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  • <p>Iron-stained bone marrow aspirate smear from a male with X-linked sideroblastic anemia demonstrating intramitochondrial iron staining (blue) ringing around late erythroblast nuclei. Several enucleated red blood cells with iron-positive granules (siderocytes) are also present. See the article by Ducamp and Fleming on page <a href="/content/133/1/59">59</a>.</p> Volume 133, Issue 1 Volume 133, Issue 1 January 3 2019 Pages 1-101 Cover image

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    Iron-stained bone marrow aspirate smear from a male with X-linked sideroblastic anemia demonstrating intramitochondrial iron staining (blue) ringing around late erythroblast nuclei. Several enucleated red blood cells with iron-positive granules (siderocytes) are also present. See the article by Ducamp and Fleming on page 59.

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  • <p>Phospho-MLKL (pMLKL) staining of bone marrow from a patient with refractory anemia with ringed sideroblasts. Bone marrow was stained with anti-pMLKL antibody (green), and bone marrow nuclei were stained with DAPI (4&#x0027;,6-diamidino-2-phenylindole; blue). See the article by Wagner et al on page <a href="/content/133/2/107">107</a>.</p>
 Volume 133, Issue 2 Volume 133, Issue 2 January 10 2019 Pages 103-182 Cover image

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    Phospho-MLKL (pMLKL) staining of bone marrow from a patient with refractory anemia with ringed sideroblasts. Bone marrow was stained with anti-pMLKL antibody (green), and bone marrow nuclei were stained with DAPI (4',6-diamidino-2-phenylindole; blue). See the article by Wagner et al on page 107.

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  • <p>Bleeding caused by cerebral cavernous malformations (CCMs). The image shows prominent hemorrhages associated with CCMs in the hindbrain of a <i>Pdcd10<sup>ECKO</sup></i> mouse. See the article by Lopez-Ramirez et al on page <a href="/content/133/3/193">193</a>.</p> Volume 133, Issue 3 Volume 133, Issue 3 January 17 2019 Pages 183-286 Cover image

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    Bleeding caused by cerebral cavernous malformations (CCMs). The image shows prominent hemorrhages associated with CCMs in the hindbrain of a Pdcd10ECKO mouse. See the article by Lopez-Ramirez et al on page 193.

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  • <p>t-Distributed stochastic neighbor embedding representation of splenic cell types in wild-type mice (blue) and mice with a functional defect in dendritic cells (red). A novel population of myeloid precursor&#x2013;like cells emerges only in the mice with functional defects in dendritic cells, the development of a myeloproliferative disorder. See the article by Humblet-Baron et al on page <a href="/content/133/4/319">319</a>.</p> Volume 133, Issue 4 Volume 133, Issue 4 January 24 2019 Pages 287-381 Cover image

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    t-Distributed stochastic neighbor embedding representation of splenic cell types in wild-type mice (blue) and mice with a functional defect in dendritic cells (red). A novel population of myeloid precursor–like cells emerges only in the mice with functional defects in dendritic cells, the development of a myeloproliferative disorder. See the article by Humblet-Baron et al on page 319.

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  • <p>Superoxide derived from acute myeloid leukemia (AML) drives bone marrow stromal cell senescence through upregulation of p16INK4a. The image shows stromal cell senescence associated &#x03B2;-galactosidase staining (blue) after culture with AML blasts. See the article by Abdul-Aziz et al on page <a href="/content/133/5/446">446</a>.</p> Volume 133, Issue 5 Volume 133, Issue 5 January 31 2019 Pages 383-502 Cover image

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    Superoxide derived from acute myeloid leukemia (AML) drives bone marrow stromal cell senescence through upregulation of p16INK4a. The image shows stromal cell senescence associated β-galactosidase staining (blue) after culture with AML blasts. See the article by Abdul-Aziz et al on page 446.

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  • <p>Immunofluorescence image showing fibrin/fibrinogen (blue), blood vessels (CD31, white), platelets (CD41, red), and <i>Salmonella</i> Typhimurium (STm, green) in the spleen of a mouse 1 day after infection with STm. Thrombi induced after STm infection do not contain bacteria. See the article by Beristain-Covarrubias et al on page <a href="/content/133/6/600">600</a>.</p> Volume 133, Issue 6 Volume 133, Issue 6 February 7 2019 Pages 503-620 Cover image

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    Immunofluorescence image showing fibrin/fibrinogen (blue), blood vessels (CD31, white), platelets (CD41, red), and Salmonella Typhimurium (STm, green) in the spleen of a mouse 1 day after infection with STm. Thrombi induced after STm infection do not contain bacteria. See the article by Beristain-Covarrubias et al on page 600.

