T Maekawa, Y Sonoda, M Taniwaki, S Misawa, T Abe, T Takino; Ph1-positive acute lymphoblastic leukemia with a 14q+ chromosome abnormality. Blood 1984; 63 (2): 310–313. doi: https://doi.org/10.1182/blood.V63.2.310.310
A 13-yr-old Japanese female with acute lymphoblastic leukemia (ALL) that was associated with a Philadelphia chromosome (Ph1) as well as a 14q+ chromosome abnormality is reported. The cell surface phenotype of leukemic cells was determined to be non-T, non-B ALL on the basis of positive Ia-like antigen, terminal deoxynucleotidyl transferase activity, and lack of receptors for sheep erythrocytes, surface immunoglobulin, or intracytoplasmic mu-chain immunoglobulin. The combination of both a Ph1 and a 14q+ has not been reported previously in patients with ALL.