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Volume 100, Issue 1

July 1 2002

In this Issue

INSIDE BLOOD
PLENARY PAPERS
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

Clotting in whole blood: analysis of a biochemical reaction network

Sriram Krishnaswamy

View Articletitled, Clotting in whole blood: analysis of a biochemical reaction network

Radiosensitization of recipient stem cells promotes engraftment

Willem E. Fibbe

View Articletitled, Radiosensitization of recipient stem cells promotes engraftment

PLENARY PAPERS

Factor V Leiden: The Copenhagen City Heart Study and 2 meta-analyses
Clinical Trials & Observations

Klaus Juul,Anne Tybjærg-Hansen,Rolf Steffensen,Steen Kofoed,Gorm Jensen,Børge Grønne Nordestgaard

View Articletitled, Factor V Leiden: The Copenhagen City Heart Study and 2 meta-analyses

CHEMOKINES

Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among Vα24⁺Vβ11⁺ NKT cell subsets with distinct cytokine-producing capacity

Chang H. Kim,Brent Johnston,Eugene C. Butcher

View Articletitled, Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among Vα24+Vβ11+ NKT cell subsets with distinct cytokine-producing capacity

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation
Clinical Trials & Observations

Emanuele Angelucci,Pietro Muretto,Antonio Nicolucci,Donatella Baronciani,Buket Erer,Javid Gaziev,Marta Ripalti,Pietro Sodani,Silvia Tomassoni,Giuseppe Visani,Guido Lucarelli

View Articletitled, Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation

HLA class II haplotype and quantitation of WT1 RNA in Japanese patients with paroxysmal nocturnal hemoglobinuria
Clinical Trials & Observations

Tsutomu Shichishima,Masatoshi Okamoto,Kazuhiko Ikeda,Toshihiko Kaneshige,Haruo Sugiyama,Takashi Terasawa,Kazuoki Osumi,Yukio Maruyama

View Articletitled, HLA class II haplotype and quantitation of WT1 RNA in Japanese patients with paroxysmal nocturnal hemoglobinuria

Impact of trisomy 8 (+8) on clinical presentation, treatment response, and survival in acute myeloid leukemia: a Southwest Oncology Group study
Clinical Trials & Observations

Sandra R. Wolman,Holly Gundacker,Frederick R. Appelbaum,Marilyn L. Slovak,for the Southwest Oncology Group

View Articletitled, Impact of trisomy 8 (+8) on clinical presentation, treatment response, and survival in acute myeloid leukemia: a Southwest Oncology Group study

High numbers of active caspase 3–positive Reed-Sternberg cells in pretreatment biopsy specimens of patients with Hodgkin disease predict favorable clinical outcome
Clinical Trials & Observations

Danny F. Dukers,Chris J. L. M. Meijer,Rosita L. ten Berge,Wim Vos,Gert J. Ossenkoppele,Joost J. Oudejans

View Articletitled, High numbers of active caspase 3–positive Reed-Sternberg cells in pretreatment biopsy specimens of patients with Hodgkin disease predict favorable clinical outcome

Persistence of lymphoblasts in bone marrow on day 15 and days 22 to 25 of remission induction predicts a dismal treatment outcome in children with acute lymphoblastic leukemia
Clinical Trials & Observations

John T. Sandlund,Patricia L. Harrison,Gaston Rivera,Frederick G. Behm,David Head,James Boyett,Jeffrey E. Rubnitz,Amar Gajjar,Susana Raimondi,Raul Ribeiro,Melissa Hudson,Mary Relling,William Evans,Ching-Hon Pui

View Articletitled, Persistence of lymphoblasts in bone marrow on day 15 and days 22 to 25 of remission induction predicts a dismal treatment outcome in children with acute lymphoblastic leukemia

Therapy for chronic graft-versus-host disease: a randomized trial comparing cyclosporine plus prednisone versus prednisone alone
Clinical Trials & Observations

