Immunosuppressive therapy was used in seven hemophiliac and three nonhemophiliac patients with factor VIII inhibiors. Permanent disappearance of the inhibitor occurred in three hemophiliac and two nonhemophiliac patients following treatment with cyclophosphamide and factor VIII. Critical factors influencing the response to therapy may include both the titer and duration of the inhibitor and the degree of intervening factor VIII exposure prior to immunosuppressive therapy. Two severe hemophiliacs with low titer inhibitors that disappeared without specific therapy are also reported.
Immunosuppressive therapy of Factor VIII inhibitors
- Share Icon Share
- Tools Icon Tools
- Search Site
- PDF LinkPDF
MB Hultin, SS Shapiro, HS Bowman, FM Gill, AT Andrews, J Martinez, EM Eyster, WC Sherwood; Immunosuppressive therapy of Factor VIII inhibitors. Blood 1976; 48 (1): 95–108. doi: https://doi.org/10.1182/blood.V48.1.95.bloodjournal48195
Download citation file: