J Yourno, J Walsh, G Kornatowski, D O'Connor, SA Kumar; Nonspecific esterases of leukemia cell lines: evidence for activation of myeloid-associated zymogens in HL-60 by phorbol esters. Blood 1984; 63 (1): 238–241. doi: https://doi.org/10.1182/blood.V18.104.22.168
Myeloid leukemia cell line HL-60 contains fluoride-sensitive, myeloid- associated isoenzymes of nonspecific esterase that increase in activity when cultures are treated with phorbol ester. These isoenzymes are not detectable in B-lymphoblast cell line KLM-2, either in control or in phorbol-ester-treated cultures. No increased de novo synthesis of the isoenzymes is detectable in HL-60 treated with phorbol ester. The data suggest stimulated conversion of a preformed, myeloid-associated zymogen in HL-60.