Two sisters in whom a diagnosis of Fanconi's anemia was made at ages 12 and 18 subsequently developed acute nonlymphocytic leukemia (ANLL). A third sibling had previously died at age 11 of apparent sepsis. Both sisters had cytogenetic studies that showed increased chromosomal breakage and a 46,XX karyotype, but subsequently developed ANLL after, or coincident with, the emergence of monosomy 7. These observations suggest that, in addition to myelodysplastic syndromes and defective neutrophil chemotaxis, monosomy 7 may be associated with the emergence of leukemia in this disorder.
Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7
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TJ Stivrins, RB Davis, W Sanger, J Fritz, DT Purtilo; Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7. Blood 1984; 64 (1): 173–176. doi: https://doi.org/10.1182/blood.V64.1.173.bloodjournal641173
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