Sibel Koc,Wendy Leisenring,Mary E. D. Flowers,Claudio Anasetti,H. Joachim Deeg,Richard A. Nash,Jean E. Sanders,Robert P. Witherspoon,Rainer Storb,Frederick R. Appelbaum,Paul J. Martin

View Articletitled, Therapy for chronic graft-versus-host disease: a randomized trial comparing cyclosporine plus prednisone versus prednisone alone

Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia
Clinical Trials & Observations

Elaine Coustan-Smith,Jose Sancho,Frederick G. Behm,Michael L. Hancock,Bassem I. Razzouk,Raul C. Ribeiro,Gaston K. Rivera,Jeffrey E. Rubnitz,John T. Sandlund,Ching-Hon Pui,Dario Campana

View Articletitled, Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease: Presented in part at the 42nd annual meeting of the American Society of Hematology, December 1-5, 2000, San Francisco, CA (abstract 3569).
Clinical Trials & Observations

Susanne Schnittger,Claudia Schoch,Martin Dugas,Wolfgang Kern,Peter Staib,Christian Wuchter,Helmut Löffler,Cristina Maria Sauerland,Hubert Serve,Thomas Büchner,Torsten Haferlach,Wolfgang Hiddemann

View Articletitled, Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease: Presented in part at the 42nd annual meeting of the American Society of Hematology, December 1-5, 2000, San Francisco, CA (abstract 3569).

Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia
Clinical Trials & Observations

Stella M. Davies,Smita Bhatia,Julie A. Ross,William R. Kiffmeyer,Paul S. Gaynon,Gretchen A. Radloff,Leslie L. Robison,John P. Perentesis

View Articletitled, Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia

GENE THERAPY

Retroviral transduction of IL2RG into CD34⁺ cells from X-linked severe combined immunodeficiency patients permits human T- and B-cell development in sheep chimeras

Emily J. Tsai,Harry L. Malech,Martha R. Kirby,Amy P. Hsu,Nancy E. Seidel,Christopher D. Porada,Esmail D. Zanjani,David M. Bodine,Jennifer M. Puck

View Articletitled, Retroviral transduction of IL2RG into CD34+ cells from X-linked severe combined immunodeficiency patients permits human T- and B-cell development in sheep chimeras

HEMATOPOIESIS

Transcriptional regulation of myeloid differentiation primary response (MyD) genes during myeloid differentiation is mediated by nuclear factor Y

Robert M. Tjin Tham Sjin,Kandasamy Krishnaraju,Barbara Hoffman,Dan A. Liebermann

View Articletitled, Transcriptional regulation of myeloid differentiation primary response (MyD) genes during myeloid differentiation is mediated by nuclear factor Y

A human Mix-like homeobox gene MIXL shows functional similarity to Xenopus Mix.1

Wei Guo,Agnes Pui-yee Chan,Hong Liang,Eric D. Wieder,Jeffrey J. Molldrem,Laurence D. Etkin,Lalitha Nagarajan

View Articletitled, A human Mix-like homeobox gene MIXL shows functional similarity to Xenopus Mix.1

Expression of the β4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells

Annarita Morena,Sabrina Riccioni,Alessandra Marchetti,Alessandro Tartaglia Polcini,Arthur M. Mercurio,Giovanni Blandino,Ada Sacchi,Rita Falcioni

View Articletitled, Expression of the β4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells

Novel transcription factors in human CD34 antigen–positive hematopoietic cells

Ignatius Gomes,Tiffany T. Sharma,Seby Edassery,Noreen Fulton,Brenton G. Mar,Carol A. Westbrook

View Articletitled, Novel transcription factors in human CD34 antigen–positive hematopoietic cells

Engraftment potential of human fetal hematopoietic cells in NOD/SCID mice is not restricted to mitotically quiescent cells

Jannine Wilpshaar,Mickie Bhatia,Humphrey H. H. Kanhai,Robert Breese,Doug K. Heilman,Cynthia S. Johnson,J. H. Frederik Falkenburg,Edward F. Srour

