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Research Article September 26 2023
Germline variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy
Daria Frank,Pradeep Kumar Patnana,Jan Vorwerk,Lianghao Mao,Lavanya Mokada Gopal,Noelle Jung,Thorben Hennig,Leo Ruhnke,Joris Maximillian Frenz,Maithreyan Kuppusamy,Robert J Autry,Lanying Wei,Kaiyan Sun,Helal Ahmed,Axel Künstner,Hauke Busch,Heiko Müller,Stephan Hutter,Gregor Hoermann,Longlong Liu,Xiaoqing Xie,Yahya Al-Matary,Subbaiah Chary Nimmagadda,Fiorella Charles Cano,Michael Heuser,Felicitas R. Thol,Gudrun Göhring,Doris Steinemann,Jürgen Thomale,Theo Leitner,Anja Fischer,Roland Rad,Christoph Röllig,Heidi Altmann,Desiree Kunadt,Wolfgang E. Berdel,Jana Hüve,Felix Neumann,Jürgen Klingauf,Virginie Calderon,Bertram Opalka,Ulrich Dührsen,Frank Rosenbauer,Martin Dugas,Julian Varghese,H. Christian H. Reinhardt, Prof.,Nikolas von Bubnoff,Tarik Möröy,Georg Lenz,Aarif M.N. Batcha,Marianna Giorgi,Murugan Selvam,Eunice S. Wang,Shannon K. McWeeney,Jeffrey W. Tyner,Friedrich Stölzel,Matthias Mann,Ashok Kumar Jayavelu,Cyrus Khandanpour
Letter September 26 2023
A human genome editing-based MLL::AF4 B-cell ALL model recapitulates key cellular and molecular leukemogenic features
Clara Bueno,Raul Torres-Ruíz,Talia Velasco-Hernandez,Oscar Molina,Paolo Petazzi,Alba Martinez-Moreno,Virginia Carolina Rodríguez-Cortez,Meritxell Vinyoles,Sandra Cantilena,Owen Williams,Nerea Vega-García,Sandra Rodriguez-Perales,José Carlos Segovia,Oscar Quintana-Bustamante,Anindita Roy,Claus Meyer,Rolf Marschalek,Alastair Smith,Thomas A. Milne,Mario F. Fraga,Juan Ramón Ramón Tejedor,Pablo Menendez
Research Article September 22 2023
Inhibition of PLK4 remodels histone methylation and activates immune response via cGAS-STING pathway in TP53 mutated AML
Research Article September 22 2023
Loss-of-function of ENT3 drives histiocytosis and inflammation through TLR-MAPK signaling
Ruth Shiloh,Ruth Lubin,Odeya David,Ifat Geron,Elimelech Okon,Idit Hazan,Marketa Zaliova,Gil Amarilyo,Yehudit Birger,Yael Borovitz,Dafna Brik,Arnon Broides,Sarit Cohen-Kedar,Liora Harel,Eyal Kristal,Daria Kozlova,Galina Ling,Mika Shapira Rootman,Noa Shefer Averbuch,Shiri Spielman,Jan Trka,Shai Izraeli,Simon Yona,Sarah Elitzur
Letter September 22 2023
Tafasitamab and lenalidomide in large B cell lymphoma: real-world outcomes in a multicenter retrospective study
David A Qualls,Nicholas Lambert,Paolo F. Caimi,Mwanasha H Merrill,Priyanka Pullarkat,Richard C. Godby,David A Bond,Graham T Wehmeyer,Jason T. Romancik,Behzad Amoozgar,Lori A. Leslie,Loretta J Nastoupil,Jennifer L. Crombie,Jeremy S Abramson,Arushi Khurana,Grzegorz S. Nowakowski,Kami J Maddocks,Sarah C. Rutherford,Brad S Kahl,Michelle Okwali,Michael J Buege,Venkatraman E Seshan,Connie L. Batlevi,Gilles A. Salles
Research Article September 22 2023
Reinforced anti-myeloma therapy via dual-lymphoid activation mediated by a panel of antibodies armed with Bridging-BiTE
Research Article September 22 2023
Natural History Study of Patients with Familial Platelet Disorder with Myeloid Malignancy
