The distribution of abnormal hemoglobins and erythrocytic glucose-6-phosphate dehydrogenase deficiency in 2000 Mexican Indians is described. It is pointed out that the frequency of hemoglobin S and G-6-PD deficiency is low and directly related to Negro admixture. On the other hand, two rare mutants were encountered: hemoglobins Mexico and Chiapas, the former in 2 unrelated subjects. The clinical, hematologic, genetic and biochemical characteristics of Hb Chiapas are described.

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