A method is described for determining quantitatively the form of the resistance distributions of red cell resistances to simple hemolysins. The normal range of variation is given for the resistance distributions to saponin, digitonin, and hypotonic NaCl, all at pH 7.0, and examples of departures from the normal, which may take the form of bimodalities after hemorrhagic or hemolytic episodes or of more persistent changes in the characteristics of the distributions, are provided.

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