Abstract

The effect of chloramphenicol and a chloramphenicol analog, thiamphenicol, on the growth of bone marrow colony-forming cells in agar was investigated. At concentrations within therapeutic range, both drugs cause a marked reduction in the number of colonies and in the size of aggregates, indicating suppressed cellular proliferation. The inhibition appears to be reversible within a 24-hr period of cell-drug contact. In addition to their effect on CFC proliferation, CAP and TAP appear to influence the type of CFC differentiation resulting in predominance of macrophage colonies.

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