The rate of appearance of C14 in the heme and globin of peripheral blood following intravenous administration of glycine-2-C14 has been measured in normals and in patients with androgen-induced erythrocytosis, polycythemia vera (iron deficiency) and virilizing Cushing’s disease with polycythemia. In all these cases of accelerated erythropoiesis a common alteration of the globin specific activity curve was observed. Heme specific activity curves were not affected.

The changes in the globin specific activity curves are best explained by consideration of the marrow erythroid cellularity during erythrocytosis.

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