THE RESULTS OF THE 6th International Workshop on Human Leukocyte Differentiation Antigens were presented on November 10 through 14, 1996 at a conference held in Kobe, Japan. More than 500 laboratories worldwide participated in the evaluation of 1,152 antibodies and the characterization of more than 190 molecules during a 2-year period. Serologic, molecular, biochemical, histochemical, and functional characterization of the monoclonal antibodies (MoAbs) and the structures defined by them was undertaken by dedicated participating laboratories. The cross-lineage blind panels for all MoAbs, including every CD, every known candidate for CD status, and all MoAbs of undefined specificity, were analyzed by flow cytometry and the results of the blind panel study were subjected to statistical analysis to identify possible antibody clusters. The results obtained by all groups showed almost perfect accordance. Detailed results of these workshop studies will be published separately.1 Concise summaries (CD guides) for each of the 190 molecules have also been written by experts and are undergoing peer review. (These summaries will be available on the WWW starting in February 1997 at http://www.ncbi.nlm.nih.gov/prow For information, send e-mail to prow@nih.gov.) In addition, the workshop database has been made accessible on the World Wide Web server to provide identifying information on all molecules and MoAbs studied in the workshop and to display and analyze quantitative expression of each molecule on more than 70 cell types used for the cross-lineage blind panel study. (The database of the workshop is accessible on the WWW at http://mol.genes.nig.ac.jp/hlda/ For information, send e-mail to hlda-master@ddbj.nig.ac.jp.) Based on these findings, the workshop organizers are pleased to recommend the adoption of 41 new CD clusters and subclusters and the redefinition of 11 previously established clusters. Table 1 summarizes the additions and changes made to the existing CD nomenclature.

Table 1.

CD Antigens 1996

CD DesignationCommon Name/RemarksWorkshop Section
CD45RC Restricted epitope of CD45 Nonlineage 
CD52 CDw52 Nonlineage 
CD65 CDw65 Myeloid 
CD65s Sialylated form of CD65 Myeloid 
CD66f PMG-1 Myeloid 
CD84 CDw84 B cell 
CD90 CDw90, Thy-1 Adhesion 
CD101 CDw101 Myeloid 
CD114 G-CSFR Myeloid 
CD109 CDw109 Endothelial 
CD116 CDw116, GM-CSFR Cytokine 
CD121a CDw121a, IL-1R; type 1 Cytokine 
CDw123 IL-3Rα Cytokine 
CD124 CDw124, IL-4R Cytokine 
CDw125 IL-5Rα Cytokine 
CD127 CDw127, IL-7R Cytokine 
CD130 CDw130, IL-6R-gp130 signal transducer Cytokine 
CDw131 Common β Cytokine 
CD132 Common γ Cytokine 
CD134 OX40 Cytokine 
CD135 Flt3, Flk2 Cytokine 
CDw136 MSP-R, macrophage stimulating protein-receptor Cytokine 
CDw137 4-1BB Cytokine 
CD138 Syndecan-1 B cell 
CD139  B cell 
CD140a PDGFRα, platelet–derived growth factor receptor Endothelial 
CD140b PDGFRβ, platelet–derived growth factor receptor Endothelial 
CD141 Thrombomodulin Endothelial 
CD142 Tissue factor Endothelial 
CD143 ACE, angiotensin converting enzyme Endothelial 
CD144 VE-cadherin Endothelial 
CDw145  Endothelial 
CD146 MUC18, S-endo Endothelial 
CD147 Neurothelin, basigin Endothelial 
CD148 HPTP-eta, p260 phosphatase Nonlineage 
CDw149 MEM-133 Nonlineage 
CDw150 SLAM, IPO-3 Nonlineage 
CD151 PETA-3 Platelet 
CD152 CTLA-4 T cell 
CD153 CD30L, CD30 ligand T cell 
CD154 CD40L, CD40 ligand, T-BAM T cell 
CD155 PVR, polio virus receptor Myeloid 
CD156 ADAM8, MS2 (mouse homologue) Myeloid 
CD157 BST-1, MO-5 Myeloid 
CD158a p58.1, MHC class-I specific NK receptors NK cell 
CD158b p58.2 MHC class-I specific NK receptors NK cell 
CD161 NKRP-1 NK cell 
CD162 PSGL-1 Adhesion 
CD163 M130 Myeloid 
CD164 MGC-24 Adhesion 
CD165 GP37/AD2 Adhesion 
CD166 ALCAM Adhesion 
   
CD DesignationCommon Name/RemarksWorkshop Section
CD45RC Restricted epitope of CD45 Nonlineage 
CD52 CDw52 Nonlineage 
CD65 CDw65 Myeloid 
CD65s Sialylated form of CD65 Myeloid 
CD66f PMG-1 Myeloid 
CD84 CDw84 B cell 
CD90 CDw90, Thy-1 Adhesion 
CD101 CDw101 Myeloid 
CD114 G-CSFR Myeloid 
CD109 CDw109 Endothelial 
CD116 CDw116, GM-CSFR Cytokine 
CD121a CDw121a, IL-1R; type 1 Cytokine 
CDw123 IL-3Rα Cytokine 
CD124 CDw124, IL-4R Cytokine 
CDw125 IL-5Rα Cytokine 
CD127 CDw127, IL-7R Cytokine 
CD130 CDw130, IL-6R-gp130 signal transducer Cytokine 
CDw131 Common β Cytokine 
CD132 Common γ Cytokine 
CD134 OX40 Cytokine 
CD135 Flt3, Flk2 Cytokine 
CDw136 MSP-R, macrophage stimulating protein-receptor Cytokine 
CDw137 4-1BB Cytokine 
CD138 Syndecan-1 B cell 
CD139  B cell 
CD140a PDGFRα, platelet–derived growth factor receptor Endothelial 
CD140b PDGFRβ, platelet–derived growth factor receptor Endothelial 
CD141 Thrombomodulin Endothelial 
CD142 Tissue factor Endothelial 
CD143 ACE, angiotensin converting enzyme Endothelial 
CD144 VE-cadherin Endothelial 
CDw145  Endothelial 
CD146 MUC18, S-endo Endothelial 
CD147 Neurothelin, basigin Endothelial 
CD148 HPTP-eta, p260 phosphatase Nonlineage 
CDw149 MEM-133 Nonlineage 
CDw150 SLAM, IPO-3 Nonlineage 
CD151 PETA-3 Platelet 
CD152 CTLA-4 T cell 
CD153 CD30L, CD30 ligand T cell 
CD154 CD40L, CD40 ligand, T-BAM T cell 
CD155 PVR, polio virus receptor Myeloid 
CD156 ADAM8, MS2 (mouse homologue) Myeloid 
CD157 BST-1, MO-5 Myeloid 
CD158a p58.1, MHC class-I specific NK receptors NK cell 
CD158b p58.2 MHC class-I specific NK receptors NK cell 
CD161 NKRP-1 NK cell 
CD162 PSGL-1 Adhesion 
CD163 M130 Myeloid 
CD164 MGC-24 Adhesion 
CD165 GP37/AD2 Adhesion 
CD166 ALCAM Adhesion 
   

Address reprint requests to Hitoshi Kikutani, MD, Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565, Japan.

REFERENCE

1
Kishimoto T, Goyert S, Kikutani H, Mason D, Miyasaka M, Moretta L, Ohno T, Okumura K, Shaw S, Springer TA, Sugamura K, Sugawara H, von dem Borne AEGKr, Zola H (eds): Leucocyte Typing VI: White Cell Differentiation Antigens. New York, NY, Garland (in press)