Paul P. Liu,Lea Cunningham,Matthew Douglas Merguerian,Katherine R. Calvo,Joie Davis,Natalie T Deuitch,Alina E. Dulau-Florea,Nisha Patel,Kai Yu,Keith Sacco,Sumona Bhattacharya,Monica Passi,Neval Ozkaya,Seila Vanessa De Leon,Shawn Nathan Chong,Kathleen Marie Craft,Jamie L Diemer,Erica Bresciani,Kevin J O'Brien,Elizabeth J Andrews,Nguyen Park,Londa Hathaway,Edward W Cowen,Theo Heller,Kerry Ryan,Amisha Barochia,Khanh Nghiem,Julie E Niemela,Sergio D Rosenzweig,David J Young,Pamela Frischmeyer-Guerrerio,Raul C. Braylan
Research Article September 22 2023
EGR1-mediated metabolic reprogramming to oxidative phosphorylation contributes to ibrutinib resistance in B cell lymphoma
Research Article September 22 2023
TCRαβ/CD19 cell-depleted HLA-haploidentical transplantation to treat pediatric acute leukemia: updated final analysis
Pietro Merli,Mattia Algeri,Federica Galaverna,Valentina Bertaina,Barbarella Lucarelli,Emilia Boccieri,Marco Becilli,Francesco Quagliarella,Chiara Rosignoli,Simone Biagini,Elia Girolami,Antonella Meschini,Giovanna Del Principe,Raffaella Sborgia,Maria Luigia Catanoso,Roberto Carta,Luisa Strocchio,Rita Maria Pinto,Barbara Buldini,Michela Falco,Raffaella Meazza,Daniela Pende,Marco Andreani,Giuseppina Li Pira,Daria Pagliara,Franco Locatelli
Research Article September 20 2023
Integrated Epigenetic and Transcriptional Single-Cell Analysis of t(11;14) Multiple Myeloma and Its BCL2 Dependency
Research Article September 13 2023
How I treat secondary CNS involvement by aggressive lymphomas
Research Article September 12 2023
Spatial Transcriptomics Reveals Distinct Tissue Niches Linked with Steroid Responsiveness in Acute Gastrointestinal GVHD
Research Article September 12 2023
Hemostasis defects underlying the hemorrhagic syndrome caused by Mammarenaviruses in a cynomolgus macaque model
Blaise Lafoux,Nicolas Baillet,Caroline Picard,Gustave Fourcaud,Virginie Borges-Cardoso,Stéphanie Reynard,Alexandra Journeaux,Clara Germain,Emeline Perthame,Mathieu Mateo,Jimmy Hortion,Xavier Carnec,Natalia Pietrosemoli,Marie Moroso,Orianne Lacroix,Ophélie Jourjon,Stéphane Barron,Audrey Vallve,Aurélie Duthey,Frédéric Jacquot,Laura Barrot,Manon Dirheimer,Hervé Raoul,Christophe Nougier,Sylvain Baize
Research Article September 8 2023
Alternative splicing of its 5' UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies
Zhiwei Ang,Luca Paruzzo,Katharina E Hayer,Carolin Schmidt,Manuel Torres-Diz,Feng Xu,Urvi Zankharia,Yunlin Zhang,Samantha S. Soldan,Sisi Zheng,Catherine D Falkenstein,Joseph Patrick Loftus,Scarlett Y Yang,Mukta Asnani,Patricia King Sainos,Vinodh Pillai,Emeline R Chong,Marilyn Li,Sarah K Tasian,Yoseph Barash,Paul M Lieberman,Marco Ruella,Stephen J. Schuster,Andrei Thomas-Tikhonenko
Research Article September 8 2023
Follicular lymphoma evolves with a surmountable dependency on acquired glycosylation motifs in the B cell receptor
Research Article September 6 2023
How I treat von Willebrand disorders in the elderly
Research Article August 30 2023
Sorafenib plus intensive chemotherapy in newly diagnosed FLT3-ITD AML:a randomized, placebo-controlled study by the ALLG
