The sera from 100 patients with chronic myeloid leukemia or acute leukemia and from 100 matched controls were screened for antibodies against a number of common viral and rickettsial antigens. No over-all depression of immune response to these antigens was noted. For 12 out of 13 antigens, there was good correspondence between patients and controls but a deficiency of leukemic patients with antibodies against adenovirus, though not formally significant, seems worthy of further study.

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