The intravenous administration of phenylhydrazine caused a significantly greater destruction of red cells in adrenalectomized rats than in controls. Cortisone given to adrenalectomized rats prevented this increased destruction and maintained red cells at a level comparable to controls. ACTH almost completely prevented phenylhydrazine anemia in intact rats and the red cell level was significantly higher than that in intact rats which did not receive ACTH.

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