View Articletitled, Engraftment potential of human fetal hematopoietic cells in NOD/SCID mice is not restricted to mitotically quiescent cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background

Edward K. Novak,Rashi Gautam,Madonna Reddington,Lucy M. Collinson,Neal G. Copeland,Nancy A. Jenkins,Michael P. McGarry,Richard T. Swank

View Articletitled, The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background

Reconstitution of adhesive properties of human platelets in liposomes carrying both recombinant glycoproteins Ia/IIa and Ibα under flow conditions: specific synergy of receptor–ligand interactions

Takako Nishiya,Mie Kainoh,Mitsuru Murata,Makoto Handa,Yasuo Ikeda

View Articletitled, Reconstitution of adhesive properties of human platelets in liposomes carrying both recombinant glycoproteins Ia/IIa and Ibα under flow conditions: specific synergy of receptor–ligand interactions

Factor VIII expression in azoxymethane-induced murine fulminant hepatic failure

Christopher B. Doering,Cassandra D. Josephson,Heather N. Craddock,Pete Lollar

View Articletitled, Factor VIII expression in azoxymethane-induced murine fulminant hepatic failure

Thrombin functions during tissue factor–induced blood coagulation

Kathleen E. Brummel,Sara G. Paradis,Saulius Butenas,Kenneth G. Mann

View Articletitled, Thrombin functions during tissue factor–induced blood coagulation

Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo

Tong Gui,Hui-Feng Lin,Da-Yun Jin,Maureane Hoffman,David L. Straight,Harold R. Roberts,Darrel W. Stafford

View Articletitled, Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo

IMMUNOBIOLOGY

Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4⁺ T cells in thymomas

Philipp Ströbel,Markus Helmreich,Georgios Menioudakis,Sharon R. Lewin,Thomas Rüdiger,Andrea Bauer,Viola Hoffacker,Ralf Gold,Wilfred Nix,Berthold Schalke,Olaf Elert,Michael Semik,Hans Konrad Müller-Hermelink,Alexander Marx

View Articletitled, Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4+ T cells in thymomas

T-cell responses against chronic lymphocytic leukemia cells: implications for immunotherapy

Angela M. Krackhardt,Sabine Harig,Mathias Witzens,Ryan Broderick,Patrick Barrett,John G. Gribben

View Articletitled, T-cell responses against chronic lymphocytic leukemia cells: implications for immunotherapy

Antigen-bearing immature dendritic cells induce peptide-specific CD8⁺ regulatory T cells in vivo in humans

Madhav V. Dhodapkar,Ralph M. Steinman

View Articletitled, Antigen-bearing immature dendritic cells induce peptide-specific CD8+ regulatory T cells in vivo in humans

Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by Vβ CDR3 spectratyping and flow cytometry

Antonio M. Risitano,Hoon Kook,Weihua Zeng,Guibin Chen,Neal S. Young,Jaroslaw P. Maciejewski

View Articletitled, Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by Vβ CDR3 spectratyping and flow cytometry

Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)–mediated activation, and autoimmune disease

Ray Wilkinson,A. Bruce Lyons,Donna Roberts,Mae-Xhum Wong,Paul A. Bartley,Denise E. Jackson

View Articletitled, Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)–mediated activation, and autoimmune disease

NEOPLASIA

Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x_L is an essential survival protein of human myeloma cells

Sophie Derenne,Brett Monia,Nicholas M. Dean,Jennifer K. Taylor,Marie-Josée Rapp,Jean-Luc Harousseau,Régis Bataille,Martine Amiot

View Articletitled, Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-xL is an essential survival protein of human myeloma cells

Transgenic expression of CD40 ligand produces an in vivo antitumor immune response against both CD40⁺ and CD40⁻ plasmacytoma cells

