A randomized crossover study of prophylactic immunoglobulin (IgG) therapy was performed in patients with chronic lymphocytic leukaemia (CLL) or non-Hodgkin's lymphoma (NHL). Twelve patients with hypogammaglobulinemia or a history of recurrent infections received infusions of IgG or placebo intravenously (IV) every 3 weeks for 1 year. They were then switched to the alternative preparation for another year. The number of serious bacterial infections was significantly less (P = .001; Mainland's cross-over method) in the months in which patients received IgG. Serious bacterial infections showed a trend to be associated with an IgG level less than 6.4 g/L (P = .046; Fisher's exact test).
Crossover study of immunoglobulin replacement therapy in patients with low-grade B-cell tumors
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H Griffiths, V Brennan, J Lea, C Bunch, M Lee, H Chapel; Crossover study of immunoglobulin replacement therapy in patients with low-grade B-cell tumors. Blood 1989; 73 (2): 366–368. doi: https://doi.org/10.1182/blood.V73.2.366.bloodjournal732366
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