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  • <p>Multiplex immunofluorescence of a biopsy specimen from a patient with relapse of Hodgkin lymphoma after autologous stem cell transplantation and pembrolizumab consolidation. Neoplastic cells (dim magenta) are embedded in an environment rich in PD-1 (yellow) positive and negative T cells (white). See the article by Armand et al on page <a href="/content/134/1/22">22</a>.</p> Volume 134, Issue 1 Volume 134, Issue 1 July 4 2019 Pages 1-95 Cover image

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    Multiplex immunofluorescence of a biopsy specimen from a patient with relapse of Hodgkin lymphoma after autologous stem cell transplantation and pembrolizumab consolidation. Neoplastic cells (dim magenta) are embedded in an environment rich in PD-1 (yellow) positive and negative T cells (white). See the article by Armand et al on page 22.

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  • <p>Double-strand breaks marked by &#x03B3;-H2AX (cyan) in nuclei (purple) of TP53-mutant hematopoietic progenitors. Progenitors were generated from induced pluripotent stem cells, a useful model of myelodysplastic syndromes and clonal evolution. See the article by Hsu et al on page <a href="/content/134/2/186">186</a>.</p> Volume 134, Issue 2 Volume 134, Issue 2 July 11 2019 Pages 97-218 Cover image

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    Double-strand breaks marked by γ-H2AX (cyan) in nuclei (purple) of TP53-mutant hematopoietic progenitors. Progenitors were generated from induced pluripotent stem cells, a useful model of myelodysplastic syndromes and clonal evolution. See the article by Hsu et al on page 186.

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  • <p>Trichrome stain of the distal femur of a warfarin-treated mouse. Warfarin treatment induces a significant reduction in cancellous bone (green), induces an increase in osteoid volume (pink), and impairs hematopoiesis via inhibiting &#x03B3;-carboxylation of macrophage-derived periostin. See the article by Verma et al on page <a href="/content/134/3/227">227</a>.</p> Volume 134, Issue 3 Volume 134, Issue 3 July 18 2019 Pages 219-332 Cover image

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    Trichrome stain of the distal femur of a warfarin-treated mouse. Warfarin treatment induces a significant reduction in cancellous bone (green), induces an increase in osteoid volume (pink), and impairs hematopoiesis via inhibiting γ-carboxylation of macrophage-derived periostin. See the article by Verma et al on page 227.

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  • <p>Immunofluorescence photomicrograph of neutrophil extracellular traps (NETs, in red) triggered by exposure of neutrophils to 16 &#x03BC;M adenosine for 4 hours. Adenosine-mediated NET formation is implicated in a monogenic form of vasculitis known as deficiency of adenosine deaminase 2 (DADA2). See the article by Carmona-Rivera et al on page <a href="/content/134/4/395">395</a>.</p> Volume 134, Issue 4 Volume 134, Issue 4 July 25 2019 Pages 333-411 Cover image

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    Immunofluorescence photomicrograph of neutrophil extracellular traps (NETs, in red) triggered by exposure of neutrophils to 16 μM adenosine for 4 hours. Adenosine-mediated NET formation is implicated in a monogenic form of vasculitis known as deficiency of adenosine deaminase 2 (DADA2). See the article by Carmona-Rivera et al on page 395.

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  • <p>Cytospin image of an erythroblastic island formed between an EPO-pretreated macrophage (the cell in the center) and erythroblasts (surrounding cells). EPO/EPOR&#x2013;mediated signal transduction in human EPOR<sup>&#x002B; </sup>macrophages enhances erythroblastic island formation. See the article by Li et al on page <a href="/content/134/5/480">480</a>.</p> Volume 134, Issue 5 Volume 134, Issue 5 August 1 2019 Pages 413-492 Cover image

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    Cytospin image of an erythroblastic island formed between an EPO-pretreated macrophage (the cell in the center) and erythroblasts (surrounding cells). EPO/EPOR–mediated signal transduction in human EPOR+ macrophages enhances erythroblastic island formation. See the article by Li et al on page 480.

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  • <p>Phosphatidylinositol 3-kinase &#x03B4; inhibitor (iPI3K-&#x03B4;)&#x2013;resistant murine E&#x03BC;-TCL1 tumors stained with forkhead box O1 (FOXO1) and DAPI (4&#x2032;,6-diamidino-2-phenylindole). Notice the FOXO1 localization in the nucleus upon exposure to iPI3K-&#x03B4;, which leads to an increase in insulin-like growth factor 1 receptor expression and downstream signaling. See the article by Scheffold et al on page <a href="/content/134/6/534">534</a>.</p> Volume 134, Issue 6 Volume 134, Issue 6 August 8 2019 Pages 493-576 Cover image

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    Phosphatidylinositol 3-kinase δ inhibitor (iPI3K-δ)–resistant murine Eμ-TCL1 tumors stained with forkhead box O1 (FOXO1) and DAPI (4′,6-diamidino-2-phenylindole). Notice the FOXO1 localization in the nucleus upon exposure to iPI3K-δ, which leads to an increase in insulin-like growth factor 1 receptor expression and downstream signaling. See the article by Scheffold et al on page 534.

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  • <p>Hematoxylin and eosin&#x2013;stained liver tissue of a Townes sickle cell mouse with selective depletion of patrolling monocytes by treatment with a low dose of liposome-encapsulated clodronate. Notice the vascular stasis and infarcts. See the article by Liu et al on page <a href="/content/134/7/579">579</a>.</p> Volume 134, Issue 7 Volume 134, Issue 7 August 15 2019 Pages 577-659 Cover image

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    Hematoxylin and eosin–stained liver tissue of a Townes sickle cell mouse with selective depletion of patrolling monocytes by treatment with a low dose of liposome-encapsulated clodronate. Notice the vascular stasis and infarcts. See the article by Liu et al on page 579.