Sun Loo,Andrew W Roberts,Natasha S Anstee,Glen A Kennedy,Simon Zhao-Xiong He,Anthony P Schwarer,Anoop Kumar Enjeti,James D'Rozario,Paula Marlton,Ian Bilmon,John M Taper,Gavin Cull,Campbell Tiley,Emma Verner,Uwe Hahn,Devendra K. Hiwase,Harry J Iland,Nicholas Edward Murphy, FRACP FRCPA,Sundra Ramanathan,John Reynolds,Doen Ming Ong,Ing Soo Tiong,Meaghan Wall,Michael Murray,Tristan Rawling,Joanna Leadbetter,Leesa Rowley,Maya Latimer,Sam L.S. Yuen,Stephen B. Ting,Chun Yew Fong,Kirk Lachlan Morris,Ashish Bajel,John F. Seymour,Mark J. Levis,Andrew H. Wei
Brief Report August 30 2023
Molecular MRD is strongly prognostic in patients with NPM1-mutated AML receiving venetoclax-based non-intensive therapy
Jad Othman,Ing Soo Tiong,Jenny O'Nions, Dr,Mike Dennis,Katya Mokretar,Adam Ivey,Michael James Austin,Annie-Louise Latif,Mariam Amer,Wei Yee Chan,Charles R Crawley,Francesca Crolla,Joe Wilson Cross,Raymond Dang,Johnathon Elliot,Chun Yew Fong,Sofia Galli,Paolo Gallipoli,Francesca Hogan,Pallavi Kalkur,Anjum Bashir Khan,Pramila Krishnamurthy,John Laurie,Sun Loo,Scott Marshall,Priyanka Mehta,Vidhya Murthy,Sateesh Nagumantry, Dr,Srinivas Pillai,Nicola Potter,Rob S. Sellar,Tom Taylor,Rui Zhao,Nigel H. Russell,Andrew H. Wei,Richard Dillon
Research Article August 30 2023
The effects of pathogenic variants for inherited hemostasis disorders in 140,214 UK Biobank participants
Luca Stefanucci,Janine H Collins,Matthew Christopher Sims,Iñigo Barrio-Hernandez,Luanluan Sun,Oliver Burren,Livia Perfetto,Isobel Bender,Tiffany J Callahan,Kathryn Fleming,Jose Antonio Guerrero,Henning Hermjakob,Maria J Martin,James David Stephenson,Kalpana Paneerselvam,Slavé Petrovski,Pablo Porras,Peter N Robinson,Quanli Wang,Xavier Watkins,Mattia Frontini,Roman A Laskowski,Pedro Beltrao,Emanuele Di Angelantonio,Keith Gomez,Michael Laffan,Willem H Ouwehand,Andrew D. Mumford,Kathleen Freson,Keren Jacqueline Carss,Kate Downes,Nicholas S Gleadall,Karyn Megy,Elspeth Bruford,Dragana Vuckovic
Research Article August 30 2023
A Phase 2 Trial of CD24Fc for Prevention of Graft-vs-Host Disease
Brief Report August 30 2023
CD19/CD22 targeting with co-transduced CAR T-cells to prevent antigen negative relapse after CAR T-cell therapy of B-ALL
Sara Ghorashian,Giovanna Lucchini,Rachel Richardson,Kyvi Nguyen,Craig Terris,Aleks Guvenel,Macarena Oporto Espuelas,Jenny Yeung,Danielle Pinner,Jan Chu,Lindsy Williams,Ka-Yuk Ko,Chloe Walding,Kelly Watts,Sarah Inglott,Rebecca Thomas,Christopher Connor,Stuart Paul Adams,Emma Gravett,Kimberley C Gilmour,Alka Lal,Bilyana Popova,Sangeetha Kunaseelan,Andre Lopes, Mr,Yenting Ngai,Allan Hackshaw,Evangelia K Kokalaki,Milena Balasch-Carulla,Khushnuma Mullanfiroze,Arina Lazareva,Vesna Pavasovic,Anupama Rao,Jack Bartram,Ajay Vora,Robert Chiesa,Juliana M Furtado Silva,Kanchan Rao,Denise Kathleen Bonney,Robert Wynn,Martin Pule,Rachael E Hough, Professor,Persis J. Amrolia
Research Article August 30 2023
A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk
Research Article August 30 2023
How I treat transplant-eligible patients with myelofibrosis
Research Article August 25 2023
Early B cell development and B cell maturation are impaired in patients with active hemophagocytic lymphohistiocytosis
