Several authors have reported the in vitro production of colony- stimulating factors (CSF) and interleukin-1 (IL-1) by the neoplastic cells from patients with acute myeloid leukemia (AML). Using a sensitive bioassay for IL-6, the capacity of the leukemic cells of 30 patients with AML to produce IL-6 was examined. IL-6 production was found to be specific for cells from patients with an AML with monocytic differentiation (12 of 15 M4 and M5 patients, 0 of 15 M1 and M2 patients). Moreover, IL-6 production was paralleled by IL-1 production. The IL-6- and IL-1-producing cells were mainly found in the more mature monocytic cell fractions, defined as CD14-positive and CD34-negative adherent cells. By limiting dilution experiments, it could be excluded that the production of IL-1 or IL-6 was due to contamination with normal monocytes.
Interleukin-6 and interleukin-1 production in acute leukemia with monocytoid differentiation
- Share Icon Share
- Tools Icon Tools
- Search Site
- PDF LinkPDF
CE van der Schoot, P Jansen, M Poorter, MR Wester, AE von dem Borne, LA Aarden, RH van Oers; Interleukin-6 and interleukin-1 production in acute leukemia with monocytoid differentiation. Blood 1989; 74 (6): 2081–2087. doi: https://doi.org/10.1182/blood.V74.6.2081.bloodjournal7462081
Download citation file: