There is now substantial evidence that a small group of V genes predominates in the Ig repertoire of preimmune B cells. This phenomenon of V gene restriction may reflect preferential accessibility of these genes to recombinase, homology-directed V gene rearrangement, promoters and enhances of V gene transcription, or positive and negative selection mediated by the anti-self binding properties of the B cells surface Ig. These mechanisms may operate alone or in combination to influence V gene rearrangement and populations of immature B cells. Although constraints on the pool of rearranged V genes may seem disadvantageous to the immune system, the mechanisms that generate the CDR3s of heavy and light chains ensure extensive diversity in the pre-B- cell population. In mature B cells, somatic mutation of V genes adds further diversity. CDR3 sequences and somatic mutations not only provide potentially useful clonal markers but also help to identify the normal counterparts of malignant B cells.
REVIEW| April 1, 1994
Immunoglobulin V regions and the B cell
Blood (1994) 83 (7): 1717-1730.
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AK Stewart, RS Schwartz; Immunoglobulin V regions and the B cell. Blood 1994; 83 (7): 1717–1730. doi: https://doi.org/10.1182/blood.V83.7.1717.bloodjournal8371717
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