Research Article August 25 2023
The oxylipin analogue CS585 prevents platelet activation and thrombosis through activation of the prostacyclin receptor
Research Article August 24 2023
Exploiting the CD200-CD200R Immune Checkpoint Axis in Multiple Myeloma to Enhance CAR-T Therapy
Research Article August 24 2023
Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress
Brief Report August 24 2023
Lineage-specific detection of residual disease predicts relapse in chronic myeloid leukemia patients stopping therapy
Review Article August 18 2023
Macrophage heterogeneity in the single cell era: facts and artefacts
Research Article August 18 2023
Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC
Shruthi Subramanian,Julie A I Thoms,Yizhou Huang,Carina Paola Cornejo Paramo,Forrest Charles Koch,Sebastien Jacquelin,Sylvie Shen,Emma Song,Swapna Joshi,Christopher Peter Brownlee, Mr,Petter S. Woll,Diego Chacon-Fajardo,Dominik Beck,David J Curtis,Kenneth Yehson,Vicki Antonenas,Tracey O'Brien,Annette Trickett,Jason A. Powell,Ian D Lewis,Stuart M Pitson,Maher K. Gandhi,Steven W Lane,Fatemeh Vafaee,Emily Wong,Berthold Gottgens,Hamid Rokny,Jason Wing Hon Wong,John E Pimanda
Letter August 18 2023
BRAFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis
Aldo A. Acosta-Medina,Paul Geraeds Kemps,Timo CE Zondag,Jithma P. Abeykoon,Jelske Forma-Borst,Eline Christine Steenwijk,Elizabeth A.M. Feijen,Jop C. Teepen,N. Nora Bennani,Susan M. Schram,Mithun Vinod Shah,Caroline Davidge-Pitts,Matthew J. Koster,Jay Ryu,Robert Vassallo,W. Oliver Tobin,Jason R. Young,Surendra Dasari,Karen L. Rech,Aishwarya Ravindran,Arjen HG Cleven,Robert M. Verdijk,Carel J.M. van Noesel,Brian V. Balgobind,Gerrit J. Bouma,Peerooz Saeed,Jos A.M. Bramer,Ruben AL de Groen,Joost S.P. Vermaat,Michiel A.J. van de Sande,Egbert F. Smit,Anton W. Langerak,Tom van Wezel,Sanne H. Tonino,Cor van den Bos,Jan AM van Laar,Ronald S. Go,Gaurav Goyal,Astrid G.S. van Halteren
Research Article August 18 2023
Genetic alterations and MRD refine risk assessment within KMT2A-rearranged B-cell precursor ALL in adult: a GRAALL study
Rathana Kim,Hugo Bergugnat,Cedric Pastoret,Florence Pasquier,Emmanuel Raffoux,Lise Larcher,Marie Passet,Nathalie Grardel,Eric Delabesse,Susanne Kubetzko,Aurélie Caye-Eude,Claus Meyer,Rolf Marschalek,Marina Lafage-Pochitaloff,Anne Thiebaut-Bertrand,Marie Balsat,Martine Escoffre-Barbe,Sabine Blum,Michael Baumann,Anne Banos,Nicole Straetmans,Maria Pilar Gallego-Hernanz,Yves Chalandon,Carlos Graux,Jean Soulier,Thibaut TL Leguay,Mathilde Hunault,Françoise Huguet,Veronique Lheritier,Herve Dombret,Nicolas Boissel,Emmanuelle Clappier
Research Article August 18 2023
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy
Peter Grant Miller,Adam S. Sperling,Christina Mayerhofer,Marie McConkey,Jana Maria Ellegast,Carmen Da Silva,Drew Nathaniel Cohen,Chuqi Wang,Azeem Sharda,Ni Yan,Subha Saha,Cameron Schluter,Ilexa Ashley Schechter,Mikołaj Słabicki,Brittany Sandoval,Josephine Kahn,Steffen Boettcher,Christopher J. Gibson,David T Scadden,Kimberly Stegmaier,Shruti Bhatt,R. Coleman Lindsley,Benjamin L Ebert
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