Intact granulocytes from man and rabbit hemolyze red cells in vitro. The hemolytic activity is related to the lysosomes. A highly-basic protein fraction from the lysosomes and lysosomal membrane material produce hemolysis in isosmotic buffered saline and increase the osmotic fragility of red cells. Sucrose does not inhibit this hemolytic activity but low temperature incubation and heparin do.

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