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  • <p>Illustration based on brain magnetic resonance imaging (MRI) of an acute lymphoblastic leukemia patient&#x2013;derived xenograft treated with CD19-directed chimeric antigen receptor T-cell (CART19) therapy and granulocyte-macrophage colony-stimulating factor (GM-CSF)&#x2013;neutralizing antibodies. GM-CSF depletion during CART19 therapy results in reduced neuroinflammation. See the article by Sterner et al on page <a href="/content/133/7/697">697</a>.</p>
 Volume 133, Issue 7 Volume 133, Issue 7 February 14 2019 Pages 621-768 Cover image

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    Illustration based on brain magnetic resonance imaging (MRI) of an acute lymphoblastic leukemia patient–derived xenograft treated with CD19-directed chimeric antigen receptor T-cell (CART19) therapy and granulocyte-macrophage colony-stimulating factor (GM-CSF)–neutralizing antibodies. GM-CSF depletion during CART19 therapy results in reduced neuroinflammation. See the article by Sterner et al on page 697.

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  • <p>This whole-mount in situ hybridization image with a probe targeting <i>cmyb</i> (cellular progenitor of the avian myeloblastosis virus oncogene) reveals a reduced number of hematopoietic stem and progenitor cells in the caudal hematopoietic tissue of <i>bcas2</i> (breast carcinoma amplified sequence 2) knockout zebrafish embryos 3 days after fertilization. See the article by Yu et al on page <a href="/content/133/8/805">805</a>.</p> Volume 133, Issue 8 Volume 133, Issue 8 February 21 2019 Pages 769-884 Cover image

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    This whole-mount in situ hybridization image with a probe targeting cmyb (cellular progenitor of the avian myeloblastosis virus oncogene) reveals a reduced number of hematopoietic stem and progenitor cells in the caudal hematopoietic tissue of bcas2 (breast carcinoma amplified sequence 2) knockout zebrafish embryos 3 days after fertilization. See the article by Yu et al on page 805.

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  • <p>Fluorescence in situ hybridization showing centromeres (red) and extra signals of the <i>CCNE2</i> gene (green) in a skin tissue specimen from a patient with cyclin D1&#x2013;negative mantle cell lymphoma with <i>CCNE1</i> and <i>CCNE2</i> overexpression and lack of <i>CCND1</i>, <i>CCND2</i>, or <i>CCND3</i> genomic rearrangement. See the article by Mart&#x00ED;n-Garcia et al on page <a href="/content/133/9/940">940</a>.</p> Volume 133, Issue 9 Volume 133, Issue 9 February 28 2019 Pages 885-1000 Cover image

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    Fluorescence in situ hybridization showing centromeres (red) and extra signals of the CCNE2 gene (green) in a skin tissue specimen from a patient with cyclin D1–negative mantle cell lymphoma with CCNE1 and CCNE2 overexpression and lack of CCND1, CCND2, or CCND3 genomic rearrangement. See the article by Martín-Garcia et al on page 940.

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  • <p>The image shows a representative megakaryocyte from a patient with a germline <i>GATA2</i> mutation that evolved to a low-grade myelodysplastic syndrome (MDS) with trisomy 8. Large megakaryocytes with hyper-convoluted nuclei are often seen in patients with <i>GATA2</i>-associated disorders that evolve to MDS or marrow hypoplasia. See the review series on MDSs in this issue.</p> Volume 133, Issue 10 Volume 133, Issue 10 March 7 2019 Pages 1001-1165 Cover image

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    The image shows a representative megakaryocyte from a patient with a germline GATA2 mutation that evolved to a low-grade myelodysplastic syndrome (MDS) with trisomy 8. Large megakaryocytes with hyper-convoluted nuclei are often seen in patients with GATA2-associated disorders that evolve to MDS or marrow hypoplasia. See the review series on MDSs in this issue.

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  • <p>Scanning electron micrograph of a fibrin clot formed in the presence of a fibrinogen-binding Affimer protein. These small conformational proteins have the ability to modulate fibrin clot properties, including clot structure and lysis, and thus they have potential as future therapeutic agents. See the article by Kearney et al on page <a href="/content/133/11/1233">1233</a>.</p> Volume 133, Issue 11 Volume 133, Issue 11 March 14 2019 Pages 1167-1265 Cover image

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    Scanning electron micrograph of a fibrin clot formed in the presence of a fibrinogen-binding Affimer protein. These small conformational proteins have the ability to modulate fibrin clot properties, including clot structure and lysis, and thus they have potential as future therapeutic agents. See the article by Kearney et al on page 1233.

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  • <p>Megakaryocyte of a patient with thrombocytopenia due to mutations in <i>PTPRJ</i> extending proplatelets on a fibrinogen-coated surface. The megakaryocyte is stained with anti&#x2013;&#x03B2;1-tubulin (red). The nucleus is counterstained with Hoechst (blue). Proplatelets exhibit an altered morphology that is characterized by reduced length and ramification of their shafts, resulting in a small number of proplatelet tips. See the article by Marconi et al on page <a href="/content/133/12/1346">1346</a>.</p> Volume 133, Issue 12 Volume 133, Issue 12 March 21 2019 Pages 1267-1386 Cover image

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    Megakaryocyte of a patient with thrombocytopenia due to mutations in PTPRJ extending proplatelets on a fibrinogen-coated surface. The megakaryocyte is stained with anti–β1-tubulin (red). The nucleus is counterstained with Hoechst (blue). Proplatelets exhibit an altered morphology that is characterized by reduced length and ramification of their shafts, resulting in a small number of proplatelet tips. See the article by Marconi et al on page 1346.

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  • <p>Megakaryocyte in the bone marrow of an Mpl-deficient mouse. A relatively small megakaryocyte with a less-lobulated nucleus is located close to blood vessels (formalin-fixed, paraffin-embedded section; hematoxylin and eosin staining; magnification &#x00D7;1000). See the article by Kohlscheen et al on page <a href="/content/133/13/1465">1465</a>.</p> Volume 133, Issue 13 Volume 133, Issue 13 March 28 2019 Pages 1387-1518 Cover image

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    Megakaryocyte in the bone marrow of an Mpl-deficient mouse. A relatively small megakaryocyte with a less-lobulated nucleus is located close to blood vessels (formalin-fixed, paraffin-embedded section; hematoxylin and eosin staining; magnification ×1000). See the article by Kohlscheen et al on page 1465.

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  • <p>Confocal microscopy image of human umbilical vein endothelial cells stained for CD31 (green), von Willebrand factor (VWF, red), and nuclei (blue) in a microfluidic chamber illustrating surface expression of VWF after 24-hour exposure to the BCR-ABL tyrosine kinase inhibitor ponatinib. See the article by Latifi et al on page <a href="/content/133/14/1597">1597</a>.</p> Volume 133, Issue 14 Volume 133, Issue 14 April 4 2019 Pages 1519-1612 Cover image

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    Confocal microscopy image of human umbilical vein endothelial cells stained for CD31 (green), von Willebrand factor (VWF, red), and nuclei (blue) in a microfluidic chamber illustrating surface expression of VWF after 24-hour exposure to the BCR-ABL tyrosine kinase inhibitor ponatinib. See the article by Latifi et al on page 1597.

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  • <p>Silver-stained marrow of a wild-type mouse transplanted with bone marrow from a JAK2V617F transgenic mouse. Macrophage depletion can prevent this severe myelofibrosis. See the article by Wakahashi et al on page <a href="/content/133/15/1619">1619</a>.</p> Volume 133, Issue 15 Volume 133, Issue 15 April 11 2019 Pages 1613-1696 Cover image

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    Silver-stained marrow of a wild-type mouse transplanted with bone marrow from a JAK2V617F transgenic mouse. Macrophage depletion can prevent this severe myelofibrosis. See the article by Wakahashi et al on page 1619.

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  • <p>Immunofluorescence micrograph of a human megakaryocyte derived from a filamin A&#x2013;mutated induced pluripotent cell line on fibrinogen. The presence of large stress fibers (green) results from the abnormal activity of the small GTPase RhoA caused by the absence of the filamin A protein. See the article by Donada et al on page <a href="/content/133/16/1778">1778</a>.</p> Volume 133, Issue 16 Volume 133, Issue 16 April 18 2019 Pages 1697-1791 Cover image

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    Immunofluorescence micrograph of a human megakaryocyte derived from a filamin A–mutated induced pluripotent cell line on fibrinogen. The presence of large stress fibers (green) results from the abnormal activity of the small GTPase RhoA caused by the absence of the filamin A protein. See the article by Donada et al on page 1778.