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  • <p>Nuclear magnetic resonance mapping interaction of an anticoagulant protein, Ixolaris, with factor X. Kunitz domains 1 and 2 are colored in wheat and light blue, respectively. The structural regions changing upon binding of factor X are colored in cyan and magenta. See the article by De Paula et al on page <a href="/content/134/8/699">699</a>.</p>
 Volume 134, Issue 8 Volume 134, Issue 8 August 22 2019 Pages 661-721 Cover image

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    Nuclear magnetic resonance mapping interaction of an anticoagulant protein, Ixolaris, with factor X. Kunitz domains 1 and 2 are colored in wheat and light blue, respectively. The structural regions changing upon binding of factor X are colored in cyan and magenta. See the article by De Paula et al on page 699.

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  • <p>Fluorescence microscopy image of hyaluronan (green) and inter-&#x03B1; inhibitor (red) in a murine model of colitis. The image shows leukocyte-adhesive hyaluronan matrices which surround intestinal microvessels and accumulate in the vessel lumen during inflammation. See the article by Petrey et al on page <a href="/content/134/9/765">765</a>.</p> Volume 134, Issue 9 Volume 134, Issue 9 August 29 2019 Pages 723-785 Cover image

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    Fluorescence microscopy image of hyaluronan (green) and inter-α inhibitor (red) in a murine model of colitis. The image shows leukocyte-adhesive hyaluronan matrices which surround intestinal microvessels and accumulate in the vessel lumen during inflammation. See the article by Petrey et al on page 765.

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  • <p>Silver-stained femur bone marrow section from a romiplostim-treated humanized NOG mouse. Elotuzumab ameliorated myelofibrosis induced by romiplostim administration. See the article by Maekawa et al on page <a href="/content/134/10/814">814</a>.</p> Volume 134, Issue 10 Volume 134, Issue 10 September 5 2019 Pages 787-843 Cover image

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    Silver-stained femur bone marrow section from a romiplostim-treated humanized NOG mouse. Elotuzumab ameliorated myelofibrosis induced by romiplostim administration. See the article by Maekawa et al on page 814.

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  • <p>B-cell receptor sequencing network for a monozygotic twin with concordant B-cell precursor acute lymphoblastic leukemia to track the clonal origin of the leukemia. See the article by Bueno et al on page <a href="/content/134/11/900">900</a>.</p> Volume 134, Issue 11 Volume 134, Issue 11 September 12 2019 Pages 845-908 Cover image

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    B-cell receptor sequencing network for a monozygotic twin with concordant B-cell precursor acute lymphoblastic leukemia to track the clonal origin of the leukemia. See the article by Bueno et al on page 900.

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  • <p>Confocal image of human umbilical vein endothelial cells expressing a Rab27a-APEX2 construct that localizes to Weibel-Palade bodies (WPBs). APEX2 activation leads to the biotinylation of proximal proteins that constitute the WPB-associated proteome. See the article by Holthenrich et al on page <a href="/content/134/12/979">979</a>.</p> Volume 134, Issue 12 Volume 134, Issue 12 September 19 2019 Pages 909-994 Cover image

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    Confocal image of human umbilical vein endothelial cells expressing a Rab27a-APEX2 construct that localizes to Weibel-Palade bodies (WPBs). APEX2 activation leads to the biotinylation of proximal proteins that constitute the WPB-associated proteome. See the article by Holthenrich et al on page 979.

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  • <p>Weak tyrosine-phosphorylated STAT3 staining (brown) in keratinocytes and lymphocytes in skin lesions from cutaneous T-cell lymphoma following aggressive antibiotic treatment, indicating that eradication of <i>Staphylococcus aureus</i> is associated with inhibition of tumor and disease activity. See the article by Lindahl et al on page <a href="/content/134/13/1072">1072</a>.</p> Volume 134, Issue 13 Volume 134, Issue 13 September 26 2019 Pages 995-1112 Cover image

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    Weak tyrosine-phosphorylated STAT3 staining (brown) in keratinocytes and lymphocytes in skin lesions from cutaneous T-cell lymphoma following aggressive antibiotic treatment, indicating that eradication of Staphylococcus aureus is associated with inhibition of tumor and disease activity. See the article by Lindahl et al on page 1072.

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  • <p>Bone marrow infiltration by T-cell prolymphocytic leukemia (T-PLL) cells depicted by immunohistologic double staining with CD5 (red) and TCL1 (brown). Notice the cytoplasmatic expression of the TCL1 oncogene that is characteristic for T-PLL. See the article by Staber et al on page <a href="/content/134/14/1132">1132</a>.</p> Volume 134, Issue 14 Volume 134, Issue 14 October 3 2019 Pages 1113-1195 Cover image

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    Bone marrow infiltration by T-cell prolymphocytic leukemia (T-PLL) cells depicted by immunohistologic double staining with CD5 (red) and TCL1 (brown). Notice the cytoplasmatic expression of the TCL1 oncogene that is characteristic for T-PLL. See the article by Staber et al on page 1132.

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  • <p>Calcified osteoblasts stained with alizarin red after in vitro differentiation of Lepr-cre<sup>&#x2212;</sup> mesenchymal stromal cells from the bone marrow niche. See the article by Mende et al on page <a href="/content/134/15/1214">1214</a>.</p> Volume 134, Issue 15 Volume 134, Issue 15 October 10 2019 Pages 1197-1272 Cover image

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    Calcified osteoblasts stained with alizarin red after in vitro differentiation of Lepr-cre mesenchymal stromal cells from the bone marrow niche. See the article by Mende et al on page 1214.

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