Gianpietro Dotti,Barbara Savoldo,Patricia Yotnda,Donna Rill,Malcolm K. Brenner

View Articletitled, Transgenic expression of CD40 ligand produces an in vivo antitumor immune response against both CD40+ and CD40− plasmacytoma cells

Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the α-emitting radionuclide, bismuth 213

Meili Zhang,Zhengsheng Yao,Kayhan Garmestani,Donald B. Axworthy,Zhuo Zhang,Robert W. Mallett,Louis J. Theodore,Carolyn K. Goldman,Martin W. Brechbiel,Jorge A. Carrasquillo,Thomas A. Waldmann

View Articletitled, Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the α-emitting radionuclide, bismuth 213

Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax

Jamie L. Szocinski,Annette R. Khaled,Julie Hixon,Douglas Halverson,Satoshi Funakoshi,William C. Fanslow,Ann Boyd,Dennis D. Taub,Scott K. Durum,Clay B. Siegall,Dan L. Longo,William J. Murphy

View Articletitled, Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax

Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma

Victoria J. Spanswick,Charles Craddock,Mallika Sekhar,Prem Mahendra,Paneesha Shankaranarayana,R. George Hughes,Daniel Hochhauser,John A. Hartley

View Articletitled, Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma

Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6

Marina Ratta,Francesco Fagnoni,Antonio Curti,Rosanna Vescovini,Paolo Sansoni,Barbara Oliviero,Miriam Fogli,Elisa Ferri,Gioacchino Robustelli Della Cuna,Sante Tura,Michele Baccarani,Roberto M. Lemoli

View Articletitled, Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice

Scott C. Kogan,Jerrold M. Ward,Miriam R. Anver,Jules J. Berman,Cory Brayton,Robert D. Cardiff,John S. Carter,Sherri de Coronado,James R. Downing,Torgny N. Fredrickson,Diana C. Haines,Alan W. Harris,Nancy Lee Harris,Hiroshi Hiai,Elaine S. Jaffe,Ian C. M. MacLennan,Pier Paolo Pandolfi,Paul K. Pattengale,Archibald S. Perkins,R. Mark Simpson,Mark S. Tuttle,Joanne F. Wong,Herbert C. Morse, III

View Articletitled, Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice

Supplemental data

Bethesda proposals for classification of lymphoid neoplasms in mice

Herbert C. Morse, III,Miriam R. Anver,Torgny N. Fredrickson,Diana C. Haines,Alan W. Harris,Nancy L. Harris,Elaine S. Jaffe,Scott C. Kogan,Ian C. M. MacLennan,Paul K. Pattengale,Jerrold M. Ward

View Articletitled, Bethesda proposals for classification of lymphoid neoplasms in mice

Supplemental data

Involvement and functional impairment of the CD34⁺CD38⁻Thy-1⁺ hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8

Lars Nilsson,Ingbritt Åstrand-Grundström,Kristina Anderson,Ingrid Arvidsson,Peter Hokland,David Bryder,Lars Kjeldsen,Bertil Johansson,Eva Hellström-Lindberg,Robert Hast,Sten Eirik W. Jacobsen

View Articletitled, Involvement and functional impairment of the CD34+CD38−Thy-1+ hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8

PHAGOCYTES

Expression and subcellular localization of NRAMP1 in human neutrophil granules

François Canonne-Hergaux,Jero Calafat,Etienne Richer,Mathieu Cellier,Sergio Grinstein,Neils Borregaard,Philippe Gros

View Articletitled, Expression and subcellular localization of NRAMP1 in human neutrophil granules

RED CELLS

Band 3 is an anchor protein and a target for SHP-2 tyrosine phosphatase in human erythrocytes

Luciana Bordin,Anna Maria Brunati,Arianna Donella-Deana,Bruno Baggio,Antonio Toninello,Giulio Clari

View Articletitled, Band 3 is an anchor protein and a target for SHP-2 tyrosine phosphatase in human erythrocytes

Nuclear magnetic resonance studies of mutations at the tetramerization region of human alpha spectrin

