Comparative studies of aspartyl-, leucyl-, seryl- and tyrosyl-tRNA by a reverse phase column co-chromatography have been performed between a human normal lymphoblast cell line (RPMI 1788) and a human myeloma cell line (RPMI 8226). The cell lines were derived from normal peripheral blood and peripheral blood of a patient with multiple myeloma and produce IgM and lambda-type light chain (Bence Jones protein), respectively. Similar chromatographic patterns were obtained for leucyl- and seryl-tRNA. Minor differences in aspartyl-tRNA and larger differences in tyrosyl-tRNA were observed.

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