The present study demonstrated that of the 18 million thymus, lymph node, or spleen cells in cultures containing PHA, on the average only 540, 990, and 6,170 small lymphocytes, respectively, were located in the blood vessels of these organs when the cell suspensions were prepared. Even if all of these cells transformed in response to PHA, it is unlikely that they could account for the transformation observed. Therefore, it was concluded that the lymphocytes of the parenchyma possessed the ability to transform in response to mitogenic agents.

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