Sunghyouk Park,Michael E. Johnson,Leslie W.-M. Fung

View Articletitled, Nuclear magnetic resonance studies of mutations at the tetramerization region of human alpha spectrin

Transferrin receptor hyperexpression in primary erythroblasts is lost on transformation by avian erythroblastosis virus

Lioba Lobmayr,Thomas Sauer,Iris Killisch,Matthias Schranzhofer,Robert B. Wilson,Prem Ponka,Hartmut Beug,Ernst W. Müllner

View Articletitled, Transferrin receptor hyperexpression in primary erythroblasts is lost on transformation by avian erythroblastosis virus

TRANSFUSION MEDICINE

Intersubunit circular permutation of human hemoglobin

Kevin E. Sanders,John Lo,Stephen G. Sligar

View Articletitled, Intersubunit circular permutation of human hemoglobin

The DAU allele cluster of the RHDgene

Franz F. Wagner,Birgit Ladewig,Katharina S. Angert,Guido A. Heymann,Nicole I. Eicher,Willy A. Flegel

View Articletitled, The DAU allele cluster of the RHDgene

TRANSPLANTATION

Growth factor treatment prior to low-dose total body irradiation increases donor cell engraftment after bone marrow transplantation in mice

Estelle J. K. Noach,Albertina Ausema,Jan H. Dillingh,Bert Dontje,Ellen Weersing,Imre Akkerman,Edo Vellenga,Gerald de Haan

View Articletitled, Growth factor treatment prior to low-dose total body irradiation increases donor cell engraftment after bone marrow transplantation in mice

Bismuth 213–labeled anti-CD45 radioimmunoconjugate to condition dogs for nonmyeloablative allogeneic marrow grafts

Brenda M. Sandmaier,Wolfgang A. Bethge,D. Scott Wilbur,Donald K. Hamlin,Erlinda B. Santos,Martin W. Brechbiel,Darrell R. Fisher,Rainer Storb

View Articletitled, Bismuth 213–labeled anti-CD45 radioimmunoconjugate to condition dogs for nonmyeloablative allogeneic marrow grafts

Enhancement of G-CSF–induced stem cell mobilization by antibodies against the β2 integrins LFA-1 and Mac-1

Gerjo A. Velders,Johannes F. M. Pruijt,Perry Verzaal,Ronald van Os,Yvette van Kooyk,Carl G. Figdor,Evert-Jan F. M. de Kruijf,Roel Willemze,Willem E. Fibbe

View Articletitled, Enhancement of G-CSF–induced stem cell mobilization by antibodies against the β2 integrins LFA-1 and Mac-1

Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide

Günther Eissner,Gabriele Multhoff,Armin Gerbitz,Silvia Kirchner,Sonja Bauer,Silvia Haffner,Daniela Sondermann,Reinhard Andreesen,Ernst Holler

View Articletitled, Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide

BRIEF REPORTS

Activated platelets of patients with paroxysmal nocturnal hemoglobinuria express cellular prion protein
Brief Report

Karel Holada,Jan Simak,Antonio M. Risitano,Jaroslaw Maciejewski,Neal S. Young,Jaroslav G. Vostal

View Articletitled, Activated platelets of patients with paroxysmal nocturnal hemoglobinuria express cellular prion protein

Glycoprotein V: the predominant target antigen in gold-induced autoimmune thrombocytopenia
Clinical Trials & Observations Brief Report

Stephen F. Garner,Kate Campbell,Paul Metcalfe,Jane Keidan,Elly Huiskes,Jing-Fei Dong,José A. López,Willem H. Ouwehand

View Articletitled, Glycoprotein V: the predominant target antigen in gold-induced autoimmune thrombocytopenia

Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis
Brief Report

E. Renate Panzer-Grümayer,Karin Fasching,Simon Panzer,Klaudia Hettinger,Klaus Schmitt,Sylvia Stöckler-Ipsiroglu,Oskar A. Haas

