Hairy cell leukemia (HCL) is frequently associated with severe pancytopenia. The authors detected high levels of tumor necrosis factor (TNF)-alpha in the bone marrow serum of patients with HCL and found anti-TNF-alpha neutralizing monoclonal antibodies (MoAbs) to be able to enhance hematopoiesis of HCL patients in in vitro colony assays. As potent producers of TNF-alpha, hairy cells could be identified, thus implicating the malignant population in the pathogenesis of hematopoietic failure due to inappropriate secretion of this cytokine.
High-level secretion of tumor necrosis factor-alpha contributes to hematopoietic failure in hairy cell leukemia [see comments]
- Share Icon Share
- Tools Icon Tools
- Search Site
- PDF LinkPDF
A Lindemann, WD Ludwig, W Oster, R Mertelsmann, F Herrmann; High-level secretion of tumor necrosis factor-alpha contributes to hematopoietic failure in hairy cell leukemia [see comments]. Blood 1989; 73 (4): 880–884. doi: https://doi.org/10.1182/blood.V73.4.880.bloodjournal734880
Download citation file: