,Jane Codd,Nigel Westwood,Matthew Arno,Keith Fishlock,Antonio Pagliuca,Stephen Devereux

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Cyclosporin A blocks the expression of lymphotoxin α, but not lymphotoxin β, in human peripheral blood mononuclear cells

Dmitry V. Kuprash,Veronica E. Boitchenko,Felix O. Yarovinsky,Nancy R. Rice,Alfred Nordheim,Andreas Rühlmann,Sergei A. Nedospasov

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IFN-γ–mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, α-galactosylceramide

Yoshihiro Hayakawa,Kazuyoshi Takeda,Hideo Yagita,Mark J. Smyth,Luc Van Kaer,Ko Okumura,Ikuo Saiki

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Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs

Arun T. Kamath,Sandrine Henri,Frank Battye,David F. Tough,Ken Shortman

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Identification of the genes differentially expressed in human dendritic cell subsets by cDNA subtraction and microarray analysis

Jung Hoon Ahn,Yoon Lee,ChoonJu Jeon,Sang-Jin Lee,Byung-Hak Lee,Kang Duk Choi,Yong-Soo Bae

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B cells immortalized by a mini–Epstein-Barr virus encoding a foreign antigen efficiently reactivate specific cytotoxic T cells

Andreas Moosmann,Naeem Khan,Mark Cobbold,Caroline Zentz,Henri-Jacques Delecluse,Gabi Hollweck,Andrew D. Hislop,Neil W. Blake,Debbie Croom-Carter,Barbara Wollenberg,Paul A. H. Moss,Reinhard Zeidler,Alan B. Rickinson,Wolfgang Hammerschmidt

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Glucocorticoids and rituximab in vitro: synergistic direct antiproliferative and apoptotic effects

Andrea L. Rose,Barbara E. Smith,David G. Maloney

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Expression patterns of Th1 and Th2 cytokine genes in childhood idiopathic thrombocytopenic purpura (ITP) at presentation and their modulation by intravenous immunoglobulin G (IVIg) treatment: their role in prognosis

Athanasia Mouzaki,Maria Theodoropoulou,Ioannis Gianakopoulos,Vassiliki Vlaha,Maria-Christina Kyrtsonis,Alice Maniatis

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Subset of DC-SIGN⁺ dendritic cells in human blood transmits HIV-1 to T lymphocytes

Anneke Engering,Sandra J. van Vliet,Teunis B. H. Geijtenbeek,Yvette van Kooyk

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NEOPLASIA

A high-resolution allelotype of B-cell chronic lymphocytic leukemia (B-CLL)

Urban Novak,Elisabeth Oppliger Leibundgut,Jörg Hager,Dominique Mühlematter,Martine Jotterand,Celine Besse,Nicolas Leupin,Daniel Ratschiller,Jeanette Papp,Gina Kearsey,Stefan Aebi,Hans Graber,Rolf Jaggi,Jean-Marc Lüthi,Sandrine Meyer-Monard,Mark Lathrop,Andreas Tobler,Martin F. Fey

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Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1

Clinical Trials & Observations

Irene M. Pedersen,Shinichi Kitada,Lorenzo M. Leoni,Juan M. Zapata,James G. Karras,Nobuhiro Tsukada,Thomas J. Kipps,Yong Sung Choi,Frank Bennett,John C. Reed

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Modulation of the activity of calcium-activated neutral proteases (calpains) in chronic lymphocytic leukemia (B-CLL) cells

Jacek M. Witkowski,Emilia Zmuda-Trzebiatowska,Jakub M. Swiercz,Miroslawa Cichorek,Hanna Ciepluch,Krzysztof Lewandowski,Ewa Bryl,Andrzej Hellmann

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Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia

Beatriz Bellosillo,Neus Villamor,Armando López-Guillermo,Silvia Marcé,Francesc Bosch,Elias Campo,Emili Montserrat,Dolors Colomer

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Generalized crystal-storing histiocytosis associated with monoclonal gammopathy: molecular analysis of a disorder with rapid clinical course and review of the literature

Clinical Trials & Observations

Annette Lebeau,Evelyn Zeindl-Eberhart,Eva-Christina Müller,Josef Müller-Höcker,Peter Roman Jungblut,Bertold Emmerich,Udo Löhrs

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Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I–infected T-cell lines and primary adult T-cell leukemia cells

Naoki Mori,Yasuaki Yamada,Shuichi Ikeda,Yoshihiro Yamasaki,Kunihiro Tsukasaki,Yuetsu Tanaka,Masao Tomonaga,Naoki Yamamoto,Masahiro Fujii

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PHAGOCYTES

Inhibitory effects of a dominant-interfering form of the Rho-GTPase Cdc42 in the chemoattractant-elicited signaling pathways leading to NADPH oxidase activation in differentiated HL-60 cells