View Articletitled, Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis

Role of GITR in activation response of T lymphocytes
Brief Report

Simona Ronchetti,Giuseppe Nocentini,Carlo Riccardi,Pier Paolo Pandolfi

View Articletitled, Role of GITR in activation response of T lymphocytes

Influence of plasma immunoglobulin level on antibody synthesis
Brief Report

Andreas Goldammer,Kurt Derfler,Kurt Herkner,Arthur R. Bradwell,Walter H. Hörl,Martin Haas

View Articletitled, Influence of plasma immunoglobulin level on antibody synthesis

Hydrops fetalis–associated congenital dyserythropoietic anemia treated with intrauterine transfusions and bone marrow transplantation
Clinical Trials & Observations Brief Report

Angel F. Remacha,Isabel Badell,Núria Pujol-Moix,Juan Parra,Eduardo Muñiz-Diaz,Gemma Ginovart,M. Pilar Sardà,Angel Hernández,Elisenda Moliner,Montserrat Torrent

View Articletitled, Hydrops fetalis–associated congenital dyserythropoietic anemia treated with intrauterine transfusions and bone marrow transplantation

The G20210A mutation does not affect the stability of prothrombin mRNA in vivo
Brief Report

Eleanor S. Pollak,Ho-Sun Lam,J. Eric Russell

View Articletitled, The G20210A mutation does not affect the stability of prothrombin mRNA in vivo

CORRESPONDENCE

A patient on hydroxyurea for sickle cell disease who developed an opportunistic infection

Pramila Venigalla,Bharat Motwani,Anitha Nallari,Sandra Allen,Manoj Agarwal,Manuel Alva,Maxwell Westerman,Lawrence Feldman

View Articletitled, A patient on hydroxyurea for sickle cell disease who developed an opportunistic infection

FLT3 internal tandem duplication mutations are rare in agnogenic myeloid metaplasia

Faisal M. Abu-Duhier,Anne C. Goodeve,Gill A. Wilson,Rory S. Carr,Ian R. Peake,John T. Reilly

View Articletitled, FLT3 internal tandem duplication mutations are rare in agnogenic myeloid metaplasia

Platelet-dependent action of high-dose factor VIIa

Maureane Hoffman,Dougald M. Monroe,Harold R. Roberts

View Articletitled, Platelet-dependent action of high-dose factor VIIa

Cyclosporine modulation in poor-risk acute myeloid leukemia

Jim V. Beattie,Paul J. Petruska

View Articletitled, Cyclosporine modulation in poor-risk acute myeloid leukemia

Binding of imatinib by α₁-acid glycoprotein

Carlo Gambacorti-Passerini,Philipp le Coutre,Massimo Zucchetti,Maurizio D'Incalci

View Articletitled, Binding of imatinib by α1-acid glycoprotein

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

Factor V Leiden: The Copenhagen City Heart Study and 2 meta-analyses Clinical Trials & Observations

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation Clinical Trials & Observations

HLA class II haplotype and quantitation of WT1 RNA in Japanese patients with paroxysmal nocturnal hemoglobinuria Clinical Trials & Observations

Impact of trisomy 8 (+8) on clinical presentation, treatment response, and survival in acute myeloid leukemia: a Southwest Oncology Group study Clinical Trials & Observations

High numbers of active caspase 3–positive Reed-Sternberg cells in pretreatment biopsy specimens of patients with Hodgkin disease predict favorable clinical outcome Clinical Trials & Observations

Persistence of lymphoblasts in bone marrow on day 15 and days 22 to 25 of remission induction predicts a dismal treatment outcome in children with acute lymphoblastic leukemia Clinical Trials & Observations

Therapy for chronic graft-versus-host disease: a randomized trial comparing cyclosporine plus prednisone versus prednisone alone Clinical Trials & Observations

Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia Clinical Trials & Observations

Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia Clinical Trials & Observations