A patient with chronic myelogenous leukemia developed anemia with evidence of increased red cell destruction. After anemia had persisted for eleven months in spite of 49 blood transfusions, splenectomy was performed. The hemolysis subsided and her health remained good during the following thirty months.

ACKNOWLEDGMENT We are indebted to Dr. George T. Harrell, Jr., Bowman Gray School of Medicine for hematologic data on the patient obtained before her admission to Duke Hospital.