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  • <p>Molecular models of human ADAMTS13 domains are fitted into an envelope determined by small angle X-ray scattering and colored as follows: metalloprotease (M, orange); disintegrin-like (D, yellow); thrombospondin-1 (T1, green); Cys-rich (C, sky blue); spacer (S, lavender); T2, T4, T5, T7, and T8 (green); T3 and T6 (yellow); linkers between T4 and T5 (T4L) and between T8 and CUBs (T8L, gray); CUB1 (red); and CUB2 (brick red). The intervening nonessential T domains extend like a hairpin away from the core MDTCS and T7-CUB domains with a hinge between T4 and T5 that allows close packing of T domains. Two studies in this issue independently report critical insights into the structure and function of ADAMTS13. For the source of this issue&#x0027;s cover image, see the article by Zhu et al on page <a href="/content/133/17/1909">1909</a>.</p> Volume 133, Issue 17 Volume 133, Issue 17 April 25 2019 Pages 1793-1920 Cover image

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    Molecular models of human ADAMTS13 domains are fitted into an envelope determined by small angle X-ray scattering and colored as follows: metalloprotease (M, orange); disintegrin-like (D, yellow); thrombospondin-1 (T1, green); Cys-rich (C, sky blue); spacer (S, lavender); T2, T4, T5, T7, and T8 (green); T3 and T6 (yellow); linkers between T4 and T5 (T4L) and between T8 and CUBs (T8L, gray); CUB1 (red); and CUB2 (brick red). The intervening nonessential T domains extend like a hairpin away from the core MDTCS and T7-CUB domains with a hinge between T4 and T5 that allows close packing of T domains. Two studies in this issue independently report critical insights into the structure and function of ADAMTS13. For the source of this issue's cover image, see the article by Zhu et al on page 1909.

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  • <p>COS-7 cells transfected with wild-type RAC2 and green fluorescent protein expression vectors. Staining of RAC2 (red) and F-actin (orange) shows a nascent phagocytic cup with high levels of RAC2 protein (cell on right). Unlike mutant RAC2[E62K], overexpression of normal RAC2[wild-type] does not affect actin formation. See the article by Hsu et al on page <a href="/content/133/18/1977">1977</a>.</p> Volume 133, Issue 18 Volume 133, Issue 18 May 2 2019 Pages 1921-1999 Cover image

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    COS-7 cells transfected with wild-type RAC2 and green fluorescent protein expression vectors. Staining of RAC2 (red) and F-actin (orange) shows a nascent phagocytic cup with high levels of RAC2 protein (cell on right). Unlike mutant RAC2[E62K], overexpression of normal RAC2[wild-type] does not affect actin formation. See the article by Hsu et al on page 1977.

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  • <p>Induction of interferon-induced transmembrane protein 3 (IFITM3) in human megakaryocytes prevents dengue virus infection. Mature CD34<sup>+</sup>-derived megakaryocytes expressing IFITM3 (magenta) are protected against dengue virus infection (yellow). Nuclei were stained with TO-PRO-3 (blue). See the article by Campbell et al on page <a href="/content/133/19/2013">2013</a>.</p> Volume 133, Issue 19 Volume 133, Issue 19 May 9 2019 Pages 2001-2109 Cover image

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    Induction of interferon-induced transmembrane protein 3 (IFITM3) in human megakaryocytes prevents dengue virus infection. Mature CD34+-derived megakaryocytes expressing IFITM3 (magenta) are protected against dengue virus infection (yellow). Nuclei were stained with TO-PRO-3 (blue). See the article by Campbell et al on page 2013.

