Chronic myeloid leukemias and 5% to 20% of acute lymphoid leukemias are characterized by the Philadelphia chromosome, a reciprocal chromosomal translocation, t(9;22)(q34;q11), generating BCR-ABL and ABL-BCR fusion genes. Cytogenetic studies have recently shown a preferential involvement of the paternally derived chromosome 9 and the maternally derived chromosome 22 in this translocation, indicating that imprinting might be involved in the formation or selection of the translocation. In this study, we have identified a BamHI polymorphism in the coding region of BCR exon 1, allowing us to investigate whether both BCR alleles are transcribed. By using a reverse transcriptase-polymerase chain reaction assay, we show that both BCR alleles are expressed in the peripheral blood cells of normal individuals.
ARTICLES| June 15, 1994
No evidence for genomic imprinting of the human BCR gene
Blood (1994) 83 (12): 3441-3444.
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T Fioretos, N Heisterkamp, J Groffen; No evidence for genomic imprinting of the human BCR gene. Blood 1994; 83 (12): 3441–3444. doi: https://doi.org/10.1182/blood.V83.12.3441.bloodjournal83123441
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