An infant with hemangioma-thrombocytopenia syndrome who was successfully treated with x-irradiation over the hemangioma is described. Studies showed suggestive platelet sequestration in the tumor (as well as spleen), decreased platelet survival, and red cell changes compatible with cell trauma. Speculations concerning the mechanism of the thrombocytopenia are discussed. It is suggested that careful attention should be given to red cell morphology in cases of giant hemangioma in children, particularly those associated with thrombocytopenia.

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