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  • <p>Confocal image of human acute myeloid leukemia 8227 CD34<sup>+</sup> CD38<sup>+</sup> cells overexpressing the PAK4 inhibitor <i>C3orf54/INKA1</i>. INKA1 regulates G<sub>0</sub> exit of leukemia stem cells by interfering with nuclear localization of PAK4 (red), with concomitant reduction of H4K16ac (green) and CDK6 (yellow; blue: DAPI [4&#x0027;,6-diamidino-2-phenylindole]) levels. See the article by Kaufmann et al on page <a href="/content/133/20/2198">2198</a>.</p> Volume 133, Issue 20 Volume 133, Issue 20 May 16 2019 Pages 2111-2244 Cover image

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    Confocal image of human acute myeloid leukemia 8227 CD34+ CD38+ cells overexpressing the PAK4 inhibitor C3orf54/INKA1. INKA1 regulates G0 exit of leukemia stem cells by interfering with nuclear localization of PAK4 (red), with concomitant reduction of H4K16ac (green) and CDK6 (yellow; blue: DAPI [4',6-diamidino-2-phenylindole]) levels. See the article by Kaufmann et al on page 2198.

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  • <p>JAK2 (cyan) is phosphorylated (magenta) in tartrate-resistant acid phosphatase (green)/cathepsin K (red)&#x2013;positive osteoclasts located along sclerotic bone trabecula of a myelofibrosis patient with a <i>JAK2</i><sup>V617F</sup> mutation. Nuclei are stained blue. See the article by Veletic et al on page <a href="/content/133/21/2320">2320</a>.</p> Volume 133, Issue 21 Volume 133, Issue 21 May 23 2019 Pages 2245-2353 Cover image

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    JAK2 (cyan) is phosphorylated (magenta) in tartrate-resistant acid phosphatase (green)/cathepsin K (red)–positive osteoclasts located along sclerotic bone trabecula of a myelofibrosis patient with a JAK2V617F mutation. Nuclei are stained blue. See the article by Veletic et al on page 2320.

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  • <p>Electron micrograph of bone marrow eosinophils from Trib1-deficient mice. Note the typical eosinophil-specific granules with a centrally located crystalloid electron-dense core as well as smaller neutrophil-type granules, reflecting the dysregulated identity of these cells in the absence of Trib1. See the article by Mack et al on page <a href="/content/133/22/2413">2413</a>.</p> Volume 133, Issue 22 Volume 133, Issue 22 May 30 2019 Pages 2355-2460 Cover image

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    Electron micrograph of bone marrow eosinophils from Trib1-deficient mice. Note the typical eosinophil-specific granules with a centrally located crystalloid electron-dense core as well as smaller neutrophil-type granules, reflecting the dysregulated identity of these cells in the absence of Trib1. See the article by Mack et al on page 2413.

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  • <p>An image of the thrombus formed 1 hour after electrolytic injury in the femoral vein of a sickle cell mouse transfused with wild-type red blood cells labeled with a DiD lipophilic tracer. Notice an incorporation of wild-type red blood cells (red) within the sickle thrombus. See the article by Faes et al on page <a href="/content/133/23/2529">2529</a>.</p> Volume 133, Issue 23 Volume 133, Issue 23 June 6 2019 Pages 2461-2551 Cover image

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    An image of the thrombus formed 1 hour after electrolytic injury in the femoral vein of a sickle cell mouse transfused with wild-type red blood cells labeled with a DiD lipophilic tracer. Notice an incorporation of wild-type red blood cells (red) within the sickle thrombus. See the article by Faes et al on page 2529.

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  • <p>Spleen section of a mouse with constitutive active CD30 in B lymphocytes 14 days after T cell&#x2013;dependent immunization. Germinal center (GC) cells, peanut agglutinin, and metallophilic macrophages are stained in blue, and B lymphocytes (immunoglobulin M) are stained in red. CD30 signaling blocks GC development, enhances plasma cell differentiation, and leads to lymphomagenesis in aged mice. See the article by Sperling et al on page <a href="/content/133/24/2597">2597</a>.</p> Volume 133, Issue 24 Volume 133, Issue 24 June 13 2019 Pages 2553-2625 Cover image

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    Spleen section of a mouse with constitutive active CD30 in B lymphocytes 14 days after T cell–dependent immunization. Germinal center (GC) cells, peanut agglutinin, and metallophilic macrophages are stained in blue, and B lymphocytes (immunoglobulin M) are stained in red. CD30 signaling blocks GC development, enhances plasma cell differentiation, and leads to lymphomagenesis in aged mice. See the article by Sperling et al on page 2597.

