J. GROEN, E. G. GODFRIED; THE OCCURRENCE OF NORMOBLASTS IN THE PERIPHERAL BLOOD IN CONGESTIVE HEART FAILURE: AN INDICATION OF UNFAVORABLE PROGNOSIS. Blood 1948; 3 (12): 1445–1452. doi: https://doi.org/10.1182/blood.V3.12.1445.1445
The authors recommend the search for normoblasts in the blood of patients with severe heart failure. When normoblasts are found, a marked interference with the oxygenation of the blood, either by pulmonary infarcts or thrombi inside the heart, is most likely to be present. It seems justifiable to consider the prognosis as very grave in these cases. This rule proved to hold even in those cases where, concomitant with an improvement in the heart failure, the normoblasts disappeared temporarily from the peripheral blood.