Human factor VIII, upon prolonged incubation at 37°C with plasmin, inhibits platelet aggregation induced by ADP, adrenaline, or collagen. The human factor VIII digests are not anticoagulant in the thrombin time or partial thromboplastin time. Factor VIII split products may interfere in vivo with platelet function and thus could contribute in some way to the hemorrhagic diathesis of fibrinolytic states.

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