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  • <p>Hematoxylin and eosin staining of AT-3 mammary tumor resected 18 hours after platelet depletion. Note the drastic increase in intratumoral hemorrhage, which was absent in control immunoglobulin G&#x2013;treated mice. A similar increase in intratumoral bleeding can also be induced by blocking the platelet receptor glycoprotein VI. See the article by Volz et al on page <a href="/content/133/25/2696">2696</a>.</p> Volume 133, Issue 25 Volume 133, Issue 25 June 20 2019 Pages 2627-2731 Cover image

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    Hematoxylin and eosin staining of AT-3 mammary tumor resected 18 hours after platelet depletion. Note the drastic increase in intratumoral hemorrhage, which was absent in control immunoglobulin G–treated mice. A similar increase in intratumoral bleeding can also be induced by blocking the platelet receptor glycoprotein VI. See the article by Volz et al on page 2696.

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  • <p>Eosinophilic extracellular amorphous Congo red&#x2013;negative deposits admixed with some plasma cells without atypia are the histological hallmark of pulmonary light chain deposition disease (LCDD), an entity clinically and molecularly distinct from systemic LCDD. See the article by Camus et al on page <a href="/content/133/26/2741">2741</a>.</p> Volume 133, Issue 26 Volume 133, Issue 26 June 27 2019 Pages 2733-2809 Cover image

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    Eosinophilic extracellular amorphous Congo red–negative deposits admixed with some plasma cells without atypia are the histological hallmark of pulmonary light chain deposition disease (LCDD), an entity clinically and molecularly distinct from systemic LCDD. See the article by Camus et al on page 2741.

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  • <p>Multiplex immunofluorescence of a biopsy specimen from a patient with relapse of Hodgkin lymphoma after autologous stem cell transplantation and pembrolizumab consolidation. Neoplastic cells (dim magenta) are embedded in an environment rich in PD-1 (yellow) positive and negative T cells (white). See the article by Armand et al on page <a href="/content/134/1/22">22</a>.</p> Volume 134, Issue 1 Volume 134, Issue 1 July 4 2019 Pages 1-95 Cover image

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    Multiplex immunofluorescence of a biopsy specimen from a patient with relapse of Hodgkin lymphoma after autologous stem cell transplantation and pembrolizumab consolidation. Neoplastic cells (dim magenta) are embedded in an environment rich in PD-1 (yellow) positive and negative T cells (white). See the article by Armand et al on page 22.

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  • <p>Double-strand breaks marked by &#x03B3;-H2AX (cyan) in nuclei (purple) of TP53-mutant hematopoietic progenitors. Progenitors were generated from induced pluripotent stem cells, a useful model of myelodysplastic syndromes and clonal evolution. See the article by Hsu et al on page <a href="/content/134/2/186">186</a>.</p> Volume 134, Issue 2 Volume 134, Issue 2 July 11 2019 Pages 97-218 Cover image

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    Double-strand breaks marked by γ-H2AX (cyan) in nuclei (purple) of TP53-mutant hematopoietic progenitors. Progenitors were generated from induced pluripotent stem cells, a useful model of myelodysplastic syndromes and clonal evolution. See the article by Hsu et al on page 186.

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  • <p>Trichrome stain of the distal femur of a warfarin-treated mouse. Warfarin treatment induces a significant reduction in cancellous bone (green), induces an increase in osteoid volume (pink), and impairs hematopoiesis via inhibiting &#x03B3;-carboxylation of macrophage-derived periostin. See the article by Verma et al on page <a href="/content/134/3/227">227</a>.</p> Volume 134, Issue 3 Volume 134, Issue 3 July 18 2019 Pages 219-332 Cover image

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    Trichrome stain of the distal femur of a warfarin-treated mouse. Warfarin treatment induces a significant reduction in cancellous bone (green), induces an increase in osteoid volume (pink), and impairs hematopoiesis via inhibiting γ-carboxylation of macrophage-derived periostin. See the article by Verma et al on page 227.

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  • <p>Immunofluorescence photomicrograph of neutrophil extracellular traps (NETs, in red) triggered by exposure of neutrophils to 16 &#x03BC;M adenosine for 4 hours. Adenosine-mediated NET formation is implicated in a monogenic form of vasculitis known as deficiency of adenosine deaminase 2 (DADA2). See the article by Carmona-Rivera et al on page <a href="/content/134/4/395">395</a>.</p> Volume 134, Issue 4 Volume 134, Issue 4 July 25 2019 Pages 333-411 Cover image

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    Immunofluorescence photomicrograph of neutrophil extracellular traps (NETs, in red) triggered by exposure of neutrophils to 16 μM adenosine for 4 hours. Adenosine-mediated NET formation is implicated in a monogenic form of vasculitis known as deficiency of adenosine deaminase 2 (DADA2). See the article by Carmona-Rivera et al on page 395.

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  • <p>Cytospin image of an erythroblastic island formed between an EPO-pretreated macrophage (the cell in the center) and erythroblasts (surrounding cells). EPO/EPOR&#x2013;mediated signal transduction in human EPOR<sup>&#x002B; </sup>macrophages enhances erythroblastic island formation. See the article by Li et al on page <a href="/content/134/5/480">480</a>.</p> Volume 134, Issue 5 Volume 134, Issue 5 August 1 2019 Pages 413-492 Cover image

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    Cytospin image of an erythroblastic island formed between an EPO-pretreated macrophage (the cell in the center) and erythroblasts (surrounding cells). EPO/EPOR–mediated signal transduction in human EPOR+ macrophages enhances erythroblastic island formation. See the article by Li et al on page 480.

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  • <p>Phosphatidylinositol 3-kinase &#x03B4; inhibitor (iPI3K-&#x03B4;)&#x2013;resistant murine E&#x03BC;-TCL1 tumors stained with forkhead box O1 (FOXO1) and DAPI (4&#x2032;,6-diamidino-2-phenylindole). Notice the FOXO1 localization in the nucleus upon exposure to iPI3K-&#x03B4;, which leads to an increase in insulin-like growth factor 1 receptor expression and downstream signaling. See the article by Scheffold et al on page <a href="/content/134/6/534">534</a>.</p> Volume 134, Issue 6 Volume 134, Issue 6 August 8 2019 Pages 493-576 Cover image

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    Phosphatidylinositol 3-kinase δ inhibitor (iPI3K-δ)–resistant murine Eμ-TCL1 tumors stained with forkhead box O1 (FOXO1) and DAPI (4′,6-diamidino-2-phenylindole). Notice the FOXO1 localization in the nucleus upon exposure to iPI3K-δ, which leads to an increase in insulin-like growth factor 1 receptor expression and downstream signaling. See the article by Scheffold et al on page 534.

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  • <p>Hematoxylin and eosin&#x2013;stained liver tissue of a Townes sickle cell mouse with selective depletion of patrolling monocytes by treatment with a low dose of liposome-encapsulated clodronate. Notice the vascular stasis and infarcts. See the article by Liu et al on page <a href="/content/134/7/579">579</a>.</p> Volume 134, Issue 7 Volume 134, Issue 7 August 15 2019 Pages 577-659 Cover image

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    Hematoxylin and eosin–stained liver tissue of a Townes sickle cell mouse with selective depletion of patrolling monocytes by treatment with a low dose of liposome-encapsulated clodronate. Notice the vascular stasis and infarcts. See the article by Liu et al on page 579.

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  • <p>Nuclear magnetic resonance mapping interaction of an anticoagulant protein, Ixolaris, with factor X. Kunitz domains 1 and 2 are colored in wheat and light blue, respectively. The structural regions changing upon binding of factor X are colored in cyan and magenta. See the article by De Paula et al on page <a href="/content/134/8/699">699</a>.</p>
 Volume 134, Issue 8 Volume 134, Issue 8 August 22 2019 Pages 661-721 Cover image

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    Nuclear magnetic resonance mapping interaction of an anticoagulant protein, Ixolaris, with factor X. Kunitz domains 1 and 2 are colored in wheat and light blue, respectively. The structural regions changing upon binding of factor X are colored in cyan and magenta. See the article by De Paula et al on page 699.

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  • <p>Fluorescence microscopy image of hyaluronan (green) and inter-&#x03B1; inhibitor (red) in a murine model of colitis. The image shows leukocyte-adhesive hyaluronan matrices which surround intestinal microvessels and accumulate in the vessel lumen during inflammation. See the article by Petrey et al on page <a href="/content/134/9/765">765</a>.</p> Volume 134, Issue 9 Volume 134, Issue 9 August 29 2019 Pages 723-785 Cover image

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    Fluorescence microscopy image of hyaluronan (green) and inter-α inhibitor (red) in a murine model of colitis. The image shows leukocyte-adhesive hyaluronan matrices which surround intestinal microvessels and accumulate in the vessel lumen during inflammation. See the article by Petrey et al on page 765.

