LAWRENCE BERMAN, ALFRED A. KLEIN, HERMAN J. LINN, GAYLORD S. BATES; HYPERSPLENISM ASSOCIATED WITH FOLLICULAR LYMPHOBLASTOMA REPORT OF A CASE WITH SPLENECTOMY. Blood 1950; 5 (3): 286–292. doi: https://doi.org/10.1182/blood.V5.3.286.286
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A patient with secondary hypersplenism due to follicular lymphoblastoma of the spleen exhibited neutropenia and thrombocytopenia, the latter being of sufficient severity to require splenectomy.
Splenectomy was followed by clinical improvement due to restoration of the platelet count and cessation of purpura, whereas the neturopenia persisted.
The significance of the blood, bone marrow, and splenic findings is discussed in the light of current concepts of the mechanism of the hypersplenic effect on the peripheral blood picture.
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