All these findings and the contradictory data in the literature show that the different types of nuclear projections in neutrophils, excluding the genetically determined drumsticks and sessile nodules, are nonspecific pseudosegments of the leukocytes. Their appearance depends on the segmentation, aging, and metabolism of the neutrophils. These features might be influenced by many factors, including possible hormonal effects. Our observations have shown, for instance, that androgens might induce an increase in the number of nuclear appendages. Although the appearance of these figures may be associated with certain diseases, it should not be regarded as a specific sign for a single pathologic or physiologic condition.