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  • <p>Silver-stained femur bone marrow section from a romiplostim-treated humanized NOG mouse. Elotuzumab ameliorated myelofibrosis induced by romiplostim administration. See the article by Maekawa et al on page <a href="/content/134/10/814">814</a>.</p> Volume 134, Issue 10 Volume 134, Issue 10 September 5 2019 Pages 787-843 Cover image

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    Silver-stained femur bone marrow section from a romiplostim-treated humanized NOG mouse. Elotuzumab ameliorated myelofibrosis induced by romiplostim administration. See the article by Maekawa et al on page 814.

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  • <p>B-cell receptor sequencing network for a monozygotic twin with concordant B-cell precursor acute lymphoblastic leukemia to track the clonal origin of the leukemia. See the article by Bueno et al on page <a href="/content/134/11/900">900</a>.</p> Volume 134, Issue 11 Volume 134, Issue 11 September 12 2019 Pages 845-908 Cover image

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    B-cell receptor sequencing network for a monozygotic twin with concordant B-cell precursor acute lymphoblastic leukemia to track the clonal origin of the leukemia. See the article by Bueno et al on page 900.

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  • <p>Confocal image of human umbilical vein endothelial cells expressing a Rab27a-APEX2 construct that localizes to Weibel-Palade bodies (WPBs). APEX2 activation leads to the biotinylation of proximal proteins that constitute the WPB-associated proteome. See the article by Holthenrich et al on page <a href="/content/134/12/979">979</a>.</p> Volume 134, Issue 12 Volume 134, Issue 12 September 19 2019 Pages 909-994 Cover image

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    Confocal image of human umbilical vein endothelial cells expressing a Rab27a-APEX2 construct that localizes to Weibel-Palade bodies (WPBs). APEX2 activation leads to the biotinylation of proximal proteins that constitute the WPB-associated proteome. See the article by Holthenrich et al on page 979.

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  • <p>Weak tyrosine-phosphorylated STAT3 staining (brown) in keratinocytes and lymphocytes in skin lesions from cutaneous T-cell lymphoma following aggressive antibiotic treatment, indicating that eradication of <i>Staphylococcus aureus</i> is associated with inhibition of tumor and disease activity. See the article by Lindahl et al on page <a href="/content/134/13/1072">1072</a>.</p> Volume 134, Issue 13 Volume 134, Issue 13 September 26 2019 Pages 995-1112 Cover image

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    Weak tyrosine-phosphorylated STAT3 staining (brown) in keratinocytes and lymphocytes in skin lesions from cutaneous T-cell lymphoma following aggressive antibiotic treatment, indicating that eradication of Staphylococcus aureus is associated with inhibition of tumor and disease activity. See the article by Lindahl et al on page 1072.

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  • <p>Bone marrow infiltration by T-cell prolymphocytic leukemia (T-PLL) cells depicted by immunohistologic double staining with CD5 (red) and TCL1 (brown). Notice the cytoplasmatic expression of the TCL1 oncogene that is characteristic for T-PLL. See the article by Staber et al on page <a href="/content/134/14/1132">1132</a>.</p> Volume 134, Issue 14 Volume 134, Issue 14 October 3 2019 Pages 1113-1195 Cover image

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    Bone marrow infiltration by T-cell prolymphocytic leukemia (T-PLL) cells depicted by immunohistologic double staining with CD5 (red) and TCL1 (brown). Notice the cytoplasmatic expression of the TCL1 oncogene that is characteristic for T-PLL. See the article by Staber et al on page 1132.

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  • <p>Calcified osteoblasts stained with alizarin red after in vitro differentiation of Lepr-cre<sup>&#x2212;</sup> mesenchymal stromal cells from the bone marrow niche. See the article by Mende et al on page <a href="/content/134/15/1214">1214</a>.</p> Volume 134, Issue 15 Volume 134, Issue 15 October 10 2019 Pages 1197-1272 Cover image

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    Calcified osteoblasts stained with alizarin red after in vitro differentiation of Lepr-cre mesenchymal stromal cells from the bone marrow niche. See the article by Mende et al on page 1214.

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