Marie-Josèphe Rabiet,Marianne Tardif,Laurence Braun,François Boulay

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Identification of a novel NCF-1 (p47-phox) pseudogene not containing the signature GT deletion: significance for A47° chronic granulomatous disease carrier detection

Paul G. Heyworth,Deborah Noack,Andrew R. Cross

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SHP-1 regulates Fcγ receptor–mediated phagocytosis and the activation of RAC

Anita M. Kant,Pradip De,Xiaodong Peng,Taolin Yi,David J. Rawlings,Jong Suk Kim,Donald L. Durden

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Role of Toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils

Evelyn A. Kurt-Jones,Leisa Mandell,Constance Whitney,Alison Padgett,Kerri Gosselin,Peter E. Newburger,Robert W. Finberg

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Essential role of the C5a receptor in E coli–induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation

Tom Eirik Mollnes,Ole-Lars Brekke,Michael Fung,Hilde Fure,Dorte Christiansen,Grethe Bergseth,Vibeke Videm,Knut Tore Lappegård,Jörg Köhl,John D. Lambris

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RED CELLS

Absence of CD47 in protein 4.2–deficient hereditary spherocytosis in man: an interaction between the Rh complex and the band 3 complex: Presented at the 43rd Annual Meeting of the American Society of Hematology, Orlando, FL, December 7-11, 2001, and abstract published in Blood. 2001;98:(suppl1):10a.

Lesley J. Bruce,Sandip Ghosh,May Jean King,D. Mark Layton,William J. Mawby,Gordon W. Stewart,Per-Arne Oldenborg,Jean Delaunay,Michael J. A. Tanner

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TRANSPLANTATION

Mixed peripheral blood stem cell transplantation for autoimmune disease in BXSB/MpJ mice

Yoshihisa Yamamoto,Bingyan Wang,Shirou Fukuhara,Susumu Ikehara,Robert A. Good

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Crucial role of timing of donor lymphocyte infusion in generating dissociated graft-versus-host and graft-versus-leukemia responses in mice receiving allogeneic bone marrow transplants

An D. Billiau,Sabine Fevery,Omer Rutgeerts,Willy Landuyt,Mark Waer

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Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen–presenting cells

Markus Y. Mapara,Yong-Mi Kim,Sheng-Ping Wang,Roderick Bronson,David H. Sachs,Megan Sykes

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BRIEF REPORTS

Cyclosporine inhibition of P-glycoprotein in chronic myeloid leukemia blast phase

Clinical Trials & Observations Brief Report

Alan F. List,Kenneth J. Kopecky,Cheryl L. Willman,David R. Head,Marilyn L. Slovak,Dan Douer,Shaker R. Dakhil,Frederick R. Appelbaum

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Homozygosity for nondeletion δ-β⁰ thalassemia resulting in a silent clinical phenotype

Brief Report

Renzo Galanello,Susanna Barella,Stefania Satta,Liliana Maccioni,Carlo Pintor,Antonio Cao

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Distinct contributions of CD4⁺ and CD8⁺naive and memory T-cell subsets to overall T-cell–receptor repertoire complexity following transplantation of T-cell–depleted CD34-selected hematopoietic progenitor cells from unrelated donors

Brief Report

Matthias Eyrich,Tanja Croner,Christine Leiler,Peter Lang,Peter Bader,Thomas Klingebiel,Dietrich Niethammer,Paul G. Schlegel

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Rta of the human herpesvirus 8/Kaposi sarcoma–associated herpesvirus up-regulates human interleukin-6 gene expression

Brief Report

Hongyu Deng,Julia T. Chu,Matthew B. Rettig,Otoniel Martinez-Maza,Ren Sun

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CORRESPONDENCE

Severe cold hemagglutinin disease (CHD) successfully treated with rituximab

Monika Engelhardt,Andreas Jakob,Björn Rüter,Martin Trepel,Friedrich Hirsch,Michael Lübbert

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Pharmacology of PEG-asparaginase in childhood acute lymphoblastic leukemia (ALL)

Joao Paulo Vieira Pinheiro,Claudia Lanvers,Gudrun Würthwein,Joachim Boos

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Idiopathic thrombocytopenic purpura, Helicobacter pylori infection, and HLA class II alleles

Dino Veneri,Michele Gottardi,Elisabetta Guizzardi,Carla Zanuso,Mauro Krampera,Massimo Franchini

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ABO blood group also influences the von Willebrand factor (VWF) antigen level in heterozygous carriers of VWF null alleles, type 2N mutation Arg854Gln, and the missense mutation Cys2362Phe

Giancarlo Castaman,Jeroen C. J. Eikenboom

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Therapy-related MDS and AML in acute promyelocytic leukemia

Mette Klarskov Andersen,Jens Pedersen-Bjergaard

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Homozygous intragenic deletion of type I hexokinase gene causes lethal hemolytic anemia of the affected fetus

Hitoshi Kanno,Koko Murakami,Yumi Hariyama,Kaoru Ishikawa,Shiro Miwa,Hisaichi Fujii

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