Two patients with acute monocytic leukemia and heterozygous for the Mediterranean variant of the X-linked enzyme, glucose-6-phosphate dehydrogenase (G6PD), were investigated to determine the number and type of progenitor cells involved. Mosaicism for Mediterranean G6PD was assessed by the different rate of utilization of 2-deoxy glucose-6- phosphate (2dG6P) by normal and Mediterranean variants of G6PD. The monocytoid blasts were found to express one type of G6PD only, indicating their clonal origin from a common progenitor cell, whereas all other hemopoietic cell populations tested expressed the heterozygous phenotype. The finding of a unique involvement of the monocytic line in two cases of acute nonlymphocytic leukemia (ANLL) represents further evidence of heterogeneity of stem cell involvement in ANLL.
Clonal origin of cells restricted to monocytic differentiation in acute nonlymphocytic leukemia
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AM Ferraris, G Broccia, T Meloni, L Canepa, M Sessarego, GF Gaetani; Clonal origin of cells restricted to monocytic differentiation in acute nonlymphocytic leukemia. Blood 1984; 64 (4): 817–820. doi: https://doi.org/10.1182/blood.V64.4.817.bloodjournal644817
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